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Research Article

Hepatic Cytochrome P450 Degradation: Mechanistic Diversity of the Cellular Sanitation Brigade

Pages 107-143 | Published online: 28 Jul 2003

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Sungjoon Cho, Xiaotong Yang, Kyoung-Jae Won, Vanessa A. Leone, Eugene B. Chang, Grace Guzman, Yeonju Ko, Ok-Nam Bae, Hyunwoo Lee & Hyunyoung Jeong. (2023) Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity. Gut Microbes 15:1.
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Sung-Mi Kim, YongQiang Wang, Noushin Nabavi, Yi Liu & Maria Almira Correia. (2016) Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. Drug Metabolism Reviews 48:3, pages 405-433.
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Cody J. Peer, Tristan M. Sissung & William D. Figg, II. (2011) CHIP and gp78-mediated ubiquitination of CYP3A4. Cancer Biology & Therapy 11:6, pages 549-551.
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Maria Almira Correia, Peter R. Sinclair & Francesco De Matteis. (2011) Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. Drug Metabolism Reviews 43:1, pages 1-26.
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Christopher M. Herndon. (2010) Clinically significant drug interactions at end of life. Progress in Palliative Care 18:3, pages 147-156.
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M. Srivastava, H. Singh & P.K. Naik. (2009) Application of the linear interaction energy method for rational design of artemisinin analogues as haeme polymerisation inhibitors. SAR and QSAR in Environmental Research 20:3-4, pages 327-355.
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Maria Almira Correia & Mingxiang Liao. (2007) Cellular proteolytic systems in P450 degradation: evolutionary conservation from Saccharomyces cerevisiae to mammalian liver. Expert Opinion on Drug Metabolism & Toxicology 3:1, pages 33-49.
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Mike Aguiar, Robert Masse & Bernard F. Gibbs. (2005) Regulation of Cytochrome P450 by Posttranslational Modification. Drug Metabolism Reviews 37:2, pages 379-404.
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F. Peter Guengerich. (2004) Cytochrome P450: What Have We Learned and What Are the Future Issues?. Drug Metabolism Reviews 36:2, pages 159-197.
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Doyoung Kwon, Sung-Mi Kim & Maria Almira Correia. (2020) Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. Acta Pharmaceutica Sinica B 10:1, pages 42-60.
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X. Ding, L. Li, L.S. Van Winkle & Q.-Y. Zhang. 2018. Comprehensive Toxicology. Comprehensive Toxicology 171 193 .
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Justin R. Bushkofsky, Meghan Maguire, Michele Campaigne Larsen, Yee Hoon Fong & Colin R. Jefcoate. (2016) Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4α and PPARα. Archives of Biochemistry and Biophysics 597, pages 30-47.
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Masataka Santoh, Seigo Sanoh, Masashi Takagi, Yoko Ejiri, Yaichiro Kotake & Shigeru Ohta. (2016) Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction. Scientific Reports 6:1.
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Mahmoud Salah Khalil. (2015) Vitamin D3 May Ameliorate the Ketoconazole Induced Adrenal Injury: Histological and Immunohistochemical Studies on Albino Rats. Acta Histochemica et Cytochemica ACTA HISTOCHEMICA ET CYTOCHEMICA 48:4, pages 103-113.
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Marta Hamilton, Julie L. Wolf, Daniel W. Drolet, Scott H. Fettner, Ashok K. Rakhit, Karsten Witt & Bert L. Lum. (2014) The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjects. Cancer Chemotherapy and Pharmacology 73:3, pages 613-621.
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Maria Almira Correia, YongQiang Wang, Sung-Mi Kim & Shenheng Guan. (2014) Hepatic cytochrome P450 ubiquitination: Conformational phosphodegrons for E2/E3 recognition?. IUBMB Life 66:2, pages 78-88.
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Yasushi Yoshigae, Ute M. Kent & Paul F. Hollenberg. (2013) Role of the Highly Conserved Threonine in Cytochrome P450 2E1: Prevention of H 2 O 2 -Induced Inactivation during Electron Transfer . Biochemistry 52:27, pages 4636-4647.
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Lianhong Xu & Manoj C. Desai. 2013. Successful Strategies for the Discovery of Antiviral Drugs. Successful Strategies for the Discovery of Antiviral Drugs 451 481 .
Yasuhiro Shigemitsu. (2012) Quantum chemical study on molecular‐level affinity of DJ‐1 binding compounds. International Journal of Quantum Chemistry 113:4, pages 574-579.
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YongQiang Wang, Shenheng Guan, Poulomi Acharya, Yi Liu, Ranjit K. Thirumaran, Relly Brandman, Erin G. Schuetz, Alma L. Burlingame & Maria Almira Correia. (2012) Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination. Molecular & Cellular Proteomics 11:2, pages M111.010132.
