Citations (68)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (7)
Chin Eng Ong, Yan Pan, Joon Wah Mak & Rusli Ismail. (2013)
In vitro approaches to investigate cytochrome P450 activities: update on current status and their applicability. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1097-1113.
Read now
Read now
Dmitri R Davydov & James R Halpert. (2008) Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?. Expert Opinion on Drug Metabolism & Toxicology 4:12, pages 1523-1535.
Read now
Read now
Stefan S De Buck & Claire E Mackie. (2007) Physiologically based approaches towards the prediction of pharmacokinetics: in vitro–in vivo extrapolation. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 865-878.
Read now
Read now
O. Pelkonen & M. Turpeinen. (2007) extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations. Xenobiotica 37:10-11, pages 1066-1089.
Read now
Read now
Keith W Ward. (2005) Recent advances in pharmacokinetic extrapolation from preclinical data to humans. Expert Opinion on Drug Metabolism & Toxicology 1:4, pages 583-594.
Read now
Read now
Olavi Pelkonen & Hannu Raunio. (2005) In vitro screening of drug metabolism during drug development: can we trust the predictions?. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 49-59.
Read now
Read now
H. C. Rawden, D. J. Carlile, A. Tindall, D. Hallifax, A. Galetin, K. Ito & J. B. Houston. (2005) Microsomal prediction of in vivo clearance and associated interindividual variability of six benzodiazepines in humans. Xenobiotica 35:6, pages 603-625.
Read now
Read now
Articles from other publishers (61)
Manuel Rivas & Manuel Reina. (2022) Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics. Alternatives to Laboratory Animals 50:2, pages 136-145.
Crossref
Crossref
Fatemeh Faramarzi, Mohammadreza Shiran, Mohammadreza Rafati, Roya Farhadi, Ebrahim Salehifar & Maryam Nakhshab. (2021) Prediction of pharmacokinetic values of two various dosages of caffeine in premature neonates with apnea. Indian Journal of Pharmacology 53:2, pages 108.
Crossref
Crossref
Christof Dücker & Jürgen Brockmöller. (2021) How precise is quantitative prediction of pharmacokinetic effects due to drug-drug interactions and genotype from in vitro data? A comprehensive analysis on the example CYP2D6 and CYP2C19 substrates. Pharmacology & Therapeutics 217, pages 107629.
Crossref
Crossref
. 2020. ANSI/AAMI/ISO 10993-16:2017; Biological evaluation of medical devices—Part 16: Toxicokinetic study design for degradation products and leachables. ANSI/AAMI/ISO 10993-16:2017; Biological evaluation of medical devices—Part 16: Toxicokinetic study design for degradation products and leachables.
Yingshu Feng, Jinyi Wan, Baoding Chen, Yuan Zhu, Caleb Kesse Firempong, Chunlai Feng, Teruko Imai, Ximing Xu & Jiangnan Yu. (2020) In Vitro Metabolic Profiling of Periplogenin in Rat Liver Microsomes and its Associated Enzyme-kinetic Evaluation. Current Pharmaceutical Analysis 16:5, pages 504-512.
Crossref
Crossref
Salvatore Genovese, Vito Alessandro Taddeo, Francesco Epifano, Serena Fiorito, Cécile Bize, Arnaud Rives & Philippe de Medina. (2017)
Characterization of the Degradation Profile of Umbelliprenin, a Bioactive Prenylated Coumarin of a
Ferulago
Species
. Journal of Natural Products 80:9, pages 2424-2431.
Crossref
Crossref
J. Vrbanac & R. Slauter. 2017. A Comprehensive Guide to Toxicology in Nonclinical Drug Development. A Comprehensive Guide to Toxicology in Nonclinical Drug Development
39
67
.
Yan-Wei Jia, Zhong-Qiu Zeng, Hai-Li Shi, Jian Liang, Yi-Ming Liu, Ya-Xiong Tang & Xun Liao. (2016)
Characterization of
in vitro
metabolites of irisflorentin by rat liver microsomes using high-performance liquid chromatography coupled with tandem mass spectrometry
. Biomedical Chromatography 30:9, pages 1363-1370.
