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Research Article

ARYLAMINE N-ACETYLTRANSFERASE ACTIVITY IN MAN

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Pages 489-502 | Published online: 05 Dec 1999

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Read on this site (3)

David W. Hein & Lori M. Millner. (2021) Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review. Expert Opinion on Drug Metabolism & Toxicology 17:1, pages 9-21.
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Jayaprakasam Bolleddula, Kevin DeMent, James P. Driscoll, Philip Worboys, Patrick J. Brassil & David L. Bourdet. (2014) Biotransformation and bioactivation reactions of alicyclic amines in drug molecules. Drug Metabolism Reviews 46:3, pages 379-419.
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Meenu Jain, Shaleen Kumar, Puneeta Lal, Anu Tiwari, U. C. Ghoshal & Balraj Mittal. (2007) Association of Genetic Polymorphisms of N-Acetyltransferase 2 and Susceptibility to Esophageal Cancer in North Indian Population. Cancer Investigation 25:5, pages 340-346.
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Articles from other publishers (55)

Sadaf Saleem, Imtiaz Mahmood Tahir, Tahira Iqbal, Amer Jamil, Huma Mehboob, Muhammad Akram & Peter Olusakin Oladoye. (2021) Genetic polymorphism of NAT1 in local Pakistani population. Gene Reports 25, pages 101343.
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Jeong Yee, So Min Kim, Ji Min Han, Nari Lee, Ha Young Yoon & Hye Sun Gwak. (2020) The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis. Scientific Reports 10:1.
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Kimberly S. Collins, Anthony L.J. Raviele, Amanda L. Elchynski, Alexander M. Woodcock, Yang Zhao, Rhonda M. Cooper-DeHoff & Michael T. Eadon. (2020) Genotype-Guided Hydralazine Therapy. American Journal of Nephrology 51:10, pages 764-776.
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David W. Hein, Giannoulis Fakis & Sotiria Boukouvala. (2018) Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles. Pharmacogenetics and Genomics 28:10, pages 238-244.
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Ines Potočnjak, Robert Likić, Iveta Šimić, Danica Juričić Nahal, Ivana Čegec, Lana Ganoci & Nada Božina. (2017) Dapsone-induced agranulocytosis-possible involvement of low-activity N -acetyltransferase 2 . Fundamental & Clinical Pharmacology 31:5, pages 580-586.
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J Matthaei, MV Tzvetkov, J Strube, D Sehrt, C Sachse-Seeboth, JB Hjelmborg, S Möller, U Halekoh, U Hofmann, M Schwab, R Kerb & J Brockmöller. (2016) Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2. Clinical Pharmacology & Therapeutics 100:6, pages 606-616.
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J. Detert & G. R. Burmester. (2016) „Treat to target“ und personalisierte Medizin („precision medicine“)Treat to target and personalized medicine (precision medicine). Zeitschrift für Rheumatologie 75:6, pages 624-632.
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Yanjie Hu, Suting Chen, Xia Yu, Guangming Dai, Lingling Dong, Yunxu Li, Liping Zhao & Hairong Huang. (2016) Rapid identification of the NAT2 genotype in tuberculosis patients by multicolor melting curve analysis . Pharmacogenomics 17:11, pages 1211-1218.
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D. M. Lukyanova, T. Yu. Smolnova & L. V. Adamyan. (2016) Modern molecular genetic and biochemical predictors of genital prolapse (a review). Problemy reproduktsii 22:4, pages 8.
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Azza M. Kamel, Gamal T. A. Ebid & Heba S. Moussa. (2015) N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemia. Tumor Biology 36:8, pages 6341-6348.
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Loredana Serpe, Roberto Canaparo, Maria Gabriella Scordo & Edoardo Spina. (2015) Pharmacogenetics of drug-metabolizing enzymes in Italian populations. Drug Metabolism and Personalized Therapy 30:2, pages 107-120.
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R. Salazar-González, R. Gómez, S. Romano-Moreno, S. Medellín-Garibay, A. Núñez-Ruíz, M. Magaña-Aquino, R. C. Milán-Segovia & D. P. Portales-Pérez. (2014) Expression of NAT2 in immune system cells and the relation of NAT2 gene polymorphisms in the anti-tuberculosis therapy in Mexican mestizo population. Molecular Biology Reports 41:12, pages 7833-7843.
