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Molecular and Cellular Biology Volume 33, 2013 - Issue 17
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Article

Oncogenic Activity of Retinoic Acid Receptor γ Is Exhibited through Activation of the Akt/NF-κB and Wnt/β-Catenin Pathways in Cholangiocarcinoma

Gui-Li Huanga Center Laboratory, First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China
,
Qi Luob Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, Xiamen Cancer Center, Xiamen, People's Republic of China
,
Gang Ruib Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, Xiamen Cancer Center, Xiamen, People's Republic of China
,
Wei Zhanga Center Laboratory, First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China
,
Qiu-Yan Zhangc State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, People's Republic of China
,
Qing-Xi Chenc State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, People's Republic of China
&
Dong-Yan Shena Center Laboratory, First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of ChinaCorrespondence[email protected]
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Pages 3416-3425 | Received 28 Mar 2013, Accepted 13 Jun 2013, Published online: 20 Mar 2023

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Gui-Li Huang, Qing-Xi Chen, Jia-Jia Ma, Si-Yao Sui, Yu-Ning Wang & Dong-Yan Shen. (2019) Retinoic acid receptor α facilitates human colorectal cancer progression via Akt and MMP2 signaling. OncoTargets and Therapy 12, pages 3087-3098.
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Gui-Li Huang, Wei Song, Pan Zhou, Qi-Rui Fu, Chen-Lu Lin, Qing-Xi Chen & Dong-Yan Shen. (2017) Oncogenic retinoic acid receptor γ knockdown reverses multi-drug resistance of human colorectal cancer via Wnt/β-catenin pathway. Cell Cycle 16:7, pages 685-692.
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Kohei Yamakawa, Michiyo Koyanagi-Aoi, Akihito Machinaga, Nobuyuki Kakiuchi, Tomonori Hirano, Yuzo Kodama & Takashi Aoi. (2023) Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase. Cancer Cell International 23:1.
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Geoffrey Brown. (2023) Retinoic acid receptor regulation of decision-making for cell differentiation. Frontiers in Cell and Developmental Biology 11.
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Geoffrey Brown. (2023) Targeting the Retinoic Acid Pathway to Eradicate Cancer Stem Cells. International Journal of Molecular Sciences 24:3, pages 2373.
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Kaiyuan Ji, Wenlong Dou, Ningfang Zhang, Bolun Wen, Mingyan Zhong, Qianbing Zhang, Shuxiang Xu, Jianlong Zhou & Jingfeng Liu. (2022) Retinoic acid receptor gamma is required for proliferation of pancreatic cancer cells. Cell Biology International 47:1, pages 144-155.
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Lin Xiu, Yuxi Zhao, Ning Li, Jia Zeng, Jing Liu, Yongliang Fu, Qiao Gao & Lingying Wu. (2022) High expression of RARG accelerates ovarian cancer progression by regulating cell proliferation. Frontiers in Oncology 12.
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Geoffrey Brown. (2022) Lessons to cancer from studies of leukemia and hematopoiesis. Frontiers in Cell and Developmental Biology 10.
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Geoffrey Brown. (2022) Antagonizing RARγ Drives Necroptosis of Cancer Stem Cells. International Journal of Molecular Sciences 23:9, pages 4814.
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Geoffrey Brown & Kevin Petrie. (2021) The RARγ Oncogene: An Achilles Heel for Some Cancers. International Journal of Molecular Sciences 22:7, pages 3632.
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Guo-Feng Zhang, Ling Qiu, Shu-Li Yang, Jia-Cheng Wu & Tong-Jun Liu. (2020) Wnt/β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma. Bioscience Reports 40:3.
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Le Wang, Hao Wang, Xianglong Duan, Penggao Dai & Jianping Li. (2019) Comprehensive Analysis of the Canonical and Non-canonical Wnt Signaling Pathways in Gastric Cancer. Digestive Diseases and Sciences 64:10, pages 2830-2842.
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Wenhui Wang, Ron Smits, Haiping Hao & Chaoyong He. (2019) Wnt/β-Catenin Signaling in Liver Cancers. Cancers 11:7, pages 926.
