580
Views
62
CrossRef citations to date
0
Altmetric
Research Article

Effect of Osmotic Pressure in the Solvent Extraction Phase on BSA Release Profile from PLGA Microspheres

, &
Pages 391-399 | Received 05 Jan 2002, Accepted 10 Mar 2002, Published online: 12 Feb 2002

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Yusuf A. Haggag, Ahmed M. Faheem, Murtaza M. Tambuwala, Mohamed A. Osman, Sanaa A. El-Gizawy, Barry O’Hagan, Nigel Irwin & Paul A. McCarron. (2018) Effect of poly(ethylene glycol) content and formulation parameters on particulate properties and intraperitoneal delivery of insulin from PLGA nanoparticles prepared using the double-emulsion evaporation procedure. Pharmaceutical Development and Technology 23:4, pages 370-381.
Read now
Santwana Padhi, Mohd. Aamir Mirza, Devina Verma, Tahir Khuroo, Amulya K. Panda, Sushama Talegaonkar, Roop Krishen Khar & Zeenat Iqbal. (2016) Revisiting the nanoformulation design approach for effective delivery of topotecan in its stable form: an appraisal of its in vitro Behavior and tumor amelioration potential. Drug Delivery 23:8, pages 2827-2837.
Read now
Jie Wu, Keke Qi, Ziwei Xu & Jin Wan. (2015) Glucagon-like peptide-2-loaded microspheres as treatment for ulcerative colitis in the murine model. Journal of Microencapsulation 32:6, pages 598-607.
Read now
Ravi Vaishya, Varun Khurana, Sulabh Patel & Ashim K Mitra. (2015) Long-term delivery of protein therapeutics. Expert Opinion on Drug Delivery 12:3, pages 415-440.
Read now
Sixing Yang, Weien Yuan & Tuo Jin. (2009) Formulating protein therapeutics into particulate forms. Expert Opinion on Drug Delivery 6:10, pages 1123-1133.
Read now
Cuifang Cai, Shirui Mao, Oliver Germershaus, Andreas Schaper, Erik Rytting, Dawei Chen & Thomas Kissel. (2009) Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA. Journal of Microencapsulation 26:4, pages 334-345.
Read now
Sabyasachi Maiti, Somasree Ray & Biswanath Sa. (2009) Controlled delivery of bovine serum albumin from carboxymethyl xanthan microparticles. Pharmaceutical Development and Technology 14:2, pages 165-172.
Read now
S Dean Allison. (2008) Analysis of initial burst in PLGA microparticles. Expert Opinion on Drug Delivery 5:6, pages 615-628.
Read now
Saowanee Jaraswekin, Sompol Prakongpan & Roland Bodmeier. (2007) Effect of poly(lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles. Journal of Microencapsulation 24:2, pages 117-128.
Read now
. (2003) Literature Alerts. Journal of Microencapsulation 20:4, pages 543-551.
Read now

Articles from other publishers (50)

Patrick A. Giolando, Kelsey Hopkins, Barrett F. Davis, Nicole Vike, Adib Ahmadzadegan, Arezoo M. Ardekani, Pavlos P. Vlachos, Joseph V. Rispoli, Luis Solorio & Tamara L. Kinzer‐Ursem. (2023) Mechanistic Computational Modeling of Implantable, Bioresorbable Drug Release Systems. Advanced Materials.
Crossref
Manoj A. Pawar, Leila Fotooh Abadi, Satish V. Rojekar, Ankita N. Yawalkar, Smita S. Kulkarni & Pradeep R. Vavia. (2023) Tenofovir alafenamide fumarate loaded long-acting microsphere for HIV pre-exposure prophylaxis. Journal of Drug Delivery Science and Technology 87, pages 104762.
Crossref
Ubaldo de Jesús Martín-Camacho, Noé Rodríguez-Barajas, Jorge Alberto Sánchez-Burgos & Alejandro Pérez-Larios. (2023) Weibull β value for the discernment of drug release mechanism of PLGA particles. International Journal of Pharmaceutics 640, pages 123017.
Crossref
Manoj A. Pawar, Lalitkumar K. Vora, Prasad Kompella, Venkata Kishan Pokuri & Pradeep R. Vavia. (2022) Long-acting microspheres of Human Chorionic Gonadotropin hormone: In-vitro and in-vivo evaluation. International Journal of Pharmaceutics 611, pages 121312.
Crossref
Jean Paul Dzoyem, Nathalie Boulens, Eric Allémann & Florence Delie. (2021) Thymol and Piperine-Loaded Poly(D,L-lactic-co-glycolic acid) Nanoparticles Modulate Inflammatory Mediators and Apoptosis in Murine Macrophages. Planta Medica International Open 8:03, pages e122-e130.
