35
Views
41
CrossRef citations to date
0
Altmetric
Article

Phosphorylation of TPL-2 on Serine 400 Is Essential for Lipopolysaccharide Activation of Extracellular Signal-Regulated Kinase in Macrophages

, , , &
Pages 7355-7364 | Received 19 Feb 2007, Accepted 10 Aug 2007, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Karine Roget, Abduelhakem Ben-Addi, Agnes Mambole-Dema, Thorsten Gantke, Huei-Ting Yang, Julia Janzen, Nick Morrice, Derek Abbott & Steven C. Ley. (2012) IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400. Molecular and Cellular Biology 32:22, pages 4684-4690.
Read now
Huei-Ting Yang, Stamatia Papoutsopoulou, Monica Belich, Christine Brender, Julia Janzen, Thorsten Gantke, Matt Handley & Steven C. Ley. (2012) Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105. Molecular and Cellular Biology 32:17, pages 3438-3451.
Read now
Yukiko Kuroda, Chihiro Hisatsune, Akihiro Mizutani, Naoko Ogawa, Koichi Matsuo & Katsuhiko Mikoshiba. (2012) Cot Kinase Promotes Ca2+ Oscillation/Calcineurin-Independent Osteoclastogenesis by Stabilizing NFATc1 Protein. Molecular and Cellular Biology 32:14, pages 2954-2963.
Read now

Articles from other publishers (38)

Taoran Zhao, Ruihua Li, Mengyin Qian, Meirong Wang, Xiaozheng Zhang, Yuhan Wang, Xinghui Zhao & Jun Xie. (2023) Whole-Transcriptome Analysis Highlights Adenylyl Cyclase Toxins-Derived Modulation of NF-κB and ERK1/2 Pathways in Macrophages. Toxins 15:2, pages 139.
Crossref
Maria Vougioukalaki, Konstantina Georgila, Emmanouil I. Athanasiadis & Aristides G. Eliopoulos. (2022) Cell adhesion tunes inflammatory TPL2 kinase signal transduction. Cellular and Molecular Life Sciences 79:3.
Crossref
Krishna Latha, Katelyn F. Jamison & Wendy T. Watford. (2021) Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection. Frontiers in Immunology 12.
Crossref
Lu Xia, Jin Gao, Ke Ma, Hexin Lin, Yixing Chen, Qi Luo & Jiabian Lian. (2021) OVOL2 attenuates the expression of MAP3K8 to suppress epithelial mesenchymal transition in colorectal cancer. Pathology - Research and Practice 224, pages 153493.
Crossref
Junhong Hao, Chaochao Shen, Nannan Wei, Minghao Yan, Xuegang Zhang, Guowei Xu, Dajun Zhang, Jing Hou, Weijun Cao, Ye Jin, Keshan Zhang, Haixue Zheng & Xiangtao Liu. (2021) Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication. Frontiers in Immunology 11.
Crossref
Ming-Hao Yan, Jun-Hong Hao, Xue-Gang Zhang, Chao-Chao Shen, Da-Jun Zhang, Ke-Shan Zhang, Hai-Xue Zheng & Xiang-Tao Liu. (2019) Advancement in TPL2-regulated innate immune response. Immunobiology 224:3, pages 383-387.
Crossref
Di Zhang, Ying Liu, Yan Cui & Sheng Cui. (2019) Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) mediates the LH-induced stimulation of progesterone synthesis in the porcine corpus luteum. Reproduction, Fertility and Development 31:9, pages 1444.
Crossref
Sambit K. Nanda, Tsunehisa Nagamori, Mark Windheim, Sylvia Amu, Gabriella Aviello, Janet Patterson-Kane, J. Simon C. Arthur, Steven C. Ley, Padraic Fallon & Philip Cohen. (2018) ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism. The Journal of Immunology 201:11, pages 3373-3382.
Crossref
Daqi Xu, Marissa L. Matsumoto, Brent S. McKenzie & Ali A. Zarrin. (2018) TPL2 kinase action and control of inflammation. Pharmacological Research 129, pages 188-193.
Crossref
Dimitra Virla, Christos Tsatsanis & Aristides G. Eliopoulos. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 5557 5566 .
