793
Views
81
CrossRef citations to date
0
Altmetric
Research Article

The Potential of Small-Scale Fusion Experiments and the Gordon-Taylor Equation to Predict the Suitability of Drug/Polymer Blends for Melt Extrusion

, , &
Pages 549-560 | Published online: 31 May 2001

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Fan Meng, Sagar Kumar Paul, Shambhavi Borde & Harsh Chauhan. (2021) Investigating crystallization tendency, miscibility, and molecular interactions of drug–polymer systems for the development of amorphous solid dispersions. Drug Development and Industrial Pharmacy 47:4, pages 579-608.
Read now
Bart Claeys, Reinout Vandeputte, Bruno G. De Geest, Jean Paul Remon & Chris Vervaet. (2016) pH-independent immediate release polymethacrylate formulations – an observational study. Drug Development and Industrial Pharmacy 42:4, pages 578-583.
Read now
Mohammad A. Altamimi & Steven H. Neau. (2016) Use of the Flory–Huggins theory to predict the solubility of nifedipine and sulfamethoxazole in the triblock, graft copolymer Soluplus. Drug Development and Industrial Pharmacy 42:3, pages 446-455.
Read now
Sue May Lim, Zyu Wenn Pang, Hwei Yuin Tan, Mohsin Shaikh, Gorajana Adinarayana & Sanjay Garg. (2015) Enhancement of docetaxel solubility using binary and ternary solid dispersion systems. Drug Development and Industrial Pharmacy 41:11, pages 1847-1855.
Read now
M. Maniruzzaman, M. M. Rana, J. S. Boateng, J. C. Mitchell & D. Douroumis. (2013) Dissolution enhancement of poorly water-soluble APIs processed by hot-melt extrusion using hydrophilic polymers. Drug Development and Industrial Pharmacy 39:2, pages 218-227.
Read now
Parinda Srinarong, Hans de Waard, Henderik W Frijlink & Wouter LJ Hinrichs. (2011) Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations. Expert Opinion on Drug Delivery 8:9, pages 1121-1140.
Read now
Tazin Mahnaj, Salah U. Ahmed & Fotios M. Plakogiannis. (2011) Evaluating the efficacy of a group of nontraditional plasticizers on the glass transition temperature of ethyl cellulose polymer. Drug Development and Industrial Pharmacy 37:3, pages 342-350.
Read now
Michael M. Crowley, Feng Zhang, Michael A. Repka, Sridhar Thumma, Sampada B. Upadhye, Sunil Kumar Battu, James W. McGinity & Charles Martin. (2007) Pharmaceutical Applications of Hot-Melt Extrusion: Part I. Drug Development and Industrial Pharmacy 33:9, pages 909-926.
Read now
Xin Zheng, Rui Yang, Xing Tang & Liangyuan Zheng. (2007) Part I: Characterization of Solid Dispersions of Nimodipine Prepared by Hot-melt Extrusion. Drug Development and Industrial Pharmacy 33:7, pages 791-802.
Read now

Articles from other publishers (72)

Alex Mathers, Matouš Pechar, Fatima Hassouna & Michal Fulem. (2023) The step-wise dissolution method: An efficient DSC-based protocol for verification of predicted API–polymer compatibility. International Journal of Pharmaceutics 648, pages 123604.
Crossref
Vaibhav G. Bhamare & Ravindra K. Kamble. (2023) Hot Melt Extrusion: A Paradigm–Changing Technology. Recent Advances in Drug Delivery and Formulation 17:2, pages 120-131.
Crossref
Birte Grönniger, Andreas Danzer, Kristof Kimpe, Abhishek Singh & Gabriele Sadowski. (2023) Viscoelastic Behavior of Supercooled and Glassy ASDs at Humid Conditions Can Be Predicted. Molecular Pharmaceutics 20:5, pages 2568-2578.
Crossref
Birte Grönniger, Espen Fritschka, Ineke Fahrig, Andreas Danzer & Gabriele Sadowski. (2023) Water Sorption in Rubbery and Glassy Polymers, Nifedipine, and Their ASDs. Molecular Pharmaceutics 20:4, pages 2194-2206.
Crossref
Zhaoxian Wang, Hao Lou, Tahnee J. Dening & Michael J. Hageman. (2023) Biorelevant Dissolution Method Considerations for the Appropriate Evaluation of Amorphous Solid Dispersions: are Two Stages Necessary?. Journal of Pharmaceutical Sciences 112:4, pages 1089-1107.
