Citations (125)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Stephanie M. Ackerson, Caroline I. Gable & Jason A. Stewart. (2020) Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress. Cell Cycle 19:24, pages 3491-3507.
Read now
Read now
Victor Chun-Lam Wong, Haley L. Cash, Jessica Morse, Shan Lu & Anatoly Zhitkovich. (2012) S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde. Cell Cycle 11:13, pages 2526-2537.
Read now
Read now
Alessia Errico & Vincenzo Costanzo. (2012) Mechanisms of replication fork protection: a safeguard for genome stability. Critical Reviews in Biochemistry and Molecular Biology 47:3, pages 222-235.
Read now
Read now
Özdemirhan Serçin & Michael G. Kemp. (2011) Characterization of functional domains in human Claspin. Cell Cycle 10:10, pages 1599-1606.
Read now
Read now
Heather L. Ball, Mark R. Ehrhardt, Daniel A. Mordes, Gloria G. Glick, Walter J. Chazin & David Cortez. (2007) Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins. Molecular and Cellular Biology 27:9, pages 3367-3377.
Read now
Read now
Keziban Ünsal-Kaçmaz, Paul D. Chastain, Ping-Ping Qu, Parviz Minoo, Marila Cordeiro-Stone, Aziz Sancar & William K. Kaufmann. (2007) The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement. Molecular and Cellular Biology 27:8, pages 3131-3142.
Read now
Read now
Articles from other publishers (119)
Genper Chi-Ngai Wong & Kim Hei-Man Chow. (2023) DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease. Journal of Alzheimer's Disease 94:s1, pages S429-S451.
Crossref
Crossref
Jinal A. Patel & Hyungjin Kim. (2023) The TIMELESS effort for timely DNA replication and protection. Cellular and Molecular Life Sciences 80:4.
Crossref
Crossref
Salman Ahmed, Waqas Alam, Michael Aschner, Khalaf F. Alsharif, Ashraf Albrakati, Luciano Saso & Haroon Khan. (2022) Natural products targeting the ATR-CHK1 signaling pathway in cancer therapy. Biomedicine & Pharmacotherapy 155, pages 113797.
Crossref
Crossref
Ramya Ravindranathan, Kavya Raveendran, Frantzeskos Papanikos, Pedro A San-Segundo & Attila Tóth. (2022) Chromosomal synapsis defects can trigger oocyte apoptosis without elevating numbers of persistent DNA breaks above wild-type levels. Nucleic Acids Research 50:10, pages 5617-5634.
Crossref
Crossref
Barbara Guerra, Thomas K. Doktor, Sabrina B. Frederiksen, Kumar Somyajit & Brage S. Andresen. (2022) Essential role of CK2α for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint. Cellular and Molecular Life Sciences 79:6.
Crossref
Crossref
Seung Ho Choi, Kyoungjoo Cho, Eun Seon Kim & Hae Yong Yoo. (2022) Proline-serine-threonine-repeat region of MDC1 mediates Chk1 phosphorylation and the DNA double-strand break repair. The International Journal of Biochemistry & Cell Biology 143, pages 106152.
Crossref
Crossref
Gabriel E. Matos-Rodrigues & Rodrigo A. P. Martins. (2021) An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo. Frontiers in Cell and Developmental Biology 9.
Crossref
Crossref
Irina Vazquez‐Villasenor, Claire J. Garwood, Julie E. Simpson, Paul R. Heath, Heather Mortiboys & Stephen B. Wharton. (2021) Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function. European Journal of Neuroscience 54:9, pages 6987-7005.
Crossref
Crossref
Jiexi Li, Xingdi Ma, Deepavali Chakravarti, Shabnam Shalapour & Ronald A. DePinho. (2021) Genetic and biological hallmarks of colorectal cancer. Genes & Development 35:11-12, pages 787-820.
Crossref
Crossref
Yuping Chen & Jian Yuan. (2021) The post translational modification of key regulators of ATR signaling in DNA replication. Genome Instability & Disease 2:2, pages 92-101.
Crossref
Crossref
Javier E. Jiménez-Salazar, Rebeca Damian-Ferrara, Marcela Arteaga, Nikola Batina & Pablo Damián-Matsumura. (2021) Non-Genomic Actions of Estrogens on the DNA Repair Pathways Are Associated With Chemotherapy Resistance in Breast Cancer. Frontiers in Oncology 11.
