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Research Article

Preparation, Characterization, and In Vitro Evaluation of 1- and 4-Month Controlled Release Orntide PLA and PLGA Microspheres

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Pages 585-596 | Received 08 Apr 2000, Accepted 24 Jun 2000, Published online: 21 Nov 2000

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Ravi Vaishya, Varun Khurana, Sulabh Patel & Ashim K Mitra. (2015) Long-term delivery of protein therapeutics. Expert Opinion on Drug Delivery 12:3, pages 415-440.
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E. Gavini, V. Sanna, C. Juliano & P. Giunchedi. (2003) Compressed biodegradable matrices of spray-dried PLGA microspheres for the modified release of ketoprofen. Journal of Microencapsulation 20:2, pages 193-201.
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Sandrine Gautier, Violetta D'Aloia, Olivier Halleux, Michaël Mazza, Philippe Lecomte & Robert Jérôme. (2003) Amphiphilic copolymers of ε-caprolactone and γ-substituted ε-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles . Journal of Biomaterials Science, Polymer Edition 14:1, pages 63-85.
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Dinesh B. Shenoy, Reshma J. D'Souza, Sandip B. Tiwari & N. Udupa. (2003) Potential Applications of Polymeric Microsphere Suspension as Subcutaneous Depot for Insulin. Drug Development and Industrial Pharmacy 29:5, pages 555-563.
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Ge Jiang, B. C. Thanoo & Patrick P. DeLuca. (2002) Effect of Osmotic Pressure in the Solvent Extraction Phase on BSA Release Profile from PLGA Microspheres. Pharmaceutical Development and Technology 7:4, pages 391-399.
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Daixu Wei, Ruirui Qiao, Jinwei Dao, Jing Su, Chengmin Jiang, Xichang Wang, Mingyuan Gao & Jian Zhong. (2018) Soybean Lecithin‐Mediated Nanoporous PLGA Microspheres with Highly Entrapped and Controlled Released BMP‐2 as a Stem Cell Platform. Small 14:22.
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Yueli Bao, Shanrong Wang, Hongli Li, Yunjiao Wang, Haiyun Chen & Minglong Yuan. (2018) Characterization, Stability and Biological Activity In Vitro of Cathelicidin-BF-30 Loaded 4-Arm Star-Shaped PEG-PLGA Microspheres. Molecules 23:2, pages 497.
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Amy C. Goodfriend, Tré R. Welch, Kytai T. Nguyen, Romaine F. Johnson, Vinod Sebastian, Surendranath Veeram Reddy, Joseph Forbess & Alan Nugent. (2016) Thermally processed polymeric microparticles for year-long delivery of dexamethasone. Materials Science and Engineering: C 58, pages 595-600.
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Barbara Albertini, Nunzio Iraci, Aurélie Schoubben, Stefano Giovagnoli, Maurizio Ricci, Paolo Blasi & Carlo Rossi. (2015) β-cyclodextrin hinders PLGA plasticization during microparticle manufacturing. Journal of Drug Delivery Science and Technology 30, pages 375-383.
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Muhammad Iqbal, Nadiah Zafar, Hatem Fessi & Abdelhamid Elaissari. (2015) Double emulsion solvent evaporation techniques used for drug encapsulation. International Journal of Pharmaceutics 496:2, pages 173-190.
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Susan D’Souza, Santos Murty, Jabar A. Faraj & Patrick P. DeLuca. (2014) In Vitro Characterization of Six Month Dosage Forms for a GnRH Antagonist . Advances in Pharmaceutics 2014, pages 1-10.
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Lili Li, Qifeng Wang, Hongli Li, Mingwei Yuan & Minglong Yuan. (2014) Preparation, Characterization, In Vitro Release and Degradation of Cathelicidin-BF-30-PLGA Microspheres. PLoS ONE 9:6, pages e100809.
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Alice W. Du & Martina H. Stenzel. (2014) Drug Carriers for the Delivery of Therapeutic Peptides. Biomacromolecules 15:4, pages 1097-1114.
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Susan D’Souza, Jabar A. Faraj, Stefano Giovagnoli & Patrick P. DeLuca. (2013) Preparation, Characterization, and In Vivo Evaluation of Olanzapine Poly(D,L-lactide-co-glycolide) Microspheres . Journal of Pharmaceutics 2013, pages 1-9.
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Tapan Kumar Giri, Chhatrapal Choudhary, Ajazuddin, Amit Alexander, Hemant Badwaik & Dulal Krishna Tripathi. (2013) Prospects of pharmaceuticals and biopharmaceuticals loaded microparticles prepared by double emulsion technique for controlled delivery. Saudi Pharmaceutical Journal 21:2, pages 125-141.
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H. A. Machado, J. J. Abercrombie, T. You, P. P. DeLuca & K. P. Leung. (2013) Release of a Wound-Healing Agent from PLGA Microspheres in a Thermosensitive Gel. BioMed Research International 2013, pages 1-11.
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Hesham M. Tawfeek, Andrew R. Evans, Abid Iftikhar, Afzal R. Mohammed, Anjum Shabir, Satyanarayana Somavarapu, Gillian A. Hutcheon & Imran Y. Saleem. (2013) Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers. International Journal of Pharmaceutics 441:1-2, pages 611-619.
