Citations (63)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (8)
Sophia M. Shi & Li Di. (2017) The role of carbonyl reductase 1 in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 13:8, pages 859-870.
Read now
Read now
Petra Malátková & Vladimír Wsól. (2014) Carbonyl reduction pathways in drug metabolism. Drug Metabolism Reviews 46:1, pages 96-123.
Read now
Read now
Lucie Skarydova, Milan Nobilis & Vladimir Wsól. (2013) Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetone in vitro. Xenobiotica 43:4, pages 346-354.
Read now
Read now
Jillissa C. Molnari & Alan L. Myers. (2012) Carbonyl reduction of bupropion in human liver. Xenobiotica 42:6, pages 550-561.
Read now
Read now
Lucie Škarydová & Vladimír Wsól. (2012) Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily. Drug Metabolism Reviews 44:2, pages 173-191.
Read now
Read now
Oleg A. Barski, Srinivas M. Tipparaju & Aruni Bhatnagar. (2008) The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification. Drug Metabolism Reviews 40:4, pages 553-624.
Read now
Read now
Yorishige Imamura, Rika Narumi & Hideaki Shimada. (2007) Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones. Journal of Enzyme Inhibition and Medicinal Chemistry 22:1, pages 105-109.
Read now
Read now
Frank Hoffmann & Edmund Maser. (2007) Carbonyl Reductases and Pluripotent Hydroxysteroid Dehydrogenases of the Short-chain Dehydrogenase/reductase Superfamily. Drug Metabolism Reviews 39:1, pages 87-144.
Read now
Read now
Articles from other publishers (55)
Jessica L. Beers, Aurora K. Authement, Nina Isoherranen & Klarissa D. Jackson. (2023) Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol. ACS Medicinal Chemistry Letters 14:5, pages 614-620.
Crossref
Crossref
Rachel Ryu & Mary F. Hebert. 2022. Clinical Pharmacology During Pregnancy. Clinical Pharmacology During Pregnancy
19
46
.
Yiding Hu, Yi Xiao, Zhesui Rao, Vasant Kumar, Hanlan Liu & Chuang Lu. (2021) Carbon-carbon Bond Cleavage Catalyzed by Human Cytochrome P450 Enzymes: α-ketol as the Key Intermediate Metabolite in Sequential Metabolism of Olanexidine. Drug Metabolism Letters 14:1, pages 41-53.
Crossref
Crossref
Marco Robello, Elisabetta Barresi, Emma Baglini, Silvia Salerno, Sabrina Taliani & Federico Da Settimo. (2021) The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities. Journal of Medicinal Chemistry 64:7, pages 3508-3545.
Crossref
Crossref
Haruka Nishimuta, Takao Watanabe & Kiyoko Bando. (2019) Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes. The AAPS Journal 21:2.
Crossref
Crossref
Diane Ramsden, Dustin Smith, Raquel Arenas, Kosea Frederick & Matthew A. Cerny. (2018) Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate. Drug Metabolism and Disposition 46:10, pages 1434-1440.
Crossref
Crossref
M. L. Maté, T. Geary, C. Mackenzie, C. Lanusse & G. Virkel. (2017) Species differences in hepatic biotransformation of the anthelmintic drug flubendazole. Journal of Veterinary Pharmacology and Therapeutics 40:5, pages 493-499.
Crossref
Crossref
Xiangmeng Wu, Qinghao Zhang, Jiamei Guo, Yufei Jia, Ziqian Zhang, Manman Zhao, Yakun Yang, Baolian Wang, Jinping Hu, Li Sheng & Yan Li. (2017) Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol. Frontiers in Pharmacology 8.
Crossref
Crossref
Hideyuki Murata, Toshiyuki Higuchi & Masaki Otagiri. (2016)
Oral pharmacokinetics and
in-vitro
metabolism of metyrapone in male rats
. Journal of Pharmacy and Pharmacology 68:8, pages 970-979.
Crossref
Crossref
Z. D. Fu, F. P. Selwyn, J. Y. Cui & C. D. Klaassen. (2016) RNA Sequencing Quantification of Xenobiotic-Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice. Drug Metabolism and Disposition 44:6, pages 842-856.
Crossref
Crossref
Jamie N. Connarn, Xinyuan Zhang, Andrew Babiskin & Duxin Sun. (2015) Metabolism of Bupropion by Carbonyl Reductases in Liver and Intestine. Drug Metabolism and Disposition 43:7, pages 1019-1027.