Crossref
Zixu Liu, Ruixuan Bu, Linxuan Zhao, Lei Liu, Nan Dong, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou & Xing Tang. (2021) Hydrogel-containing PLGA microspheres of palonosetron hydrochloride for achieving dual-depot sustained release. Journal of Drug Delivery Science and Technology 65, pages 102775.
Crossref
Sreejith Thrivikraman Nair, Kaladhar Kamalasanan, Ashna Moidu, Pooja Shyamsundar, Lakshmi J. Nair & Venkatesan P. (2021) Ethyl cellulose coated sustained release aspirin spherules for treating COVID-19: DOE led rapid optimization using arbitrary interface; applicable for emergency situations. International Journal of Biological Macromolecules 182, pages 1769-1784.
Crossref
Ying Li, Anthony W. Frei, Irayme M. Labrada, Yanan Rong, Jia-Pu Liang, Magdalena M. Samojlik, Chuqiao Sun, Steven Barash, Benjamin G. Keselowsky, Allison L. Bayer & Cherie L. Stabler. (2021) Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants. Frontiers in Immunology 12.
Crossref
Kinam Park, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin & Yan Wang. (2021) Formulation composition, manufacturing process, and characterization of poly(lactide-co-glycolide) microparticles. Journal of Controlled Release 329, pages 1150-1161.
Crossref
Anum Khan, Amna Bibi, Huma Ali, Asim ur Rehman, Maimoona Qindeel, Muhammad Irfan, Aamer Ali Shah, Malik Badshah, Fariha Hasan & Samiullah Khan. (2020) Development of Resistant Starch Film Coated Microparticles for an Oral Colon‐Specific Drug Delivery. Starch - Stärke 72:7-8.
Crossref
Shir Reen Chia, Malcolm S. Y. Tang, Yin Hui Chow, Chien Wei Ooi, Krishnamoorthy Rambabu, Liandong Zhu & Pau Loke Show. (2019) Recent Developments of Reverse Micellar Techniques for Lysozyme, Bovine Serum Albumin, and Bromelain Extraction. Molecular Biotechnology 61:10, pages 715-724.
Crossref
Pan Qi, Ruixuan Bu, Hui Zhang, Jiaojiao Yin, Jin Chen, Anan Zhang, Jingxin Gou, Tian Yin, Yu Zhang, Haibing He, Puxiu Wang, Xing Tang & Yanjiao Wang. (2019) Goserelin Acetate Loaded Poloxamer Hydrogel in PLGA Microspheres: Core–Shell Di-Depot Intramuscular Sustained Release Delivery System. Molecular Pharmaceutics 16:8, pages 3502-3513.
Crossref
Lianne W. Y. Roode, Ulyana Shimanovich, Si Wu, Sarah Perrett & Tuomas P. J. Knowles. 2019. Biological and Bio-inspired Nanomaterials. Biological and Bio-inspired Nanomaterials 223 263 .
Yusuf A. Haggag, Kyle B. Matchett, El-Habib Dakir, Paul Buchanan, Mohammed A. Osman, Sanaa A. Elgizawy, Mohamed El-Tanani, Ahmed M. Faheem & Paul A. McCarron. (2017) Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells. International Journal of Pharmaceutics 521:1-2, pages 40-53.
Crossref
Likai Hou, Yukun Ren, Yankai Jia, Xiaoming Chen, Xiaokang Deng, Zheng Tang, Qingming Hu, Ye Tao & Hongyuan Jiang. (2017) Osmolarity-controlled swelling behaviors of dual-cored double-emulsion drops. Microfluidics and Nanofluidics 21:4.
Crossref
D. Dutta, C. Fauer, K. Hickey, M. Salifu & S. E. Stabenfeldt. (2017) Tunable delayed controlled release profile from layered polymeric microparticles. Journal of Materials Chemistry B 5:23, pages 4487-4498.
Crossref
Xuewei Guan, Likai Hou, Yukun Ren, Xiaokang Deng, Qi Lang, Yankai Jia, Qingming Hu, Ye Tao, Jiangwei Liu & Hongyuan Jiang. (2016) A dual-core double emulsion platform for osmolarity-controlled microreactor triggered by coalescence of encapsulated droplets. Biomicrofluidics 10:3.
Crossref
Ariel Gilert, Limor Baruch, Tomer Bronshtein & Marcelle Machluf. (2016) PLGA-Listeriolysin O microspheres: Opening the gate for cytosolic delivery of cancer antigens. Biomedical Microdevices 18:2.