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Himanshu Agrawal, Nipa Thacker & Ambikanandan Misra. 2011. Challenges in Delivery of Therapeutic Genomics and Proteomics. Challenges in Delivery of Therapeutic Genomics and Proteomics 531 622 .
Heidi M. Mansour, MinJi Sohn, Abeer Al-Ghananeem & Patrick P. DeLuca. (2010) Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects. International Journal of Molecular Sciences 11:9, pages 3298-3322.
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Shunmugaperumal Tamilvanan. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 49 .
Mingshi Yang & Sven Frokjaer. 2009. Delivery Technologies for Biopharmaceuticals. Delivery Technologies for Biopharmaceuticals 9 28 .
Xiaohong Wei, Yong-kyu Lee, Kang Moo Huh, Sungwon Kim & Kinam Park. 2009. Safety of Nanoparticles. Safety of Nanoparticles 63 88 .
Ying LIN, Jiali SUN, Guoqiang JIANG, Jia ZAN & Fuxin DING. (2007) In vitro Evaluation of Lysozyme-loaded Microspheres in Thermosensitive Methylcellulose-based Hydrogel. Chinese Journal of Chemical Engineering 15:4, pages 566-572.
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J. Siepmann, F. Siepmann & A.T. Florence. (2006) Local controlled drug delivery to the brain: Mathematical modeling of the underlying mass transport mechanisms. International Journal of Pharmaceutics 314:2, pages 101-119.
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Susan S. D'Souza & Patrick P. DeLuca. (2006) Methods to Assess in Vitro Drug Release from Injectable Polymeric Particulate Systems. Pharmaceutical Research 23:3, pages 460-474.
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Susan S. D’Souza, Jabar A. Faraj & Patrick P. DeLuca. (2005) A model-dependent approach to correlate accelerated with real-time release from biodegradable microspheres. AAPS PharmSciTech 6:4, pages E553-E564.
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Wasfi Al-Azzam, Emil A. Pastrana, Brian King, Jessica Méndez & Kai Griebenow. (2005) Effect of the covalent modification of horseradish peroxidase with poly(ethylene glycol) on the activity and stability upon encapsulation in polyester microspheres. Journal of Pharmaceutical Sciences 94:8, pages 1808-1819.
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Santos B. Murty, B.C. Thanoo, Qui Wei & Patrick P. DeLuca. (2005) Impurity formation studies with peptide-loaded polymeric microspheres. International Journal of Pharmaceutics 297:1-2, pages 50-61.
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Ugo Bilati, Eric Allémann & Eric Doelker. (2005) Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles. European Journal of Pharmaceutics and Biopharmaceutics 59:3, pages 375-388.
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U.g.o. Bilati, Carla Pasquarello, Garry L. Corthals, Denis F. Hochstrasser, Eric Allémann & Eric Doelker. (2005) Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry for quantitation and molecular stability assessment of insulin entrapped within PLGA nanoparticles. Journal of Pharmaceutical Sciences 94:3, pages 688-694.
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Santos B. Murty, Qui Wei, B. C. Thanoo & Patrick P. DeLuca. (2004) In vivo release kinetics of octreotide acetate from experimental polymeric microsphere formulations using oil/water and oil/oil processes. AAPS PharmSciTech 5:3, pages 90-99.
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Deborah J Quick & Kristi S Anseth. (2004) DNA delivery from photocrosslinked PEG hydrogels: encapsulation efficiency, release profiles, and DNA quality. Journal of Controlled Release 96:2, pages 341-351.
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Fariyal Ahmed & Dennis E Discher. (2004) Self-porating polymersomes of PEG–PLA and PEG–PCL: hydrolysis-triggered controlled release vesicles. Journal of Controlled Release 96:1, pages 37-53.
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Susan S. D'Souza, Francesca Selmin, Santos B Murty, Wei Qiu, BC Thanoo & Patrick P DeLuca. (2015) Assessment of fertility in male rats after extended chemical castration with a GnRH antagonist. AAPS PharmSci 6:1, pages 94-99.
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Shao-Qiong Liu, Yi-Yan Yang, Xue-Ming Liu & Yen-Wah Tong. (2003) Preparation and Characterization of Temperature-Sensitive Poly( N -isopropylacrylamide)- b -poly( d , l -lactide) Microspheres for Protein Delivery . Biomacromolecules 4:6, pages 1784-1793.
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V.R. Sinha & Aman Trehan. (2003) Biodegradable microspheres for protein delivery. Journal of Controlled Release 90:3, pages 261-280.
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Janusz W Kostanski, Ge Jiang, Bhas A Dani, Santos B Murty, Wei Qiu, Bruce Schrier, B C Thanoo & Patrick P DeLuca. (2001) Return to fertility after extended chemical castration with a GnRH antagonist. BMC Cancer 1:1.
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