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Article

FANCD2-Controlled Chromatin Access of the Fanconi-Associated Nuclease FAN1 Is Crucial for the Recovery of Stalled Replication Forks

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Pages 3939-3954 | Received 02 Apr 2014, Accepted 01 Aug 2014, Published online: 20 Mar 2023

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Dana Branzei & Barnabas Szakal. (2017) Building up and breaking down: mechanisms controlling recombination during replication. Critical Reviews in Biochemistry and Molecular Biology 52:4, pages 381-394.
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Crossref
Tamar Kavlashvili, Wenpeng Liu, Taha M. Mohamed, David Cortez & James M. Dewar. (2023) Replication fork uncoupling causes nascent strand degradation and fork reversal. Nature Structural & Molecular Biology 30:1, pages 115-124.
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Daniel Solvie, Apoorva Baluapuri, Leonie Uhl, Daniel Fleischhauer, Theresa Endres, Dimitrios Papadopoulos, Amel Aziba, Abdallah Gaballa, Ivan Mikicic, Ekaterina Isaakova, Celeste Giansanti, Jennifer Jansen, Marvin Jungblut, Teresa Klein, Christina Schülein-Völk, Hans Maric, Sören Doose, Markus Sauer, Petra Beli, Andreas Rosenwald, Matthias Dobbelstein, Elmar Wolf & Martin Eilers. (2022) MYC multimers shield stalled replication forks from RNA polymerase. Nature 612:7938, pages 148-155.
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Crossref
Delisa E Clay, Erin A Jezuit, Ruth A Montague & Donald T Fox. (2022) Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks . G3 Genes|Genomes|Genetics 12:8.
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Nibal Badra Fajardo, Stavros Taraviras & Zoi Lygerou. (2022) Fanconi anemia proteins and genome fragility: unraveling replication defects for cancer therapy. Trends in Cancer 8:6, pages 467-481.
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Ayeong So, Elodie Dardillac, Ali Muhammad, Catherine Chailleux, Laura Sesma-Sanz, Sandrine Ragu, Eric Le Cam, Yvan Canitrot, Jean Yves Masson, Pauline Dupaigne, Bernard S Lopez & Josée Guirouilh-Barbat. (2022) RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function. Nucleic Acids Research 50:5, pages 2651-2666.
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Xiaonan Zhao, Huiyan Lu & Karen Usdin. (2021) FAN1’s protection against CGG repeat expansion requires its nuclease activity and is FANCD2-independent. Nucleic Acids Research 49:20, pages 11643-11652.
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Simon Willaume, Emilie Rass, Paula Fontanilla-Ramirez, Angela Moussa, Paul Wanschoor & Pascale Bertrand. (2021) A Link between Replicative Stress, Lamin Proteins, and Inflammation. Genes 12:4, pages 552.
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Matthew Nolan, Kenneth Knudson, Marina K. Holz & Indrajit Chaudhury. (2021) Fanconi anemia and mTOR pathways functionally interact during stalled replication fork recovery. FEBS Letters 595:5, pages 595-603.
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Amit L. Deshmukh, Antonio Porro, Mohiuddin Mohiuddin, Stella Lanni, Gagan B. Panigrahi, Marie-Christine Caron, Jean-Yves Masson, Alessandro A. Sartori & Christopher E. Pearson. (2021) FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders. Journal of Huntington's Disease 10:1, pages 95-122.
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Maya Raghunandan, Jung Eun Yeo, Ryan Walter, Kai Saito, Adam J Harvey, Stacie Ittershagen, Eun-A Lee, Jihyeon Yang, Maureen E Hoatlin, Anja K Bielinsky, Eric A Hendrickson, Orlando Schärer & Alexandra Sobeck. (2020) Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Human Molecular Genetics 29:7, pages 1083-1095.
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Lok Ming Tam, Nathan E. Price & Yinsheng Wang. (2020) Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair. Chemical Research in Toxicology 33:3, pages 709-726.
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Mihoko Rikitake, Ryosuke Fujikane, Yuko Obayashi, Kyoko Oka, Masao Ozaki & Masumi Hidaka. (2020) MLH1‐mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O 6 ‐methylguanine . Genes to Cells 25:3, pages 175-186.
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Ambika Dattani & Shane R. Wilkinson. (2019) Deciphering the interstrand crosslink DNA repair network expressed by Trypanosoma brucei. DNA Repair 78, pages 154-166.
