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Research Article

Preparation and Characterization of Heparin-Loaded Polymeric Microparticles

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Pages 1033-1041 | Published online: 28 Aug 2002

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Umut Can Oz, Burcu Devrim, Asuman Bozkır & Kandemir Canefe. (2015) Development of reconstitutable suspensions containing diclofenac sodium-loaded microspheres for pediatric delivery. Journal of Microencapsulation 32:4, pages 317-328.
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Nahla S. Barakat, Gamal A. Shazly & Azza H. Almedany. (2013) Influence of polymer blends on the characterization of gliclazide – encapsulated into poly (Æ-caprolactone) microparticles. Drug Development and Industrial Pharmacy 39:2, pages 352-362.
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Raghavendra C. Mundargi, Vidhya Rangaswamy & Tejraj M. Aminabhavi. (2011) pH-Sensitive oral insulin delivery systems using Eudragit microspheres. Drug Development and Industrial Pharmacy 37:8, pages 977-985.
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M. Socha, P. Bartecki, C. Passirani, A. Sapin, C. Damgé, T. Lecompte, J. Barré, F. El Ghazouani & P. Maincent. (2009) Stealth nanoparticles coated with heparin as peptide or protein carriers. Journal of Drug Targeting 17:8, pages 575-585.
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Nusrat Motlekar & Bi-Botti Youan. (2008) Optimization of experimental parameters for the production of LMWH-loaded polymeric microspheres. Drug Design, Development and Therapy 2, pages 39-47.
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Vishwanath S. Nande, Umesh U. Barabde, Dinesh M. Morkhade, Arun T. Patil & Siddheshwar B. Joshi. (2007) Sustained Release Microspheres of Diclofenac Sodium Using PEGylated Rosin Derivatives. Drug Development and Industrial Pharmacy 33:10, pages 1090-1100.
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V. Hoffart, N. Ubrich, C. Simonin, V. Babak, C. Vigneron, M. Hoffman, T. Lecompte & P. Maincent. (2002) Low Molecular Weight Heparin-Loaded Polymeric Nanoparticles: Formulation, Characterization, and Release Characteristics. Drug Development and Industrial Pharmacy 28:9, pages 1091-1099.
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Lubna Shahzadi, Amna Ramzan, Awais Anjum, Faiza Jabbar, Ather Farooq Khan, Faisal Manzoor, Sohail Anjum Shahzad, Aqif Anwar Chaudhry, Ihtesham ur Rehman & Muhammad Yar. (2022) An efficient new method for electrospinning chitosan and heparin for the preparation of pro‐angiogenic nanofibrous membranes for wound healing applications. Journal of Applied Polymer Science 139:48.
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Ashwini Kumar Mishra & Pravat Kumar Sahoo. 2022. Phytoantioxidants and Nanotherapeutics. Phytoantioxidants and Nanotherapeutics 239 265 .
Jasvinder Singh, Pulak Mohan Pandey, Tejinder Kaur & Neetu Singh. (2022) Effect of heparin drug loading on biodegradable polycaprolactone–iron pentacarbonyl powder blend stents fabricated by solvent cast 3D printing. Rapid Prototyping Journal 28:7, pages 1361-1373.
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Saumen Karan, Souvik Debnath, Ketousetuo Kuotsu & Tapan Kumar Chatterjee. (2020) In-vitro and in-vivo evaluation of polymeric microsphere formulation for colon targeted delivery of 5-fluorouracil using biocompatible natural gum katira. International Journal of Biological Macromolecules 158, pages 922-936.
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A. Momoh Mumuni, C. Jackson Tenderwealth, O. Musiliu Adedokun, F. Chimaobi Kenechukwu, C. Darlington Youngson & C. Ofokansi Kenneth. (2017) Microspheres of insulin-Eudragit complex: Formulation, characterization and in vivo studies. African Journal of Pharmacy and Pharmacology 11:29, pages 327-341.
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Dana Hales, Laurian Vlase, Sebastian Alin Porav, Andreea Bodoki, Lucian Barbu-Tudoran, Marcela Achim & Ioan Tomuță. (2017) A quality by design (QbD) study on enoxaparin sodium loaded polymeric microspheres for colon-specific delivery. European Journal of Pharmaceutical Sciences 100, pages 249-261.
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Ožbej Zupančič, Julia Anita Grieβinger, Julia Rohrer, Irene Pereira de Sousa, Lukas Danninger, Alexandra Partenhauser, Nadine Elli Sündermann, Flavia Laffleur & Andreas Bernkop-Schnürch. (2016) Development, in vitro and in vivo evaluation of a self-emulsifying drug delivery system (SEDDS) for oral enoxaparin administration. European Journal of Pharmaceutics and Biopharmaceutics 109, pages 113-121.
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Lubna Shahzadi, Muhammad Yar, Arshad Jamal, Saadat Anwar Siddiqi, Aqif Anwar Chaudhry, Saba Zahid, Muhammad Tariq, Ihtesham ur Rehman & Sheila MacNeil. (2016) Triethyl orthoformate covalently cross-linked chitosan-(poly vinyl) alcohol based biodegradable scaffolds with heparin-binding ability for promoting neovascularisation. Journal of Biomaterials Applications 31:4, pages 582-593.
