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Research Article

DEVELOPMENT AND UTILIZATION OF PRIMARY HEPATOCYTE CULTURE SYSTEMS TO EVALUATE METABOLISM, DNA BINDING, AND DNA REPAIR OF XENOBIOTICS*

Pages 1-13 | Published online: 15 Apr 2001

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Annie M. Jarabek, Lynn H. Pottenger, Larry S. Andrews, Daniel Casciano, Michelle R. Embry, James H. Kim, R. Julian Preston, M. Vijayaraj Reddy, Rita Schoeny, David Shuker, Julie Skare, James Swenberg, Gary M. Williams & Errol Zeiger. (2009) Creating context for the use of DNA adduct data in cancer risk assessment: I. Data organization. Critical Reviews in Toxicology 39:8, pages 659-678.
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Mahima Bajpayee, Alok K. Pandey, Devendra Parmar & Alok Dhawan. (2005) Current Status of Short-Term Tests for Evaluation of Genotoxicity, Mutagenicity, and Carcinogenicity of Environmental Chemicals and NCEs. Toxicology Mechanisms and Methods 15:3, pages 155-180.
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Peggy Papeleu, Tamara Vanhaecke, Greetje Elaut, Mathieu Vinken, Tom Henkens, Sarah Snykers & Vera Rogiers. (2005) Differential Effects of Histone Deacetylase Inhibitors in Tumor and Normal Cells—What Is the Toxicological Relevance?. Critical Reviews in Toxicology 35:4, pages 363-378.
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Articles from other publishers (15)

Meital Charni-Natan & Ido Goldstein. (2020) Protocol for Primary Mouse Hepatocyte Isolation. STAR Protocols 1:2, pages 100086.
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Long Zhou, Lilin Wang, Xuhuai Hu & Yuantao Li. (2018) PTEN in propofol‑induced insulin resistance in mouse primary hepatocytes. Experimental and Therapeutic Medicine.
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LONG ZHOU, LILIN WANG, BAOCHENG YANG, JINFENG ZENG, QINGGUO ZHANG, HONGYI LEI & SHIYUAN XU. (2015) Protective effect of pretreatment with propofol against tumor necrosis factor-α-induced hepatic insulin resistance. Experimental and Therapeutic Medicine 10:1, pages 289-294.
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Xiujuan Zhang, Yongfeng Song, Mei Feng, Xinli Zhou, Yingli Lu, Ling Gao, Chunxiao Yu, Xiuyun Jiang & Jiajun Zhao. (2015) Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver. Journal of Lipid Research 56:5, pages 963-971.
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Peter J. Evans. (2015) Maintenance of in vivo induced cytochrome P-450s in hepatocyte monolayers at non freezing temperatures. Cryobiology 70:2, pages 204-207.
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Yu Saito, Mitsuo Shimada, Tohru Utsunomiya, Tetsuya Ikemoto, Shinichiro Yamada, Yuji Morine, Satoru Imura, Hiroki Mori, Koji Sugimoto, Shuichi Iwahashi & Michihito Asanoma. (2013) The protective effect of adipose-derived stem cells against liver injury by trophic molecules. Journal of Surgical Research 180:1, pages 162-168.
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Jiaojiao Chu, Hangxiang Zhang, Xiuqing Huang, Yajun Lin, Tao Shen, Beidong Chen, Yong Man, Shu Wang & Jian Li. (2013) Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ. PLoS ONE 8:2, pages e57231.
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Daniel A. Casciano. 2012. New Technologies for Toxicity Testing. New Technologies for Toxicity Testing 210 220 .
K. Mathijs, K. J. J. Brauers, D. G. J. Jennen, D. Lizarraga, J. C. S. Kleinjans & J. H. M. van Delft. (2010) Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds. Mutagenesis 25:6, pages 561-568.
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Guosheng Chen, John Gingerich, Lynda Soper, George R. Douglas & Paul A. White. (2009) Induction of lacZ mutations in Muta™Mouse primary hepatocytes . Environmental and Molecular Mutagenesis 51:4, pages 330-337.
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Hao Yin, Linling Cheng, Michael Holt, Numsen HailJrJr, Robert MacLaren & Cynthia Ju. (2010) Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology, pages NA-NA.
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Alok Dhawan. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Karen Mathijs, Anne S. Kienhuis, Karen J. J. Brauers, Danyel G. J. Jennen, Agustin Lahoz, Jos C. S. Kleinjans & Joost H. M. van Delft. (2009) Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes. Drug Metabolism and Disposition 37:6, pages 1305-1311.
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Daniela Maurici, Marilyn Aardema, Raffaella Corvi, Marcus Kleber, Cyrille Krul, Christian Laurent, Nicola Loprieno, Markku Pasanen, Stefan Pfuhler, Barry Phillips, Enrico Sabbioni, Tore Sanner & Philippe Vanparys. (2019) 3.7. Genotoxicity and Mutagenicity. Alternatives to Laboratory Animals 33:1_suppl, pages 117-130.
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Gary M. Williams & Michael J. Iatropoulos. (2016) Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and Toxicity. Toxicologic Pathology 30:1, pages 41-53.
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