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Journal of Liquid Chromatography & Related Technologies Volume 26, 2003 - Issue 12
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Original Articles

Selective Removal of a Pharmaceutical Process Impurity Using a Reactive Resin

Christopher J. Welch Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065, USACorrespondence[email protected]
,
Mirlinda Biba Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065, USA
,
Antoinette Drahus Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065, USA
,
David A. Conlon Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065, USA
,
Hsien Hsin Tung Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065, USA
&
Paul Collins Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey, 07065, USA
Pages 1959-1968 | Received 16 Jan 2003, Accepted 10 Feb 2003, Published online: 02 Jun 2007

Citations (15)

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Mukesh Maithani, Richa Raturi, Vikas Gupta & Parveen Bansal. (2017) Evolution of regulatory aspects of genotoxic impurities in pharmaceuticals: Survival of the fittest. Journal of Liquid Chromatography & Related Technologies 40:15, pages 759-769.
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Articles from other publishers (14)

Alice J. C. Wahart, Jonathan P. Dolan, Simon D. Anderson, Aisling Ní Cheallaigh, Jessica Staniland, Marcelo A. Lima, Mark A. Skidmore, Gavin J. Miller & Sebastian C. Cosgrove. (2023) Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem.
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. 2021. Mutagenic Impurities. Mutagenic Impurities 233 268 .
D. C. Gernat, E. Brouwer & M. Ottens. (2019) Aldehydes as Wort Off-Flavours in Alcohol-Free Beers—Origin and Control. Food and Bioprocess Technology 13:2, pages 195-216.
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Christopher J. Welch. (2019) High throughput analysis enables high throughput experimentation in pharmaceutical process research. Reaction Chemistry & Engineering 4:11, pages 1895-1911.
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Alline V. B. de Oliveira, Vinicius Kartnaller, Claudio Costa Neto & João Cajaiba. (2019) Effects of Solvent Polarity on the Reaction of Aldehydes and Ketones with a Hydrazide-Bound Scavenger Resin. ACS Omega 4:8, pages 13530-13537.
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Kerstin Zawatzky, Mikhail Reibarkh, Nicole Canfield, Ting-Chuan Wang, Shanren Li, Liangcheng Du & Christopher J. Welch. (2016) Visualizing small differences using subtractive chromatographic analysis. Journal of Chromatography A 1468, pages 245-249.
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Gyorgy Szekely, Miriam C. Amores de Sousa, Marco Gil, Frederico Castelo Ferreira & William Heggie. (2015) Genotoxic Impurities in Pharmaceutical Manufacturing: Sources, Regulations, and Mitigation. Chemical Reviews 115:16, pages 8182-8229.
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Rustem Kecili, David Nivhede, Johan Billing, Mats Leeman, Börje Sellergren & Ecevit Yilmaz. (2012) Removal of Acrolein from Active Pharmaceutical Ingredients Using Aldehyde Scavengers. Organic Process Research & Development 16:6, pages 1225-1229.
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Andrew Teasdale, Dave Elder & Simon Fenner. 2011. Genotoxic Impurities. Genotoxic Impurities 219 247 .
Claire LeeRoy HelmyChristopher StrulsonJolanta PlewaElizabeth KolodziejVincent AntonucciBing MaoChristopher J. WelchZhihong GeMohammad A. Al-Sayah. (2010) Removal of Electrophilic Potential Genotoxic Impurities Using Nucleophilic Reactive Resins. Organic Process Research & Development 14:4, pages 1021-1026.
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Christopher J. Welch, Xiaoyi Gong, Wes Schafer, Edwin C. Pratt, Tanja Brkovic, Zainab Pirzada, James F. Cuff & Birgit Kosjek. (2010) MISER chromatography (multiple injections in a single experimental run): the chromatogram is the graph. Tetrahedron: Asymmetry 21:13-14, pages 1674-1681.
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Roy HelmyWes SchaferLeah BuhlerStephen MarcinkoBrian MusselmanErin GuidryHerb JenkinsFred FleitzChristopher J. Welch. (2010) Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development. Organic Process Research & Development 14:2, pages 386-392.
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Christopher J. WelchWilliam R. LeonardDerek W. HendersonBenjamin DornerKarla Glaser ChildersJohn Y. L. ChungFrederick W. HartnerJennifer Albaneze-WalkerPeter Sajonz. (2008) Adsorbent Screening Using Microplate Spectroscopy for Selective Removal of Colored Impurities from Active Pharmaceutical Intermediates. Organic Process Research & Development 12:1, pages 81-87.
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Christopher J. Welch, Mirlinda Biba & Peter Sajonz. (2006) Fast methods of enantiopurity determination for the Soai reaction: Towards a general enantioenrichment detector?. Chirality 19:1, pages 34-43.
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