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Molecular and Cellular Biology Volume 30, 2010 - Issue 12
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Article

Lin9, a Subunit of the Mammalian DREAM Complex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor Suppression

Nina Reichert1 University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, Germany
,
Sebastian Wurster1 University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, Germany
,
Tanja Ulrich1 University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, Germany
,
Kathrin Schmitt1 University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, Germany
,
Stefanie Hauser1 University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, Germany
,
Leona Probst1 University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, Germany
,
Rudolf Götz2 University of Wuerzburg, Institut fuer Medizinische Strahlenkunde und Zellforschung, Wuerzburg, Germany
,
Fatih Ceteci3 Max Planck Institute for Biochemistry, Department of Molecular Biology, Am Klopferspitz 18, D-82152Martinsried, Germany
,
Roland Moll4 University of Marburg, Institute of Pathology, Marburg, Germany
,
Ulf Rapp3 Max Planck Institute for Biochemistry, Department of Molecular Biology, Am Klopferspitz 18, D-82152Martinsried, Germany
&
Stefan Gaubatz1 University of Wuerzburg, Department of Physiological Chemistry I, Biocenter, Wuerzburg, GermanyCorrespondence[email protected]
 show all
Pages 2896-2908 | Received 11 Jan 2010, Accepted 10 Apr 2010, Published online: 20 Mar 2023

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Steffen Hanselmann, Dörthe Gertzmann, Woo Jin Shin, Carsten P. Ade & Stefan Gaubatz. (2023) Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus. Cell Cycle 22:4, pages 419-432.
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Martin Fischer & Gerd A. Müller. (2017) Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes. Critical Reviews in Biochemistry and Molecular Biology 52:6, pages 638-662.
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Chantal Forristal, Shauna A. Henley, James I. MacDonald, Jason R. Bush, Carley Ort, Daniel T. Passos, Srikanth Talluri, Charles A. Ishak, Michael J. Thwaites, Chris J. Norley, Larisa Litovchick, James A. DeCaprio, Gabriel DiMattia, David W. Holdsworth, Frank Beier & Frederick A. Dick. (2014) Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation. Molecular and Cellular Biology 34:12, pages 2221-2234.
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Taira Matsuo, Hiroyo Kuramoto, Tsutomu Kumazaki, Youji Mitsui & Tomoko Takahashi. (2012) LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression. Cell Cycle 11:17, pages 3227-3236.
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Articles from other publishers (43)