Crossref
Shahed Behzadi, Christine Rosenauer, Michael Kappl, Kristin Mohr, Katharina Landfester & Daniel Crespy. (2016) Osmotic pressure-dependent release profiles of payloads from nanocontainers by co-encapsulation of simple salts. Nanoscale 8:26, pages 12998-13005.
Crossref
Pedro Fonte, Francisca Araújo, Vítor Seabra, Salette Reis, Marco van de Weert & Bruno Sarmento. (2015) Co-encapsulation of lyoprotectants improves the stability of protein-loaded PLGA nanoparticles upon lyophilization. International Journal of Pharmaceutics 496:2, pages 850-862.
Crossref
Xiaozhou Huang, Na Li, Dajiang Wang, Yuyan Luo, Ziyu Wu, Zhefei Guo, Qixing Jin, Zhuying Liu, Yafei Huang, Yongming Zhang & Chuanbin Wu. (2015) Quantitative three-dimensional analysis of poly (lactic-co-glycolic acid) microsphere using hard X-ray nano-tomography revealed correlation between structural parameters and drug burst release. Journal of Pharmaceutical and Biomedical Analysis 112, pages 43-49.
Crossref
C. Martín-Sabroso, A.I. Fraguas-Sánchez, J. Aparicio-Blanco, M.F. Cano-Abad & A.I. Torres-Suárez. (2015) Critical attributes of formulation and of elaboration process of PLGA-protein microparticles. International Journal of Pharmaceutics 480:1-2, pages 27-36.
Crossref
Robert Moglia, Michael Whitely, Megan Brooks, Jennifer Robinson, Michael Pishko & Elizabeth Cosgriff-Hernandez. (2014) Solvent-Free Fabrication of polyHIPE Microspheres for Controlled Release of Growth Factors. Macromolecular Rapid Communications 35:14, pages 1301-1305.
Crossref
Ulyana Shimanovich, Gonçalo J. L. Bernardes, T. P. J. Knowles & Artur Cavaco-Paulo. (2014) Protein micro- and nano-capsules for biomedical applications. Chem. Soc. Rev. 43:5, pages 1361-1371.
Crossref
Harri Heiskanen, Peter Denifl, Päivi Pitkänen & Markku Hurme. (2012) Effect of concentration and temperature on the properties of the microspheres prepared using an emulsion–solvent extraction process. Advanced Powder Technology 23:6, pages 779-786.
Crossref
Brijeshkumar Patel, Vivek Gupta & Fakhrul Ahsan. (2012) PEG–PLGA based large porous particles for pulmonary delivery of a highly soluble drug, low molecular weight heparin. Journal of Controlled Release 162:2, pages 310-320.
Crossref
Fuquan Tu & Daeyeon Lee. (2012) Controlling the Stability and Size of Double-Emulsion-Templated Poly(lactic- co -glycolic) Acid Microcapsules . Langmuir 28:26, pages 9944-9952.
Crossref
Amir H. Ghassemi, Mies J. van Steenbergen, Arjan Barendregt, Herre Talsma, Robbert J. Kok, Cornelus F. van Nostrum, Daan J. A. Crommelin & Wim E. Hennink. (2011) Controlled Release of Octreotide and Assessment of Peptide Acylation from Poly(D,L-lactide-co-hydroxymethyl glycolide) Compared to PLGA Microspheres. Pharmaceutical Research 29:1, pages 110-120.
Crossref
Sam N. Rothstein & Steven R. Little. (2011) A “tool box” for rational design of degradable controlled release formulations. J. Mater. Chem. 21:1, pages 29-39.
Crossref
Mingbo Wang, Qingling Feng, Xiaodong Guo, Zhending She & Rongwei Tan. (2011) A dual microsphere based on PLGA and chitosan for delivering the oligopeptide derived from BMP-2. Polymer Degradation and Stability 96:1, pages 107-113.
Crossref
Namdev B. Shelke, Ajit P. Rokhade & Tejraj M. Aminabhavi. (2010) Preparation and evaluation of novel blend microspheres of poly(lactic- co -glycolic)acid and pluronic F68/127 for controlled release of repaglinide . Journal of Applied Polymer Science 116:1, pages 366-372.
Crossref
Zheng Wang. (2009) Effects of the process parameters on the initial burst release of poly(lactide‐ co ‐glycolide) microspheres containing bovine serum albumin by the double‐emulsion solvent evaporation/extraction method . Journal of Applied Polymer Science 115:5, pages 2599-2608.