Crossref
Weili Heng, Xiaoshuang He, Yutong Song, Jiawei Han, Zunting Pang, Shuai Qian, Jianjun Zhang, Yuan Gao & Yuanfeng Wei. (2022) Insights into Cocrystallization and Coamorphization Engineering Techniques in the Delivery of Traditional Chinese Medicine: Formation Mechanism, Solid-State Characterization, and Improved Pharmaceutical Properties. Crystal Growth & Design 22:8, pages 5110-5134.
Crossref
Susanne Page, Reto Maurer, Nicole Wyttenbach & Felix Ditzinger. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 287 326 .
Samarth D. Thakore, Junia Akhtar, Ranjna Jain, Amrit Paudel & Arvind K. Bansal. (2021) Analytical and Computational Methods for the Determination of Drug-Polymer Solubility and Miscibility. Molecular Pharmaceutics 18:8, pages 2835-2866.
Crossref
Chloé Parulski, Olivier Jennotte, Anna Lechanteur & Brigitte Evrard. (2021) Challenges of fused deposition modeling 3D printing in pharmaceutical applications: Where are we now?. Advanced Drug Delivery Reviews 175, pages 113810.
Crossref
Sixue Cheng & Gregory B. McKenna. (2021) Isothermal Crystallization and Time–Temperature Transformation of Amorphous Nifedipine: A Case of Polymorphism Formation and Conversion. Molecular Pharmaceutics 18:7, pages 2786-2802.
Crossref
Marta F. Simões, Rui M. A. Pinto & Sérgio Simões. (2021) Hot-Melt Extrusion: a Roadmap for Product Development. AAPS PharmSciTech 22:5.
Crossref
Hao Cheng, Weili Heng, Jiawei Han, Yuanfeng Wei, Linghe Zhang, Shuai Qian, Jianjun Zhang & Yuan Gao. 2021. Novel Drug Delivery Systems for Chinese Medicines. Novel Drug Delivery Systems for Chinese Medicines 239 276 .
Yannick Guinet, Laurent Paccou & Alain Hédoux. (2020) Analysis of xylitol – citric acid system forming deep eutectic solvent: Application for dissolving poorly water-soluble drugs. A combination of calorimetric and Raman investigations. Journal of Molecular Liquids 318, pages 114317.
Crossref
Dana E. Moseson, Madison A. Jordan, Dishan D. Shah, Isaac D. Corum, Benedito R. Alvarenga Jr.Lynne S. Taylor. (2020) Application and limitations of thermogravimetric analysis to delineate the hot melt extrusion chemical stability processing window. International Journal of Pharmaceutics 590, pages 119916.
Crossref
Palpandi Pandi, Raviteja Bulusu, Nagavendra Kommineni, Wahid Khan & Mandip Singh. (2020) Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products. International Journal of Pharmaceutics 586, pages 119560.
Crossref
Olivier Jennotte, Nathan Koch, Anna Lechanteur & Brigitte Evrard. (2020) Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: A review. International Journal of Pharmaceutics 580, pages 119200.
Crossref
Meiling Su, Yanming Xia, Yajing Shen, Weili Heng, Yuanfeng Wei, Linghe Zhang, Yuan Gao, Jianjun Zhang & Shuai Qian. (2020) A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide. RSC Advances 10:1, pages 565-583.
Crossref
Marta F. Simões, Rui M.A. Pinto & Sérgio Simões. (2019) Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application. Drug Discovery Today 24:9, pages 1749-1768.
Crossref
Frédéric Bier, Jean‐Luc Six & Alain Durand. (2019) DOPO‐Based Phosphorus‐Containing Methacrylic (Co)Polymers: Glass Transition Temperature Investigation. Macromolecular Materials and Engineering 304:4, pages 1800645.
Crossref
Chang-Soo Han, Seungsu Kim, Dong-Won Oh, Jeong Yoon, Eun-Seok Park, Yun-Seok Rhee, Ju-Young Kim, Dae Shin, Dong-Wook Kim & Chun-Woong Park. (2019) Preparation, Characterization, and Stability Evaluation of Taste-Masking Lacosamide Microparticles. Materials 12:6, pages 1000.
Crossref
Yinshan Chen, Zhenxuan Chen, Michael Tylinski, M. D. Ediger & Lian Yu. (2019) Effect of molecular size and hydrogen bonding on three surface-facilitated processes in molecular glasses: Surface diffusion, surface crystal growth, and formation of stable glasses by vapor deposition. The Journal of Chemical Physics 150:2.
Crossref
Mohammad A. Altamimi & Steven H. Neau. (2018) A study to identify the contribution of Soluplus® component homopolymers to the solubilization of nifedipine and sulfamethoxazole using the melting point depression method. Powder Technology 338, pages 576-585.