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Xian-Liang Lai, Zhi-Feng Deng, Xin-Gen Zhu & Zhi-Hua Chen. (2019) Apc gene suppresses intracranial aneurysm formation and rupture through inhibiting the NF-κB signaling pathway mediated inflammatory response . Bioscience Reports 39:3.
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Hong-Yi Yang, Jin-Xing Shen, Yi Wang, Yu Liu, Dong-Yan Shen & Song Quan. (2019) Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/ β -Catenin Signaling . BioMed Research International 2019, pages 1-14.
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Maria J. Perugorria, Paula Olaizola, Ibone Labiano, Aitor Esparza-Baquer, Marco Marzioni, Jose J. G. Marin, Luis Bujanda & Jesus M. Banales. (2018) Wnt–β-catenin signalling in liver development, health and disease. Nature Reviews Gastroenterology & Hepatology 16:2, pages 121-136.
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Jie Liu, Jian-gang Huang & Jin-Zhang Zeng. 2019. Retinoid and Rexinoid Signaling. Retinoid and Rexinoid Signaling 15 31 .
Xiao-Mei Mao, Hua Li, Xiao-Yun Zhang, Pan Zhou, Qi-Rui Fu, Qian-En Chen, Jin-Xing Shen, Yu Liu, Qing-Xi Chen & Dong-Yan Shen. (2018) Retinoic Acid Receptor α Knockdown Suppresses the Tumorigenicity of Esophageal Carcinoma via Wnt/β-catenin Pathway. Digestive Diseases and Sciences 63:12, pages 3348-3358.
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Brian A. Aguado, Rachel M. Hartfield, Grace G. Bushnell, Joseph T. Decker, Samira M. Azarin, Dhaval Nanavati, Matthew J. Schipma, Shreyas S. Rao, Robert S. Oakes, Yining Zhang, Jacqueline S. Jeruss & Lonnie D. Shea. (2018) Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment. Advanced Healthcare Materials 7:10, pages 1700903.
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Jie Jiang, Hong‑Yue Ren, Guo‑Jun Geng, Yan‑Jun Mi, Yu Liu, Ning Li, Shu‑Yu Yang & Dong‑Yan Shen. (2017) Oncogenic activity of insulin in the development of non‑small cell lung carcinoma. Oncology Letters.
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Fu-Hui Zhang, Hong-Yue Ren, Jin-Xing Shen, Xiao-Yun Zhang, Hui-Ming Ye & Dong-Yan Shen. (2017) Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway. Biomedicine & Pharmacotherapy 94, pages 474-480.
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C. M. López Fontana, L. E. Zyla, F. E. Santiano, C. V. Sasso, F. D. Cuello-Carrión, V. Pistone Creydt, M. A. Fanelli & R. W. Carón. (2017) Hypothyroidism reduces mammary tumor progression via Β-catenin-activated intrinsic apoptotic pathway in rats. Histochemistry and Cell Biology 147:6, pages 759-769.
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Gui-Li Huang, Wei Zhang, Hong-Yue Ren, Pan Zhou, Yun Chen, Qing-Xi Chen & Dong-Yan Shen. (2017) Oncogenic retinoic acid receptor α promotes human colorectal cancer growth through simultaneously regulating p21 transcription and GSK3β/β-catenin signaling. Cancer Letters 388, pages 118-129.
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Hong-Yue Ren, Fan Liu, Gui-Li Huang, Yu Liu, Jin-Xing Shen, Pan Zhou, Wen-Ming Liu & Dong-Yan Shen. (2016) Positive feedback loop of IL-1β/Akt/RARα/Akt signaling mediates oncogenic property of RARα in gastric carcinoma. Oncotarget 8:4, pages 6718-6729.
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Wen-Juan Gan, Jing-Ru Wang, Xiao-Li Zhu, Xiao-Shun He, Peng-Da Guo, Shen Zhang, Xiu-Ming Li, Jian-Ming Li & Hua Wu. (2016) RARγ-induced E-cadherin downregulation promotes hepatocellular carcinoma invasion and metastasis. Journal of Experimental & Clinical Cancer Research 35:1.
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Hong-Yue Ren, Bo Chen, Gui-Li Huang, Yu Liu & Dong-Yan Shen. (2016) Upregulation of retinoic acid receptor-β reverses drug resistance in cholangiocarcinoma cells by enhancing susceptibility to apoptosis. Molecular Medicine Reports 14:4, pages 3602-3608.
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Peng-Da Guo, Xing-Xing Lu, Wen-Juan Gan, Xiu-Ming Li, Xiao-Shun He, Shen Zhang, Qing-Hua Ji, Feng Zhou, Yue Cao, Jing-Ru Wang, Jian-Ming Li & Hua Wu. (2016) RARγ Downregulation Contributes to Colorectal Tumorigenesis and Metastasis by Derepressing the Hippo–Yap Pathway. Cancer Research 76:13, pages 3813-3825.
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