Crossref
Crossref
H.-C. Chien, A. A. Zur, T. S. Maurer, S. W. Yee, J. Tolsma, P. Jasper, D. O. Scott & K. M. Giacomini. (2015) Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Drug Metabolism and Disposition 44:3, pages 356-364.
Crossref
Crossref
Chunyu Wang, Yinfeng Dong, Hang Zhao, Chunyan Wang, Rong Li, Neng Qiu, Haoyu Ye, Minghai Tang & Lijuan Chen. (2015) Characterization of in vitro primary metabolic profile of SKLB-M8, a novel antitumor compound, using liquid chromatography coupled with triple quadrupole tandem mass spectrometry and quadrupole time-of-flight tandem mass spectrometry. International Journal of Mass Spectrometry 383-384, pages 23-30.
Crossref
Crossref
Lucas Maciel Mauriz Marques, Eduardo Afonso da Silva-Junior, Dayana Rubio Gouvea, Ricardo Vessecchi, Mônica Tallarico Pupo, Norberto Peporine Lopes, Massuo Jorge Kato & Anderson Rodrigo Moraes de Oliveira. (2014) In vitro metabolism of the alkaloid piplartine by rat liver microsomes. Journal of Pharmaceutical and Biomedical Analysis 95, pages 113-120.
Crossref
Crossref
Tycho Heimbach, Rakesh Gollen & Handan He. 2014. Predictive ADMET. Predictive ADMET
319
352
.
Md L T Vieira, B Kirby, I Ragueneau-Majlessi, A Galetin, J Y L Chien, H J Einolf, O A Fahmi, V Fischer, A Fretland, K Grime, S D Hall, R Higgs, D Plowchalk, R Riley, E Seibert, K Skordos, J Snoeys, K Venkatakrishnan, T Waterhouse, R S Obach, E G Berglund, L Zhang, P Zhao, K S Reynolds & S-M Huang. (2013) Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug. Clinical Pharmacology & Therapeutics 95:2, pages 189-198.
Crossref
Crossref
Tonika Bohnert & Lawrence L. Gan. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics
1
61
.
Jim Vrbanac & Richard Slauter. 2013. A Comprehensive Guide to Toxicology in Preclinical Drug Development. A Comprehensive Guide to Toxicology in Preclinical Drug Development
3
30
.
Peng Zou, Yanke Yu, Nan Zheng, Yongsheng Yang, Hayley J. Paholak, Lawrence X. Yu & Duxin Sun. (2012) Applications of Human Pharmacokinetic Prediction in First-in-Human Dose Estimation. The AAPS Journal 14:2, pages 262-281.
Crossref
Crossref
Claudia Mugnaini, Stefania Nocerino, Valentina Pedani, Serena Pasquini, Andrea Tafi, Maria De Chiaro, Luca Bellucci, Massimo Valoti, Francesca Guida, Livio Luongo, Stefania Dragoni, Alessia Ligresti, Avraham Rosenberg, Daniele Bolognini, Maria Grazia Cascio, Roger G. Pertwee, Ruin Moaddel, Sabatino Maione, Vincenzo Di Marzo & Federico Corelli. (2012) Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach. ChemMedChem 7:5, pages 920-934.
Crossref
Crossref
Takushi Kanazu, Norihito Sato, Kyoko Kadono, Akira Touchi, Yuri Takeda, Yoshitaka Yamaguchi & Takahiko Baba. (2012) Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats. Biopharmaceutics & Drug Disposition 33:4, pages 195-206.
Crossref
Crossref
Chun Li & Nataraj Kalyanaraman. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development
189
212
.
J Yang, W M Atkins, N Isoherranen, M F Paine & K E Thummel. (2011) Evidence of CYP3A Allosterism In Vivo: Analysis of Interaction Between Fluconazole and Midazolam. Clinical Pharmacology & Therapeutics 91:3, pages 442-449.
Crossref
Crossref
Alexander V. LyubimovMeihua Rose Feng, Nan Zheng, Xinyuan Zhang, Yea Min Huh & Jing‐yu Yu. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
36
.
Alexander V. LyubimovWalter A. Korfmacher. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
18
.
