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Molecular and Cellular Biology Volume 39, 2019 - Issue 19
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Research Article

Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia

Giselle A. Josepha Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
,
Sharon X. Wanga Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
,
Cody E. Jacobsa Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
,
Weihua Zhoua Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
,
Garrett C. Kimblea Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
,
Herman W. Tsea Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
,
John K. Easha Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
,
Tea Shavlakadzea Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA
&
David J. Glassa Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6187-4164
ORCID Icon show all
Article: e00141-19 | Received 27 Mar 2019, Accepted 05 Jul 2019, Published online: 03 Mar 2023

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Chun-Seok Cho, Yongsung Kim, Sung-Rye Park, Boyoung Kim, Carol Davis, Irene Hwang, Susan V. Brooks, Jun Hee Lee & Myungjin Kim. (2022) Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation. Autophagy 18:10, pages 2303-2322.
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