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Pharmaceutical Development and Technology Volume 9, 2005 - Issue 3
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Research Article

Application of a Mixture Experimental Design in the Optimization of a Self‐Emulsifying Formulation with a High Drug Load

Ping Gao Michigan Pharmaceutical Sciences, Pfizer Inc., 301 Henrietta Street, Kalamazoo, Michigan, 49007, USA
,
Martha J. Witt Michigan Pharmaceutical Sciences, Pfizer Inc., 301 Henrietta Street, Kalamazoo, Michigan, 49007, USA
,
Roy J. Haskell Michigan Pharmaceutical Sciences, Pfizer Inc., 301 Henrietta Street, Kalamazoo, Michigan, 49007, USA
,
Kathryn M. Zamora Michigan Pharmaceutical Sciences, Pfizer Inc., 301 Henrietta Street, Kalamazoo, Michigan, 49007, USA
&
John R. Shifflett Michigan Pharmaceutical Sciences, Pfizer Inc., 301 Henrietta Street, Kalamazoo, Michigan, 49007, USA
Pages 301-309 | Received 08 Sep 2003, Accepted 13 Nov 2003, Published online: 08 Sep 2004

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Wai Thet Aung & Veerakiet Boonkanokwong. (2023) Preparation, optimization using a mixture design, and characterization of a novel astaxanthin-loaded rice bran oil self-microemulsifying delivery system formulation. Journal of Dispersion Science and Technology 44:8, pages 1336-1349.
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Siti Hajar Musa, Mahiran Basri, Hamid Reza Fard Masoumi, Norashikin Shamsudin & Norazlinaliza Salim. (2017) Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action. International Journal of Nanomedicine 12, pages 2427-2441.
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Grishma Patel, Pragna Shelat & Anita Lalwani. (2016) Statistical modeling, optimization and characterization of solid self-nanoemulsifying drug delivery system of lopinavir using design of experiment. Drug Delivery 23:8, pages 3027-3042.
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Osama AA Ahmed, Mohsen I Afouna, Khalid M El-Say, Ashraf B Abdel-Naim, Alaa Khedr & Zainy M Banjar. (2014) Optimization of self-nanoemulsifying systems for the enhancement of in vivo hypoglycemic efficacy of glimepiride transdermal patches. Expert Opinion on Drug Delivery 11:7, pages 1005-1013.
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Myung Joo Kang, Soo Young Jung, Woo Heon Song, Jun Sang Park, Sung-Up Choi, Kyung Taek Oh, Hyung-Kyoon Choi, Young Wook Choi, Jaehwi Lee, Beom-Jin Lee & Sang-Cheol Chi. (2011) Immediate release of ibuprofen from Fujicalin®-based fast-dissolving self-emulsifying tablets. Drug Development and Industrial Pharmacy 37:11, pages 1298-1305.
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Mona H. Aburahma, Hanan M. El-Laithy & Yassin El-Said Hamza. (2010) Oral bioavailability enhancement of vinpocetine using self-microemulsifying drug delivery system containing long chain triglycerides: Preparation and in vitro/in vivo evaluation. Clinical Research and Regulatory Affairs 27:4, pages 97-107.
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Kenichi Sakai, Takayuki Yoshimori, Kouki Obata & Hiroyuki Maeda. (2010) Design of self-microemulsifying drug delivery systems using a high-throughput formulation screening system. Drug Development and Industrial Pharmacy 36:10, pages 1245-1252.
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Hazem Ali, Akhtar Siddiqui & Sami Nazzal. (2010) The Effect of Media Composition, pH, and Formulation Excipients on the In Vitro Lipolysis of Self-Emulsifying Drug Delivery Systems (SEDDS). Journal of Dispersion Science and Technology 31:2, pages 226-232.
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K. C. Ofokansi, K. I. Chukwu & S. I. Ugwuanyi. (2009) The Use of Liquid Self-Microemulsifying Drug Delivery Systems Based on Peanut Oil/Tween 80 in the Delivery of Griseofulvin. Drug Development and Industrial Pharmacy 35:2, pages 185-191.
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Kenichi Sakai, Hiroyuki Maeda, Takayuki Yoshimori, Kouki Obata & Yutaka Ogawa. (2009) High-throughput formulation screening system for self-microemulsifying drug delivery. Drug Development and Industrial Pharmacy 35:6, pages 746-755.
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Jian Meng & Liangyuan Zheng. (2007) Application of Mixture Experimental Design to Simvastatin Apparent Solubility Predictions in the Microemulsifion Formed by Self-Microemulsifying. Drug Development and Industrial Pharmacy 33:9, pages 927-931.
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R. Holm, I. H. M. Jensen & J. Sonnergaard. (2006) Optimization of Self-Microemulsifying Drug Delivery Systems (SMEDDS) Using a D-Optimal Design and the Desirability Function. Drug Development and Industrial Pharmacy 32:9, pages 1025-1032.
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. (2004) Literature Alerts. Drug Delivery 12:1, pages 61-66.
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Ahmed R. Gardouh, Ahmed M. Nasef, Yasser Mostafa & Shadeed Gad. (2020) Design and evaluation of combined atorvastatin and ezetimibe optimized self- nano emulsifying drug delivery system. Journal of Drug Delivery Science and Technology 60, pages 102093.
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Xumeng Wang, Qunjie Xu, Haikun Yu & Jie Xu. (2019) Synthesis of high-solid, low-viscosity hydroxy acrylic resin modified with TBCHA. Journal of Saudi Chemical Society 23:7, pages 992-998.
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Vivek P. Chavda & Dhaval Shah. 2017. Nanostructures for Cancer Therapy. Nanostructures for Cancer Therapy 653 718 .
Osama A.A. Ahmed, Shaimaa M. Badr-Eldin, Mona K. Tawfik, Tarek A. Ahmed, Khalid M. El-Say & Jihan M. Badr. (2014) Design and Optimization of Self-Nanoemulsifying Delivery System to Enhance Quercetin Hepatoprotective Activity in Paracetamol-Induced Hepatotoxicity. Journal of Pharmaceutical Sciences 103:2, pages 602-612.
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Z. Islambulchilar, H. Valizadeh & P. Zakeri-Milani. (2014) Systematic development of DoE optimized SNEDDS of sirolimus with enhanced intestinal absorption. Journal of Drug Delivery Science and Technology 24:6, pages 620-627.
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Shahinaze A. Fouad, Emad B. Basalious, Mohamed A. El-Nabarawi & Saadia A. Tayel. (2013) Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: In vitro/in vivo evaluation. International Journal of Pharmaceutics 453:2, pages 569-578.
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S. Furlanetto, M. Cirri, G. Piepel, N. Mennini & P. Mura. (2011) Mixture experiment methods in the development and optimization of microemulsion formulations. Journal of Pharmaceutical and Biomedical Analysis 55:4, pages 610-617.
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Emad B. Basalious, Nevine Shawky & Shaimaa M. Badr-Eldin. (2010) SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: Development and optimization. International Journal of Pharmaceutics 391:1-2, pages 203-211.
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Walt Morozowich & Ping Gao. 2009. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 443 468 .
John Cannon & Michelle Long. 2008. Water-Insoluble Drug Formulation, Second Edition. Water-Insoluble Drug Formulation, Second Edition 227 254 .
Jochem Alsenz & Manfred Kansy. (2007) High throughput solubility measurement in drug discovery and development. Advanced Drug Delivery Reviews 59:7, pages 546-567.
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