Caihong Xu, Meijuan Zou, Yi Liu, Jungang Ren, Ye Tian, Jing Yan, Yiping Wang & Gang Cheng. (2011) Pharmacokinetics of carbamazepine polymorphs and dihydrate in rats, related to dogs and humans. Archives of Pharmacal Research 34:11, pages 1973-1982.
Crossref
Crossref
Walter Korfmacher. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition
383
406
.
Snježana Dragojević, Vitomir Šunjić, Vlatka Bencetić-Mihaljević, Jovica Ralić, Milan Mesić, Ivaylo Jivkov Elenkov, Anita Filipović Sučić, Andreja Čempuh Klonkay, Lidija Lerman, Marina Ilijaš, Vesna Gabelica-Marković & Ivica Malnar. (2011) Determination of aqueous stability and degradation products of series of coumarin dimers. Journal of Pharmaceutical and Biomedical Analysis 54:1, pages 37-47.
Crossref
Crossref
Tobias Pähler & Jochen Maas. 2011. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology
9
13
.
. 2010. Mixture Toxicity. Mixture Toxicity
229
269
.
Cuyue Tang & Thomayant Prueksaritanont. (2010) Use of In Vivo Animal Models to Assess Pharmacokinetic Drug-Drug Interactions. Pharmaceutical Research 27:9, pages 1772-1787.
Crossref
Crossref
Dieter Gallemann, Elmar Wimmer, Constance C. Höfer, Achim Freisleben, Markus Fluck, Bernhard Ladstetter & Hugues Dolgos. (2010) In Vitro Characterization of Sarizotan Metabolism: Hepatic Clearance, Identification and Characterization of Metabolites, Drug-Metabolizing Enzyme Identification, and Evaluation of Cytochrome P450 Inhibition. Drug Metabolism and Disposition 38:6, pages 905-916.
Crossref
Crossref
James W. Paxton. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
22
.
Jane R. Kenny, Dermot F. McGinnity, Ken Grime & Robert J. Riley. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
38
.
Olavi Pelkonen, Ari Tolonen, Miia Turpeinen & Jouko Uusitalo. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
32
.
Akihiro Hisaka, Yoshiyuki Ohno, Takehito Yamamoto & Hiroshi Suzuki. (2010) Prediction of pharmacokinetic drug–drug interaction caused by changes in cytochrome P450 activity using in vivo information. Pharmacology & Therapeutics 125:2, pages 230-248.
Crossref
Crossref
Aleksandra Galetin, Michael Gertz & J. Brian Houston. (2010) Contribution of Intestinal Cytochrome P450-Mediated Metabolism to Drug-Drug Inhibition and Induction Interactions. Drug Metabolism and Pharmacokinetics 25:1, pages 28-47.
Crossref
Crossref
J. Brian Houston & Aleksandra Galetin. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions
169
215
.
Ramesh B. Bambal & Stephen E. Clarke. 2009. Evaluation of Drug Candidates for Preclinical Development. Evaluation of Drug Candidates for Preclinical Development
55
107
.
Aleksandra Galetin & J. Brian Houston. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development
315
343
.
Tonika Bohnert & Liang‐Shang Gan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development
91
176
.
Silvio Caccia, Silvio Garattini, Luca Pasina & Alessandro Nobili. (2009) Predicting the Clinical Relevance of Drug Interactions From Pre-Approval Studies. Drug Safety 32:11, pages 1017-1039.
Crossref
Crossref
. 2009. Handbook of Basic Pharmacokinetics … Including Clinical Applications, Seventh Edition. Handbook of Basic Pharmacokinetics … Including Clinical Applications, Seventh Edition.
Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao & Xi-Ling Jiang. (2009) Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis. Drug Metabolism and Disposition 37:1, pages 170-177.
Crossref
Crossref
Yury Kapelyukh, Mark J. I. Paine, Jean-Didier Maréchal, Michael J. Sutcliffe, C. Roland Wolf & Gordon C. K. Roberts. (2008)
Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules
. Drug Metabolism and Disposition 36:10, pages 2136-2144.
Crossref
Crossref
Miki Katoh, Chise Tateno, Katsutoshi Yoshizato & Tsuyoshi Yokoi. (2008) Chimeric mice with humanized liver. Toxicology 246:1, pages 9-17.