Crossref
Crossref
Rudolf Andrýs, Lucie Zemanová, Juraj Lenčo, Zuzana Bílková & Vladimír Wsól. (2015) Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier. Chemico-Biological Interactions 234, pages 169-177.
Crossref
Crossref
Jian Meng, Dafang Zhong, Liang Li, Zhengyu Yuan, Hong Yuan, Cen Xie, Jialan Zhou, Chen Li, Mikhail Fedorovich Gordeev, Jinqian Liu & Xiaoyan Chen. (2015) Metabolism of MRX-I, a Novel Antibacterial Oxazolidinone, in Humans: The Oxidative Ring Opening of 2,3-Dihydropyridin-4-One Catalyzed by Non-P450 Enzymes. Drug Metabolism and Disposition 43:5, pages 646-659.
Crossref
Crossref
Osama Y. Alshogran, Judith Naud, Andrew J. Ocque, François A. Leblond, Vincent Pichette & Thomas D. Nolin. (2015) Effect of Experimental Kidney Disease on the Functional Expression of Hepatic Reductases. Drug Metabolism and Disposition 43:1, pages 100-106.
Crossref
Crossref
Rick J. Alleman, Lalage A. Katunga, Margaret A. M. Nelson, David A. Brown & Ethan J. Anderson. (2014) The “Goldilocks Zone†from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle. Frontiers in Physiology 5.
Crossref
Crossref
Karen Larsen, Roberto Najle, Adrián Lifschitz, María L. Maté, Carlos Lanusse & Guillermo L. Virkel. (2014) Effects of Sublethal Exposure to a Glyphosate-Based Herbicide Formulation on Metabolic Activities of Different Xenobiotic-Metabolizing Enzymes in Rats. International Journal of Toxicology 33:4, pages 307-318.
Crossref
Crossref
Adolfo Quiñones-Lombraña, Daniel Ferguson, Rachael Hageman Blair, James L. Kalabus, Almedina Redzematovic & Javier G. Blanco. (2014) Interindividual Variability in the Cardiac Expression of Anthracycline Reductases in Donors With and Without Down Syndrome. Pharmaceutical Research 31:7, pages 1644-1655.
Crossref
Crossref
B.S. Raccor, A.M. Teitelbaum, J.C. Dinh & R.A. Totah. 2014. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Yong Wu, Zhao-Ying Liu, Yan Cao, Xiao-Jun Chen, Jian-Guo Zeng & Zhi-Liang Sun. (2013) Reductive metabolism of the sanguinarine iminium bond by rat liver preparations. Pharmacological Reports 65:5, pages 1391-1400.
Crossref
Crossref
Bernard Testa. (2013) Organic Stereochemistry. Part 8. Helvetica Chimica Acta 96:8, pages 1409-1451.
Crossref
Crossref
Haruka Nishimuta, Tetsuya Nakagawa, Naruaki Nomura & Masashi Yabuki. (2013) Significance of Reductive Metabolism in Human Intestine and Quantitative Prediction of Intestinal First-Pass Metabolism by Cytosolic Reductive Enzymes. Drug Metabolism and Disposition 41:5, pages 1104-1111.
Crossref
Crossref
Lucie Škarydová, Rudolf Andrýs, Lucie Holubová, Hana Štambergová, Jana Kňavová, Vladimír Wsól & Zuzana Bílková. (2013) Efficient isolation of carbonyl-reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand. Journal of Separation Science 36:7, pages 1176-1184.
Crossref
Crossref
Alexander V. LyubimovRobert S. Foti, Dan A. Rock, Larry C. Wienkers & Jan L. Wahlstrom. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
68
.
Takafumi Akabane, Nicolas Gerst, Yoichi Naritomi, Jeffrey N. Masters & Kouichi Tamura. (2012) A Practical and Direct Comparison of Intrinsic Metabolic Clearance of Several Non-CYP Enzyme Substrates in Freshly Isolated and Cryopreserved Hepatocytes. Drug Metabolism and Pharmacokinetics 27:2, pages 181-191.
Crossref
Crossref
Bo Wen & Sidney D. Nelson. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition
13
41
.
Adam Skarka, Lucie Škarydová, Hana Štambergová & Vladimír Wsól. (2011) Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase. Chemico-Biological Interactions 191:1-3, pages 66-74.
