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Molecular and Cellular Biology Volume 33, 2013 - Issue 20
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Article

Pdx-1 Activates Islet α- and β-Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2

Heather L. Hayesa Sarah W. Stedman Nutrition and Metabolism Center and Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina, USA;b Departments of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
,
Larry G. Mossa Sarah W. Stedman Nutrition and Metabolism Center and Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina, USA;c Medicine, Duke University Medical Center, Durham, North Carolina, USA
,
Jonathan C. Schislera Sarah W. Stedman Nutrition and Metabolism Center and Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina, USA
,
Jonathan M. Haldemana Sarah W. Stedman Nutrition and Metabolism Center and Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina, USA;b Departments of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
,
Zhushan Zhangc Medicine, Duke University Medical Center, Durham, North Carolina, USA
,
Paul B. Rosenberga Sarah W. Stedman Nutrition and Metabolism Center and Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina, USA;c Medicine, Duke University Medical Center, Durham, North Carolina, USA
,
Christopher B. Newgarda Sarah W. Stedman Nutrition and Metabolism Center and Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina, USA;b Departments of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA;c Medicine, Duke University Medical Center, Durham, North Carolina, USA
&
Hans E. Hohmeiera Sarah W. Stedman Nutrition and Metabolism Center and Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina, USA;c Medicine, Duke University Medical Center, Durham, North Carolina, USACorrespondence[email protected]
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Pages 4017-4029 | Received 19 Apr 2013, Accepted 31 Jul 2013, Published online: 20 Mar 2023

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Mark Anthony Jara, Joao Pedro Werneck-De-Castro, Camila Lubaczeuski, James D. Johnson & Ernesto Bernal-Mizrachi. (2020) Pancreatic and duodenal homeobox-1 (PDX1) contributes to β-cell mass expansion and proliferation induced by Akt/PKB pathway. Islets 12:2, pages 32-40.
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Heather L. Hayes, Lu Zhang, Thomas C. Becker, Jonathan M. Haldeman, Samuel B. Stephens, Michelle Arlotto, Larry G. Moss, Christopher B. Newgard & Hans E. Hohmeier. (2016) A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. Molecular and Cellular Biology 36:23, pages 2918-2930.
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Zhe Yang, Qiao Zhang, Qin Lu, Zhuqing Jia, Ping Chen, Kangtao Ma, Weiping Wang & Chunyan Zhou. (2015) ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex. Cell Cycle 14:24, pages 3820-3829.
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Amanda Hobson, Carrie Draney, Andrew Stratford, Thomas C Becker, Danhong Lu, Michelle Arlotto & Jeffery S Tessem. (2015) Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway. Islets 7:1.
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Sharon Baumel-Alterzon & Donald K. Scott. (2022) Regulation of Pdx1 by oxidative stress and Nrf2 in pancreatic beta-cells. Frontiers in Endocrinology 13.
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T. Hilton Grayson, Timothy V. Murphy & Shaun L. Sandow. (2017) Transient receptor potential canonical type 3 channels: Interactions, role and relevance - A vascular focus. Pharmacology & Therapeutics 174, pages 79-96.
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Yousra M El-Far, Mahmoud M Zakaria, Mahmoud M Gabr, Amal M El Gayar, Ibrahim M El-Sherbiny & Laila A Eissa. (2016) A newly developed silymarin nanoformulation as a potential antidiabetic agent in experimental diabetes. Nanomedicine 11:19, pages 2581-2602.
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Baburajan Radha, Gnanaraj Muniraj & Ravikumar Rasu. (2016) The Making of Pancreatic β Cells: Advances and Apprehensions. International Journal of Pharmacology, Phytochemistry and Ethnomedicine 5, pages 34-51.
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Dan-dan Zhang, Ji-gang Zhang, Yu-zhu Wang, Ying Liu, Gao-lin Liu & Xiao-yu Li. (2015) Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism. Nutrients 7:9, pages 7437-7450.
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Chen Wang, Kazim Husain, Anying Zhang, Barbara A. Centeno, Dung-Tsa Chen, Zhongsheng Tong, Säid M. Sebti & Mokenge P. Malafa. (2015) EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells. The Journal of Nutritional Biochemistry 26:8, pages 797-807.
Crossref
Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell & Jennifer P. Wang. (2015) Viral Infection of Engrafted Human Islets Leads to Diabetes. Diabetes 64:4, pages 1358-1369.
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LiLi Gao, Wei Tang, ZhengZheng Ding, DingYu Wang, XiaoQiang Qi, HuiWen Wu & Jun Guo. (2015) Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells. Molecular Medicine 21:1, pages 154-166.
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Brian P. Boerner, Nicholas M. George, Shakeel U.R. Mir & Nora E. Sarvetnick. (2015) WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocrine Journal 62:4, pages 379-386.
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Xiaodong Gao, Lujun Song, Kuntang Shen, Hongshan Wang, Mengjia Qian, Weixin Niu & Xinyu Qin. (2014) Bone marrow mesenchymal stem cells promote the repair of islets from diabetic mice through paracrine actions. Molecular and Cellular Endocrinology 388:1-2, pages 41-50.
Crossref
Gerald Thiel, Isabelle Müller & Oliver G. Rössler. (2014) Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues. Molecular and Cellular Endocrinology 388:1-2, pages 10-19.
Crossref
Jeffery S. Tessem, Larry G. Moss, Lily C. Chao, Michelle ArlottoDanhong LuMette V. Jensen, Samuel B. Stephens, Peter Tontonoz, Hans E. Hohmeier & Christopher B. Newgard. (2014) Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proceedings of the National Academy of Sciences 111:14, pages 5242-5247.
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Mireille Chevallet, Louis Jarvis, Amélie Harel, Sylvie Luche, Sébastien Degot, Violaine Chapuis, Guylain Boulay, Thierry Rabilloud & Alexandre Bouron. (2014) Functional consequences of the over-expression of TRPC6 channels in HEK cells: impact on the homeostasis of zinc. Metallomics 6:7, pages 1269.
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