Crossref
Atsushi Watanabe, Yoshihiro Takebayashi, Toshiro Ohtsubo & Mutsuhisa Furukawa. (2009) Permeation of urea through various polyurethane membranes. Pest Management Science 65:11, pages 1233-1240.
Crossref
Atsushi Watanabe, Yoshihiro Takebayashi, Toshiro Ohtsubo & Mutsuhisa Furukawa. (2009) Dependence of biodegradation and release behavior on physical properties of poly(caprolactone)‐based polyurethanes. Journal of Applied Polymer Science 114:1, pages 246-253.
Crossref
Ying Zhang, Andreas M. Sophocleous & Steven P. Schwendeman. (2009) Inhibition of Peptide Acylation in PLGA Microspheres with Water-soluble Divalent Cationic Salts. Pharmaceutical Research 26:8, pages 1986-1994.
Crossref
Guo-dong SHI. (2008) Preparation of injectable sustained-release nanoparticles carrying brain-derived neurotrophic factor and evaluation of their drug releasing characteristics. Academic Journal of Second Military Medical University 28:5, pages 538-542.
Crossref
Howard Kim, Charles H. Tator & Molly S. Shoichet. (2008) Design of Protein‐Releasing Chitosan Channels. Biotechnology Progress 24:4, pages 932-937.
Crossref
S. Dean Allison. (2008) Effect Of Structural Relaxation On The Preparation And Drug Release Behavior Of Poly(lactic-co-glycolic)acid Microparticle Drug Delivery Systems. Journal of Pharmaceutical Sciences 97:6, pages 2022-2035.
Crossref
Sam N. Rothstein, William J. Federspiel & Steven R. Little. (2008) A simple model framework for the prediction of controlled release from bulk eroding polymer matrices. Journal of Materials Chemistry 18:16, pages 1873.
Crossref
D. Cun, F. Cui, L. Yang, M. Yang, Y. Yu & R. Yang. (2008) Characterization and release mechanism of melittin entrapped poly (lactic acid-co-glycolic acid) microspheres. Journal of Drug Delivery Science and Technology 18:4, pages 267-272.
Crossref
Jayoung KimDasom HongYounglim ChungHongkee Sah. (2007) Ammonolysis-Induced Solvent Removal: A Facile Approach for Solidifying Emulsion Droplets into PLGA Microspheres. Biomacromolecules 8:12, pages 3900-3907.
Crossref
L. Al haushey, M.A. Bolzinger, C. Bordes, J.Y. Gauvrit & S. Briançon. (2007) Improvement of a bovine serum albumin microencapsulation process by screening design. International Journal of Pharmaceutics 344:1-2, pages 16-25.
Crossref
A. Sheikh Hasan, M. Socha, A. Lamprecht, F. El Ghazouani, A. Sapin, M. Hoffman, P. Maincent & N. Ubrich. (2007) Effect of the microencapsulation of nanoparticles on the reduction of burst release. International Journal of Pharmaceutics 344:1-2, pages 53-61.
Crossref
Hongkee Sah & Beom-Jin Lee. (2006) Development of New Microencapsulation Techniques Useful for the Preparation of PLGA Microspheres. Macromolecular Rapid Communications 27:21, pages 1845-1851.
Crossref
Bi‐Botti Celestin Youan. (2006) Influence of protein content on the physicochemistry of poly(ϵ‐caprolactone) microparticles. Journal of Applied Polymer Science 101:2, pages 1042-1050.
Crossref
Yogesh K. Katare & Amulya K. Panda. (2006) Influences of excipients on in vitro release and in vivo performance of tetanus toxoid loaded polymer particles. European Journal of Pharmaceutical Sciences 28:3, pages 179-188.
Crossref
Jae Hyung Park, Mingli Ye, Yoon Yeo, Woo-Kyoung Lee, Connie Paul & Kinam Park. (2005) Reservoir-Type Microcapsules Prepared by the Solvent Exchange Method:  Effect of Formulation Parameters on Microencapsulation of Lysozyme. Molecular Pharmaceutics 3:2, pages 135-143.
Crossref
Hyunjoo Kim, Mihyun Cho & Hongkee Sah. (2005) Development of new reverse micellar microencapsulation technique to load water-soluble drug into PLGA microspheres. Archives of Pharmacal Research 28:3, pages 370-375.
Crossref
. (2004) Patterns of Protein Leaching to Dispersion Medium during W/O/W Double Emulsion-Based Microencapsulation Processes. Journal of Korean Pharmaceutical Sciences 34:5, pages 369-377.
Crossref
Yoon Yeo & Kinam Park. (2004) Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Archives of Pharmacal Research 27:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.