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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 24
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Original Articles

Organic Reactions in Ionic Liquids: Ionic Liquid Promoted Knoevenagel Condensation of Aromatic Aldehydes with (2‐Thio)Barbituric Acid

Yi Hu Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P. R. China
,
Zhen‐Chu Chen Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P. R. ChinaCorrespondence[email protected]
,
Zhang‐Gao Le Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P. R. China; Department of Applied Chemistry, East China Institute of Technology, Fuzhou, P. R. China
&
Qin‐Guo Zheng Pharmaceutical Science Research Institute, Aston University, Aston Triangle, Birmingham, United Kingdom
Pages 4521-4529 | Received 01 Jul 2004, Published online: 10 Jan 2011

Citations (27)

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JagirS. Sandhu. (2011) Recent advances in ionic liquids: green unconventional solvents of this century: part I. Green Chemistry Letters and Reviews 4:4, pages 289-310.
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Yi Hu, Ping Wei, He Huang, Shi‐Qing Han & Ping‐Kai Ouyang. (2006) Synthesis of 2‐Aminothiophenes on Ionic Liquid Phase Support using the Gewald Reaction. Synthetic Communications 36:11, pages 1543-1548.
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Articles from other publishers (25)

Sara Haghpanah-Kouchesfehani, Zahra Azizi, Nader Daneshvar, Farhad Shirini & Hassan Tajik. (2023) Succinimidium Perchlorate as a Novel and Efficient Brönsted Acidic Ionic Liquid Promoter for the Synthesis of 5-arylidene Barbituric Acid and pyrano[2,3-d] Pyrimidinone Derivatives. Current Organocatalysis 10:4, pages 331-344.
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Sanaz Sahrapeyma, Farhad Shirini & Manouchehr Mamaghani. (2023) Introduction of a DABCO-Based Ionic Liquid for the Promotion of the Synthesis of Two Important (Thio)barbituric Acid Derivatives. Iranian Journal of Science 47:5-6, pages 1553-1564.
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Mahdieh Yahyazadehfar, Enayatollah Sheikhhosseini, Sayed Ali Ahmadi & Dadkhoda Ghazanfari. (2022) Microwave-assisted synthetic method of novel Bi2O3 nanostructure and its application as a high-performance nano-catalyst in preparing benzylidene barbituric acid derivatives. Frontiers in Chemistry 10.
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Gilda Aleaba, Shaghayegh Khedmatgozar Asadi, Nader Daneshvar & Farhad Shirini. (2022) [2,2'-Bipyridine]-1,1'-diium perchlorate as a new and efficient dicationic organic salt for the promotion of the synthesis of bis(4-hydroxycoumarin), 5-arylidene barbituric acid and pyrano[2,3-d]pyrimidinone derivatives in water. Research on Chemical Intermediates 48:5, pages 1953-1969.
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S. H. Sukanya, Talavara Venkatesh, S.J. Aditya Rao, N. Shivakumara & Muthipeedika Nibin Joy. (2021) Facile synthesis of some 5-(3-substituted-thiophene)-pyrimidine derivatives and their pharmacological and computational studies. Chimica Techno Acta 8:4.
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Letcy Vincent Theresa, Govindan Avudaiappan, Machingal Shaibuna, Kottayil Hiba & Krishnapillai Sreekumar. (2021) A study on the physical properties of low melting mixtures and their use as catalysts/solvent in the synthesis of barbiturates. Journal of Heterocyclic Chemistry 58:9, pages 1849-1860.
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Ahmed El-Mekabaty, Hassan A. Etman, Ahmed Mosbah & Ahmed A. Fadda. (2020) Reactivity of Barbituric, Thiobarbituric Acids and Their Related Analogues: Synthesis of Substituted and Heterocycles-based Pyrimidines. Current Organic Chemistry 24:14, pages 1610-1642.
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Ming-Hua Hsu, Cheng-Ying Hsieh, Mohit Kapoor, Jui-Hsun Chang, Hsueh-Liang Chu, Tsai-Mu Cheng, Kai-Cheng Hsu, Tony Eight Lin, Fu-Yuan Tsai & Jia-Cherng Horng. (2020) Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation. Bioorganic Chemistry 98, pages 103729.
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Mahdieh Yahyazadehfar, Enayatollah Sheikhhosseini, Sayed Ali Ahmadi & Dadkhoda Ghazanfari. (2019) Microwave‐associate synthesis of Co 3 O 4 nanoparticles as an effcient nanocatalyst for the synthesis of arylidene barbituric and Meldrum's acid derivatives in green media . Applied Organometallic Chemistry.
