Advanced search
Publication Cover
Journal of Receptors and Signal Transduction Volume 23, 2003 - Issue 2-3
Submit an article Journal homepage
130
Views
41
CrossRef citations to date
0
Altmetric
Research Article

Binding Interactions of Antagonists with 5‐Hydroxytryptamine3A Receptor Models

Gábor Maksay Department of Molecular Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P.O. Box 17, Budapest, 1025, Hungary
,
Zsolt Bikádi Department of Molecular Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P.O. Box 17, Budapest, 1025, Hungary
&
Miklós Simonyi Department of Molecular Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P.O. Box 17, Budapest, 1025, Hungary
Pages 255-270 | Published online: 10 Jul 2003

Citations (41)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Francesca De Rienzo, Arménio J. Moura Barbosa, Marta A.S. Perez, Pedro A. Fernandes, Maria J. Ramos & Maria Cristina Menziani. (2012) The extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study. Journal of Biomolecular Structure and Dynamics 30:3, pages 280-298.
Read now
Andrew J Thompson & Sarah CR Lummis. (2007) The 5-HT3 receptor as a therapeutic target. Expert Opinion on Therapeutic Targets 11:4, pages 527-540.
Read now
Nora L. Sullivan, Nora L. Sullivan, Andrew J. Thompson, Kerry L. Price & Sarah C. R. Lummis. (2006) Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Molecular Membrane Biology 23:5, pages 442-451.
Read now

Articles from other publishers (38)

