Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 28, 2004 - Issue 2
240
Views
39
CrossRef citations to date
0
Altmetric
Original Article

Safety of Purified Poloxamer 188 in Sickle Cell Disease: Phase I Study of a Non‐ionic Surfactant in the Management of Acute Chest Syndrome

, M.D., , , , , , , , & show all
Pages 85-102 | Received 14 Apr 2003, Accepted 31 Oct 2003, Published online: 24 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Meghna S. Jayaraman, Kaitlin Graham & Evan C. Unger. (2021) Injectable oxygenation therapeutics: evaluating the oxygen delivery efficacy of artificial oxygen carriers and kosmotropes in vitro. Artificial Cells, Nanomedicine, and Biotechnology 49:1, pages 317-324.
Read now
Nicola Conran. (2015) Prospects for early investigational therapies for sickle cell disease. Expert Opinion on Investigational Drugs 24:5, pages 595-602.
Read now
Sandy D Kotiah & Samir K Ballas. (2009) Investigational drugs in sickle cell anemia. Expert Opinion on Investigational Drugs 18:12, pages 1817-1828.
Read now
Winfred C Wang. (2008) The pharmacotherapy of sickle cell disease. Expert Opinion on Pharmacotherapy 9:17, pages 3069-3082.
Read now
DeWayne Townsend, Soichiro Yasuda & Joseph Metzger. (2007) Cardiomyopathy of Duchenne muscular dystrophy: pathogenesis and prospect of membrane sealants as a new therapeutic approach. Expert Review of Cardiovascular Therapy 5:1, pages 99-109.
Read now
Samir K. Ballas, Beatrice Files, Lori Luchtman-Jones, Lennette Benjamin, Paul Swerdlow, Lee Hilliard, Thomas Coates, Miguel Abboud, Slawomir Wojtowicz-Praga, Frans A. Kuypers & J. Michael Grindel. (2006) Secretory Phospholipase A2 Levels in Patients with Sickle Cell Disease and Acute Chest Syndrome. Hemoglobin 30:2, pages 165-170.
Read now

Articles from other publishers (33)

Daniel A. Real, Ailen Gagliano, Lucas Orzan, Darío Leonardi & Claudio J. Salomon. (2023) Amorphous solid dispersions of triclabendazole: Keeping the supersaturated drug solution using poloxamers. Journal of Drug Delivery Science and Technology, pages 105223.
Crossref
Addeli Bez Batti Angulski, Nora Hosny, Houda Cohen, Ashley A. Martin, Dongwoo Hahn, Jack Bauer & Joseph M. Metzger. (2023) Duchenne muscular dystrophy: disease mechanism and therapeutic strategies. Frontiers in Physiology 14.
Crossref
Dongwoo Hahn, Joseph D. Quick, Brian R. Thompson, Adelyn Crabtree, Benjamin J. Hackel, Frank S. Bates & Joseph M. Metzger. (2023) Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers. Skeletal Muscle 13:1.
Crossref
Michael Lowe, Zarna Bambhroliya, Hesha Patel, Vishva J Patel, Sunil Akshara Vudugula, Naga Pratyusha Cheruvu, Shafaat Raza & Oluwasemilore I Okunlola. (2023) Emerging Therapies for the Management of Pain and Vaso-Occlusive Crises in Patients With Sickle Cell Disease: A Systematic Review of Randomized Controlled Trials. Cureus.
Crossref
Lukas Bollenbach, Julia Buske, Karsten Mäder & Patrick Garidel. (2022) Poloxamer 188 as surfactant in biological formulations – An alternative for polysorbate 20/80?. International Journal of Pharmaceutics 620, pages 121706.
Crossref
James F. Casella, Shari S. Kronsberg & Rebecca T. Gorney. (2021) Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease—Reply. JAMA 326:10, pages 975.
Crossref
Madeleine Lu, Celeste K. Kanne, Riley C. Reddington, Dalia L. Lezzar, Vivien A. Sheehan & Sergey S. Shevkoplyas. (2021) Concurrent Assessment of Deformability and Adhesiveness of Sickle Red Blood Cells by Measuring Perfusion of an Adhesive Artificial Microvascular Network. Frontiers in Physiology 12.
