Advanced search
Publication Cover
Molecular and Cellular Biology Volume 28, 2008 - Issue 18
Submit an article Journal homepage
47
Views
52
CrossRef citations to date
0
Altmetric
Article

The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF-κB Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for Association

Ryan R. McCullyDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland21205
&
Joel L. PomerantzDepartment of Biological Chemistry and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland21205Correspondence[email protected]
Pages 5668-5686 | Received 12 Mar 2008, Accepted 02 Jul 2008, Published online: 27 Mar 2023

Citations (52)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Sarah M. Pedersen, Waipan Chan, Rakhi P. Jattani, deMauri S. Mackie & Joel L. Pomerantz. (2016) Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181. Molecular and Cellular Biology 36:5, pages 794-808.
Read now
Stefanie L. Makowski, Zhaoquan Wang & Joel L. Pomerantz. (2015) A Protease-Independent Function for SPPL3 in NFAT Activation. Molecular and Cellular Biology 35:2, pages 451-467.
Read now
Waipan Chan, Thomas B. Schaffer & Joel L. Pomerantz. (2013) A Quantitative Signaling Screen Identifies CARD11 Mutations in the CARD and LATCH Domains That Induce Bcl10 Ubiquitination and Human Lymphoma Cell Survival. Molecular and Cellular Biology 33:2, pages 429-443.
Read now
Hiromitsu Hara, Eiichi IIzasa, Mako Nakaya & Hiroki Yoshida. (2010) L-CBM signaling in lymphocyte development and function. Journal of Blood Medicine 1, pages 93-104.
Read now
Miguel E. Moreno-García, Karen Sommer, Hisaaki Shinohara, Ashok D. Bandaranayake, Tomohiro Kurosaki & David J. Rawlings. (2010) MAGUK-Controlled Ubiquitination of CARMA1 Modulates Lymphocyte NF-κB Activity. Molecular and Cellular Biology 30:4, pages 922-934.
Read now

Articles from other publishers (47)

Donghyo Kim, Doyeon Ha, Kwanghwan Lee, Heetak Lee, Inhae Kim & Sanguk Kim. (2023) An evolution-based machine learning to identify cancer type-specific driver mutations. Briefings in Bioinformatics 24:1.
Crossref
Stanley B. DeVore & Gurjit K. Khurana Hershey. (2022) The role of the CBM complex in allergic inflammation and disease. Journal of Allergy and Clinical Immunology 150:5, pages 1011-1030.
Crossref
Kerstin Kutzner, Simone Woods, Ozge Karayel, Torben GehringHongli YinAndrew Flatley, Carina GraßNicole Wimberger, Marie J. TofauteThomas Seeholzer, Regina Feederle, Matthias Mann & Daniel Krappmann. (2022) Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells. Science Signaling 15:723.
Crossref
Jacquelyn R. Bedsaul, Neha Shah, Shelby M. Hutcherson & Joel L. Pomerantz. (2022) Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants. iScience 25:2, pages 103810.
Crossref
Henry Y. Lu, Mehul Sharma, Ashish A. Sharma, Atilano Lacson, Ashley Szpurko, Joanne Luider, Poonam Dharmani-Khan, Afshin Shameli, Peter A. Bell, Gregory M.T. Guilcher, Victor A. Lewis, Marta Rojas Vasquez, Sunil Desai, Lyle McGonigle, Luis Murguia-Favela, Nicola A.M. Wright, Consolato Sergi, Eytan Wine, Christopher M. Overall, Sneha Suresh & Stuart E. Turvey. (2021) Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency. Journal of Allergy and Clinical Immunology 148:6, pages 1559-1574.e13.
Crossref
Peiwei Zhao, Qingjie Meng, Yufeng Huang, Lei Zhang, Sukun Luo, Xiankai Zhang, Li Tan, Aifen Zhou, Hao Xiong & Xuelian He. (2021) Identification and Characterization of a Germline Mutation in CARD11 From a Chinese Case of B Cell Expansion With NF-κB and T Cell Anergy. Frontiers in Immunology 12.