Crossref
Crossref
Camilla Frattini, Alexy Promonet, Emile Alghoul, Sophie Vidal-Eychenie, Marie Lamarque, Marie-Pierre Blanchard, Serge Urbach, Jihane Basbous & Angelos Constantinou. (2021) TopBP1 assembles nuclear condensates to switch on ATR signaling. Molecular Cell 81:6, pages 1231-1245.e8.
Crossref
Crossref
Katelyn B. Cassidy, Scott Bang, Manabu Kurokawa & Scott A. Gerber. (2019) Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1. The FEBS Journal 287:10, pages 1985-1999.
Crossref
Crossref
Li Ding, Vijay S. Madamsetty, Spencer Kiers, Olga Alekhina, Andrey Ugolkov, John Dube, Yu Zhang, Jin-San Zhang, Enfeng Wang, Shamit K. Dutta, Daniel M. Schmitt, Francis J. Giles, Alan P. Kozikowski, Andrew P. Mazar, Debabrata Mukhopadhyay & Daniel D. Billadeau. (2019) Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response. Clinical Cancer Research 25:21, pages 6452-6462.
Crossref
Crossref
Michael Charles Lanz, Diego Dibitetto & Marcus Bustamante Smolka. (2019)
DNA
damage kinase signaling: checkpoint and repair at 30 years
. The EMBO Journal 38:18.
Crossref
Crossref
Alice BourgeoisSébastien BonnetSandra Breuils-BonnetKarima HabboutRenée ParadisEve TremblayMarie-Claude LampronMark E. OrcholskiFrancois PotusThomas BerteroThibaut PeterliniStephen Y. ChanKaren A NorrisRoxane PaulinSteeve ProvencherOlivier Boucherat. (2019) Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology 39:8, pages 1667-1681.
Crossref
Crossref
Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver & Laurence H Pearl. (2019) Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. eLife 8.
Crossref
Crossref
Wioletta Rozpędek, Dariusz Pytel, Alicja Nowak-Zduńczyk, Dawid Lewko, Radosław Wojtczak, J. Alan Diehl & Ireneusz Majsterek. (2019) Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment. Current Medicinal Chemistry 26:8, pages 1425-1445.
Crossref
Crossref
Julien N. Bianco, Valérie Bergoglio, Yea-Lih Lin, Marie-Jeanne Pillaire, Anne-Lyne Schmitz, Julia Gilhodes, Amelie Lusque, Julien Mazières, Magali Lacroix-Triki, Theodoros I. Roumeliotis, Jyoti Choudhary, Jérôme Moreaux, Jean-Sébastien Hoffmann, Hélène Tourrière & Philippe Pasero. (2019) Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner. Nature Communications 10:1.
Crossref
Crossref
Fuminori Ito, Chiharu Yoshimoto, Yuki Yamada, Tamotsu Sudo & Hiroshi Kobayashi. (2018) The HNF-1β―USP28―Claspin pathway upregulates DNA damage-induced Chk1 activation in ovarian clear cell carcinoma. Oncotarget 9:25, pages 17512-17522.
Crossref
Crossref
Hironori Abe, Kris G Alavattam, Yasuko Kato, Diego H Castrillon, Qishen Pang, Paul R Andreassen & Satoshi H Namekawa. (2018) CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice. Human Molecular Genetics 27:7, pages 1136-1149.
Crossref
Crossref
Elodie Bournique, Marina Dall’Osto, Jean-Sébastien Hoffmann & Valérie Bergoglio. (2018) Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 808, pages 62-73.
Crossref
Crossref
Emilio Lecona & Oscar Fernández-Capetillo. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy
35
61
.
Na Song, Xiaofang Che, Lu Xu, Jinglei Qu, Huachuan Zheng, Kezuo Hou, Xiujuan Qu & Yunpeng Liu. (2017) A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells. Molecular and Cellular Biochemistry 436:1-2, pages 29-38.
Crossref
Crossref
Elias ElInatiHelen R. RussellObah A. OjarikreMahesh SangrithiTakayuki HirotaDirk G. de Rooij, Peter J. McKinnonJames M. A. Turner. (2017) DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line. Proceedings of the National Academy of Sciences 114:47, pages 12536-12541.