Crossref
David Lopez-Martinez, Marian Kupculak, Di Yang, Yasunaga Yoshikawa, Chih-Chao Liang, Ronghu Wu, Steven P. Gygi & Martin A. Cohn. (2019) Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage. Cell Reports 27:10, pages 2990-3005.e5.
Crossref
Chunmin Ge, Chrystelle L. Vilfranc, Lixiao Che, Raj K. Pandita, Shashank Hambarde, Paul R. Andreassen, Liang Niu, Olugbenga Olowokure, Shimul Shah, Susan E. Waltz, Lee Zou, Jiang Wang, Tej K. Pandita & Chunying Du. (2019) The BRUCE‐ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development. Hepatology 69:6, pages 2608-2622.
Crossref
Arindam Datta & Robert M. Brosh Jr.. (2019) Holding All the Cards—How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability. Genes 10:2, pages 170.
Crossref
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre, Pamela Farshim, Gill P Bates, Peter Holmans, Lesley Jones & Sarah J Tabrizi. (2019) FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat . Human Molecular Genetics 28:4, pages 650-661.
Crossref
Seong Min Kim & Susan L. Forsburg. (2018) Regulation of Structure-Specific Endonucleases in Replication Stress. Genes 9:12, pages 634.
Crossref
Maïlyn Yates & Alexandre Maréchal. (2018) Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication. International Journal of Molecular Sciences 19:10, pages 2909.
Crossref
Diego Bonetti, Chiara Vittoria Colombo, Michela Clerici & Maria Pia Longhese. (2018) Processing of DNA Ends in the Maintenance of Genome Stability. Frontiers in Genetics 9.
Crossref
Hyeonseok Jin, Upasana Roy, Gwangrog Lee, Orlando D. Schärer & Yunje Cho. (2018) Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease. Journal of Biological Chemistry 293:17, pages 6482-6496.
Crossref
Maria B. Federico, Paola Campodónico, Natalia S. Paviolo & Vanesa Gottifredi. (2018) Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 808, pages 83-92.
Crossref
Philippe PaseroAlessandro Vindigni. (2017) Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts. Annual Review of Genetics 51:1, pages 477-499.
Crossref
Elizabeth L. Thompson, Jung E. Yeo, Eun-A Lee, Yinan Kan, Maya Raghunandan, Constanze Wiek, Helmut Hanenberg, Orlando D. Schärer, Eric A. Hendrickson & Alexandra Sobeck. (2017) FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Research 45:20, pages 11837-11857.
Crossref
Antonio Porro, Matteo Berti, Julia Pizzolato, Serena Bologna, Svenja Kaden, Anja Saxer, Yue Ma, Kazuo Nagasawa, Alessandro A. Sartori & Josef Jiricny. (2017) FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2. Nature Communications 8:1.
Crossref
Masamichi Ishiai, Koichi Sato, Junya Tomida, Hiroyuki Kitao, Hitoshi Kurumizaka & Minoru Takata. (2017) Activation of the FA pathway mediated by phosphorylation and ubiquitination. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 803-805, pages 89-95.
Crossref
Maria B. Federico, Paola Campodónico, Natalia S. Paviolo & Vanesa Gottifredi. (2017) WITHDRAWN: Beyond interstrand crosslinks repair: Contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.
Crossref
Hyeonseok Jin & Yunje Cho. (2017) Structural and functional relationships of FAN1. DNA Repair 56, pages 135-143.
Crossref
Ji Jiang, Marina Bellani, Lin Li, Pengcheng Wang, Michael M. Seidman & Yinsheng Wang. (2017) Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair. ACS Chemical Biology 12:7, pages 1858-1866.
Crossref
Michele Giannattasio & Dana Branzei. (2017) S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion. Cellular and Molecular Life Sciences 74:13, pages 2361-2380.
Crossref
Alessandro Vindigni & Massimo Lopes. (2017) Combining electron microscopy with single molecule DNA fiber approaches to study DNA replication dynamics. Biophysical Chemistry 225, pages 3-9.
Crossref
Pierre-Marie Dehé & Pierre-Henri L. Gaillard. (2017) Control of structure-specific endonucleases to maintain genome stability. Nature Reviews Molecular Cell Biology 18:5, pages 315-330.
Crossref
Eva Vesela, Katarina Chroma, Zsofia Turi & Martin Mistrik. (2017) Common Chemical Inductors of Replication Stress: Focus on Cell‐Based Studies. Biomolecules 7:4, pages 19.
