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Research Article

Pathophysiological Factors Affecting CAR Gene Expression

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Pages 255-268 | Published online: 12 Aug 2003

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Pankajini Mallick, Guncha Taneja, Bhagavatula Moorthy & Romi Ghose. (2017) Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics–small molecule drug interactions. Expert Opinion on Drug Metabolism & Toxicology 13:6, pages 605-616.
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Zdenek Dvorak & Peotr Pavek. (2010) Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metabolism Reviews 42:4, pages 621-635.
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Thomas K. H. Chang & David J. Waxman. (2006) Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR). Drug Metabolism Reviews 38:1-2, pages 51-73.
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Susumu Kodama, Chika Koike, Masahiko Negishi & Yukio Yamamoto. (2004) Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes. Molecular and Cellular Biology 24:18, pages 7931-7940.
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Subrata Deb & Scott Arrighi. (2021) Potential Effects of COVID-19 on Cytochrome P450-Mediated Drug Metabolism and Disposition in Infected Patients. European Journal of Drug Metabolism and Pharmacokinetics 46:2, pages 185-203.
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Katalin Monostory, Andrea Nagy, Katalin Tóth, Tamás Bűdi, Ádám Kiss, Máté Déri & Gábor Csukly. (2018) Relevance of CYP2C9 Function in Valproate Therapy. Current Neuropharmacology 17:1, pages 99-106.
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Laura A. Bourque, Stephen Raverty, Carmon Co, Brandon N. Lillie, Pierre-Yves Daoust, Mary Ellen Clark & Jeff L. Caswell. (2018) Benzo(a)pyrene suppresses tracheal antimicrobial peptide gene expression in bovine tracheal epithelial cells. Veterinary Immunology and Immunopathology 203, pages 40-46.
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Tibor Kovács, Máté Déri, András Fülöp, Tímea Pálházy, Edit Háfra, Dávid Sirok, Ádám Ferenc Kiss, Gábor Lotz, Attila Szijártó & Katalin Monostory. (2018) Isoform-Dependent Changes in Cytochrome P450-Mediated Drug Metabolism after Portal Vein Ligation in the Rat. European Surgical Research 59:5-6, pages 301-319.
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C??line Bertrand-Thiebault, Christine Masson, G??rard Siest, Anne-Marie Batt & Sophie Visvikis-Siest. (2007) Effect of HMGCoA Reductase Inhibitors on Cytochrome P450 Expression in Endothelial Cell Line. Journal of Cardiovascular Pharmacology 49:5, pages 306-315.
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Sawako Shindo, Satoshi Numazawa & Takemi Yoshida. (2007) A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction. Biochemical Journal 401:3, pages 735-741.
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Andy Wullaert, Karen Heyninck & Rudi Beyaert. (2006) Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes. Biochemical Pharmacology 72:9, pages 1090-1101.
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Martin Modrianský & Zdeněk Dvořák. (2005) MICROTUBULE DISRUPTORS AND THEIR INTERACTION WITH BIOTRANSFORMATION ENZYMES. Biomedical Papers 149:2, pages 213-215.
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Paul Dent, Song Iy Han, Clint Mitchell, Elaine Studer, Adly Yacoub, Jennifer Grandis, Steven Grant, Geoffrey W. Krystal & Philip B. Hylemon. (2005) Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes. Biochemical Pharmacology 70:11, pages 1685-1696.
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Satoshi Numazawa, Sawako Shindo, Keiji Maruyama, Fumika Chibana, Yosuke Kawahara, Takashi Ashino, Sachiko Tanaka & Takemi Yoshida. (2005) Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: Association with an attenuated CYP2B induction by phenobarbital. FEBS Letters 579:17, pages 3560-3564.
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Radim Vrzal, Jitka Ulrichová & Zdeněk Dvořák. (2004) AROMATIC HYDROCARBON RECEPTOR STATUS IN THE METABOLISM OF XENOBIOTICS UNDER NORMAL AND PATHOPHYSIOLOGICAL CONDITIONS. Biomedical Papers 148:1, pages 3-10.
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