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Samira Karami, Ahmad Reza Momeni & Jalal Albadi. (2019) Preparation and application of triphenyl(propyl-3-hydrogen sulfate)phosphonium bromide as new efficient ionic liquid catalyst for synthesis of 5-arylidene barbituric acids and pyrano[2,3-d]pyrimidine derivatives. Research on Chemical Intermediates 45:6, pages 3395-3408.
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Niloufar Safari, Farhad Shirini & Hassan Tajik. (2018) Verjuice as a green and bio-degradable solvent/catalyst for facile and eco-friendly synthesis of 5-arylmethylenepyrimidine-2,4,6-trione, pyrano[2,3-d]pyrimidinone and pyrimido[4,5-d]pyrimidinone derivatives. Journal of the Iranian Chemical Society 16:4, pages 887-897.
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Shila Darvishzad, Nader Daneshvar, Farhad Shirini & Hassan Tajik. (2019) Introduction of piperazine-1,4-diium dihydrogen phosphate as a new and highly efficient dicationic brönsted acidic ionic salt for the synthesis of (thio)barbituric acid derivatives in water. Journal of Molecular Structure 1178, pages 420-427.
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Megha Jagadale, Dolly Kale, Rajashri Salunkhe, Mohan Rajmane & Gajanan Rashinkar. (2018) Compatibility of supported ionic liquid phase catalysts under ultrasonication. Journal of Molecular Liquids 265, pages 525-535.
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Nader Daneshvar, Farhad Shirini, Mohaddeseh Safarpoor Nikoo Langarudi & Reyhaneh Karimi-Chayjani. (2018) Taurine as a green bio-organic catalyst for the preparation of bio-active barbituric and thiobarbituric acid derivatives in water media. Bioorganic Chemistry 77, pages 68-73.
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Nader Daneshvar, Mitra Nasiri, Maryam Shirzad, Mohaddeseh Safarpoor Nikoo Langarudi, Farhad Shirini & Hassan Tajik. (2018) The introduction of two new imidazole-based bis-dicationic Brönsted acidic ionic liquids and comparison of their catalytic activity in the synthesis of barbituric acid derivatives. New Journal of Chemistry 42:12, pages 9744-9756.
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Praveen Naik, Rui Su, Dickson D. Babu, Ahmed El-Shafei & Airody Vasudeva Adhikari. (2017) Structurally simple D–A-type organic sensitizers for dye-sensitized solar cells: effect of anchoring moieties on the cell performance. Journal of the Iranian Chemical Society 14:11, pages 2457-2466.
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Narges Seyyedi, Farhad Shirini & Mohaddeseh Safarpoor Nikoo Langarudi. (2016) DABCO-based ionic liquids: green and recyclable catalysts for the synthesis of barbituric and thiobarbituric acid derivatives in aqueous media. RSC Advances 6:50, pages 44630-44640.
Crossref
Subarna Jyoti Kalita, Hormi Mecadon & Dibakar Chandra Deka. (2014) Reaction of 6-aminouracils with aldehydes in water as both solvent and reactant under FeCl 3 ·6H 2 O catalysis: towards 5-alkyl/arylidenebarbituric acids . RSC Adv. 4:61, pages 32207-32213.
Crossref
Nace Zidar & Danijel Kikelj. (2011) Convergent Domino Knoevenagel Hetero‐ DielsAlder and Domino Oxidation Hetero‐ DielsAlder Reactions Encountered in an Unexpected Formation of Novel 5‐Aryl‐1 H ‐pyrano[2,3‐ d ]pyrimidine‐2,4(3 H ,5 H )‐diones and 5‐Aryl‐2,3‐dihydro‐2‐thioxo‐1 H ‐pyrano[2,3‐ d ]pyrimidin‐4(5 H )‐ones . Helvetica Chimica Acta 94:5, pages 859-867.
Crossref
Zerong Wang. 2010. Comprehensive Organic Name Reactions and Reagents. Comprehensive Organic Name Reactions and Reagents.
Jitender M. Khurana & Kanika Vij. (2010) Nickel Nanoparticles Catalyzed Knoevenagel Condensation of Aromatic Aldehydes with Barbituric Acids and 2-Thiobarbituric Acids. Catalysis Letters 138:1-2, pages 104-110.
Crossref
Rafael Martínez-Palou. (2009) Microwave-assisted synthesis using ionic liquids. Molecular Diversity 14:1, pages 3-25.
Crossref
Qin Yan, Rihui Cao, Wei Yi, Liang Yu, Zhiyong Chen, Lin Ma & Huacan Song. (2009) Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters 19:15, pages 4055-4058.
Crossref
M. Iglesias, A. Torres, R. Gonzalez-Olmos & D. Salvatierra. (2008) Effect of temperature on mixing thermodynamics of a new ionic liquid: {2-Hydroxy ethylammonium formate (2-HEAF)+short hydroxylic solvents}. The Journal of Chemical Thermodynamics 40:1, pages 119-133.
Crossref
Yi Hu, Zhen‐Chu Chen, Zhang‐Gao Le & Qin‐Guo Zhang. (2005) Organic Reactions in Ionic Liquids: Ionic Liquid Promoted Knoevenagel Condensation of Aromatic Aldehydes with (2‐Thio)barbituric Acid.. ChemInform 36:20.
Crossref

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