Crossref
Crossref
Seung Ho Choi, Ji-Hong Park, Tram Thi Ngoc Nguyen, Hee Jin Shim & Young-Han Song. (2017)
Initiation of
Drosophila
chorion gene amplification requires
Claspin
and
mus101
, whereas
Claspin
, but not
mus101
, plays a major role during elongation
. Developmental Dynamics 246:6, pages 466-474.
Crossref
Crossref
Graeme Hewitt & Viktor I. Korolchuk. (2017) Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance. Trends in Cell Biology 27:5, pages 340-351.
Crossref
Crossref
Stuart Rundle, Alice Bradbury, Yvette Drew & Nicola Curtin. (2017) Targeting the ATR-CHK1 Axis in Cancer Therapy. Cancers 9:12, pages 41.
Crossref
Crossref
Divya Iyer & Nicholas Rhind. (2017) The Intra-S Checkpoint Responses to DNA Damage. Genes 8:2, pages 74.
Crossref
Crossref
Edel McGarry, David Gaboriau, Michael D. Rainey, Umberto Restuccia, Angela Bachi & Corrado Santocanale. (2016) The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase. Cancer Research 76:8, pages 2384-2393.
Crossref
Crossref
L Alfano, C Costa, A Caporaso, A Altieri, P Indovina, M Macaluso, A Giordano & F Pentimalli. (2015) NONO regulates the intra-S-phase checkpoint in response to UV radiation. Oncogene 35:5, pages 567-576.
Crossref
Crossref
Zhongdao Li, Alexander H. Pearlman & Peggy Hsieh. (2016) DNA mismatch repair and the DNA damage response. DNA Repair 38, pages 94-101.
Crossref
Crossref
William F. Osorio-Zambrano & Scott Davey. (2015) Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling. PLOS ONE 10:12, pages e0144434.
Crossref
Crossref
Se Hee Han, Soo-Hyun Hahm, An Hue Vy Tran, Ji Hyung Chung, Myoung-Ki Hong, Hyun-Dong Paik, Key-Sun Kim & Ye Sun Han. (2015) A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells. Cell & Bioscience 5:1.
Crossref
Crossref
Christine A. King, Xiaofan Li, Arturo Barbachano-Guerrero & Sumita Bhaduri-McIntosh. (2015) STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus. Journal of Virology 89:22, pages 11347-11355.
Crossref
Crossref
Veronique A. J. Smits & David A. Gillespie. (2015) DNA damage control: regulation and functions of checkpoint kinase 1. FEBS Journal 282:19, pages 3681-3692.
Crossref
Crossref
Nikunj R. Shah & Michael Mahmoudi. (2015) The role of DNA damage and repair in atherosclerosis: A review. Journal of Molecular and Cellular Cardiology 86, pages 147-157.
Crossref
Crossref
Jing Hao, Christelle de Renty, Yongming Li, Haijie Xiao, Michael G Kemp, Zhiyong Han, Melvin L DePamphilis & Wenge Zhu. (2015) And‐1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. The EMBO Journal 34:15, pages 2096-2110.
Crossref
Crossref
Lei Gao, Dantong Li, Ke Ma, Wenjuan Zhang, Tao Xu, Cong Fu, Changbin Jing, Xiaoe Jia, Shuang Wu, Xin Sun, Mei Dong, Min Deng, Yi Chen, Wenge Zhu, Jinrong Peng, Fengyi Wan, Yi Zhou, Leonard I. Zon & Weijun Pan. (2015) TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLOS Genetics 11:7, pages e1005346.
Crossref
Crossref
Robert Hollingworth, George Skalka, Grant Stewart, Andrew Hislop, David Blackbourn & Roger Grand. (2015) Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses 7:6, pages 2908-2927.
Crossref
Crossref
Robert Hollingworth & Roger Grand. (2015) Modulation of DNA Damage and Repair Pathways by Human Tumour Viruses. Viruses 7:5, pages 2542-2591.
Crossref
Crossref
Sriramana Kanginakudru, Marsha DeSmet, Yanique Thomas, Iain M. Morgan & Elliot J. Androphy. (2015) Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication. Virology 478, pages 129-136.
