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Molecular and Cellular Biology Volume 34, 2014 - Issue 12
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Article

Neurofibromatosis Type 1 Alternative Splicing Is a Key Regulator of Ras Signaling in Neurons

Melissa N. Hinmana Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
,
Alok Sharmaa Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
,
Guangbin Luoa Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;c Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
&
Hua Loua Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;b Center for RNA Molecular Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;c Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USACorrespondence[email protected]
Pages 2188-2197 | Received 06 Jan 2014, Accepted 21 Mar 2014, Published online: 20 Mar 2023

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Ting Wu, Hao Yang, Liuli Xu, Qing Huang, Qi He, Rong Wu & Yun-Zhu Mu. (2022) NF1 Gene Novel Splicing Mutations in a Chinese Family with Neurofibromatosis Type 1: Case Series. Clinical, Cosmetic and Investigational Dermatology 15, pages 2345-2351.
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Alok Sharma, Hieu Nguyen, Lu Cai & Hua Lou. (2015) Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation in cardiomyocytes. Nucleus 6:4, pages 273-278.
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Articles from other publishers (22)

Juan Báez-Flores, Mario Rodríguez-Martín & Jesus Lacal. (2023) The therapeutic potential of neurofibromin signaling pathways and binding partners. Communications Biology 6:1.
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Juan Mo, Stefanie L. Moye, Renee M. McKay & Lu Q. Le. (2022) Neurofibromin and suppression of tumorigenesis: beyond the GAP. Oncogene 41:9, pages 1235-1251.
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Karl Andreas Mader & Hua Lou. 2022. Clinical and Basic Aspects of Neurofibromatosis Type 1. Clinical and Basic Aspects of Neurofibromatosis Type 1.
Robert Siddaway, Scott Milos, Arun Kumaran Anguraj Vadivel, Tara H. W. Dobson, Jyothishmathi Swaminathan, Scott Ryall, Sanja Pajovic, Palak G. Patel, Javad Nazarian, Oren Becher, Michael Brudno, Arun Ramani, Vidya Gopalakrishnan & Cynthia Hawkins. (2022) Splicing is an alternate oncogenic pathway activation mechanism in glioma. Nature Communications 13:1.
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Maximilian Scheer, Sandra Leisz, Eberhard Sorge, Olha Storozhuk, Julian Prell, Ivy Ho & Anja Harder. (2021) Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas. International Journal of Molecular Sciences 23:1, pages 352.
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Cristina Perez‐Becerril, D. Gareth Evans & Miriam J. Smith. (2021) Pathogenic noncoding variants in the neurofibromatosis and schwannomatosis predisposition genes. Human Mutation 42:10, pages 1187-1207.
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Josep Biayna, Helena Mazuelas, Bernat Gel, Ernest Terribas, Gabrijela Dumbovic, Inma Rosas, Juana Fernández-Rodriguez, Ignacio Blanco, Elisabeth Castellanos, Meritxell Carrió, Conxi Lazaro & Eduard Serra. (2021) Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation. Scientific Reports 11:1.
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Hui Li Kwong, Yong-Kwang Tay & Ene-Choo Tan. (2021) Case Report: Mosaicism of a novel nonsense variant in the neurofibromin gene underlies a mosaic generalized NF1 phenotype. F1000Research 10, pages 148.
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Hui Li Kwong, Yong-Kwang Tay & Ene-Choo Tan. (2021) Case Report: Mosaicism of a novel nonsense variant in the neurofibromin gene underlies a mosaic generalized NF1 phenotype. F1000Research 10, pages 148.
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Junyan Tao, Dantong Sun, Lina Dong, Hua Zhu & Helei Hou. (2020) Advancement in research and therapy of NF1 mutant malignant tumors. Cancer Cell International 20:1.
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Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin, Béatrice Vallée & Hélène Bénédetti. (2020) Neurofibromin Structure, Functions and Regulation. Cells 9:11, pages 2365.
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Claudia Riccardi, Lorena Perrone, Filomena Napolitano, Simone Sampaolo & Mariarosa Anna Beatrice Melone. (2020) Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design. Cancers 12:10, pages 2965.
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Haizhou Lou, Chongya Zhai, Liu Gong, Hong Pan, Hongming Pan, Yihong Zhang, Mei Yang & Zimin Hu. (2020) NF1 germline mutation in a Chinese family with colon cancer . Journal of International Medical Research 48:8, pages 030006051989643.
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Wupeng Yan, Evan Markegard, Srisathiyanarayanan Dharmaiah, Anatoly Urisman, Matthew Drew, Dominic Esposito, Klaus Scheffzek, Dwight V. Nissley, Frank McCormick & Dhirendra K. Simanshu. (2020) Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Reports 32:3, pages 107909.
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Yuxin Zheng, Guiying Qiu, Huatuo Dai, Chengyao Zhu, Dan Xue & Yunqing Ren. (2020) Two novel mutations of NF1 gene identified in Chinese patients with severe neurofibromatosis type 1. Indian Journal of Dermatology, Venereology and Leprology 86:1, pages 76.
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Yan Cui & Helen Morrison. (2019) Construction of cloning-friendly minigenes for mammalian expression of full-length human NF1 isoforms. Human Mutation 40:2, pages 187-192.
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Bin Mao, Siyu Chen, Xin Chen, Xiumei Yu, Xiaojia Zhai, Tao Yang, Lulu Li, Zheng Wang, Xiuli Zhao & Xue Zhang. (2018) Clinical characteristics and spectrum of NF1 mutations in 12 unrelated Chinese families with neurofibromatosis type 1. BMC Medical Genetics 19:1.
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SungKyoung Lee, Benjamin Cieply, Yueqin Yang, Natoya Peart, Carl Glaser, Patricia Chan & Russ P. Carstens. (2018) Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity. Cell Reports 25:9, pages 2417-2430.e5.
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Robert J. Allaway, Sara J. C. Gosline, Salvatore La Rosa, Pamela Knight, Annette Bakker, Justin Guinney & Lu Q. Le. (2018) Cutaneous neurofibromas in the genomics era: current understanding and open questions. British Journal of Cancer 118:12, pages 1539-1548.
Crossref
Hieu T. Nguyen, Melissa N. Hinman, Xuan Guo, Alok Sharma, Hiroyuki Arakawa, Guangbin Luo & Hua Lou. (2017) Neurofibromatosis type 1 alternative splicing is a key regulator of Ras/ERK signaling and learning behaviors in mice. Human Molecular Genetics 26:19, pages 3797-3807.
Crossref
Nancy Ratner & Shyra J. Miller. (2015) A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nature Reviews Cancer 15:5, pages 290-301.
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Alok SharmaHieu NguyenCuiyu GengMelissa N. HinmanGuangbin Luo & Hua Lou. (2014) Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes. Proceedings of the National Academy of Sciences 111:46.
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