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Yipei Chen, Yuzhuo Li, Wenjia Shen, Kun Li, Lin Yu, Qinghua Chen & Jiandong Ding. (2016) Controlled release of liraglutide using thermogelling polymers in treatment of diabetes. Scientific Reports 6:1.
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Ana Neves, Marta Correia-da-Silva, Emília Sousa & Madalena Pinto. (2016) Strategies to Overcome Heparins’ Low Oral Bioavailability. Pharmaceuticals 9:3, pages 37.
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Taoyu Wan, George K. Stylios, Marilena Giannoudi & Peter V. Giannoudis. (2015) Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections. Injury 46, pages S39-S43.
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Bettina Ralay-Ranaivo, Delphine Borgel, Patrick Couvreur & Ruxandra Gref. (2015) Trends in the development of oral anticoagulants. Therapeutic Delivery 6:6, pages 685-703.
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Adam L. Sisson, Duygu Ekinci & Andreas Lendlein. (2013) The contemporary role of ε-caprolactone chemistry to create advanced polymer architectures. Polymer 54:17, pages 4333-4350.
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Angela Viehof & Alf Lamprecht. (2013) Oral Delivery of Low Molecular Weight Heparin by Polyaminomethacrylate Coacervates. Pharmaceutical Research 30:8, pages 1990-1998.
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Felisa Reyes-Ortega, Gema Rodríguez, María Rosa Aguilar, Megan Lord, John Whitelock, Martina H. Stenzel & Julio San Román. (2013) Encapsulation of low molecular weight heparin (bemiparin) into polymeric nanoparticles obtained from cationic block copolymers: properties and cell activity. J. Mater. Chem. B 1:6, pages 850-860.
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Tatyana S Levchenko, William C Hartner & Vladimir P Torchilin. (2012) Liposomes for cardiovascular targeting. Therapeutic Delivery 3:4, pages 501-514.
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Alison Matalanis, Owen Griffith Jones & David Julian McClements. (2011) Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic compounds. Food Hydrocolloids 25:8, pages 1865-1880.
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S. Teixeira, L. Yang, P. J. Dijkstra, M. P. Ferraz & F. J. Monteiro. (2010) Heparinized hydroxyapatite/collagen three-dimensional scaffolds for tissue engineering. Journal of Materials Science: Materials in Medicine 21:8, pages 2385-2392.
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Owen Griffith Jones & David Julian McClements. (2010) Functional Biopolymer Particles: Design, Fabrication, and Applications. Comprehensive Reviews in Food Science and Food Safety 9:4, pages 374-397.
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Bum-Keun Kim, Won-Jae Lee, Se-Jong Oh, Jin-Man Kim & Dong-June Park. (2010) Preparation of Folic Acid-loaded WPI (Whey Protein Isolate) Nanoparticles by Cold-induced Gelation. Korean Journal for Food Science of Animal Resources 30:1, pages 95-101.
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Sabyasachi Maiti, Paramita Dey, Santanu Kaity, Somasree Ray, Sushomasri Maji & Biswanath Sa. (2009) Investigation on Processing Variables for the Preparation of Fluconazole-Loaded Ethyl Cellulose Microspheres by Modified Multiple Emulsion Technique. AAPS PharmSciTech 10:3.
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Emma Luong-Van, Lisbeth Grøndahl, Victor Nurcombe & Simon Cool. (2007) In vitro biocompatibility and bioactivity of microencapsulated heparan sulfate. Biomaterials 28:12, pages 2127-2136.
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G. A. Silva, P. Ducheyne & R. L. Reis. (2007) Materials in particulate form for tissue engineering. 1. Basic concepts. Journal of Tissue Engineering and Regenerative Medicine 1:1, pages 4-24.
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Emma Luong-Van, Lisbeth Grøndahl, Kian Ngiap Chua, Kam W. Leong, Victor Nurcombe & Simon M. Cool. (2006) Controlled release of heparin from poly(ε-caprolactone) electrospun fibers. Biomaterials 27:9, pages 2042-2050.
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Nusrat A. Motlekar, Kalkunte S. Srivenugopal, Mitchell S. Wachtel & Bi‐Botti C. Youan. (2006) Evaluation of the oral bioavailability of low molecular weight heparin formulated with glycyrrhetinic acid as permeation enhancer. Drug Development Research 67:2, pages 166-174.
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V.R. Sinha, K. Bansal, R. Kaushik, R. Kumria & A. Trehan. (2004) Poly-ϵ-caprolactone microspheres and nanospheres: an overview. International Journal of Pharmaceutics 278:1, pages 1-23.
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Yulia V. Chernysheva, Valery G. Babak, Natalia R. Kildeeva, Franck Boury, Jean P. Benoit, Nathalie Ubrich & Philippe Maincent. (2003) Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification?solvent evaporation. Mendeleev Communications 13:2, pages 65-67.
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