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Molecular and Cellular Biology Volume 34, 2014 - Issue 15
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Article

KAP-1 Promotes Resection of Broken DNA Ends Not Protected by γ-H2AX and 53BP1 in G1-Phase Lymphocytes

Anthony T. Tubbsa Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Yair Dorsetta Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Elizabeth Chanb Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA
,
Beth Helminka Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Baeck-Seung Leea Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Putzer Hunga Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Rosmy Georgea Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Andrea L. Bredemeyera Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Anuradha Mittalc Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University, St. Louis, Missouri, USA
,
Rohit V. Pappuc Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University, St. Louis, Missouri, USA
,
Dipanjan Chowdhuryd Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts, USA
,
Nima Mosammaparasta Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
,
Michael S. Krangelb Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA
&
Barry P. Sleckmana Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USACorrespondence[email protected]
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Pages 2811-2821 | Received 01 Apr 2014, Accepted 12 May 2014, Published online: 20 Mar 2023

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Putzer J. Hung, Bo-Ruei Chen, Rosmy George, Caleb Liberman, Abigail J. Morales, Pedro Colon-Ortiz, Jessica K. Tyler, Barry P. Sleckman & Andrea L. Bredemeyer. (2017) Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes. Cell Cycle 16:3, pages 286-295.
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Articles from other publishers (17)

Rachel Johnston, Brendan Mathias, Stephanie J Crowley, Haley A Schmidt, Lynn S White, Nima Mosammaparast, Abby M Green & Jeffrey J Bednarski. (2022) Nuclease‐independent functions of RAG1 direct distinct DNA damage responses in B cells . EMBO reports 24:1.
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Bo-Ruei Chen & Barry P. Sleckman. (2022) The regulation of DNA end resection by chromatin response to DNA double strand breaks. Frontiers in Cell and Developmental Biology 10.
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Xiaolu Ma, Chen Wang, Bo Zhou, Zina Cheng, Zhiyong Mao, Tie-Shan Tang & Caixia Guo. (2022) DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1. Journal of Biological Chemistry 298:5, pages 101861.
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Alice Libri, Timea Marton & Ludovic Deriano. (2022) The (Lack of) DNA Double-Strand Break Repair Pathway Choice During V(D)J Recombination. Frontiers in Genetics 12.
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Rachel Johnston, Lynn S. White & Jeffrey J. Bednarski. 2022. DNA Damage Responses. DNA Damage Responses 69 80 .
Bo-Ruei Chen & Barry P. Sleckman. 2022. DNA Damage Responses. DNA Damage Responses 15 27 .
Bo-Ruei Chen, Yinan Wang, Zih-Jie Shen, Amelia Bennett, Issa Hindi, Jessica K. Tyler & Barry P. Sleckman. (2021) The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining. DNA Repair 108, pages 103217.
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Bo-Ruei Chen, Yinan Wang, Anthony Tubbs, Dali Zong, Faith C Fowler, Nicholas Zolnerowich, Wei Wu, Amelia Bennett, Chun-Chin Chen, Wendy Feng, Andre Nussenzweig, Jessica K Tyler & Barry P Sleckman. (2021) LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells. eLife 10.
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Meng Yuan, Yang Wang, Mengting Qin, Xiaohui Zhao, Xiaodong Chen, Dandan Li, Yinsha Miao, Wood Otieno Odhiambo, Huasheng Liu, Yunfeng Ma & Yanhong Ji. (2021) RAG enhances BCR‐ABL1 ‐positive leukemic cell growth through its endonuclease activity in vitro and in vivo . Cancer Science 112:7, pages 2679-2691.
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Chun-Chin Chen, Weiran Feng, Pei Xin LimElizabeth M. KassMaria Jasin. (2018) Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer. Annual Review of Cancer Biology 2:1, pages 313-336.
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Li-Ya Chiu, Fade Gong & Kyle M. Miller. (2017) Bromodomain proteins: repairing DNA damage within chromatin. Philosophical Transactions of the Royal Society B: Biological Sciences 372:1731, pages 20160286.
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Chun-Chin ChenElizabeth M. KassWei-Feng YenThomas LudwigMary Ellen Moynahan, Jayanta ChaudhuriMaria Jasin. (2017) ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair. Proceedings of the National Academy of Sciences 114:29, pages 7665-7670.
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Takao Fujisawa & Panagis Filippakopoulos. (2017) Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nature Reviews Molecular Cell Biology 18:4, pages 246-262.
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Chloé Lescale, Vincent Abramowski, Marie Bedora-Faure, Valentine Murigneux, Gabriella Vera, David B. Roth, Patrick Revy, Jean-Pierre de Villartay & Ludovic Deriano. (2016) RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair. Nature Communications 7:1.
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Vipul Kumar & Frederick W. Alt. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology 107 114 .
Cuifang Chang, Zhipeng Niu, Ningning Gu, Weiming Zhao, Gaiping Wang, Yifeng Jia, Deming Li & Cunshuan Xu. (2015) Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level. BMC Cell Biology 16:1.
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Yair Dorsett, Yanjiao Zhou, Anthony T. Tubbs, Bo-Ruei Chen, Caitlin Purman, Baeck-Seung Lee, Rosmy George, Andrea L. Bredemeyer, Jiang-yang Zhao, Erica Sodergen, George M. Weinstock, Nathan D. Han, Alejandro Reyes, Eugene M. Oltz, Dale Dorsett, Ziva Misulovin, Jacqueline E. Payton & Barry P. Sleckman. (2014) HCoDES Reveals Chromosomal DNA End Structures with Single-Nucleotide Resolution. Molecular Cell 56:6, pages 808-818.
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