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Ellen M. McDonagh, Sotiria Boukouvala, Eleni Aklillu, David W. Hein, Russ B. Altman & Teri E. Klein. (2014) PharmGKB summary. Pharmacogenetics and Genomics 24:8, pages 409-425.
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Petra Seibold, Alina Vrieling, Judith Heinz, Nadia Obi, Hans-Peter Sinn, Dieter Flesch-Janys & Jenny Chang-Claude. (2014) Pre-diagnostic smoking behaviour and poorer prognosis in a German breast cancer patient cohort – Differential effects by tumour subtype, NAT2 status, BMI and alcohol intake. Cancer Epidemiology 38:4, pages 419-426.
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Julia Stingl (formerly Kirchheiner)Jürgen Brockmöller. 2013. Pharmacogenomics. Pharmacogenomics 309 341 .
Anne M.J. Gilsing, Sonja I Berndt, Elizabeth 
H Ruder, Barry I Graubard, Leah M Ferrucci, Laura Burdett, Joel L. Weissfeld, Amanda J Cross & Rashmi Sinha. (2012) Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer. Carcinogenesis 33:7, pages 1332-1339.
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Ingolf Cascorbi. 2012. Pharmacogenetics and Individualized Therapy. Pharmacogenetics and Individualized Therapy 81 100 .
David W Hein & Mark A Doll. (2012) Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes . Pharmacogenomics 13:1, pages 31-41.
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Aminata Touré, Mathilde Cabral, Cheikh Diop, Nar Diéne, Mamadou Fall, Amadou Moctar Diéye, Amadou Diouf, Michel Lhermitte & Luc Humbert. (2012) Détermination du polymorphisme d’acétylation de la N-acétyltransférase 2 dans la population sénégalaise par utilisation du test à la caféine. Annales de Toxicologie Analytique 24:3, pages 119-127.
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Takuya Terai, Kazuya Kikuchi, Yasuteru Urano, Hirotatsu Kojima & Tetsuo Nagano. (2012) A long-lived luminescent probe to sensitively detect arylamine N-acetyltransferase (NAT) activity of cells. Chemical Communications 48:16, pages 2234.
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Mike UferRobert Häsler, Gunnar Jacobs, Sierk HaenischSandra LächeltFrank FaltracoChristian Sina, Philip Rosenstiel, Susanna Nikolaus, Stefan Schreiber & Ingolf Cascorbi. (2009) Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity. Pharmacogenomics 10:12, pages 1941-1953.
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Evgeny Krynetskiy & Ina Lee Calligaro. (2009) Introducing Pharmacy Students to Pharmacogenomic Analysis. American Journal of Pharmaceutical Education 73:4, pages 71.
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Margareta Littorin, Saimei Hou, Karin Broberg, Jonas Björk, Susanne Fält, Galbani Abdoulaye, Malgorzata Kalemba, Charlotta Ryk & Staffan Skerfving. (2007) Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate. International Archives of Occupational and Environmental Health 81:4, pages 429-441.
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Christine B. Ambrosone, Silke Kropp, Jun Yang, Song Yao, Peter G. Shields & Jenny Chang-Claude. (2008) Cigarette Smoking, N-Acetyltransferase 2 Genotypes, and Breast Cancer Risk: Pooled Analysis and Meta-analysis . Cancer Epidemiology, Biomarkers & Prevention 17:1, pages 15-26.
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Ivar Roots, Gabriele Laschinski & Urs A. Meyer. 2008. Grundlagen der Molekularen Medizin. Grundlagen der Molekularen Medizin 314 331 .
K. Dilger, D. Trenk, M. Rössle, M. Cap, A. Zähringer, V. Wacheck, C. Remmler, I. Cascorbi, W. Kreisel & G. Novacek. (2007) A clinical trial on absorption and N-acetylation of oral and rectal mesalazine. European Journal of Clinical Investigation 37:7, pages 558-565.
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Michael R. Franklin. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 5 .