Crossref
Crossref
L. MATÉ, G. VIRKEL, A. LIFSCHITZ, J. SALLOVITZ, M. BALLENT & C. LANUSSE. (2010) Phase 1 and phase 2 metabolic activities along the small intestine in adult male sheep1. Journal of Veterinary Pharmacology and Therapeutics 33:6, pages 537-545.
Crossref
Crossref
Weixue Huang, Liya Ding, Qiang Huang, Hairong Hu, Shan Liu, Xianmei Yang, Xiaohui Hu, Yongjun Dang, Suqin Shen, Jie Li, Xiaona Ji, Songmin Jiang, Jun O. Liu & Long Yu. (2010) Carbonyl reductase 1 as a novel target of (?)-epigallocatechin gallate against hepatocellular carcinoma. Hepatology 52:2, pages 703-714.
Crossref
Crossref
Xiaoming Wang, Doaa R. Abdelrahman, Olga L. Zharikova, Svetlana L. Patrikeeva, Gary D.V. Hankins, Mahmoud S. Ahmed & Tatiana N. Nanovskaya. (2010) Bupropion metabolism by human placenta. Biochemical Pharmacology 79:11, pages 1684-1690.
Crossref
Crossref
Zeen Tong, Appavu Chandrasekaran, Hongshan Li, Yakov Rotshteyn, John C. L. Erve, William DeMaio, Rasmy Talaat, Theresa Hultin & JoAnn Scatina. (2010) In Vitro Metabolism and Identification of Human Enzymes Involved in the Metabolism of Methylnaltrexone. Drug Metabolism and Disposition 38:5, pages 801-807.
Crossref
Crossref
Faraj Hijaz, Tej B. Shrestha, Stefan H. Bossman, Faris Hussain & J. Scott Smith. (2010) In Vitro and In Vivo Metabolism of the Radiolytic Compound 2-Dodecylcyclobutanone. Journal of Food Science 75:4, pages T72-T80.
Crossref
Crossref
Chunze Li, Bing Lu, Robert M. Garbaccio, Edward S. Tasber, Mark E. Fraley, George D. Hartman, Jingjing Ye, Jane C. Harrelson & Thomayant Prueksaritanont. (2010) Stereospecific reduction of a potent kinesin spindle protein (KSP) inhibitor in human tissues. Biochemical Pharmacology 79:10, pages 1526-1533.
Crossref
Crossref
Stefan Blech, Eva Ludwig-Schwellinger, Eva Ulrike Gräfe-Mody, Barbara Withopf & Klaus Wagner. (2010) The Metabolism and Disposition of the Oral Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, in Humans. Drug Metabolism and Disposition 38:4, pages 667-678.
Crossref
Crossref
Lucie ?karydov?Adam Skarka, Romana Novotn?Lucie ?ivn?Hans-J?rg Martin, Vladim?r Ws?l & Edmund Maser. (2009) Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin. Toxicology 264:1-2, pages 52-60.
Crossref
Crossref
Jianping Zhang & Javier G. Blanco. (2009) Identification of the Promoter of Human Carbonyl Reductase 3 (CBR3) and Impact of Common Promoter Polymorphisms on Hepatic CBR3 mRNA Expression. Pharmaceutical Research 26:9, pages 2209-2215.
Crossref
Crossref
Vanessa Gonzalez-Covarrubias, Jianping Zhang, James L. Kalabus, Mary V. Relling & Javier G. Blanco. (2009)
Pharmacogenetics of Human Carbonyl Reductase 1 (
CBR1
) in Livers from Black and White Donors
. Drug Metabolism and Disposition 37:2, pages 400-407.
Crossref
Crossref
Rita Scarpelli, Annalise Di Marco, Federica Ferrigno, Ralph Laufer, Isabella Marcucci, Ester Muraglia, Jesus M. Ontoria, Michael Rowley, Sergio Serafini, Christian Steinkühler & Philip Jones. (2008) Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors. Bioorganic & Medicinal Chemistry Letters 18:23, pages 6078-6082.
Crossref
Crossref
Yorishige IMAMURA. (2008) Structure and Function of Peroxisomal Tetrameric Carbonyl Reductaseペルオキシソームに局在する4量体カルボニル還元酵素の構造と機能. YAKUGAKU ZASSHI 128:11, pages 1665-1672.