Crossref
Crossref
Seung Ho Choi, Heekyoung Yang, Seung Ho Lee, Joo-Hyun Ki, Do-Hyun Nam & Hae Yong Yoo. (2014) TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases. Molecular Cancer 13:1.
Crossref
Crossref
Jian Yuan, Kuntian Luo, Min Deng, Yunhui Li, Ping Yin, Bowen Gao, Yuan Fang, Puqiang Wu, Tongzheng Liu & Zhenkun Lou. (2014) HERC2-USP20 axis regulates DNA damage checkpoint through Claspin. Nucleic Acids Research 42:21, pages 13110-13121.
Crossref
Crossref
Richard O. Adeyemi & David J. Pintel. (2014) The ATR Signaling Pathway Is Disabled during Infection with the Parvovirus Minute Virus of Mice. Journal of Virology 88:17, pages 10189-10199.
Crossref
Crossref
Yuan-Hao Lee, Youping Sun & Randolph Glickman. (2014) Ursolic Acid-Regulated Energy Metabolism—Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage?. Proteomes 2:3, pages 399-425.
Crossref
Crossref
Hyungshin Yim & Raymond L. Erikson. (2014) Plk1-targeted therapies in TP53- or RAS-mutated cancer. Mutation Research/Reviews in Mutation Research 761, pages 31-39.
Crossref
Crossref
Nicholas A. Wallace & Denise A. Galloway. (2014) Manipulation of cellular DNA damage repair machinery facilitates propagation of human papillomaviruses. Seminars in Cancer Biology 26, pages 30-42.
Crossref
Crossref
Amanda Torrentes-Carvalho, Cintia Ferreira Marinho, Luzia Maria de Oliveira-Pinto, Débora Batista de Oliveira, Paulo Vieira Damasco, Rivaldo Venâncio Cunha, Luiz José de Souza, Elzinandes Leal de Azeredo & Claire Fernandes Kubelka. (2014) Regulation of T lymphocyte apoptotic markers is associated to cell activation during the acute phase of dengue. Immunobiology 219:5, pages 329-340.
Crossref
Crossref
Roman Alpatov, Bluma J. Lesch, Mika Nakamoto-Kinoshita, Andres Blanco, Shuzhen Chen, Alexandra Stützer, Karim J. Armache, Matthew D. Simon, Chao Xu, Muzaffar Ali, Jernej Murn, Sladjana Prisic, Tatiana G. Kutateladze, Christopher R. Vakoc, Jinrong Min, Robert E. Kingston, Wolfgang Fischle, Stephen T. Warren, David C. Page & Yang Shi. (2014) A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response. Cell 157:4, pages 869-881.
Crossref
Crossref
Youwei Zhang & Tony Hunter. (2013) Roles of Chk1 in cell biology and cancer therapy. International Journal of Cancer 134:5, pages 1013-1023.
Crossref
Crossref
Lingyan Jiang, Rong Rong, M. Saeed Sheikh & Ying Huang. (2014) Mitotic Arrest by Tumor Suppressor RASSF1A Is Regulated via CHK1 Phosphorylation. Molecular Cancer Research 12:1, pages 119-129.
Crossref
Crossref
Hyuk-Jin Cha & Hyungshin Yim. (2013) The accumulation of DNA repair defects is the molecular origin of carcinogenesis. Tumor Biology 34:6, pages 3293-3302.
Crossref
Crossref
Ivana Murfuni, Giorgia Basile, Shyamal Subramanyam, Eva Malacaria, Margherita Bignami, Maria Spies, Annapaola Franchitto & Pietro Pichierri. (2013) Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function. PLoS Genetics 9:10, pages e1003910.
Crossref
Crossref
Antoine Aze, Jin Chuan Zhou, Alessandro Costa & Vincenzo Costanzo. (2013) DNA replication and homologous recombination factors: acting together to maintain genome stability. Chromosoma 122:5, pages 401-413.
Crossref
Crossref
Rémy Bétous, Marie-Jeanne Pillaire, Laura Pierini, Siem van der Laan, Bénédicte Recolin, Emma Ohl-Séguy, Caixia Guo, Naoko Niimi, Petr Grúz, Takehiko Nohmi, Errol Friedberg, Christophe Cazaux, Domenico Maiorano & Jean-Sébastien Hoffmann. (2013) DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. The EMBO Journal 32:15, pages 2172-2185.
