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Clinical and Experimental Optometry Volume 95, 2012 - Issue 3
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Diabetes and the Posterior Eye

The role of glia in retinal vascular disease

Nathan J CooreySave Sight Institute, The University of Sydney, Sydney, Australia. E‐mail: [email protected]
, BSc (Adv Hons I),
Weiyong ShenSave Sight Institute, The University of Sydney, Sydney, Australia. E‐mail: [email protected]
, MD PhD,
Sook H ChungSave Sight Institute, The University of Sydney, Sydney, Australia. E‐mail: [email protected]
, BSc (Hons),
Ling ZhuSave Sight Institute, The University of Sydney, Sydney, Australia. E‐mail: [email protected]
, PhD &
Mark C GilliesSave Sight Institute, The University of Sydney, Sydney, Australia. E‐mail: [email protected]
, MBBS PhD FRACO
Pages 266-281 | Received 01 Nov 2011, Accepted 18 Jan 2012, Published online: 15 Apr 2021

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Yu Xia, Qihui Luo, Jingfei Chen, Chao Huang, Asad Jahangir, Ting Pan, Xiaoli Wei, Wentao Liu & Zhengli Chen. (2022) Retinal Astrocytes and Microglia Activation in Diabetic Retinopathy Rhesus Monkey Models. Current Eye Research 47:2, pages 297-303.
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Aftab Taiyab, Anthony Saraco, Monica Akula, Paula Deschamps, Alexander K. Ball, Trevor Williams & Judith A. West-Mays. (2021) Progressive Loss of Retinal Ganglion Cells in Activating Protein-2β Neural Crest Cell Knockout Mice. Current Eye Research 46:10, pages 1509-1515.
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Xiaolei Wang, Jier Su, Jingwen Ding, Song Han, Wei Ma, Hong Luo, Guy Hughes, Zhaoyang Meng, Yi Yin, Yanling Wang & Junfa Li. (2016) α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Design, Development and Therapy 10, pages 3449-3457.
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Mohamed Al-Shabrawey, Mohamed Elsherbiny, Julian Nussbaum, Amira Othman, Sylvia Megyerdi & Amany Tawfik. (2013) Targeting neovascularization in ischemic retinopathy: recent advances. Expert Review of Ophthalmology 8:3, pages 267-286.
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Nathan Efron & Erica Fletcher. (2012) Research in diabetes and the eye: evolution or revolution?. Clinical and Experimental Optometry 95:3, pages 251-253.
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Amitoj Singh, Hozana Andrade Castillo, Julie Brown, Jan Kaslin, Karen M. Dwyer & Yann Gibert. (2019) High glucose levels affect retinal patterning during zebrafish embryogenesis. Scientific Reports 9:1.
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Laura Fernández-Sánchez, Gema Esquiva, Isabel Pinilla, Pedro Lax & Nicolás Cuenca. (2018) Retinal Vascular Degeneration in the Transgenic P23H Rat Model of Retinitis Pigmentosa. Frontiers in Neuroanatomy 12.
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Ismail S. Zaitoun, Ulas Cikla, Dila Zafer, Eshwar Udho, Reem Almomani, Andrew Suscha, Pelin Cengiz, Christine M. Sorenson & Nader Sheibani. (2018) Attenuation of Retinal Vascular Development in Neonatal Mice Subjected to Hypoxic-Ischemic Encephalopathy. Scientific Reports 8:1.
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Paula V. Subirada, María C. Paz, Magali E. Ridano, Valeria E. Lorenc, María V. Vaglienti, Pablo F. Barcelona, José D. Luna & María C. Sánchez. (2018) A journey into the retina: Müller glia commanding survival and death. European Journal of Neuroscience 47:12, pages 1429-1443.
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Senthil Selvam, Tejas Kumar & Marcus Fruttiger. (2018) Retinal vasculature development in health and disease. Progress in Retinal and Eye Research 63, pages 1-19.
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Melissa K. Jones, Bin Lu, Sergey Girman & Shaomei Wang. (2017) Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases. Progress in Retinal and Eye Research 58, pages 1-27.
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Darya V. Telegina, Oyuna S. Kozhevnikova, Sergey I. Bayborodin & Nataliya G. Kolosova. (2017) Contributions of age-related alterations of the retinal pigment epithelium and of glia to the AMD-like pathology in OXYS rats. Scientific Reports 7:1.
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Elena Vecino, F.David Rodriguez, Noelia Ruzafa, Xandra Pereiro & Sansar C. Sharma. (2016) Glia–neuron interactions in the mammalian retina. Progress in Retinal and Eye Research 51, pages 1-40.