Santosh T. R. B. Rao, Ilona Turek & Helen R. Irving. (2023) Phylogenetic analyses of 5-hydroxytryptamine 3 (5-HT3) receptors in Metazoa. PLOS ONE 18:3, pages e0281507.
Crossref
Pedro Merino. 2019. Chemical Biology of Neurodegeneration. Chemical Biology of Neurodegeneration 81 120 .
Sandip Basak, Yvonne Gicheru, Abhijeet Kapoor, Megan L. Mayer, Marta Filizola & Sudha Chakrapani. (2019) Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor. Nature Communications 10:1.
Crossref
Katie Alix, Shailesh Khatri, Philip D. Mosier, Samantha Casterlow, Dong Yan, Heather L. Nyce, Michael M. White, Marvin K. Schulte & Małgorzata Dukat. (2016) Superagonist, Full Agonist, Partial Agonist, and Antagonist Actions of Arylguanidines at 5-Hydroxytryptamine-3 (5-HT 3 ) Subunit A Receptors . ACS Chemical Neuroscience 7:11, pages 1565-1574.
Crossref
Sarah C.R. Lummis. (2012) 5-HT3 Receptors. Journal of Biological Chemistry 287:48, pages 40239-40245.
Crossref
Noah H. Duffy, Henry A. Lester & Dennis A. Dougherty. (2012) Ondansetron and Granisetron Binding Orientation in the 5-HT 3 Receptor Determined by Unnatural Amino Acid Mutagenesis . ACS Chemical Biology 7:10, pages 1738-1745.
Crossref
Olga N. Zefirova, Tatiana Yu. Baranova, Konstantin A. Lyssenko, Nikolai A. Zefirov, Nikolai V. Zyk, Pavel M. Vassiliev, Dmitrii S. Yakovlev & Alexander A. Spasov. (2012) Synthesis and biological testing of conformationally restricted serotonin analogues with bridgehead moieties. Mendeleev Communications 22:2, pages 75-77.
Crossref
Koutilya Buchapudi, Xiaohe Xu, Yeganeh Ataian, Hai-Feng Ji & Marvin Schulte. (2012) Micromechanical measurement of AChBP binding for label-free drug discovery. The Analyst 137:1, pages 263-268.
Crossref
Andrew J. Thompson, Henry A. Lester & Sarah C. R. Lummis. (2010) The structural basis of function in Cys-loop receptors. Quarterly Reviews of Biophysics 43:4, pages 449-499.
Crossref
Arménio J. Moura Barbosa, Francesca De Rienzo, Maria J. Ramos & Maria Cristina Menziani. (2010) Computational analysis of ligand recognition sites of homo- and heteropentameric 5-HT3 receptors. European Journal of Medicinal Chemistry 45:11, pages 4746-4760.
Crossref
M. Lochner & S.C.R. Lummis. (2010) Agonists and Antagonists Bind to an A-A Interface in the Heteromeric 5-HT3AB Receptor. Biophysical Journal 98:8, pages 1494-1502.
Crossref
Eszter Hazai, Prasad Joshi, Edward C. Skoviak, Asha Suryanarayanan, Marvin K. Schulte & Zsolt Bikadi. (2009) A comprehensive study on the 5-hydroxytryptamine3A receptor binding of agonists serotonin and m-chlorophenylbiguanidine. Bioorganic & Medicinal Chemistry 17:16, pages 5796-5805.
Crossref
Elena MorelliSandra GemmaRoberta BudriesiGiuseppe CampianiEttore NovellinoCaterina FattorussoBruno CatalanottiSalvatore Sanna CocconeSindu RosGiuseppe BorrelliMarco PersicoIsabella FioriniVito NacciPierfranco IoanAlberto ChiariniMichel HamonAlfredo CagnottoTiziana MenniniClaudia FracassoMilena ColovicSilvio CacciaStefania Butini. (2009) Specific Targeting of Peripheral Serotonin 5-HT 3 Receptors. Synthesis, Biological Investigation, and Structure−Activity Relationships . Journal of Medicinal Chemistry 52:11, pages 3548-3562.
Crossref
Nicholas M. Barnes, Tim G. Hales, Sarah C.R. Lummis & John A. Peters. (2009) The 5-HT3 receptor – the relationship between structure and function. Neuropharmacology 56:1, pages 273-284.
Crossref
Kerry L. Price, Kiowa S. Bower, Andrew J. Thompson, Henry A. Lester, Dennis A. Dougherty & Sarah C. R. Lummis. (2008) A Hydrogen Bond in Loop A Is Critical for the Binding and Function of the 5-HT 3 Receptor . Biochemistry 47:24, pages 6370-6377.
Crossref
Maria N. Modica, Giuseppe Romeo, Loredana Salerno, Valeria Pittalà, Maria A. Siracusa, Ilario Mereghetti, Alfredo Cagnotto, Tiziana Mennini, Róbert Gáspár, Adrienn Gál, George Falkay, Márta Palkó, Gábor Maksay & Ferenc Fülöp. (2008) Synthesis and Receptor Binding of New Thieno[2,3‐ d ]‐pyrimidines as Selective Ligands of 5‐HT 3 Receptors . Archiv der Pharmazie 341:6, pages 333-343.
Crossref
Ya-Ju Zhou, Li-Ping Zhu, Yun Tang & De-Yong Ye. (2007) Structure-based 3D-QSAR studies on heteroarylpiperazine derivatives as 5-HT3 receptor antagonists. European Journal of Medicinal Chemistry 42:7, pages 977-984.
Crossref
Zhe Yang, Agnieszka Ney, Brett A. Cromer, Hooi-Ling Ng, Michael W. Parker & Joseph W. Lynch. (2007) Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition. Journal of Neurochemistry 100:3, pages 758-769.
Crossref