Crossref
James F. Casella, Bruce A. Barton, Julie Kanter, L. Vandy Black, Suvankar Majumdar, Adlette Inati, Yasser Wali, Richard A. Drachtman, Miguel R. Abboud, Yurdanur Kilinc, Beng R. Fuh, Murtadha K. Al-Khabori, Clifford M. Takemoto, Emad Salman, Sharada A. Sarnaik, Nirmish Shah, Claudia R. Morris, Jennifer Keates-Baleeiro, Ashok Raj, Ofelia A. Alvarez, Lewis L. Hsu, Alexis A. Thompson, India Y. Sisler, Betty S. Pace, Suzie A. Noronha, Joseph L. LaskyIIIIII, Elena Cela de Julian, Kamar Godder, Courtney Dawn Thornburg, Natalie L. Kamberos, Rachelle Nuss, Anne M. Marsh, William C. Owen, Anne Schaefer, Cameron K. Tebbi, Christophe F. Chantrain, Debra E. Cohen, Zeynep Karakas, Connie M. Piccone, Alex George, Jason M. Fixler, Tammuella C. Singleton, Thomas Moulton, Charles T. Quinn, Clarisse Lopes de Castro Lobo, Abdulkareem M. Almomen, Meenakshi Goyal-Khemka, Philip Maes, Marty Emanuele, Rebecca T. Gorney, Claire S. Padgett, Ed Parsley, Shari S. Kronsberg, Gregory J. Kato & Mark T. Gladwin. (2021) Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease. JAMA 325:15, pages 1513.
Crossref
Zeynep Özözen Ayas, Gülgün Uncu & Demet Özbabalık Adapınar. 2020. Disorders of Consciousness - A Review of Important Issues. Disorders of Consciousness - A Review of Important Issues.
Evelyne M. Houang, Jason Bartos, Benjamin J. Hackel, Timothy P. Lodge, Demetris Yannopoulos, Frank S. Bates & Joseph M. Metzger. (2019) Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury. JACC: Basic to Translational Science 4:2, pages 275-287.
Crossref
Junaid Ansari & Felicity N.E. Gavins. (2019) Ischemia-Reperfusion Injury in Sickle Cell Disease. The American Journal of Pathology 189:4, pages 706-718.
Crossref
Evelyne M. Houang, Yuk Y. Sham, Frank S. Bates & Joseph M. Metzger. (2018) Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers. Skeletal Muscle 8:1.
Crossref
Evelyne M. Houang, Frank S. Bates, Yuk Y. Sham & Joseph M. Metzger. (2017) All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions. The Journal of Physical Chemistry B 121:47, pages 10657-10664.
Crossref
Forum Kamdar, Pradeep P. A. Mammen & Daniel J. Garry. 2017. Congestive Heart Failure and Cardiac Transplantation. Congestive Heart Failure and Cardiac Transplantation 175 196 .
Shahida A. Khan, Ghazi Damanhouri, Ashraf Ali, Sarah A. Khan, Aziz Khan, Ahmed Bakillah, Samy Marouf, Ghazi Al Harbi, Saeed H. Halawani & Ahmad Makki. (2016) Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. Nutrition & Metabolism 13:1.
Crossref
Ruth Tevlin, Adrian McArdle, Elizabeth Brett, Michael T. Chung, Kevin Paik, Eun Young Seo, Graham G. Walmsley, Christopher R. Duldulao, David Atashroo, Elizabeth Zielins, Stephanie Vistnes, Charles K. F. Chan, Derrick C. Wan & Michael T. Longaker. (2016) A Novel Method of Human Adipose-Derived Stem Cell Isolation with Resultant Increased Cell Yield. Plastic & Reconstructive Surgery 138:6, pages 983e-996e.
Crossref
Marilyn J. Telen. (2016) Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease. Blood 127:7, pages 810-819.
