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Research Article

STRUCTURAL BIOLOGY AND FUNCTION OF SOLUTE TRANSPORTERS: IMPLICATIONS FOR IDENTIFYING AND DESIGNING SUBSTRATES

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Pages 709-750 | Published online: 27 Nov 2002

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Francesco Lai, Anna Maria Fadda & Chiara Sinico. (2013) Liposomes for brain delivery. Expert Opinion on Drug Delivery 10:7, pages 1003-1022.
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Isabel Gomez-Orellana. (2005) Strategies to improve oral drug bioavailability. Expert Opinion on Drug Delivery 2:3, pages 419-433.
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Bhumika Kumar, Mukesh Pandey, Faizana Fayaz, Tareq Abu Izneid, Faheem Hyder Pottoo, Satish Manchanda, Anjali Sharma & Pravat Kumar Sahoo. (2020) Applications of Exosomes in Targeted Drug Delivery for the Treatment of Parkinson’s Disease: A Review of Recent Advances and Clinical Challenges. Current Topics in Medicinal Chemistry 20:30, pages 2777-2788.
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Smriti Gupta, Saurabh Dhanda & Rajat Sandhir. 2019. Brain Targeted Drug Delivery System. Brain Targeted Drug Delivery System 7 31 .
M. R. Lee & R. D. Jayant. (2018) Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression. Cell and Tissue Research 375:1, pages 287-293.
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Wenpeng Zhang, Yanyan Li, Peng Zou, Man Wu, Zhenqing Zhang & Tao Zhang. (2016) The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters—an Update. The AAPS Journal 18:4, pages 830-843.
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N. Joan Abbott, Adjanie A.K. Patabendige, Diana E.M. Dolman, Siti R. Yusof & David J. Begley. (2010) Structure and function of the blood–brain barrier. Neurobiology of Disease 37:1, pages 13-25.
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Sean Ekins & Dana L. Abramovitz. 2009. Transporters as Drug Carriers. Transporters as Drug Carriers 363 385 .
Liya Xu, Ian S. Haworth, Ashutosh A. Kulkarni, Michael B. Bolger & Daryl L. Davies. (2009) Mutagenesis and Cysteine Scanning of Transmembrane Domain 10 of the Human Dipeptide Transporter. Pharmaceutical Research 26:10, pages 2358-2366.
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S Ekins, J Mestres & B Testa. (2007) In silico pharmacology for drug discovery: applications to targets and beyond . British Journal of Pharmacology 152:1, pages 21-37.
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Anand Balakrishnan & James E. Polli. (2006) Apical Sodium Dependent Bile Acid Transporter (ASBT, SLC10A2):  A Potential Prodrug Target. Molecular Pharmaceutics 3:3, pages 223-230.
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Anand Balakrishnan, Stephen A. Wring, Andrew Coop & James E. Polli. (2006) Influence of Charge and Steric Bulk in the C-24 Region on the Interaction of Bile Acids with Human Apical Sodium-Dependent Bile Acid Transporter. Molecular Pharmaceutics 3:3, pages 282-292.
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S. L. Clardy, X. Wang, W. Zhao, W. Liu, G. A. Chase, J. L. Beard, B. True Felt & J. R. Connor. 2006. Oxidative Stress and Neuroprotection. Oxidative Stress and Neuroprotection 173 196 .
Rajinder K. Bhardwaj, Dea Herrera-Ruiz, Patrick J. Sinko, Olafur S. Gudmundsson & Gregory Knipp. (2005) Delineation of Human Peptide Transporter 1 (hPepT1)-Mediated Uptake and Transport of Substrates with Varying Transporter Affinities Utilizing Stably Transfected hPepT1/Madin-Darby Canine Kidney Clones and Caco-2 Cells. Journal of Pharmacology and Experimental Therapeutics 314:3, pages 1093-1100.
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