Crossref
V. Sai Krishna Anand, Sujata D. Sakhare, K.S. Navya Sree, Athira R. Nair, K. Raghava Varma, Karthik Gourishetti & Swapnil J. Dengale. (2018) The relevance of co-amorphous formulations to develop supersaturated dosage forms: In-vitro, and ex-vivo investigation of Ritonavir-Lopinavir co-amorphous materials. European Journal of Pharmaceutical Sciences 123, pages 124-134.
Crossref
Christian Luebbert & Gabriele Sadowski. (2018) In-situ determination of crystallization kinetics in ASDs via water sorption experiments. European Journal of Pharmaceutics and Biopharmaceutics 127, pages 183-193.
Crossref
Hiroshi Ueda, Wenqi Wu, Korbinian Löbmann, Holger Grohganz, Anette Müllertz & Thomas Rades. (2018) Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and l -Arginine . Molecular Pharmaceutics 15:5, pages 2036-2044.
Crossref
Dipen Desai, Harpreet Sandhu, Navnit Shah, Waseem Malick, Hossein Zia, Wantanee Phuapradit & Siva Ram Kiran Vaka. (2018) Selection of Solid-State Plasticizers as Processing Aids for Hot-Melt Extrusion. Journal of Pharmaceutical Sciences 107:1, pages 372-379.
Crossref
Maria Doreth, Korbinian Löbmann, Petra Priemel, Holger Grohganz, Robert Taylor, René Holm, Heidi Lopez de Diego & Thomas Rades. (2018) Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin. European Journal of Pharmaceutics and Biopharmaceutics 122, pages 62-69.
Crossref
Anh Q. Vo, Xin Feng, Manjeet Pimparade, Xinyou Ye, Dong Wuk Kim, Scott T. Martin & Michael A. Repka. (2017) Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion. European Journal of Pharmaceutical Sciences 102, pages 71-84.
Crossref
Mohammad A. Altamimi & Steven H. Neau. (2017) Investigation of the in vitro performance difference of drug-Soluplus® and drug-PEG 6000 dispersions when prepared using spray drying or lyophilization. Saudi Pharmaceutical Journal 25:3, pages 419-439.
Crossref
Peter J. Skrdla, Philip D. Floyd & Philip C. Dell’Orco. (2017) The amorphous state: first-principles derivation of the Gordon–Taylor equation for direct prediction of the glass transition temperature of mixtures; estimation of the crossover temperature of fragile glass formers; physical basis of the “Rule of 2/3”. Physical Chemistry Chemical Physics 19:31, pages 20523-20532.
Crossref
A. Newman. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 497 518 .
Sheng Qi. 2016. Disordered Pharmaceutical Materials. Disordered Pharmaceutical Materials 467 490 .
Stefania Marano, Susan Anne Barker, Bahijja Tolulope Raimi-Abraham, Shahrzad Missaghi, Ali Rajabi-Siahboomi & Duncan Q.M. Craig. (2016) Development of micro-fibrous solid dispersions of poorly water-soluble drugs in sucrose using temperature-controlled centrifugal spinning. European Journal of Pharmaceutics and Biopharmaceutics 103, pages 84-94.
Crossref
Mehak Mehta, Gregory B. McKenna & Raj Suryanarayanan. (2016) Molecular mobility in glassy dispersions. The Journal of Chemical Physics 144:20.
Crossref
Pratchaya TipduangtaPeter BeltonLászló FábiánLi Ying Wang, Huiru Tang, Mark EddlestonSheng Qi. (2015) Electrospun Polymer Blend Nanofibers for Tunable Drug Delivery: The Role of Transformative Phase Separation on Controlling the Release Rate. Molecular Pharmaceutics 13:1, pages 25-39.
Crossref
Shuai Qian, Zhen Li, Weili Heng, Shujun Liang, Di Ma, Yuan Gao, Jianjun Zhang & Yuanfeng Wei. (2016) Charge-assisted intermolecular hydrogen bond formed in coamorphous system is important to relieve the pH-dependent solubility behavior of lurasidone hydrochloride. RSC Advances 6:108, pages 106396-106412.
Crossref
Susanne Page, Reto Maurer & Nicole Wyttenbach. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 329 382 .
Hemlata Patil, Roshan Tiwari & Michael Repka. 2015. Handbook of Encapsulation and Controlled Release. Handbook of Encapsulation and Controlled Release 213 233 .
Muhammad T. Islam, Nikolaos Scoutaris, Mohammed Maniruzzaman, Hiren G. Moradiya, Sheelagh A. Halsey, Michael S.A. Bradley, Babur Z. Chowdhry, Martin J. Snowden & Dennis Douroumis. (2015) Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing. European Journal of Pharmaceutics and Biopharmaceutics 96, pages 106-116.