Crossref
Shelby M. Hutcherson, Jacquelyn R. Bedsaul & Joel L. Pomerantz. (2021) Pathway-Specific Defects in T, B, and NK Cells and Age-Dependent Development of High IgE in Mice Heterozygous for a CADINS-Associated Dominant Negative   CARD11 Allele . The Journal of Immunology 207:4, pages 1150-1164.
Crossref
Joel L. Pomerantz. (2021) Reconsidering phosphorylation in the control of inducible CARD11 scaffold activity during antigen receptor signaling. Advances in Biological Regulation 79, pages 100775.
Crossref
Zhaoquan Wang, Shelby M. Hutcherson, Chao Yang, Rakhi P. Jattani, Julia M. Tritapoe, Yong-Kang Yang & Joel L. Pomerantz. (2019) Coordinated regulation of scaffold opening and enzymatic activity during CARD11 signaling. Journal of Biological Chemistry 294:40, pages 14648-14660.
Crossref
Michael J. Holliday, Axel Witt, Alejandro Rodríguez Gama, Benjamin T. Walters, Christopher P. Arthur, Randal Halfmann, Alexis Rohou, Erin C. Dueber & Wayne J. Fairbrother. (2019) Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation. Nature Communications 10:1.
Crossref
Shilei Zhang & Xin Lin. (2019) CARMA3: Scaffold Protein Involved in NF-κB Signaling. Frontiers in Immunology 10.
Crossref
Thomas Seeholzer, Susanne Kurz, Florian Schlauderer, Simone Woods, Torben Gehring, Simon Widmann, Katja Lammens & Daniel Krappmann. (2018) BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation. Frontiers in Immunology 9.
Crossref
An Thys, Tiphaine Douanne & Nicolas Bidère. (2018) Post-translational Modifications of the CARMA1-BCL10-MALT1 Complex in Lymphocytes and Activated B-Cell Like Subtype of Diffuse Large B-Cell Lymphoma. Frontiers in Oncology 8.
Crossref
Jacquelyn R. Bedsaul, Nicole M. Carter, Katelynn E. Deibel, Shelby M. Hutcherson, Tyler A. Jones, Zhaoquan Wang, Chao Yang, Yong-Kang Yang & Joel L. Pomerantz. (2018) Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease. Frontiers in Immunology 9.
Crossref
Harjit Dadi, Tyler A. Jones, Daniele Merico, Nigel Sharfe, Adi Ovadia, Yael Schejter, Brenda Reid, Mark Sun, Linda Vong, Adelle Atkinson, Sasson Lavi, Joel L. Pomerantz & Chaim M. Roifman. (2018) Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11). Journal of Allergy and Clinical Immunology 141:5, pages 1818-1830.e2.
Crossref
Swadhinya Arjunaraja, Pamela Angelus, Helen C. Su & Andrew L. Snow. (2018) Impaired Control of Epstein–Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease. Frontiers in Immunology 9.
Crossref
Swadhinya Arjunaraja, Brent D. Nosé, Gauthaman Sukumar, Nathaniel M. Lott, Clifton L. Dalgard & Andrew L. Snow. (2017) Intrinsic Plasma Cell Differentiation Defects in B Cell Expansion with NF-κB and T Cell Anergy Patient B Cells. Frontiers in Immunology 8.
Crossref
Chi A Ma, Jeffrey R Stinson, Yuan Zhang, Jordan K Abbott, Michael A Weinreich, Pia J Hauk, Paul R Reynolds, Jonathan J Lyons, Celeste G Nelson, Elisa Ruffo, Batsukh Dorjbal, Salomé Glauzy, Natsuko Yamakawa, Swadhinya Arjunaraja, Kelsey Voss, Jennifer Stoddard, Julie Niemela, Yu Zhang, Sergio D Rosenzweig, Joshua J McElwee, Thomas DiMaggio, Helen F Matthews, Nina Jones, Kelly D Stone, Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti, Brian Kim, Megan A Cooper, Neil Romberg, Eric Meffre, Erwin W Gelfand, Andrew L Snow & Joshua D Milner. (2017) Germline hypomorphic CARD11 mutations in severe atopic disease. Nature Genetics 49:8, pages 1192-1201.