Crossref
Evelyne M Houang, Karen J Haman, Antonio Filareto, Rita C Perlingeiro, Frank S Bates, Dawn A Lowe & Joseph M Metzger. (2015) Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo. Molecular Therapy - Methods & Clinical Development 2, pages 15042.
Crossref
Aaron J. MullerJeremy D. Marks. (2014) Hypoxic-Ischemic Brain Injury: Potential Therapeutic Interventions for the Future. NeoReviews 15:5, pages e177-e186.
Crossref
Deepa ManwaniPaul S. Frenette. (2013) Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Hematology 2013:1, pages 362-369.
Crossref
Deepa ManwaniPaul S. Frenette. (2013) Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Blood 122:24, pages 3892-3898.
Crossref
Jon Detterich, Tamas Alexy, Miklos Rabai, Rosalinda Wenby, Ani Dongelyan, Thomas Coates, John Wood & Herbert Meiselman. (2013) Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion 53:2, pages 297-305.
Crossref
Samir K. Ballas, Muge R. Kesen, Morton F. Goldberg, Gerard A. Lutty, Carlton Dampier, Ifeyinwa Osunkwo, Winfred C. Wang, Carolyn Hoppe, Ward Hagar, Deepika S. Darbari & Punam Malik. (2012) Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management. The Scientific World Journal 2012, pages 1-55.
Crossref
Christopher F Spurney, Alfredo D Guerron, Qing Yu, Arpana Sali, Jack H van der Meulen, Eric P Hoffman & Kanneboyina Nagaraju. (2011) Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice. BMC Cardiovascular Disorders 11:1.
Crossref
Maria Plataki, Yang D. Lee, Deborah L. Rasmussen & Rolf D. Hubmayr. (2011) Poloxamer 188 Facilitates the Repair of Alveolus Resident Cells in Ventilator-injured Lungs. American Journal of Respiratory and Critical Care Medicine 184:8, pages 939-947.
Crossref
Rabindra N. Paul, Oswaldo L. Castro, Anita Aggarwal & Patricia A. Oneal. (2011) Acute chest syndrome: sickle cell disease. European Journal of Haematology 87:3, pages 191-207.
Crossref
Christopher F. Spurney. (2011) Cardiomyopathy of duchenne muscular dystrophy: Current understanding and future directions. Muscle & Nerve 44:1, pages 8-19.
Crossref
J.A. Jung, B.M. Choi, S.H. Cho, S.M. Choe, J.L. Ghim, H.M. Lee, Y.J. Roh & G.J. Noh. (2010) Effectiveness, safety, and pharmacokinetic and pharmacodynamic characteristics of microemulsion propofol in patients undergoing elective surgery under total intravenous anaesthesia. British Journal of Anaesthesia 104:5, pages 563-576.
Crossref
Sandra S. Renteria, Courtney C. Clemens & Maria A. Croyle. (2010) Development of a nasal adenovirus-based vaccine: Effect of concentration and formulation on adenovirus stability and infectious titer during actuation from two delivery devices. Vaccine 28:9, pages 2137-2148.
Crossref
Rongzhen Zhang, Robert L. Hunter, Ernest A. Gonzalez & Frederick A. Moore. (2009) POLOXAMER 188 PROLONGS SURVIVAL OF HYPOTENSIVE RESUSCITATION AND DECREASES VITAL TISSUE INJURY AFTER FULL RESUSCITATION. Shock 32:4, pages 442-450.
Crossref
A.E. Fawibe. (2008) Managing acute chest syndrome of sickle cell disease in an African setting. Transactions of the Royal Society of Tropical Medicine and Hygiene 102:6, pages 526-531.
Crossref
Alexandros C MakisEleftheria C HatzimichaelJustin Stebbing. (2006) The genomics of new drugs in sickle cell disease. Pharmacogenomics 7:6, pages 909-917.
Crossref
Tamas Alexy, Eszter Pais, Jonathan K. Armstrong, Herbert J. Meiselman, Cage S. Johnson & Timothy C. Fisher. (2006) Rheologic behavior of sickle and normal red blood cell mixtures in sickle plasma: implications for transfusion therapy. Transfusion 46:6, pages 912-918.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.