Crossref
Crossref
Dmitri R. Davydov, Nadezhda Y. Davydova, Tamara N. Tsalkova & James R. Halpert. (2008) Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4. Archives of Biochemistry and Biophysics 471:2, pages 134-145.
Crossref
Crossref
Harshica Fernando, James R. Halpert & Dmitri R. Davydov. (2008) Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein. Archives of Biochemistry and Biophysics 471:1, pages 20-31.
Crossref
Crossref
Franca M. Buratti & Emanuela Testai. (2007) Evidences for CYP3A4 autoactivation in the desulfuration of dimethoate by the human liver. Toxicology 241:1-2, pages 33-46.
Crossref
Crossref
David Hallifax & J. Brian Houston. (2007) Saturable Uptake of Lipophilic Amine Drugs into Isolated Hepatocytes: Mechanisms and Consequences for Quantitative Clearance Prediction. Drug Metabolism and Disposition 35:8, pages 1325-1332.
Crossref
Crossref
M. Dickins, A. Galetin & N. Proctor. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
827
846
.
Thomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr & Jiunn H. Lin. (2006) In Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction Studies. Drug Metabolism and Disposition 34:9, pages 1546-1555.
Crossref
Crossref
Timothy S Tracy. (2006) Atypical Cytochrome P450 Kinetics. Drugs in R & D 7:6, pages 349-363.
Crossref
Crossref
R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan, Emily A. Gaman, J. Brian Houston & Larry M. Tremaine. (2006) The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions. Journal of Pharmacology and Experimental Therapeutics 316:1, pages 336-348.
Crossref
Crossref
H John SmithGlyn Taylor. 2005. Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition. Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition
55
75
.
Dana L Anger, Maria-Alexandra Petre & Denis J Crankshaw. (2005) Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols. British Journal of Pharmacology 145:7, pages 926-933.
Crossref
Crossref
Aleksandra Galetin, Kiyomi Ito, David Hallifax & J. Brian Houston. (2005) CYP3A4 Substrate Selection and Substitution in the Prediction of Potential Drug-Drug Interactions. Journal of Pharmacology and Experimental Therapeutics 314:1, pages 180-190.
Crossref
Crossref
Kiyomi Ito, David Hallifax, R. Scott Obach & J. Brian Houston. (2005) IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM. Drug Metabolism and Disposition 33:6, pages 837-844.
Crossref
Crossref
Olavi Pelkonen, Miia Turpeinen, Jouko Uusitalo, Arja Rautio & Hannu Raunio. (2005) Prediction of Drug Metabolism and Interactions on the Basis of in vitro Investigations. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 96:3, pages 167-175.
Crossref
Crossref
J. Brian Houston & Aleksandra Galetin. (2005) Modelling atypical CYP3A4 kinetics: principles and pragmatism. Archives of Biochemistry and Biophysics 433:2, pages 351-360.
Crossref
Crossref
Weili Huang, Yvonne S. Lin, Donavon J. McConnIIII, Justina C. Calamia, Rheem A. Totah, Nina Isoherranen, Mary Glodowski & Kenneth E. Thummel. (2004) EVIDENCE OF SIGNIFICANT CONTRIBUTION FROM CYP3A5 TO HEPATIC DRUG METABOLISM. Drug Metabolism and Disposition 32:12, pages 1434-1445.
Crossref
Crossref
Robert J. Riley & Ken Grime. (2004) Metabolic screening in vitro: metabolic stability, CYP inhibition and induction. Drug Discovery Today: Technologies 1:4, pages 365-372.
Crossref
Crossref
Dermot F. McGinnity, Matthew G. Soars, Richard A. Urbanowicz & Robert J. Riley. (2004) EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE. Drug Metabolism and Disposition 32:11, pages 1247-1253.
Crossref
Crossref
Hannu RaunioPäivi TaavitsainenPaavo HonkakoskiRisto JuvonenOlavi Pelkonen. (2019)
In Vitro
Methods in the Prediction of Kinetics of Drugs: Focus on Drug Metabolism
. Alternatives to Laboratory Animals 32:4, pages 425-430.
Crossref
Crossref