Crossref
Crossref
Junya Unno, Masatoshi Takagi, Jinhua Piao, Masataka Sugimoto, Fumiko Honda, Daisuke Maeda, Mitsuko Masutani, Tohru Kiyono, Fumiaki Watanabe, Tomohiro Morio, Hirobumi Teraoka & Shuki Mizutani. (2013) Artemis-dependent DNA double-strand break formation at stalled replication forks. Cancer Science 104:6, pages 703-710.
Crossref
Crossref
Bunsyo Shiotani, Hai Dang Nguyen, Pelle Håkansson, Alexandre Maréchal, Alice Tse, Hidetoshi Tahara & Lee Zou. (2013) Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1. Cell Reports 3:5, pages 1651-1662.
Crossref
Crossref
Shizhou Liu, Chu Kwen HoJian OuyangLee Zou. (2013) Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling. Proceedings of the National Academy of Sciences 110:6, pages 2175-2180.
Crossref
Crossref
Lee Zou. (2013) Four pillars of the S-phase checkpoint. Genes & Development 27:3, pages 227-233.
Crossref
Crossref
Ronit I. Yarden, Sally Metsuyanim, Itay Pickholtz, Shabana Shabbeer, Hadass Tellio & Moshe Z. Papa. (2012) BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest. The International Journal of Biochemistry & Cell Biology 44:11, pages 1761-1769.
Crossref
Crossref
Eun-Mi Lee, Tram Thi Bich Trinh, Hee Jin Shim, Suk-Young Park, Trang Thi Thu Nguyen, Min-Joo Kim & Young-Han Song. (2012) Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks. DNA Repair 11:9, pages 741-752.
Crossref
Crossref
P Pichierri, S Nicolai, L Cignolo, M Bignami & A Franchitto. (2011) The RAD9–RAD1–HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling. Oncogene 31:23, pages 2809-2823.
Crossref
Crossref
Youngsoo Lee, Sachin Katyal, Susanna M Downing, Jingfeng Zhao, Helen R Russell & Peter J McKinnon. (2012) Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nature Neuroscience 15:6, pages 819-826.
Crossref
Crossref
Juliana Speroni, María Belén Federico, Sabrina F. Mansilla, Gastón Soria & Vanesa Gottifredi. (2012) Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA. Proceedings of the National Academy of Sciences 109:19, pages 7344-7349.
Crossref
Crossref
Robert T. Abraham & Thanos D. Halazonetis. 2012. Signaling Pathways in Cancer Pathogenesis and Therapy. Signaling Pathways in Cancer Pathogenesis and Therapy
23
37
.
Akari Yoshimura, Motomu Akita, Yoshifumi Hosono, Takuya Abe, Masahiko Kobayashi, Ken-ichi Yamamoto, Shusuke Tada, Masayuki Seki & Takemi Enomoto. (2011) Functional relationship between Claspin and Rad17. Biochemical and Biophysical Research Communications 414:2, pages 298-303.
Crossref
Crossref
Zheng Meng, Luisa Capalbo, David M. Glover & William G. Dunphy. (2011) Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Molecular Biology of the Cell 22:16, pages 2834-2847.
Crossref
Crossref
Daniele G. Soares, Aude Battistella, Céline J. Rocca, Renata Matuo, João A. P. Henriques, Annette K. Larsen & Alexandre E. Escargueil. (2011) Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. Biochemical Journal 437:1, pages 63-73.
Crossref
Crossref
Shizhou Liu, Bunsyo Shiotani, Mayurika Lahiri, Alexandre Maréchal, Alice Tse, Charles Chung Yun Leung, J.N. Mark Glover, Xiaohong H. Yang & Lee Zou. (2011) ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation. Molecular Cell 43:2, pages 192-202.
Crossref
Crossref
Jean-Hugues Guervilly, Emilie Renaud, Minoru Takata & Filippo Rosselli. (2011) USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation. Human Molecular Genetics 20:11, pages 2171-2181.
Crossref
Crossref
Laura A. Lindsey-Boltz & Aziz Sancar. (2011) Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1). Journal of Biological Chemistry 286:22, pages 19229-19236.