Crossref
Sujinda Keratichewanun, Yasuo Yoshihashi, Narueporn Sutanthavibul, Katsuhide Terada & Jittima Chatchawalsaisin. (2015) An Investigation of Nifedipine Miscibility in Solid Dispersions Using Raman Spectroscopy. Pharmaceutical Research 32:7, pages 2458-2473.
Crossref
Lynne S. Taylor. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 39 .
Ann Newman. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 32 .
Padma Narayan, William W. PorterIIIIII, Meinolf Brackhagen & Christopher Tucker. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 43 .
Abhishek Singh, Jan Van Humbeeck & Guy Van den Mooter. (2014) A New Twist in the Old Story-can Compression Induce Mixing of Phase Separated Solid Dispersions? A Case Study of Spray-Dried Miconazole-PVP VA64 Solid Dispersions. Pharmaceutical Research 31:11, pages 3191-3200.
Crossref
Qingyan Hu, Nicole Wyttenbach, Koji Shiraki & Duk Soon Choi. 2014. Amorphous Solid Dispersions. Amorphous Solid Dispersions 165 195 .
Ziyaur Rahman, Akhtar Siddiqui, Abhay Gupta & Mansoor Khan. 2014. Amorphous Solid Dispersions. Amorphous Solid Dispersions 545 563 .
Nikoletta Fotaki, Chiau Ming Long, Kin Tang & Hitesh Chokshi. 2014. Amorphous Solid Dispersions. Amorphous Solid Dispersions 487 514 .
Sejal Shah, Sindhuri Maddineni, Jiannan Lu & Michael A. Repka. (2013) Melt extrusion with poorly soluble drugs. International Journal of Pharmaceutics 453:1, pages 233-252.
Crossref
Matthias E. Lauer, Monira Siam, Joseph Tardio, Susanne Page, Johannes H. Kindt & Olaf Grassmann. (2013) Rapid Assessment of Homogeneity and Stability of Amorphous Solid Dispersions by Atomic Force Microscopy?From Bench to Batch. Pharmaceutical Research 30:8, pages 2010-2022.
Crossref
Ashish L. Sarode, Harpreet Sandhu, Navnit Shah, Waseem Malick & Hossein Zia. (2013) Hot melt extrusion (HME) for amorphous solid dispersions: Predictive tools for processing and impact of drug–polymer interactions on supersaturation. European Journal of Pharmaceutical Sciences 48:3, pages 371-384.
Crossref
Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman, Ravi M. Shanker, William N. Charman, Colin W. Pouton & Christopher J. H. Porter. (2013) Strategies to Address Low Drug Solubility in Discovery and Development. Pharmacological Reviews 65:1, pages 315-499.
Crossref
Christoph Kindermann, Karin Matth?e, Frank Sievert & J?rg Breitkreutz. (2012) Electrolyte-Stimulated Biphasic Dissolution Profile and Stability Enhancement for Tablets Containing Drug-Polyelectrolyte Complexes. Pharmaceutical Research 29:10, pages 2710-2721.
Crossref
Huiju Liu, Xueyan Zhang, Herman Suwardie, Peng Wang & Costas G. Gogos. (2012) Miscibility Studies of Indomethacin and Eudragit? E PO by Thermal, Rheological, and Spectroscopic Analysis. Journal of Pharmaceutical Sciences 101:6, pages 2204-2212.
Crossref
Jared A. Baird & Lynne S. Taylor. (2012) Evaluation of amorphous solid dispersion properties using thermal analysis techniques. Advanced Drug Delivery Reviews 64:5, pages 396-421.
Crossref
Mohammed Maniruzzaman, Joshua S. Boateng, Marion Bonnefille, Attila Aranyos, John C. Mitchell & Dennis Douroumis. (2012) Taste masking of paracetamol by hot-melt extrusion: An in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics 80:2, pages 433-442.
Crossref
Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Oskar Kalb, Susanne Page & Nicole Wyttenbach. 2012. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 267 310 .
Jian X. Wu, Mingshi Yang, Frans van den Berg, Jari Pajander, Thomas Rades & Jukka Rantanen. (2011) Influence of solvent evaporation rate and formulation factors on solid dispersion physical stability. European Journal of Pharmaceutical Sciences 44:5, pages 610-620.
Crossref
Jingjun Huang, Ying Li, Rodney J. Wigent, Waseem A. Malick, Harpreet K. Sandhu, Dharmendra Singhal & Navnit H. Shah. (2011) Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers. International Journal of Pharmaceutics 420:1, pages 59-67.