Georgia Salanti, Julian P. T. Higgins & Ian R. White. (2006) Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene–gene–environment interaction. Statistics in Medicine 25:24, pages 4147-4163.
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I. V. Goldenkova-Pavlova, S. A. Brouskin, R. M. Abdeev, E. V. Markarova, S. G. Bigvava, L. A. Radkevich, H. A. Kurdanov, Zh. M. Kozhekbaeva, A. S. Glotov, O. A. Gra, A. S. Zasedatelev, T. V. Nasedkina & E. S. Piruzyan. (2006) Comparative analysis of N-acetylation polymorphism in humans as determined by phenotyping and genotyping. Russian Journal of Genetics 42:8, pages 947-953.
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D W Hein. (2006) N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk. Oncogene 25:11, pages 1649-1658.
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Esther F.A. Brandon, Tessa M. Bosch, Maarten J. Deenen, Rianne Levink, Everdina van der Wal, Joyce B.M. van Meerveld, Monique Bijl, Jos H. Beijnen, Jan H.M. Schellens & Irma Meijerman. (2006) Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines. Toxicology and Applied Pharmacology 211:1, pages 1-10.
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Carmen Lilla, Emaculate Verla-Tebit, Angela Risch, Birgit Jäger, Michael Hoffmeister, Hermann Brenner & Jenny Chang-Claude. (2006) Effect of NAT1 and NAT2 Genetic Polymorphisms on Colorectal Cancer Risk Associated with Exposure to Tobacco Smoke and Meat Consumption . Cancer Epidemiology, Biomarkers & Prevention 15:1, pages 99-107.
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Daya SL Srivastava & Rama D Mittal. (2005) Genetic polymorphism of the N-acetyltransferase 2 gene, and susceptibility to prostate cancer: a pilot study in north Indian population. BMC Urology 5:1.
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S.S. Lin, J.G. Chung, J.P. Lin, J.Y. Chuang, W.C. Chang, J.Y. Wu & Y.S. Tyan. (2005) Berberine inhibits arylamine N-acetyltransferase activity and gene expression in mouse leukemia L 1210 cells. Phytomedicine 12:5, pages 351-358.
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Evgeniya V. Belogubova, Ekatherina Sh. Kuligina, Alexandr V. Togo, Maria B. Karpova, Julia M. Ulibina, Vladimir A. Shutkin, Kaido P. Hanson, Katrin Popowski, Igor Mosyagin, Ingolf Cascorbi, Ari Hirvonen & Evgeny N. Imyanitov. (2005) ‘Comparison of extremes’ approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. Cancer Letters 221:2, pages 177-183.
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K. Skrętkowicz, J. Skrętkowicz, B. Gawrońska-Szklarz, W. Górnik, M. Rychlik-Sych & A. Sysa-Jędrzejowska. (2004) Lack of association between arylamine N-acetyltransferase 2 (NAT2) polymorphism and systemic sclerosis. European Journal of Clinical Pharmacology 60:11, pages 773-778.
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Anne C. Deitz, Nathanial Rothman, Timothy R. Rebbeck, Richard B. Hayes, Wong-Ho Chow, Wei Zheng, David W. Hein & Montserrat García-Closas. (2004) Impact of Misclassification in Genotype-Exposure Interaction Studies: Example of N -Acetyltransferase 2 ( NAT2 ), Smoking, and Bladder Cancer . Cancer Epidemiology, Biomarkers & Prevention 13:9, pages 1543-1546.
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Richard Weinshilboum & Liewei Wang. (2004) Pharmacogenomics: bench to bedside. Nature Reviews Drug Discovery 3:9, pages 739-748.
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Rama D. Mittal, Daya S.L. Srivastava & Anil Mandhani. (2004) NAT2 gene polymorphism in bladder cancer: a study from North India. International braz j urol 30:4, pages 279-285.
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Luisa Airoldi, Cinzia Magagnotti, Roberta Pastorelli & Roberto Fanelli. (2004) Enzyme polymorphisms influencing the metabolism of heterocyclic aromatic amines. Journal of Chromatography B 802:1, pages 175-181.