Crossref
Isabel Meininger & Daniel Krappmann. (2016) Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome. Biological Chemistry 397:12, pages 1315-1333.
Crossref
Yong-Kang Yang, Chao Yang, Waipan Chan, Zhaoquan Wang, Katelynn E. Deibel & Joel L. Pomerantz. (2016) Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling. Journal of Biological Chemistry 291:50, pages 25921-25936.
Crossref
Ashleigh HowesPaul A. O'SullivanFelix BreyerAshavari GhoseLi CaoDaniel Krappmann, Anne M. BowcockSteven C. Ley. (2016) Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation. Biochemical Journal 473:12, pages 1759-1768.
Crossref
Rakhi P. Jattani, Julia M. Tritapoe & Joel L. Pomerantz. (2016) Intramolecular Interactions and Regulation of Cofactor Binding by the Four Repressive Elements in the Caspase Recruitment Domain-containing Protein 11 (CARD11) Inhibitory Domain. Journal of Biological Chemistry 291:16, pages 8338-8348.
Crossref
Rakhi P. Jattani, Julia M. Tritapoe & Joel L. Pomerantz. (2016) Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements. Journal of Biological Chemistry 291:16, pages 8324-8336.
Crossref
Swadhinya Arjunaraja & Andrew L. Snow. (2015) Gain-of-function mutations and immunodeficiency. Current Opinion in Allergy & Clinical Immunology 15:6, pages 533-538.
Crossref
Stephen A. Watt, Karin J. Purdie, Nicoline Y. den Breems, Michelle Dimon, Sarah T. Arron, Angela T. McHugh, Dylan J. Xue, Jasbani H.S. Dayal, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh & Andrew P. South. (2015) Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation. The American Journal of Pathology 185:9, pages 2354-2363.
Crossref
Ivan Scudiero, Pasquale Vito & Romania Stilo. (2014) The Three CARMA Sisters: So Different, So Similar: A Portrait of the Three CARMA Proteins and Their Involvement in Human Disorders. Journal of Cellular Physiology 229:8, pages 990-997.
Crossref
Pasquale Vito & Romania Stilo. (2014) 1999–2014: 15 years of BCL10. Immunology Letters 160:1, pages 102-103.
Crossref
Luigi D. Notarangelo. 2014. 121 190 .
Johann Greil, Tobias Rausch, Thomas Giese, Obul R. Bandapalli, Volker Daniel, Isabelle Bekeredjian-Ding, Adrian M. Stütz, Christoph Drees, Susanne Roth, Jürgen Ruland, Jan O. Korbel & Andreas E. Kulozik. (2013) Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency. Journal of Allergy and Clinical Immunology 131:5, pages 1376-1383.e3.
Crossref
Sara Gorjestani, Bryant G. Darnay & Xin Lin. (2012) Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGFβ-activated Kinase 1 (TAK1) Play Essential Roles in the C-type Lectin Receptor Signaling in Response to Candida albicans Infection. Journal of Biological Chemistry 287:53, pages 44143-44150.
Crossref
Yogesh S. Jeelall, James Q. Wang, Hsei-Di Law, Heather Domaschenz, Herman K.H. Fung, Axel Kallies, Stephen L. Nutt, Christopher C. Goodnow & Keisuke Horikawa. (2012) Human lymphoma mutations reveal CARD11 as the switch between self-antigen–induced B cell death or proliferation and autoantibody production. Journal of Experimental Medicine 209:11, pages 1907-1917.
Crossref
Kian-Huat Lim, Yibin Yang & Louis M. Staudt. (2012) Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies. Immunological Reviews 246:1, pages 359-378.
