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Original Articles

Cancer Prevention and Treatment by Ganoderma, a Mushroom with Medicinal Properties

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Pages 275-325 | Published online: 06 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Qiaofen Yang, Kejun He, Shiyu Qiu, Aoyi Zheng, Qiuyue Hu, Zuhong Ma, Miao Dong & Min Zhou. (2020) A new lanostane triterpenoid from Ganoderma resinaceum. Journal of Asian Natural Products Research 22:11, pages 1095-1099.
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Hui-Fang Chiu, Hui-Yu Fu, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kamesh Venkatakrishnan, Oksana Golovinskaia & Chin-Kun Wang. (2017) Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharmaceutical Biology 55:1, pages 1041-1046.
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Anita Thyagarajan, Andrej Jedinak, Hai Nguyen, Colin Terry, Lee Ann Baldridge, Jiahua Jiang & Daniel Sliva. (2010) Triterpenes From Ganoderma Lucidum Induce Autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK). Nutrition and Cancer 62:5, pages 630-640.
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Canjun Li, Yiming Li & Hao H. Sun. (2006) New ganoderic acids, bioactive triterpenoid metabolites from the mushroom . Natural Product Research 20:11, pages 985-991.
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Yihuai Gao, He Gao, Eli Chan, Wenbo Tang, Anlong Xu, Hongyuan Yang, Min Huang, Jin Lan, Xiaotian Li, Wei Duan, Congjian Xu & Shufeng Zhou. (2005) Antitumor Activity and Underlying Mechanisms of Ganopoly, The Refined Polysaccharides Extracted from Ganoderma Lucidum, in Mice. Immunological Investigations 34:2, pages 171-198.
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Yihuai Gao, He Gao, Eli Chan, Wenbo Tang, Xiaotian Li, Jun Liang & Shufeng Zhou. (2005) Protective Effect of Ganoderma (a Mushroom with Medicinal Properties) Against Various Liver Injuries. Food Reviews International 21:1, pages 27-52.
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Jiahua Jiang, Veronika Slivova, Kevin Harvey, Tatiana Valachovicova & Daniel Sliva. (2004) Ganoderma lucidum Suppresses Growth of Breast Cancer Cells Through the Inhibition of Akt/NF-κB Signaling. Nutrition and Cancer 49:2, pages 209-216.
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Yihuai Gao, Eli Chan & Shufeng Zhou. (2004) Immunomodulating Activities of Ganoderma, a Mushroom with Medicinal Properties. Food Reviews International 20:2, pages 123-161.
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Articles from other publishers (33)