Ran ZhangXiaofei WenJulius MilitanteBrent HesterHeather E. RhubottomHongwei SunNancy J. LeidenheimerDong YanMichael M. WhiteTina K. Machu. (2007) The Role of Loop F Residues in Determining Differential d -Tubocurarine Potencies in Mouse and Human 5-Hydroxytryptamine 3A Receptors . Biochemistry 46:5, pages 1194-1204.
Crossref
Li-Ping Zhu, De-Yong Ye & Yun Tang. (2006) Structure-based 3D-QSAR studies on thiazoles as 5-HT3 receptor antagonists. Journal of Molecular Modeling 13:1, pages 121-131.
Crossref
Dong Yan, Julia K. Meyer & Michael M. White. (2006) Mapping Residues in the Ligand-Binding Domain of the 5-HT 3 Receptor onto d -Tubocurarine Structure . Molecular Pharmacology 70:2, pages 571-578.
Crossref
Neil J. Harrison & Sarah C.R. Lummis. (2006) Locating the Carboxylate Group of GABA in the Homomeric rho GABAA Receptor Ligand-binding Pocket. Journal of Biological Chemistry 281:34, pages 24455-24461.
Crossref
Li Zhang & Sarah Lummis. 2006. Allosteric Receptor Modulation in Drug Targeting. Allosteric Receptor Modulation in Drug Targeting 135 154 .
Ran Zhang, Natalie A. White, Ferenc S. Soti, William R. Kem & Tina K. Machu. (2006) N-Terminal Domains in Mouse and Human 5-Hydroxytryptamine 3A Receptors Confer Partial Agonist and Antagonist Properties to Benzylidene Analogs of Anabaseine . Journal of Pharmacology and Experimental Therapeutics 317:3, pages 1276-1284.
Crossref
A.J. Thompson, P.-L. Chau, S.L. Chan & S.C.R. Lummis. (2006) Unbinding Pathways of an Agonist and an Antagonist from the 5-HT3 Receptor. Biophysical Journal 90:6, pages 1979-1991.
Crossref
Neil J. Harrison & Sarah C.R. Lummis. (2005) Molecular modeling of the GABAC receptor ligand-binding domain. Journal of Molecular Modeling 12:3, pages 317-324.
Crossref
Prasad R. Joshi, Asha Suryanarayanan, Eszter Hazai, Marvin K. Schulte, Gábor Maksay & Zsolt Bikádi. (2006) Interactions of Granisetron with an Agonist-Free 5-HT 3A Receptor Model . Biochemistry 45:4, pages 1099-1105.
Crossref
Andrew J. Thompson, Li Zhang & Sarah C. R. Lummis. 2006. The Serotonin Receptors. The Serotonin Receptors 439 457 .
Alexandra M. Person, Kathy L. Bills, Hong Liu, Shaleen K. Botting, Jon Lindstrom & Gregg B. Wells. (2005) Extracellular Domain Nicotinic Acetylcholine Receptors Formed by α4 and β2 Subunits. Journal of Biological Chemistry 280:48, pages 39990-40002.
Crossref
Dong Yan & Michael M. White. (2005) Spatial Orientation of the Antagonist Granisetron in the Ligand-Binding Site of the 5-HT 3 Receptor . Molecular Pharmacology 68:2, pages 365-371.
Crossref
Asha Suryanarayanan, Prasad R. Joshi, Zsolt Bikádi, Muthalagi Mani, Trupti R. Kulkarni, Chandra Gaines & Marvin K. Schulte. (2005) The Loop C Region of the Murine 5-HT 3A Receptor Contributes to the Differential Actions of 5-Hydroxytryptamine and m -Chlorophenylbiguanide . Biochemistry 44:25, pages 9140-9149.
Crossref
Andrew J. Thompson, Kerry L. Price, David C. Reeves, S. Ling Chan, P.-L. Chau & Sarah C.R. Lummis. (2005) Locating an Antagonist in the 5-HT3 Receptor Binding Site Using Modeling and Radioligand Binding. Journal of Biological Chemistry 280:21, pages 20476-20482.
Crossref
Andrea Cappelli, Andrea Gallelli, Monica Manini, Maurizio Anzini, Laura Mennuni, Francesco Makovec, M. Cristina Menziani, Stefano Alcaro, Francesco Ortuso & Salvatore Vomero. (2005) Further Studies on the Interaction of the 5-Hydroxytryptamine 3 (5-HT 3 ) Receptor with Arylpiperazine Ligands. Development of a New 5-HT 3 Receptor Ligand Showing Potent Acetylcholinesterase Inhibitory Properties . Journal of Medicinal Chemistry 48:10, pages 3564-3575.
Crossref
G?bor Maksay, T?mea B?r?Gyula Bugovics. (2005) Allosteric modulation of 5-HT3 serotonin receptors. European Journal of Pharmacology 514:1, pages 17-24.
Crossref
Joanna Grudzinska, Rudolf Schemm, Svenja Haeger, Annette Nicke, Guenther Schmalzing, Heinrich Betz & Bodo Laube. (2005) The β Subunit Determines the Ligand Binding Properties of Synaptic Glycine Receptors. Neuron 45:5, pages 727-739.
Crossref
Erwin Ilegems, Horst M. Pick, Cédric Deluz, Stephan Kellenberger & Horst Vogel. (2004) Noninvasive Imaging of 5-HT3 Receptor Trafficking in Live Cells. Journal of Biological Chemistry 279:51, pages 53346-53352.
Crossref
Darren L. Beene, Kerry L. Price, Henry A. Lester, Dennis A. Dougherty & Sarah C. R. Lummis. (2004) Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine 3 Receptor Revealed by Unnatural Amino Acid Mutagenesis . The Journal of Neuroscience 24:41, pages 9097-9104.
Crossref
G�bor Maksay, Mikl�s Simonyi & Zsolt Bik�di. (2005) Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists. Journal of Computer-Aided Molecular Design 18:10, pages 651-664.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.