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Rosa de Hoz, Blanca Rojas, Ana I. Ramírez, Juan J. Salazar, Beatriz I. Gallego, Alberto Triviño & José M. Ramírez. (2016) Retinal Macroglial Responses in Health and Disease. BioMed Research International 2016, pages 1-13.
Crossref
Simon E. SkalickySimon E. Skalicky. 2016. Ocular and Visual Physiology. Ocular and Visual Physiology 105 142 .
Laura Fernández-Sánchez, Pedro Lax, Laura Campello, Isabel Pinilla & Nicolás Cuenca. (2015) Astrocytes and Müller Cell Alterations During Retinal Degeneration in a Transgenic Rat Model of Retinitis Pigmentosa. Frontiers in Cellular Neuroscience 9.
Crossref
Anna Wójcik-Gryciuk, Małgorzata Skup & Wioletta J. Waleszczyk. (2015) Glaucoma –state of the art and perspectives on treatment. Restorative Neurology and Neuroscience 34:1, pages 107-123.
Crossref
Ying Yu, Hui Chen & Shao Bo Su. (2015) Neuroinflammatory responses in diabetic retinopathy. Journal of Neuroinflammation 12:1.
Crossref
Yoshihiko UsuiPeter D. Westenskow, Salome MurinelloMichael I. Dorrell, Lea ScheppkeFelicitas BucherSusumu SakimotoLiliana P. ParisEdith AguilarMartin Friedlander. (2015) Angiogenesis and Eye Disease. Annual Review of Vision Science 1:1, pages 155-184.
Crossref
Li Chen, Yong Tao & YanRong Jiang. (2015) Apelin activates the expression of inflammatory cytokines in microglial BV2 cells via PI-3K/Akt and MEK/Erk pathways. Science China Life Sciences 58:6, pages 531-540.
Crossref
Andrea Matteucci, Monica Varano, Cinzia Mallozzi, Lucia Gaddini, Marika Villa, Sara Gabrielli, Giuseppe Formisano, Flavia Pricci & Fiorella Malchiodi-Albedi. (2015) Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview. BioMed Research International 2015, pages 1-16.
Crossref
Nicolás Cuenca, Laura Fernández-Sánchez, Laura Campello, Victoria Maneu, Pedro De la Villa, Pedro Lax & Isabel Pinilla. (2014) Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases. Progress in Retinal and Eye Research 43, pages 17-75.
Crossref
Fen Zhou, Yikui Zhang, Ding Chen, Zhitao Su, Ling Jin, Lei Wang, Zhixiang Hu, Zhisheng Ke & Zongming Song. (2014) Potential Role of Cyr61 Induced Degeneration of Human Müller Cells in Diabetic Retinopathy. PLoS ONE 9:10, pages e109418.
Crossref
Weiyong Shen, Sook H. Chung, Mohammad R. Irhimeh, Shiying Li, So-Ra Lee & Mark C. Gillies. (2014) Systemic Administration of Erythropoietin Inhibits Retinopathy in RCS Rats. PLoS ONE 9:8, pages e104759.
Crossref
Weiyong Shen, So-Ra Lee, Joana Araujo, Sook H. Chung, Ling Zhu & Mark C. Gillies. (2014) Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Müller cell ablation. Glia 62:7, pages 1110-1124.
Crossref
Jie Zhang, Simon J. O'Carroll, Kimiora Henare, Lai-Ming Ching, Susan Ormonde, Louise F.B. Nicholson, Helen V. Danesh-Meyer & Colin R. Green. (2014) Connexin hemichannel induced vascular leak suggests a new paradigm for cancer therapy. FEBS Letters 588:8, pages 1365-1371.
Crossref
Adviye Ergul, Mohammed Abdelsaid, Abdelrahman Y Fouda & Susan C Fagan. (2014) Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond. Journal of Cerebral Blood Flow & Metabolism 34:4, pages 553-563.
Crossref
Jiong Hu, Rüdiger Popp, Timo Frömel, Manuel Ehling, Khader Awwad, Ralf H. Adams, Hans-Peter Hammes & Ingrid Fleming. (2014) Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. Journal of Experimental Medicine 211:2, pages 281-295.
Crossref
Jose Javier Garcia-Medina, Monica del-Rio-Vellosillo, Manuel Garcia-Medina, Vicente Zanon-Moreno, Roberto Gallego-Pinazo & Maria Dolores Pinazo-Duran. 2014. Diabetes: Oxidative Stress and Dietary Antioxidants. Diabetes: Oxidative Stress and Dietary Antioxidants 33 40 .
Margaret To, Alexandra Goz, Leon Camenzind, Philipp Oertle, Joseph Candiello, Mara Sullivan, Paul Bernhard Henrich, Marko Loparic, Farhad Safi, Andrew Eller & Willi Halfter. (2013) Diabetes-induced morphological, biomechanical, and compositional changes in ocular basement membranes. Experimental Eye Research 116, pages 298-307.
Crossref
K. Pollinger, R. Hennig, A. Ohlmann, R. Fuchshofer, R. Wenzel, M. Breunig, J. Tessmar, E. R. Tamm & A. Goepferich. (2013) Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application. Proceedings of the National Academy of Sciences 110:15, pages 6115-6120.
Crossref
Weiyong Shen, Ling Zhu, So-Ra Lee, Sook H Chung & Mark C Gillies. (2013) Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Müller cell ablation. Journal of Neuroinflammation 10:1, pages 137.
Crossref

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