Mohammed Sharif Swallah, Precious Bondzie-Quaye, Han Wang, Chang-Sheng Shao, Pei Hua, Mona Alrasheed Bashir, Joseph Benjamin Holman, Frederick Leo Sossah & Qing Huang. (2023) Potentialities of Ganoderma lucidum extracts as functional ingredients in food formulation. Food Research International 172, pages 113161.
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Seren Gündoğdu & Nadire Özenver. 2023. Mushrooms with Therapeutic Potentials. Mushrooms with Therapeutic Potentials 221 240 .
Suhrud Pathak, Nick Martin, Shannon Kim, Sindhu Ramesh, Rishi M. Nadar, Jack DeRuiter, Timothy Moore, Dinesh Chandra Agrawal & Muralikrishnan Dhanasekaran. 2023. Mushrooms with Therapeutic Potentials. Mushrooms with Therapeutic Potentials 493 509 .
Li Yang, De-Xian Kong, Na Xiao, Qing-Yun Ma, Qing-Yi Xie, Jiao-Cen Guo, Chun Ying Deng, Hai-Xia Ma, Yan Hua, Hao-Fu Dai & You-Xing Zhao. (2022) Antidiabetic lanostane triterpenoids from the fruiting bodies of Ganoderma weberianum. Bioorganic Chemistry 127, pages 106025.
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Rongchen Dai, Mengfan Liu, Wan Najbah Nik Nabil, Zhichao Xi & Hongxi Xu. (2021) Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities. Molecules 26:4, pages 1113.
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Sharareh Rezaeian & Hamid R. Pourianfar. (2018) A comparative study on cytotoxicity and antiproliferative activities of crude extracts and fractions from Iranian wild-growing and cultivated Agaricus spp.. Journal of Food Measurement and Characterization 12:4, pages 2377-2384.
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Yu Cao, Xiaowei Xu, Shujing Liu, Linfang Huang & Jian Gu. (2018) Ganoderma: A Cancer Immunotherapy Review. Frontiers in Pharmacology 9.
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Guibin Pang, Fujun Wang & Leshuai W. Zhang. (2018) Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment. Carbohydrate Polymers 195, pages 243-256.
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Xiuqing Zhang, Zhangyang Xu, Haisheng Pei, Zhou Chen, Xiaoyan Tan, Jing Hu, Bin Yang & Junshe Sun. (2017) Intraspecific Variation and Phylogenetic Relationships Are Revealed by ITS1 Secondary Structure Analysis and Single-Nucleotide Polymorphism in Ganoderma lucidum. PLOS ONE 12:1, pages e0169042.
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Yu-Ping Zhou, Min-Hua Chen, Jun-Jie Lu, Xun Kang, Qiong-Hua Chen, Xiao-Ling Huang & Chang-En Tian. (2015) A simple and efficient genetic transformation method of Ganoderma weberianum. Folia Microbiologica 60:5, pages 417-423.
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N.P. Sudheesh, T.A. Ajith & K.K. Janardhanan. (2013) Ganoderma lucidum ameliorate mitochondrial damage in isoproterenol-induced myocardial infarction in rats by enhancing the activities of TCA cycle enzymes and respiratory chain complexes. International Journal of Cardiology 165:1, pages 117-125.
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Thulasi G. Pillai & P. Uma Devi. (2013) Mushroom beta glucan: Potential candidate for post irradiation protection. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 751:2, pages 109-115.
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Yun Cao, Sheng-Hua Wu & Yu-Cheng Dai. (2012) Species clarification of the prize medicinal Ganoderma mushroom “Lingzhi”. Fungal Diversity 56:1, pages 49-62.
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Shu-Feng Zhou. 2012. Materia Medica for Various Cancers. Materia Medica for Various Cancers 353 395 .
Xiao Tong Wu, Qi Wei Ren, Jie Zhang, Ji Zhao, Su Ting Han & Cui Ying Li. (2011) Optimization of Extraction Condition of Mycelium Polysaccharide from <i>Tricholoma mongolium</i> by Response Surface Methodology. Advanced Materials Research 361-363, pages 770-776.
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John Yuen, John Buswell & Iris Benzie. 2011. Herbal Medicine. Herbal Medicine 175 199 .
Thulasi G. Pillai, Mathew John & Gifty Sara Thomas. (2011) Prevention of cisplatin induced nephrotoxicity by terpenes isolated from Ganoderma lucidum occurring in Southern Parts of India. Experimental and Toxicologic Pathology 63:1-2, pages 157-160.
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Hesham El Enshasy. 2011. Industrial Applications. Industrial Applications 165 194 .
Ke Xu, Xin Liang, Feng Gao, Jianjiang Zhong & Jianwen Liu. (2010) Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion. Process Biochemistry 45:8, pages 1261-1267.
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N.P. Sudheesh, T.A. Ajith, V. Ramnath & K.K. Janardhanan. (2010) Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice. Clinical Nutrition 29:3, pages 406-412.
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Shuang Yang, Xiaodong Ren, Jingxue Sheng, Jiahui Lu, Tingting Li, Fangrong Tang, Yanfeng Wang, Lingjun Meng, Qingfan Meng & Lirong Teng. (2009) Preparation and the antitumor activity in vitro of polysaccharides from Tricholoma matsutake. World Journal of Microbiology and Biotechnology 26:3, pages 497-503.
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Yi Chen, Wolfgang Bicker, JunYan Wu, Ming Yong Xie & Wolfgang Lindner. (2010) Ganoderma species discrimination by dual-mode chromatographic fingerprinting: A study on stationary phase effects in hydrophilic interaction chromatography and reduction of sample misclassification rate by additional use of reversed-phase chromatography. Journal of Chromatography A 1217:8, pages 1255-1265.
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Jiri Adamec, Amber Jannasch, Shailesh Dudhgaonkar, Andrej Jedinak, Miroslav Sedlak & Daniel Sliva. (2009) Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: Determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds . Journal of Separation Science 32:23-24, pages 4052-4058.
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Jia-hui Lu, Yi-bo Zhang, Qing-fan Meng, Qiu-hong Xie & Li-rong Teng. (2009) Application of Wavelet Packet Transform-Radial Basis Function Neural Network in NIR Spectroscopy for Non-destructive Determination of Tricholoma Matsutake. Application of Wavelet Packet Transform-Radial Basis Function Neural Network in NIR Spectroscopy for Non-destructive Determination of Tricholoma Matsutake.
Nian-Hong Chen & Jian-Jiang Zhong. (2009) Ganoderic acid Me induces G1 arrest in wild-type p53 human tumor cells while G1/S transition arrest in p53-null cells. Process Biochemistry 44:8, pages 928-933.
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T.A. Ajith, N.P. Sudheesh, D. Roshny, G. Abishek & K.K. Janardhanan. (2009) Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats. Experimental Gerontology 44:3, pages 219-223.
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Guan Wang, Jian Zhao, Jianwen Liu, Yongping Huang, Jian-Jiang Zhong & Wen Tang. (2007) Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. International Immunopharmacology 7:6, pages 864-870.
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Wen Tang, Jian-Wen Liu, Wei-Ming Zhao, Dong-Zhi Wei & Jian-Jiang Zhong. (2006) Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sciences 80:3, pages 205-211.
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Xiao Chen, Ze-Ping Hu, Xiao-Xia Yang, Min Huang, Yihuai Gao, Wenbo Tang, Sui Yung Chan, Xihu Dai, Jinxian Ye, Paul Chi-Liu Ho, Wei Duan, Hong-Yuan Yang, Yi-Zhun Zhu & Shu-Feng Zhou. (2006) Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. International Immunopharmacology 6:3, pages 499-508.
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Snait Tamir & N Michael Eskin. 2005. Dictionary of Nutraceuticals and Functional Foods. Dictionary of Nutraceuticals and Functional Foods 505 507 .
Wenbo TangYihuai GaoGuoliang ChenHe GaoXihu DaiJinxian YeEli ChanMin HuangShufeng Zhou. (2005) A Randomized, Double-Blind and Placebo-Controlled Study of a Ganoderma lucidum Polysaccharide Extract in Neurasthenia . Journal of Medicinal Food 8:1, pages 53-58.
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Yihuai GaoWenbo TangHe GaoEli ChanJin LanShufeng Zhou. (2004) Ganoderma lucidum Polysaccharide Fractions Accelerate Healing of Acetic Acid-Induced Ulcers in Rats . Journal of Medicinal Food 7:4, pages 417-421.
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Yihuai Gao, He Gao, Eli Chan, Wenbo Tan, Jin Lan, Hwee-Ling Koh, Guoliang Chen & Shufeng Zhou. (2004) Hypoglycemic Properties of Polysaccharides Extracted from Ganoderma lucidum in Alloxan-Induced Diabetic Rats. Preventive Nutrition and Food Science 9:3, pages 240-244.
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