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Roberta Cacioppo & Catherine Lindon. (2022) Regulating the regulator: a survey of mechanisms from transcription to translation controlling expression of mammalian cell cycle kinase Aurora A. Open Biology 12:9.
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Gerd A. Müller, Anushweta Asthana & Seth M. Rubin. (2022) Structure and function of MuvB complexes. Oncogene 41:21, pages 2909-2919.
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Lulu Wang & Xiaowei Liu. (2022) Comprehensive Analysis of the Expression and Prognosis for the DREAM Complex in Human Cancers. Frontiers in Genetics 13.
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Congcong Wang, Kunying Hao, Lixia Dong, Jingnan Wang, Linchun Zhao, Lijun Xu, Yin Xia, Qing Jiang & Jinzhong Qin. (2022) The MuvB complex safeguards embryonic stem cell identity through regulation of the cell cycle machinery. Journal of Biological Chemistry 298:3, pages 101701.
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Carson D. Broeker & Eran R. Andrechek. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 277 311 .
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Pirunthan Perampalam, Haider M. Hassan, Grace E. Lilly, Daniel T. Passos, Joseph Torchia, Patti K. Kiser, Andrea Bozovic, Vathany Kulasingam & Frederick A. Dick. (2021) Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice. Journal of Clinical Investigation 131:4.
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K.M. Kampa-Schittenhelm, T. Haverkamp, M. Bonin, V. Tsintari, H.J. Bühring, L. Haeusser, G. Blumenstock, S.T. Dreher, T. Ganief, F. Akmut, B. Illing, U.A. Mau-Holzmann, I. Bonzheim, E. Schleicher, W. Vogel & M.M. Schittenhelm. (2020) Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine 54, pages 102678.
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Hongna Lai, Rui Wang, Shunying Li, Qianfeng Shi, Zijie Cai, Yudong Li & Yujie Liu. (2019) LIN9 confers paclitaxel resistance in triple negative breast cancer cells by upregulating CCSAP. Science China Life Sciences 63:3, pages 419-428.
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Jerrin R Cherian, Katherine V Adams & Lisa N Petrella. (2020) Wnt Signaling Drives Ectopic Gene Expression and Larval Arrest in the Absence of the Caenorhabditis elegans DREAM Repressor Complex . G3 Genes|Genomes|Genetics 10:2, pages 863-874.
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Akella Radha Rama Devi, Aparna Ganapathy, Ashraf U. Mannan, Shefali Sabharanjak & Shaik M. Naushad. (2019) 1q42.12q42.2 Deletion in a Child with Midline Defects and Hypoplasia of the Corpus Callosum. Molecular Syndromology 10:3, pages 161-166.
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Keelan Z. GuileyAudra N. InessSiddharth SainiSarvind Tripathi, Joseph S. Lipsick, Larisa LitovchickSeth M. Rubin. (2018) Structural mechanism of Myb–MuvB assembly. Proceedings of the National Academy of Sciences 115:40, pages 10016-10021.
Crossref
Audra N. Iness & Larisa Litovchick. (2018) MuvB: A Key to Cell Cycle Control in Ovarian Cancer. Frontiers in Oncology 8.
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Paul D. Goetsch, Jacob M. Garrigues & Susan Strome. (2017) Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes. PLOS Genetics 13:11, pages e1007088.
Crossref
Jennifer M. Sahni, Sylvia S. Gayle, Bryan M. Webb, Kristen L. Weber-Bonk, Darcie D. Seachrist, Salendra Singh, Steven T. Sizemore, Nicole A. Restrepo, Gurkan Bebek, Peter C. Scacheri, Vinay Varadan, Matthew K. Summers & Ruth A. Keri. (2017) Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors. Cancer Research 77:19, pages 5395-5408.
Crossref
Christina FS Mages, Axel Wintsche, Stephan H Bernhart & Gerd A Müller. (2017) The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence. eLife 6.
Crossref
James MacDonald, Yudith Ramos-Valdes, Pirunthan Perampalam, Larissa Litovchick, Gabriel E. DiMattia & Frederick A. Dick. (2017) A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy. Molecular Cancer Research 15:4, pages 371-381.
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Patrick Wolter, Steffen Hanselmann, Grit Pattschull, Eva Schruf & Stefan Gaubatz. (2017) Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy. Oncotarget 8:7, pages 11160-11172.
Crossref
F Iltzsche, K Simon, S Stopp, G Pattschull, S Francke, P Wolter, S Hauser, D J Murphy, P Garcia, A Rosenwald & S Gaubatz. (2016) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene 36:1, pages 110-121.
Crossref
Weijing Zhang, Weiling He, Yongjie Shi, Haifeng Gu, Min Li, Zhimin Liu, Yanling Feng, Nianzhen Zheng, Chuanmiao Xie & Yanna Zhang. (2016) High Expression of KIF20A Is Associated with Poor Overall Survival and Tumor Progression in Early-Stage Cervical Squamous Cell Carcinoma. PLOS ONE 11:12, pages e0167449.
Crossref
Martin Fischer, Marianne Quaas, Annina Nickel & Kurt Engeland. (2015) Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex . Oncotarget 6:39, pages 41402-41417.
Crossref
Keelan Z. Guiley, Tyler J. Liban, Jessica G. Felthousen, Parameshwaran Ramanan, Larisa Litovchick & Seth M. Rubin. (2015) Structural mechanisms of DREAM complex assembly and regulation. Genes & Development 29:9, pages 961-974.
Crossref
Y Hu, W Song, D Cirstea, D Lu, N C Munshi & K C Anderson. (2014) CSNK1α1 mediates malignant plasma cell survival. Leukemia 29:2, pages 474-482.
Crossref
Ryan D. Baron & Francis A. Barr. 2015. Kinesins and Cancer. Kinesins and Cancer 193 222 .
Sihem Zitouni, Catarina Nabais, Swadhin Chandra Jana, Adán Guerrero & Mónica Bettencourt-Dias. (2014) Polo-like kinases: structural variations lead to multiple functions. Nature Reviews Molecular Cell Biology 15:7, pages 433-452.
Crossref
Tomoko M Tabuchi, Andreas Rechtsteiner, Susan Strome & Kirsten A Hagstrom. (2014) Opposing Activities of DRM and MES-4 Tune Gene Expression and X-Chromosome Repression in Caenorhabditis elegans Germ Cells . G3 Genes|Genomes|Genetics 4:1, pages 143-153.
Crossref
Subhashini Sadasivam & James A. DeCaprio. (2013) The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nature Reviews Cancer 13:8, pages 585-595.
Crossref
Jasmina Esterlechner, Nina Reichert, Fabian Iltzsche, Michael Krause, Florian Finkernagel & Stefan Gaubatz. (2013) LIN9, a Subunit of the DREAM Complex, Regulates Mitotic Gene Expression and Proliferation of Embryonic Stem Cells. PLoS ONE 8:5, pages e62882.
Crossref
Martin Fischer, Inga Grundke, Sindy Sohr, Marianne Quaas, Saskia Hoffmann, Arne Knörck, Catalina Gumhold & Karen Rother. (2013) p53 and Cell Cycle Dependent Transcription of kinesin family member 23 (KIF23) Is Controlled Via a CHR Promoter Element Bound by DREAM and MMB Complexes. PLoS ONE 8:5, pages e63187.
Crossref
Ulrike Begley, Maria Soledad Sosa, Alvaro Avivar‐Valderas, Ashish Patil, Lauren Endres, Yeriel Estrada, Clement T.Y. Chan, Dan Su, Peter C. Dedon, Julio A. Aguirre‐Ghiso & Thomas Begley. (2013) A human tRNA methyltransferase 9‐like protein prevents tumour growth by regulating LIN9 and HIF1‐α. EMBO Molecular Medicine 5:3, pages 366-383.
Crossref
Christin F. Down, Julie Millour, Eric W.-F. Lam & Roger J. Watson. (2012) Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1819:8, pages 855-862.
Crossref
S Hauser, T Ulrich, S Wurster, K Schmitt, N Reichert & S Gaubatz. (2011) Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth. Oncogene 31:14, pages 1859-1868.
Crossref
Patrick Wolter, Kathrin Schmitt, Marc Fackler, Heidi Kremling, Leona Probst, Stefanie Hauser, Oliver J. Gruss & Stefan Gaubatz. (2012) GAS2L3, a novel target gene of the dream complex, is required for proper cytokinesis and genomic stability. Journal of Cell Science.
Crossref
Jyoti Iyer, Saili Moghe, Manabu Furukawa & Ming-Ying Tsai. (2011) What's Nu(SAP) in mitosis and cancer?. Cellular Signalling 23:6, pages 991-998.
Crossref

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