Crossref
Crossref
Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Marc Labroli, Frances Shanahan, Nicole Davis, Lorena Taricani, Derek Wiswell, Wolfgang Seghezzi, Ervin Penaflor, Bhagyashree Bhagwat, Wei Wang, Danling Gu, Yunsheng Hsieh, Suining Lee, Ming Liu & David Parry. (2011) Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening. Molecular Cancer Therapeutics 10:4, pages 591-602.
Crossref
Crossref
Amy L. TienSucharita SenbanerjeeAtul KulkarniRaksha MudbharyBernadette GoudreauShridar GanesanKirsten C. SadlerChinweike Ukomadu. (2011) UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis. Biochemical Journal 435:1, pages 175-185.
Crossref
Crossref
Sung Woong Bang, Min Ji Ko, Sukhyun Kang, Gwang Su Kim, Dongmin Kang, JooHun Lee & Deog Su Hwang. (2011) Human TopBP1 localization to the mitotic centrosome mediates mitotic progression. Experimental Cell Research 317:7, pages 994-1004.
Crossref
Crossref
Yoon Jeon, Eun Ko, Kyung Yong Lee, Min Ji Ko, Seo Young Park, Jeeheon Kang, Chang Hwan Jeon, Ho Lee & Deog Su Hwang. (2011) TopBP1 Deficiency Causes an Early Embryonic Lethality and Induces Cellular Senescence in Primary Cells. Journal of Biological Chemistry 286:7, pages 5414-5422.
Crossref
Crossref
Susanne M. Germann, Vibe H. Oestergaard, Caroline Haas, Pauline Salis, Akira Motegi & Michael Lisby. (2011) Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination. DNA Repair 10:2, pages 210-224.
Crossref
Crossref
Fred Bunz. 2011. Molecular Determinants of Radiation Response. Molecular Determinants of Radiation Response
35
52
.
Abdallah Al-Hakim, Cristina Escribano-Diaz, Marie-Claude Landry, Lara O’Donnell, Stephanie Panier, Rachel K. Szilard & Daniel Durocher. (2010) The ubiquitous role of ubiquitin in the DNA damage response. DNA Repair 9:12, pages 1229-1240.
Crossref
Crossref
Niall Steven Kenneth, Sharon Mudie & Sonia Rocha. (2010) IKK and NF-κB-mediated regulation of Claspin impacts on ATR checkpoint function. The EMBO Journal 29:17, pages 2966-2978.
Crossref
Crossref
Angela Poehlmann & Albert Roessner. (2010) Importance of DNA damage checkpoints in the pathogenesis of human cancers. Pathology - Research and Practice 206:9, pages 591-601.
Crossref
Crossref
Magda Granata, Federico Lazzaro, Daniele Novarina, Davide Panigada, Fabio Puddu, Carla Manuela Abreu, Ramesh Kumar, Muriel Grenon, Noel F. Lowndes, Paolo Plevani & Marco Muzi-Falconi. (2010) Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity. PLoS Genetics 6:8, pages e1001047.
Crossref
Crossref
Andrew N. BlackfordRakesh N. PatelNatalie A. ForresterKathrin Theil, Peter Groitl, Grant S. StewartA. Malcolm R. TaylorIain M. Morgan, Thomas Dobner, Roger J. A. GrandAndrew S. Turnell. (2010) Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation. Proceedings of the National Academy of Sciences 107:27, pages 12251-12256.
Crossref
Crossref
Da-Qiang Li, Kazufumi Ohshiro, Mudassar N. Khan & Rakesh Kumar. (2010) Requirement of MTA1 in ATR-mediated DNA Damage Checkpoint Function. Journal of Biological Chemistry 285:26, pages 19802-19812.
Crossref
Crossref
Liyong Zhang, Chi-Hoon Park, Jing Wu, Hyun Kim, Weijun Liu, Takeo Fujita, Manimalha Balasubramani, Emanuel M Schreiber, Xiao-Fan Wang & Yong Wan. (2010) Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. The EMBO Journal 29:10, pages 1726-1737.
Crossref
Crossref
Michael G. Kemp, Zafer Akan, Seçil Yilmaz, Mary Grillo, Stephanie L. Smith-Roe, Tae-Hong Kang, Marila Cordeiro-Stone, William K. Kaufmann, Robert T. Abraham, Aziz Sancar & Keziban Ünsal-Kaçmaz. (2010) Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress. Journal of Biological Chemistry 285:22, pages 16562-16571.
