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Research Article

Influence of Hydroxypropyl Methylcellulose Mixture, Apparent Viscosity, and Tablet Hardness on Drug Release Using a 23 Full Factorial Design

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Pages 601-608 | Published online: 30 May 2002

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Darjan Košir, Tadej Ojsteršek & Franc Vrečer. (2018) Does the performance of wet granulation and tablet hardness affect the drug dissolution profile of carvedilol in matrix tablets?. Drug Development and Industrial Pharmacy 44:9, pages 1543-1550.
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M.L. Vueba, L.A.E. Batista de Carvalho, F. Veiga, J.J. Sousa & M.E. Pina. (2006) Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M. Pharmaceutical Development and Technology 11:2, pages 213-228.
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Ye Huang, Kavita H. Khanvilkar, Angela D. Moore & Marquetta Hilliard-Lott. (2003) Effects of Manufacturing Process Variables on In Vitro Dissolution Characteristics of Extended-Release Tablets Formulated with Hydroxypropyl Methylcellulose. Drug Development and Industrial Pharmacy 29:1, pages 79-88.
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Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Kamran Ahmed, Fahad Siddiqui, Zafar Alam Mahmood, Muhammad Sikandar & Muhammad Suleman Imtiaz. (2022) SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™. Frontiers in Pharmacology 13.
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Shoaeb M. Syed, Pratiksha V. Rathi, Kiran G. Gawale & Dipali C. Hamde. (2022) Formulation and evaluation of pH activated dosage form as minitablets in capsule for delivery of fesoterodine. Journal of Taibah University Medical Sciences 17:1, pages 72-81.
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Zara Khizer, Muhammad R. Akram, Rai M. Sarfraz, Jorabar Singh Nirwan, Samia Farhaj, Maria Yousaf, Tariq Hussain, Shan Lou, Peter Timmins, Barbara R. Conway & Muhammad Usman Ghori. (2019) Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies. Polymers 11:7, pages 1095.
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Loghman Golbaghi, Mehrdad Khamforoush & Tahmasb Hatami. (2017) Carboxymethyl cellulose production from sugarcane bagasse with steam explosion pulping: Experimental, modeling, and optimization. Carbohydrate Polymers 174, pages 780-788.
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J.D.N. Ogbonna, F.C. Kenechukwu, S.A. Chime & A.A. Attama. 2017. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 270 300 .
Po-Chun Peng, Chien-Ming Hsieh, Chueh-Pin Chen, Tsuimin Tsai & Chin-Tin Chen. (2016) Assessment of Photodynamic Inactivation against Periodontal Bacteria Mediated by a Chitosan Hydrogel in a 3D Gingival Model. International Journal of Molecular Sciences 17:11, pages 1821.
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J Ogbonna, F Kenechukwu, S Chime & A Attama. 2015. Handbook of Encapsulation and Controlled Release. Handbook of Encapsulation and Controlled Release 535 574 .
Konstantinos Stamatopoulos, Hannah K. Batchelor, Federico Alberini, John Ramsay & Mark J.H. Simmons. (2015) Understanding the impact of media viscosity on dissolution of a highly water soluble drug within a USP 2 mini vessel dissolution apparatus using an optical planar induced fluorescence (PLIF) method. International Journal of Pharmaceutics 495:1, pages 362-373.
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Chueh-Pin Chen, Chien-Ming Hsieh, Tsuimin Tsai, Jen-Chang Yang & Chin-Tin Chen. (2015) Optimization and Evaluation of a Chitosan/Hydroxypropyl Methylcellulose Hydrogel Containing Toluidine Blue O for Antimicrobial Photodynamic Inactivation. International Journal of Molecular Sciences 16:9, pages 20859-20872.
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Marina Levina & Ali R. Rajabi-Siahboomi. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 53 85 .
Cristina Maderuelo, Aránzazu Zarzuelo & José M. Lanao. (2011) Critical factors in the release of drugs from sustained release hydrophilic matrices. Journal of Controlled Release 154:1, pages 2-19.
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Shayne Cox GadRichard N. McGrath & Dennis K.J. Lin. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Elnazeer I. Hamedelniel, János Bajdik & Klára Pintye-Hódi. (2010) Optimization of preparation of matrix pellets containing ethylcellulose. Chemical Engineering and Processing: Process Intensification 49:1, pages 120-124.
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Naveen K. Bejugam, Helen J. Parish & Gita N. Shankar. (2009) Influence of Formulation Factors on Tablet Formulations with Liquid Permeation Enhancer Using Factorial Design. AAPS PharmSciTech 10:4.
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Shawn A. Mitchell & Karen M. Balwinski. (2008) A Framework to Investigate Drug Release Variability Arising from Hypromellose Viscosity Specifications in Controlled Release Matrix Tablets. Journal of Pharmaceutical Sciences 97:6, pages 2277-2285.
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János Bajdik, Gabriella Baki, András Kelemen & Klára Pintye-Hódi. (2008) The effect of wetting of powder mixture on the preparation of hydrophilic matrix granules with high-shear granulator. Chemical Engineering Research and Design 86:1, pages 1-7.
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N Anthony Armstrong. 2006. Pharmaceutical Experimental Design and Interpretation, 2nd Edition. Pharmaceutical Experimental Design and Interpretation, 2nd Edition 83 133 .

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