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Drug Metabolism Reviews Volume 36, 2004 - Issue 3-4
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Research Article

Detoxification of Lithocholic Acid, A Toxic Bile Acid: Relevance to Drug Hepatotoxicity

Alan F. Hofmann Department of Medicine, Division of Gastroenterology, University of California, San Diego, CaliforniaUSA
, M.D.
Pages 703-722 | Published online: 25 Oct 2004

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Yuan Tian, Wei Gui, Imhoi Koo, Philip B. Smith, Erik L. Allman, Robert G. Nichols, Bipin Rimal, Jingwei Cai, Qing Liu & Andrew D. Patterson. (2020) The microbiome modulating activity of bile acids. Gut Microbes 11:4, pages 979-996.
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Neel Deferm, Tom De Vocht, Bing Qi, Pieter Van Brantegem, Eva Gijbels, Mathieu Vinken, Peter de Witte, Thomas Bouillon & Pieter Annaert. (2019) Current insights in the complexities underlying drug-induced cholestasis. Critical Reviews in Toxicology 49:6, pages 520-548.
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Takehiko Shimohira, Katsuhisa Kurogi, Ming-Cheh Liu, Masahito Suiko & Yoichi Sakakibara. (2018) The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids. Bioscience, Biotechnology, and Biochemistry 82:8, pages 1359-1365.
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Ndeye Mareme Ba & Mehmet Öztürk. (2018) Molecular Cloning and Characterization of Bile Salt Hydrolase from Lactobacillus gasseri ATCC 33323 Strain. Food Biotechnology 32:2, pages 95-111.
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Yongshou Yang, Dwi Eva Nirmagustina, Thanutchaporn Kumrungsee, Yukako Okazaki, Hiroyuki Tomotake & Norihisa Kato. (2017) Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer. Bioscience, Biotechnology, and Biochemistry 81:9, pages 1796-1804.
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Jing-Chun Han, Jian Yu & Ya-Jie Gao. (2014) Lipidomics investigation of reversal effect of glycyrrhizin (GL) towards lithocholic acid (LCA)-induced alteration of phospholipid profiles. Pharmaceutical Biology 52:12, pages 1624-1628.
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Charles N. Falany & Katie Jo Rohn-Glowacki. (2013) SULT2B1: unique properties and characteristics of a hydroxysteroid sulfotransferase family. Drug Metabolism Reviews 45:4, pages 388-400.
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Tiangang Li & John Y. L. Chiang. (2013) Nuclear receptors in bile acid metabolism. Drug Metabolism Reviews 45:1, pages 145-155.
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M. Miyata, H. Watase, W. Hori, M. Shimada, K. Nagata, F. J. Gonzalez & Y. Yamazoe. (2006) Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity. Xenobiotica 36:7, pages 631-644.
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Manisha Iyer, Erica J Reschly & Matthew D Krasowski. (2006) Functional evolution of the pregnane X receptor. Expert Opinion on Drug Metabolism & Toxicology 2:3, pages 381-397.
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Jan Gustafsson, Gunvor Alvelius, Ingemar Björkhem & Antal Nemeth. (2006) Bile Acid Metabolism in Extrahepatic Biliary Atresia. Upsala Journal of Medical Sciences 111:1, pages 131-136.
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