Crossref
Hirofumi Jono, Jae Hyang Lim, Haidong Xu & Jian-Dong Li. (2012) PKCθ Synergizes with TLR-Dependent TRAF6 Signaling Pathway to Upregulate MUC5AC Mucin via CARMA1. PLoS ONE 7:1, pages e31049.
Crossref
Huai-Chia Chuang, Joung-Liang Lan, Der-Yuan Chen, Chia-Yu Yang, Yi-Ming Chen, Ju-Pi Li, Ching-Yu Huang, Pao-En Liu, Xiaohong Wang & Tse-Hua Tan. (2011) The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nature Immunology 12:11, pages 1113-1118.
Crossref
Lixin Rui, Roland Schmitz, Michele Ceribelli & Louis M Staudt. (2011) Malignant pirates of the immune system. Nature Immunology 12:10, pages 933-940.
Crossref
Sreenivasa Rao Oruganti, Sofia Edin, Christine Grundström & Thomas Grundström. (2011) CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB. Molecular Immunology 48:12-13, pages 1448-1460.
Crossref
Andrea C Eitelhuber, Sebastian Warth, Gisela Schimmack, Michael Düwel, Kamyar Hadian, Katrin Demski, Wolfgang Beisker, Hisaaki Shinohara, Tomohiro Kurosaki, Vigo Heissmeyer & Daniel Krappmann. (2011) Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation. The EMBO Journal 30:3, pages 594-605.
Crossref
Marzenna Blonska & Xin Lin. (2010) NF-κB signaling pathways regulated by CARMA family of scaffold proteins. Cell Research 21:1, pages 55-70.
Crossref
Rebecca L. Lamason, Abraham Kupfer & Joel L. Pomerantz. (2010) The Dynamic Distribution of CARD11 at the Immunological Synapse Is Regulated by the Inhibitory Kinesin GAKIN. Molecular Cell 40:5, pages 798-809.
Crossref
Rebecca L. Lamason, Ryan R. McCully, Stefanie M. Lew & Joel L. Pomerantz. (2010) Oncogenic CARD11 Mutations Induce Hyperactive Signaling by Disrupting Autoinhibition by the PKC-Responsive Inhibitory Domain. Biochemistry 49:38, pages 8240-8250.
Crossref
Rebecca L. Lamason, Stefanie M. Lew & Joel L. Pomerantz. (2010) Transcriptional target-based expression cloning of immunoregulatory molecules. Immunologic Research 47:1-3, pages 172-178.
Crossref
Rupa Srivastava, Brandon J. Burbach & Yoji Shimizu. (2010) NF-κB Activation in T Cells Requires Discrete Control of IκB Kinase α/β (IKKα/β) Phosphorylation and IKKγ Ubiquitination by the ADAP Adapter Protein. Journal of Biological Chemistry 285:15, pages 11100-11105.
Crossref
Lara M. Kingeter & Brian C. Schaefer. (2010) Malt1 and cIAP2–Malt1 as effectors of NF-κB activation: Kissing cousins or distant relatives?. Cellular Signalling 22:1, pages 9-22.
Crossref
Miguel E. Moreno-García, Karen Sommer, Claudia Haftmann, Clayton Sontheimer, Sarah F. Andrews & David J. Rawlings. (2009) Serine 649 Phosphorylation within the Protein Kinase C-Regulated Domain Down-Regulates CARMA1 Activity in Lymphocytes. The Journal of Immunology 183:11, pages 7362-7370.
Crossref
Hisaaki Shinohara & Tomohiro Kurosaki. (2009) Comprehending the complex connection between PKCβ, TAK1, and IKK in BCR signaling. Immunological Reviews 232:1, pages 300-318.
Crossref
Hiromitsu Hara & Takashi Saito. (2009) CARD9 versus CARMA1 in innate and adaptive immunity. Trends in Immunology 30:5, pages 234-242.
Crossref
Marzenna Blonska & Xin Lin. (2009) CARMA1-mediated NF-κB and JNK activation in lymphocytes. Immunological Reviews 228:1, pages 199-211.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.