Crossref
Korbinian Löbmann, Riikka Laitinen, Holger Grohganz, Keith C. Gordon, Clare Strachan & Thomas Rades. (2011) Coamorphous Drug Systems: Enhanced Physical Stability and Dissolution Rate of Indomethacin and Naproxen. Molecular Pharmaceutics 8:5, pages 1919-1928.
Crossref
M. Nystr?m, M. Murtomaa & J. Salonen. (2011) Fabrication of amorphous pharmaceutical materials by electrospraying into reduced pressure. Journal of Electrostatics 69:4, pages 351-356.
Crossref
Jessica Albers, Karin Matth?e, Klaus Knop & Peter Kleinebudde. (2011) Evaluation of Predictive Models for Stable Solid Solution Formation. Journal of Pharmaceutical Sciences 100:2, pages 667-680.
Crossref
Lei Zhu, Janan Jona, Karthik Nagapudi & Tian Wu. (2010) Fast Surface Crystallization of Amorphous Griseofulvin Below T g. Pharmaceutical Research 27:8, pages 1558-1567.
Crossref
Qiongyu Guo, Pamela T. Knight, Jian Wu & Patrick T. Mather. (2010) Blends of Paclitaxel with POSS-Based Biodegradable Polyurethanes: Morphology, Miscibility, and Specific Interactions. Macromolecules 43:11, pages 4991-4999.
Crossref
Clare J Strachan, Thomas Rades & Keith C Gordon. (2007) A theoretical and spectroscopic study of γ-crystalline and amorphous indometacin. Journal of Pharmacy and Pharmacology 59:2, pages 261-269.
Crossref
Michael Tobyn, Jonathan Brown, Andrew B Dennis, Michael Fakes, Qi gao, John Gamble, Yaroslav Z Khimyak, Gary Mcgeorge, Chhaya Patel, Wayne Sinclair, Peter Timmins & Shawn Yin. (2009) Amorphous Drug-PVP Dispersions: Application of Theoretical, Thermal and Spectroscopic Analytical Techniques to the Study of a Molecule With Intermolecular Bonds in Both the Crystalline and Pure Amorphous State. Journal of Pharmaceutical Sciences 98:9, pages 3456-3468.
Crossref
Jessica Albers, Rainer Alles, Karin Matth?e, Klaus Knop, Julia Schulze Nahrup & Peter Kleinebudde. (2009) Mechanism of drug release from polymethacrylate-based extrudates and milled strands prepared by hot-melt extrusion. European Journal of Pharmaceutics and Biopharmaceutics 71:2, pages 387-394.
Crossref
Jingjun Huang, Rodney J. Wigent & Joseph B. Schwartz. (2008) Drug–polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend. Journal of Pharmaceutical Sciences 97:1, pages 251-262.
Crossref
T. P. Shakhtshneider, F. Danède, F. Capet, J. F. Willart, M. Descamps, S. A. Myz, E. V. Boldyreva & V. V. Boldyrev. (2007) Grinding of drugs with pharmaceutical excipients at cryogenic temperatures. Journal of Thermal Analysis and Calorimetry 89:3, pages 699-707.
Crossref
David C. Apperley, Angus H. Forster, Romain Fournier, Robin K. Harris, Paul Hodgkinson, Robert W. Lancaster & Thomas Rades. (2005) Characterisation of indomethacin and nifedipine using variable‐temperature solid‐state NMR. Magnetic Resonance in Chemistry 43:11, pages 881-892.
Crossref
Rina J. Chokshi, Harpreet K. Sandhu, Raman M. Iyer, Navnit H. Shah, A.Waseem Malick & Hossein Zia. (2005) Characterization of Physico-Mechanical Properties of Indomethacin and Polymers to Assess their Suitability for Hot-Melt Extrusion Processs as a Means to Manufacture Solid Dispersion/Solution**Mailing address of the place where the work was carried out, Hoffmann-La Roche, Inc., 340 Kingsland Street, Nutley, NJ, 07110.. Journal of Pharmaceutical Sciences 94:11, pages 2463-2474.
Crossref
Nora Anne Urbanetz & Bernhard Christian Lippold. (2005) Solid dispersions of nimodipine and polyethylene glycol 2000: dissolution properties and physico-chemical characterisation. European Journal of Pharmaceutics and Biopharmaceutics 59:1, pages 107-118.
Crossref
D.J. van Drooge, W.L.J. Hinrichs & H.W. Frijlink. (2004) Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions. Journal of Controlled Release 97:3, pages 441-452.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.