Kate Senger, Victoria C. PhamEugene Varfolomeev, Jason A. Hackney, Cesar A. CorzoJenna Collier, Vivian W. C. Lau, Zhiyu HuangKajal HamidzhadehPatrick Caplazi, Ivan PengA. Francesca SetiadiRoss FrancisAndres Paler-Martinez, Youngsu C. Kwon, Vladimir Ramirez-Carrozzi, Yonglian Sun, Patricia W. Grigg, Merone Roose-GirmaSurinder JeetKai H. BarckAnna Pham, Naruhisa OtaConnie Ha, Jeremy StinsonJoseph GuilloryLucinda TamZora ModrusanClaire EmsonBrent S. McKenzieMichael J. TownsendRichard A. D. Carano, Søren Warming, Domagoj VucicJason DeVossWyne P. LeeJennie R. Lill & Ali A. Zarrin. (2017) The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation. Science Signaling 10:475.
Crossref
Hua Li, Jeong-Hyun Yoon, Hyo-Jun Won, Hyeon-Seon Ji, Heong Joo Yuk, Ki Hun Park, Ho-Yong Park & Tae-Sook Jeong. (2017) Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-κB and TLR/MAPK signaling in LPS-induced RAW264.7 cells. International Immunopharmacology 45, pages 110-119.
Crossref
Jun-Han Lee, Joo-Hyung Lee, Sang Hyuk Lee, Sung-Im Do, Sung-Dae Cho, Ola Forslund, Kyung-Soo Inn, Jeong-Sang Lee, Fang-Ming Deng, Jonathan Melamed, Jae U. Jung & Joseph H. Jeong. (2016) TPL2 Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma . Cancer Research 76:22, pages 6712-6722.
Crossref
Dimitra Virla, Christos Tsatsanis & Aristides G. Eliopoulos. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 10 .
Tina Gruosso, Camille Garnier, Sophie Abelanet, Yann Kieffer, Vincent Lemesre, Dorine Bellanger, Ivan Bieche, Elisabetta Marangoni, Xavier Sastre-Garau, Virginie Mieulet & Fatima Mechta-Grigoriou. (2015) MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas. Nature Communications 6:1.
Crossref
Sascha Gutmann, Alexandra Hinniger, Gabriele Fendrich, Peter Drückes, Sylvie Antz, Henri Mattes, Henrik Möbitz, Silvio Ofner, Niko Schmiedeberg, Aleksandar Stojanovic, Sebastien Rieffel, André Strauss, Thomas Troxler, Ralf Glatthar & Helmut Sparrer. (2015) The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold. Journal of Biological Chemistry 290:24, pages 15210-15218.
Crossref
Hye Lee, Han Choi, Kyeung Joo & Do-Hyun Nam. (2015) Tumor Progression Locus 2 (Tpl2) Kinase as a Novel Therapeutic Target for Cancer: Double-Sided Effects of Tpl2 on Cancer. International Journal of Molecular Sciences 16:3, pages 4471-4491.
Crossref
Mousumi Ghosh, Vladimir Aguirre, Khine Wai, Hady Felfly, W. Dalton Dietrich & Damien D. Pearse. (2015) The Interplay between Cyclic AMP, MAPK, and NF- κ B Pathways in Response to Proinflammatory Signals in Microglia . BioMed Research International 2015, pages 1-18.
Crossref
Teneema Kuriakose, Balázs Rada & Wendy T. Watford. (2014) Tumor Progression Locus 2-dependent Oxidative Burst Drives Phosphorylation of Extracellular Signal-regulated Kinase during TLR3 and 9 Signaling. Journal of Biological Chemistry 289:52, pages 36089-36100.
Crossref
Emilie Jacque, Edina Schweighoffer, Alexander Visekruna, Stamatia Papoutsopoulou, Julia Janzen, Rachel Zillwood, David M. Tarlinton, Victor L.J. Tybulewicz & Steven C. Ley. (2014) IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell–dependent antigen. Journal of Experimental Medicine 211:10, pages 2085-2101.
Crossref
Guy Martel & Simon Rousseau. (2014) TPL2 signalling: From Toll-like receptors-mediated ERK1/ERK2 activation to Cystic Fibrosis lung disease. The International Journal of Biochemistry & Cell Biology 52, pages 146-151.
Crossref
Abduelhakem Ben-AddiAgnes Mambole-DemaChristine BrenderStephen R. MartinJulia JanzenSven Kjaer, Stephen J. Smerdon & Steven C. Ley. (2014) IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases. Proceedings of the National Academy of Sciences 111:23.