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Cinzia Magagnotti, Roberta Pastorelli, Simonetta Pozzi, Bruno Andreoni, Roberto Fanelli & Luisa Airoldi. (2003) Genetic polymorphisms and modulation of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP)‐DNA adducts in human lymphocytes . International Journal of Cancer 107:6, pages 878-884.
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Fatima Vrtic, Walter E. Haefeli, Jürgen Drewe, Stephan Krähenbühl & Markus Wenk. (2003) Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug. British Journal of Clinical Pharmacology 55:2, pages 191-198.
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Petra Zschieschang, Falk Hiepe, Erika Gromnica-Ihle, Ivar Roots & Ingolf Cascorbi. (2002) Lack of association between arylamine N-acetyltransferase 2 (NAT2) polymorphism and systemic lupus erythematosus. Pharmacogenetics 12:7, pages 559-563.
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Loı̈c Le Marchand, Jean H Hankin, Lisa M Pierce, Rashmi Sinha, Pratibha V Nerurkar, Adrian A Franke, Lynne R Wilkens, Laurence N Kolonel, Timothy Donlon, Ann Seifried, Laurie J Custer, Annette Lum-Jones & Wendy Chang. (2002) Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 506-507, pages 205-214.
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Peter Meisel. (2002) Arylamine N-acetyltransferases and drug response. Pharmacogenomics 3:3, pages 349-366.
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Alexandre Loktionov, William Moore, Steven P. Spencer, Hester Vorster, Theo Nell, Ian K. O’Neill, Sheila A. Bingham & John H. Cummings. (2002) Differences in N-acetylation genotypes between Caucasians and Black South Africans: implications for cancer prevention. Cancer Detection and Prevention 26:1, pages 15-22.
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P Wong, K Banerjee, J Massengill, S Nowell, N Lang & B Leyland-Jones. (2001) Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping. Journal of Immunological Methods 251:1-2, pages 1-9.
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H. Wikman, S. Thiel, B. J??ger, P. Schmezer, B. Spiegelhalder, L. Edler, H. Dienemann, K. Kayser, V. Schulz, P. Drings, H. Bartsch & A. Risch. (2001) Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. Pharmacogenetics 11:2, pages 157-168.
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Peter Meisel, Dorit Arndt, Eberhard Scheuch, Klaus-J??rgen Klebingat & Werner Siegmund. (2001) Prediction of Metabolic Activity From Genotype: The Gene???Dose Effect of N-Acetyltransferase. Therapeutic Drug Monitoring 23:1, pages 9-14.
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Mehmet Simsek, Musbah O.M Tanira, Khalid A Al-Baloushi, Hameeda S Al-Barwani, Khulood M Lawatia & Riad A.L Bayoumi. (2000) Improved detection of the T341C polymorphism in human N-acetyltransferase (NAT2) gene by using two complementary PCR-RFLP methods: better than automated DNA sequencing for detection of heterozygotes. Clinical Biochemistry 33:7, pages 585-588.
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Christian Meisel, Ivar Roots, Ingolf Cascorbi, Ulrich Brinkmann & Jürgen Brockmöller. (2000) How to Manage Individualized Drug Therapy: Application of Pharmacogenetic Knowledge of Drug Metabolism and Transport. cclm 38:9, pages 869-876.
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Tiziana Martone, Paolo Vineis, Christian Malaveille & Benedetto Terracini. (2000) Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer. Mutation Research/Reviews in Mutation Research 462:2-3, pages 303-309.
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William M. O'Neil, Robert K. Drobitch, Rodger D. MacArthur, Marti J. Farrough, Mark A. Doll, Adrian J. Fretland, David W. Hein, Lawrence R. Crane & Craig K. Svensson. (2000) Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype. Pharmacogenetics 10:2, pages 171-182.
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Jürgen Brockmöller, Ingolf Cascorbi, Stefan Henning, Christian Meisel & Ivar Roots. (2000) Molecular Genetics of Cancer Susceptibility. Pharmacology 61:3, pages 212-227.
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Ralph I. Freudenthal, Ellen Stephens & Daniel P. Anderson. (2016) Determining the Potential of Aromatic Amines to Induce Cancer of the Urinary Bladder. International Journal of Toxicology 18:5, pages 353-359.
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