Crossref
Crossref
Ryo Sakasai, Hirobumi Teraoka, Masatoshi Takagi & Randal S. Tibbetts. (2010) Transcription-dependent Activation of Ataxia Telangiectasia Mutated Prevents DNA-dependent Protein Kinase-mediated Cell Death in Response to Topoisomerase I Poison. Journal of Biological Chemistry 285:20, pages 15201-15208.
Crossref
Crossref
Rebekka A Schwab, Andrew N Blackford & Wojciech Niedzwiedz. (2010) ATR activation and replication fork restart are defective in FANCM-deficient cells. The EMBO Journal 29:4, pages 806-818.
Crossref
Crossref
Florian Fuchs, Gregoire Pau, Dominique Kranz, Oleg Sklyar, Christoph Budjan, Sandra Steinbrink, Thomas Horn, Angelika Pedal, Wolfgang Huber & Michael Boutros. (2010) Clustering phenotype populations by genome‐wide RNAi and multiparametric imaging. Molecular Systems Biology 6:1.
Crossref
Crossref
Laura A. Lindsey-Boltz, Özdemirhan Serçin, Jun-Hyuk Choi & Aziz Sancar. (2009) Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase. Journal of Biological Chemistry 284:48, pages 33107-33114.
Crossref
Crossref
XiaoFang Li, Tarsha Ward, XueBiao Yao & JiaRui Wu. (2009) Chk1 prevents abnormal mitosis of S-phase HeLa cells containing DNA damage. Chinese Science Bulletin 54:22, pages 4205-4213.
Crossref
Crossref
Jun-Sub Im, Sang-Hee Ki, Andrea Farina, Dong-Soo Jung, Jerard Hurwitz & Joon-Kyu Lee. (2009) Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. Proceedings of the National Academy of Sciences 106:37, pages 15628-15632.
Crossref
Crossref
Ali Pedram, Mahnaz Razandi, Albert J. Evinger, Eva Lee & Ellis R. Levin. (2009) Estrogen Inhibits ATR Signaling to Cell Cycle Checkpoints and DNA Repair. Molecular Biology of the Cell 20:14, pages 3374-3389.
Crossref
Crossref
H Christian Reinhardt & Michael B Yaffe. (2009) Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Current Opinion in Cell Biology 21:2, pages 245-255.
Crossref
Crossref
Jannie M. Rendtlew Danielsen, Dorthe Helena Larsen, Kenneth B⊘dtker Schou, Raimundo Freire, Jacob Falck, Jiri Bartek & Jiri Lukas. (2009) HCLK2 Is Required for Activity of the DNA Damage Response Kinase ATR. Journal of Biological Chemistry 284:7, pages 4140-4147.
Crossref
Crossref
Helene Faustrup, Simon Bekker-Jensen, Jiri Bartek, Jiri Lukas & Niels Mailand. (2009) USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin. Journal of Cell Biology 184:1, pages 13-19.
Crossref
Crossref
Ryo Sakasai & Randal S. Tibbetts. 2009. The DNA Damage Response: Implications on Cancer Formation and Treatment. The DNA Damage Response: Implications on Cancer Formation and Treatment
81
107
.
Daniel A. Mordes & David Cortez. 2009. The DNA Damage Response: Implications on Cancer Formation and Treatment. The DNA Damage Response: Implications on Cancer Formation and Treatment
25
45
.
Karlene A. Cimprich & David Cortez. (2008) ATR: an essential regulator of genome integrity. Nature Reviews Molecular Cell Biology 9:8, pages 616-627.
Crossref
Crossref
Fabrizio d'Adda di Fagagna. (2008) Living on a break: cellular senescence as a DNA-damage response. Nature Reviews Cancer 8:7, pages 512-522.
Crossref
Crossref
Daniel A. Mordes, Gloria G. Glick, Runxiang Zhao & David Cortez. (2008) TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes & Development 22:11, pages 1478-1489.
Crossref
Crossref
Eva Petermann, Thomas Helleday & Keith W. Caldecott. (2008) Claspin Promotes Normal Replication Fork Rates in Human Cells. Molecular Biology of the Cell 19:6, pages 2373-2378.