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Qian Wu, Yong-He Zhang, Xin Zhao, Wan-Lu Shi & Xiao-Ping Pu. (2011) Proteome studies on liver tissue in a phenobarbital-induced rat model. European Journal of Pharmacology 670:2-3, pages 333-340.
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YongQiang Wang, Shenheng Guan, Poulomi Acharya, Dennis R. Koop, Yi Liu, Mingxiang Liao, Alma L. Burlingame & Maria Almira Correia. (2011) Ubiquitin-dependent Proteasomal Degradation of Human Liver Cytochrome P450 2E1. Journal of Biological Chemistry 286:11, pages 9443-9456.
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Poulomi Acharya, Mingxiang Liao, Juan C. Engel & Maria Almira Correia. (2011) Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation. Journal of Biological Chemistry 286:5, pages 3815-3828.
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Sung-Mi Kim, Poulomi Acharya, Juan C. Engel & Maria Almira Correia. (2010) Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases. Journal of Biological Chemistry 285:46, pages 35866-35877.
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Mark N. Milton. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 218 .
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Erin E. Bessette, Michael J. Fasco, Brian T. Pentecost, Andrew Reilly & Laurence S. Kaminsky. (2009) Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: The role of heme oxygenase-1. Journal of Biochemical and Molecular Toxicology 23:3, pages 222-232.
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Bernard P. Murray. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 535 553 .
Etienne P. A. Neve & Magnus Ingelman-Sundberg. (2008) Intracellular transport and localization of microsomal cytochrome P450. Analytical and Bioanalytical Chemistry 392:6, pages 1075-1084.
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Christine Medower, Lian Wen & William W. Johnson. (2008) Cytochrome P450 Oxidation of the Thiophene-Containing Anticancer Drug 3-[(Quinolin-4-ylmethyl)-amino]-thiophene-2-carboxylic Acid (4-Trifluoromethoxy-phenyl)-amide to an Electrophilic Intermediate. Chemical Research in Toxicology 21:8, pages 1570-1577.
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Saadia Faouzi, Katalin F. Medzihradszky, Colleen Hefner, Jacquelyn J. Maher & Maria Almira Correia. (2007) Characterization of the Physiological Turnover of Native and Inactivated Cytochromes P450 3A in Cultured Rat Hepatocytes:  A Role for the Cytosolic AAA ATPase p97?. Biochemistry 46:26, pages 7793-7803.
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Gunnar Boysen, Cameron O. Scarlett, Brenda Temple, Terry P. Combs, Natasha L. Brooks, Christoph H. Borchers & James A. Swenberg. (2007) Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro. Chemico-Biological Interactions 166:1-3, pages 170-175.
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Mingxiang Liao, Saadia Faouzi, Andrey Karyakin & Maria Almira Correia. (2006) Endoplasmic Reticulum-Associated Degradation of Cytochrome P450 CYP3A4 in Saccharomyces cerevisiae : Further Characterization of Cellular Participants and Structural Determinants . Molecular Pharmacology 69:6, pages 1897-1904.
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Jiunn H. Lin. (2006) CYP Induction-Mediated Drug Interactions: in Vitro Assessment and Clinical Implications. Pharmaceutical Research 23:6, pages 1089-1116.
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Elzbieta Szczesna-Skorupa & Byron Kemper. (2006) BAP31 Is Involved in the Retention of Cytochrome P450 2C2 in the Endoplasmic Reticulum. Journal of Biological Chemistry 281:7, pages 4142-4148.
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Maria Almira CorreiaSheila SadeghiEduardo Mundo-Paredes. (2005) CYTOCHROME P450 UBIQUITINATION: Branding for the Proteolytic Slaughter?. Annual Review of Pharmacology and Toxicology 45:1, pages 439-464.
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Geoff Saunders. (2016) Overview of drug therapy for multiple myeloma. Journal of Oncology Pharmacy Practice 11:3, pages 83-100.
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Mingxiang Liao, Victor G. Zgoda, Bernard P. Murray & Maria Almira Correia. (2005) Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae : Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic Reticulum P450 Proteins . Molecular Pharmacology 67:5, pages 1460-1469.
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Pratap Singh, Anastasiah M. Mhaka, Soren B. Christensen, Jeffrey J. Gray, Samuel R. Denmeade & John T. Isaacs. (2005) Applying Linear Interaction Energy Method for Rational Design of Noncompetitive Allosteric Inhibitors of the Sarco- and Endoplasmic Reticulum Calcium-ATPase. Journal of Medicinal Chemistry 48:8, pages 3005-3014.
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Silvio Bandiera, Simone Weidlich, Volker Harth, Peter Broede, Yun Ko & Thomas Friedberg. (2005) Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression. Molecular Pharmacology 67:2, pages 435-443.
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