Crossref
Advaitha Madireddy & Jeannine Gerhardt. 2017. DNA Replication. DNA Replication 549 581 .
Koichi Sato, Mayo Shimomuki, Yoko Katsuki, Daisuke Takahashi, Wataru Kobayashi, Masamichi Ishiai, Hiroyuki Miyoshi, Minoru Takata & Hitoshi Kurumizaka. (2016) FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end. Nucleic Acids Research 44:22, pages 10758-10771.
Crossref
Amélie Fradet-Turcotte, Justine Sitz, Damien Grapton & Alexandre Orthwein. (2016) BRCA2 functions: from DNA repair to replication fork stabilization. Endocrine-Related Cancer 23:10, pages T1-T17.
Crossref
David Lopez-Martinez, Chih-Chao Liang & Martin A. Cohn. (2016) Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway. Cellular and Molecular Life Sciences 73:16, pages 3097-3114.
Crossref
Raphael Ceccaldi, Prabha Sarangi & Alan D. D'Andrea. (2016) The Fanconi anaemia pathway: new players and new functions. Nature Reviews Molecular Cell Biology 17:6, pages 337-349.
Crossref
Zeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O’Leary, David Kozono, Alan D. D’Andrea & Raphael Ceccaldi. (2016) FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair. Cell Reports 15:11, pages 2488-2499.
Crossref
Supawat Thongthip, Marina Bellani, Siobhan Q. Gregg, Sunandini Sridhar, Brooke A. Conti, Yanglu Chen, Michael M. Seidman & Agata Smogorzewska. (2016) Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction . Genes & Development 30:6, pages 645-659.
Crossref
Christophe LachaudAlberto MorenoFrancesco MarchesiRachel TothJ. Julian BlowJohn Rouse. (2016) Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability. Science 351:6275, pages 846-849.
Crossref
Matteo Berti & Alessandro Vindigni. (2016) Replication stress: getting back on track. Nature Structural & Molecular Biology 23:2, pages 103-109.
Crossref
María Belén Federico, María Belén Vallerga, Analía Radl, Natalia Soledad Paviolo, José Luis Bocco, Marina Di Giorgio, Gastón Soria & Vanesa Gottifredi. (2016) Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks. PLOS Genetics 12:1, pages e1005792.
Crossref
María Belén Vallerga, Sabrina F. Mansilla, María Belén Federico, Agustina P. Bertolin & Vanesa Gottifredi. (2015) Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation. Proceedings of the National Academy of Sciences 112:48.
Crossref
Julia Pizzolato, Shivam Mukherjee, Orlando D. Schärer & Josef Jiricny. (2015) FANCD2-associated Nuclease 1, but Not Exonuclease 1 or Flap Endonuclease 1, Is Able to Unhook DNA Interstrand Cross-links in Vitro. Journal of Biological Chemistry 290:37, pages 22602-22611.
Crossref
Massimo Bogliolo & Jordi Surrallés. (2015) Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics. Current Opinion in Genetics & Development 33, pages 32-40.
Crossref
Jong-Min Lee, Vanessa C. Wheeler, Michael J. Chao, Jean Paul G. Vonsattel, Ricardo Mouro Pinto, Diane Lucente, Kawther Abu-Elneel, Eliana Marisa Ramos, Jayalakshmi Srinidhi Mysore, Tammy Gillis, Marcy E. MacDonald, James F. Gusella, Denise Harold, Timothy C. Stone, Valentina Escott-Price, Jun Han, Alexey Vedernikov, Peter Holmans, Lesley Jones, Seung Kwak, Mithra Mahmoudi, Michael Orth, G. Bernhard Landwehrmeyer, Jane S. Paulsen, E. Ray Dorsey, Ira Shoulson & Richard H. Myers. (2015) Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease. Cell 162:3, pages 516-526.
Crossref
Natalie J. Herrmann, Alexander Knoll & Holger Puchta. (2015) The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81. Nucleic Acids Research 43:7, pages 3653-3666.
Crossref
Kaushlendra Tripathi, Usama K. Hussein, Roja Anupalli, Reagan Barnett, Lavanya Bachaboina, Jennifer Scalici, Rodney P. Rocconi, Laurie B. Owen, Gary A. Piazza & Komaraiah Palle. (2015) Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation. Oncotarget 6:7, pages 5237-5252.
Crossref
Peng-xian Yan, Yan-gao Huo & Tao Jiang. (2014) Crystal structure of human Fanconi-associated nuclease 1. Protein & Cell 6:3, pages 225-228.
Crossref

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