Crossref
Crossref
Jennifer Scorah, Meng-Qiu Dong, John R. YatesIIIIII, Mary Scott, David Gillespie & Clare H. McGowan. (2008) A Conserved Proliferating Cell Nuclear Antigen-interacting Protein Sequence in Chk1 Is Required for Checkpoint Function. Journal of Biological Chemistry 283:25, pages 17250-17259.
Crossref
Crossref
Xiaohong H. Yang, Bunsyo Shiotani, Marie Classon & Lee Zou. (2008) Chk1 and Claspin potentiate PCNA ubiquitination. Genes & Development 22:9, pages 1147-1152.
Crossref
Crossref
Jean-Hugues Guervilly, Gaëtane Macé-Aimé & Filippo Rosselli. (2008) Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. Human Molecular Genetics 17:5, pages 679-689.
Crossref
Crossref
N Bucher & C D Britten. (2008) G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. British Journal of Cancer 98:3, pages 523-528.
Crossref
Crossref
Joseph M. Ackermann & Wafik S. El-Deiry. 2008. Checkpoint Responses in Cancer Therapy. Checkpoint Responses in Cancer Therapy
93
116
.
J Bartkova, Z Hořejs̆í, M Sehested, J M Nesland, E Rajpert-De Meyts, N E Skakkebæk, M Stucki, S Jackson, J Lukas & J Bartek. (2007) DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene 26:53, pages 7414-7422.
Crossref
Crossref
Yael Zermati, Shahul Mouhamad, Lilli Stergiou, Benjamin Besse, Lorenzo Galluzzi, Simone Boehrer, Anne-Laure Pauleau, Filippo Rosselli, Marcello D'Amelio, Roberto Amendola, Maria Castedo, Michael Hengartner, Jean-Charles Soria, Francesco Cecconi & Guido Kroemer. (2007) Nonapoptotic Role for Apaf-1 in the DNA Damage Checkpoint. Molecular Cell 28:4, pages 624-637.
Crossref
Crossref
Kate M. Sleeth, Claus Storgaard Sørensen, Natalia Issaeva, Jaroslaw Dziegielewski, Jiri Bartek & Thomas Helleday. (2007) RPA Mediates Recombination Repair During Replication Stress and Is Displaced from DNA by Checkpoint Signalling in Human Cells. Journal of Molecular Biology 373:1, pages 38-47.
Crossref
Crossref
Yesu Jeon, Kyung Yong Lee, Min Ji Ko, Yong Sun Lee, Sukhyun Kang & Deog Su Hwang. (2007) Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition. Journal of Biological Chemistry 282:20, pages 14882-14890.
Crossref
Crossref
Xinping Chen, Runxiang Zhao, Gloria G. Glick & David Cortez. (2007) Function of the ATR N-terminal domain revealed by an ATM/ATR chimera. Experimental Cell Research 313:8, pages 1667-1674.
Crossref
Crossref
Archie N. Tse, Richard Carvajal & Gary K. Schwartz. (2007) Targeting Checkpoint Kinase 1 in Cancer Therapeutics. Clinical Cancer Research 13:7, pages 1955-1960.
Crossref
Crossref
Jiri Bartek & Jiri Lukas. (2007) DNA damage checkpoints: from initiation to recovery or adaptation. Current Opinion in Cell Biology 19:2, pages 238-245.
Crossref
Crossref
Min Zhu & Robert S. Weiss. (2007)
Increased Common Fragile Site Expression, Cell Proliferation Defects, and Apoptosis following Conditional Inactivation of Mouse
Hus1
in Primary Cultured Cells
. Molecular Biology of the Cell 18:3, pages 1044-1055.
Crossref
Crossref
Ge Li, Robert T. Elder, Kefeng Qin, Hyeon Ung Park, Dong Liang & Richard Y. Zhao. (2007) Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1. Journal of Biological Chemistry 282:10, pages 7287-7298.
Crossref
Crossref
Laura R. Barkley, Haruo Ohmori & Cyrus Vaziri. (2007) Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts. Cell Biochemistry and Biophysics 47:3, pages 392-408.
Crossref
Crossref
Danny M. Chou & Stephen J. Elledge. (2006) Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proceedings of the National Academy of Sciences 103:48, pages 18143-18147.
Crossref
Crossref
Claudia C.S. Chini & Junjie Chen. (2006) Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function. Journal of Biological Chemistry 281:44, pages 33276-33282.
Crossref
Crossref