Crossref
Crossref
John F. Kenneke, Christopher S. Mazur, Susan E. Ritger & Thomas J. Sack. (2008) Mechanistic Investigation of the Noncytochrome P450-Mediated Metabolism of Triadimefon to Triadimenol in Hepatic Microsomes. Chemical Research in Toxicology 21:10, pages 1997-2004.
Crossref
Crossref
Nina Kassner, Klaus Huse, Hans-Jörg Martin, Ute Gödtel-Armbrust, Annegret Metzger, Ingolf Meineke, Jürgen Brockmöller, Kathrin Klein, Ulrich M. Zanger, Edmund Maser & Leszek Wojnowski. (2008)
Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver
. Drug Metabolism and Disposition 36:10, pages 2113-2120.
Crossref
Crossref
Martina Gavelová, Jana Hladíková, Lenka Vildová, Romana Novotná, Jan Vondráček, Pavel Krčmář, Miroslav Machala & Lenka Skálová. (2008) Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells. Chemico-Biological Interactions 176:1, pages 9-18.
Crossref
Crossref
Magnus Carlquist, Torbj?rn Frejd & Marie F. Gorwa-Grauslund. (2008) Flavonoids as inhibitors of human carbonyl reductase 1. Chemico-Biological Interactions 174:2, pages 98-108.
Crossref
Crossref
Christopher S. Mazur & John F. Kenneke. (2007) Cross-Species Comparison of Conazole Fungicide Metabolites Using Rat and Rainbow Trout (Onchorhynchus mykiss) Hepatic Microsomes and Purified Human CYP 3A4. Environmental Science & Technology 42:3, pages 947-954.
Crossref
Crossref
Jyan-Gwo J. Su, Pei-Jyuan Liao, Min-Cong Huang, Wen-Cheng Chu, Shin-Chang Lin & Yu-Jung Chang. (2008) Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis. Toxicology 244:2-3, pages 257-270.
Crossref
Crossref
Sukhwinder S. Lakhman, Xiaomin Chen, Vanessa Gonzalez-Covarrubias, Erin G. Schuetz & Javier G. Blanco. (2007)
Functional Characterization of the Promoter of Human Carbonyl Reductase 1 (
CBR1
). Role of
XRE
Elements in Mediating the Induction of
CBR1
by Ligands of the Aryl Hydrocarbon Receptor
. Molecular Pharmacology 72:3, pages 734-743.
Crossref
Crossref
Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala & Javier G. Blanco. (2007)
A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (
CBR1
V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
. Drug Metabolism and Disposition 35:6, pages 973-980.
Crossref
Crossref
Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
Crossref
Crossref
Yi JinTrevor M. Penning. (2007) Aldo-Keto Reductases and Bioactivation/Detoxication. Annual Review of Pharmacology and Toxicology 47:1, pages 263-292.
Crossref
Crossref
Hideaki Shimada, Koji Imaishi, Takaomi Hirashima, Takeshi Kitano, Shuhei Ishikura, Akira Hara & Yorishige Imamura. (2007) Stereoselective reduction of 4-benzoylpyridine in the heart of vertebrates. Life Sciences 80:6, pages 554-558.
Crossref
Crossref
R.A. Totah & A.E. Rettie. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
167
191
.
W.F. Trager. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II
87
132
.
Vanessa Gonzalez Covarrubias, Sukhwinder S. Lakhman, Alan Forrest, Mary V. Relling & Javier G. Blanco. (2006) Higher activity of polymorphic NAD(P)H:quinone oxidoreductase in liver cytosols from blacks compared to whites. Toxicology Letters 164:3, pages 249-258.
Crossref
Crossref
Leah M. Hesse, David J. Greenblatt, Lisa L. von Moltke & Michael H. Court. (2006) Ritonavir Has Minimal Impact on the Pharmacokinetic Disposition of a Single Dose of Bupropion Administered to Human Volunteers. The Journal of Clinical Pharmacology 46:5, pages 567-576.
Crossref
Crossref
John S. Walsh. 2006. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery. Optimizing the “Drug-Like” Properties of Leads in Drug Discovery
49
80
.
M. Jane Cox Rosemond. (2005) Measurement of Xenobiotic Carbonyl Reduction in Human Liver Fractions. Current Protocols in Toxicology 25:1.
Crossref
Crossref