Crossref
Guadalupe Sabio & Roger J. Davis. (2014) TNF and MAP kinase signalling pathways. Seminars in Immunology 26:3, pages 237-245.
Crossref
Sean M. Rowley, Teneema Kuriakose, Lee M. Dockery, Thi Tran-Ngyuen, Aaron D. Gingerich, Lai Wei & Wendy T. Watford. (2014) Tumor Progression Locus 2 (Tpl2) Kinase Promotes Chemokine Receptor Expression and Macrophage Migration during Acute Inflammation. Journal of Biological Chemistry 289:22, pages 15788-15797.
Crossref
J. Simon C. Arthur & Steven C. Ley. (2013) Mitogen-activated protein kinases in innate immunity. Nature Reviews Immunology 13:9, pages 679-692.
Crossref
Thorsten GantkeSabrina BoussoufJulia JanzenNicholas A. MorriceSteven HowellElke MÜHLBERGERSteven C. Ley. (2013) Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells. Biochemical Journal 452:2, pages 359-365.
Crossref
Guy Martel, Julie Bérubé & Simon Rousseau. (2013) The Protein Kinase TPL2 Is Essential for ERK1/ERK2 Activation and Cytokine Gene Expression in Airway Epithelial Cells Exposed to Pathogen-Associated Molecular Patterns (PAMPs). PLoS ONE 8:3, pages e59116.
Crossref
Thorsten Gantke, Srividya Sriskantharajah, Michael Sadowski & Steven C. Ley. (2012) IκB kinase regulation of the TPL-2/ERK MAPK pathway. Immunological Reviews 246:1, pages 168-182.
Crossref
Marta López-Peláez, Irene Soria-Castro, Lisardo Boscá, Margarita Fernández & Susana Alemany. (2011) Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression. European Journal of Immunology 41:6, pages 1733-1741.
Crossref
Virginie Mieulet & Richard F. Lamb. (2011) Arginine et réponse immunitaire innée. médecine/sciences 27:5, pages 461-463.
Crossref
Maria Vougioukalaki, Dimitris C. Kanellis, Kalliopi Gkouskou & Aristides G. Eliopoulos. (2011) Tpl2 kinase signal transduction in inflammation and cancer. Cancer Letters 304:2, pages 80-89.
Crossref
Huei-Ting Yang, Yanyan Wang, Xixing Zhao, Ezana Demissie, Stamatia Papoutsopoulou, Agnes Mambole, Anne O’Garra, Michal F. Tomczak, Susan E. Erdman, James G. Fox, Steven C. Ley & Bruce H. Horwitz. (2011) NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages through TPL-2–Dependent ERK Activation. The Journal of Immunology 186:4, pages 1989-1996.
Crossref
Thorsten Gantke, Srividya Sriskantharajah & Steven C Ley. (2010) Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. Cell Research 21:1, pages 131-145.
Crossref
Irene Soria-Castro, Agnieszka Krzyzanowska, Marta López Pelaéz, Javier Regadera, Gema Ferrer, Lluis Montoliu, Rosario Rodríguez-Ramos, Margarita Fernández & Susana Alemany. (2010) Cot/tpl2 (MAP3K8) Mediates Myeloperoxidase Activity and Hypernociception following Peripheral Inflammation*. Journal of Biological Chemistry 285:44, pages 33805-33815.
Crossref
Virginie MieuletLijun YanCaroline ChoisyKatherine SullyJulia ProcterAndreas KouroumalisSteve KrywawychMario PendeSteven C. LeyChristophe MoinardRichard F. Lamb. (2010) TPL-2–Mediated Activation of MAPK Downstream of TLR4 Signaling Is Coupled to Arginine Availability. Science Signaling 3:135.
Crossref
Hosea HandoyoMargaret J. StaffordEamon McManusDionissios BaltzisMark PeggiePhilip Cohen. (2009) IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2. Biochemical Journal 424:1, pages 109-118.
Crossref
P. Khanal, K.-Y. Lee, K.-W. Kang, B. S. Kang & H. S. Choi. (2009) Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator protein 1 induced by EGF. Carcinogenesis 30:4, pages 682-689.
Crossref
Simon Rousseau, Matoula Papoutsopoulou, Antony Symons, Dorthe Cook, John M. Lucocq, Alan R. Prescott, Anne O'Garra, Steven C. Ley & Philip Cohen. (2008) TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNFα in LPS-stimulated macrophages. Journal of Cell Science 121:2, pages 149-154.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.