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Molecular and Cellular Biology Volume 36, 2016 - Issue 1
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Article

Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor β-KLF5 Pathway

Yuka Nakajimaa Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan;b Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, JapanCorrespondence[email protected]
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Asami Osakabeb Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, JapanView further author information
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Tsuyoshi Wakuc Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, JapanView further author information
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Takashi Suzukid Department of Pathology and Histotechnology, Graduate School of Medicine, Tohoku University, Sendai, JapanView further author information
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Kensuke Akaogib Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, JapanView further author information
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Tetsuya Fujimurae Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, JapanView further author information
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Yukio Hommae Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, JapanView further author information
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Satoshi Inouef Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan;g Department of Anti-Aging Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan;h Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, JapanView further author information
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Junn Yanagisawaa Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan;b Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, JapanView further author information
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Pages 144-156 | Received 22 Jun 2015, Accepted 09 Oct 2015, Published online: 18 Mar 2023

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Tsuyoshi Waku, Nanami Nakamura, Misaki Koji, Hidenori Watanabe, Hiroki Katoh, Chika Tatsumi, Natsuko Tamura, Atsushi Hatanaka, Shuuhei Hirose, Hiroyuki Katayama, Misato Tani, Yuki Kubo, Jun Hamazaki, Takao Hamakubo, Akira Watanabe, Shigeo Murata & Akira Kobayashi. (2020) NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein. Molecular and Cellular Biology 40:10.
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Chen Guan, Lingling Zhang, Sixuan Wang, Luye Long, Huaibin Zhou, Shihan Qian, Mengni Ma, Fumao Bai, Qing H Meng & Jianxin Lyu. (2019) Upregulation of MicroRNA-21 promotes tumorigenesis of prostate cancer cells by targeting KLF5. Cancer Biology & Therapy 20:8, pages 1149-1161.
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Yuchen Zhang, Chongjie Yao, Ziyong Ju, Danli Jiao, Dan Hu, Li Qi, Shimin Liu, Xueqing Wu & Chen Zhao. (2023) Krüppel-like factors in tumors: Key regulators and therapeutic avenues. Frontiers in Oncology 13.
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Rocío Alejandra Ruiz Manzano, Karen Elizabeth Nava-Castro, Margarita Isabel Palacios-Arreola, Rosalía Hernández-Cervantes, Víctor Hugo Del Río-Araiza, Mariana Segovia-Mendoza, Armando Pérez-Torres, Manuel Iván Girón-Pérez & Jorge Morales-Montor. (2022) Intratumoral Treatment with 5-Androstene-3β, 17α-Diol Reduces Tumor Size and Lung Metastasis in a Triple-Negative Experimental Model of Breast Cancer. International Journal of Molecular Sciences 23:19, pages 11944.
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Z. M. Nidoieva, L. L. Lukash & A. P. Yatsyshyna. (2022) Effect of β-estradiol on the expression of human MGMT gene in cells in vitro. Faktori eksperimental'noi evolucii organizmiv 31, pages 113-117.
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Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Daniel G. Stover & Mathew A. Cherian. (2022) Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer. Frontiers in Oncology 12.
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Yao Luo & Ceshi Chen. (2021) The roles and regulation of the KLF5 transcription factor in cancers. Cancer Science 112:6, pages 2097-2117.
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Ziyan Xie, Junye Chen, Chenyu Wang, Jiahao Zhang, Yanxiang Wu & Xiaowei Yan. (2021) Current knowledge of Krüppel-like factor 5 and vascular remodeling: providing insights for therapeutic strategies. Journal of Molecular Cell Biology 13:2, pages 79-90.
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Rahul Mal, Alexa Magner, Joel David, Jharna Datta, Meghna Vallabhaneni, Mahmoud Kassem, Jasmine Manouchehri, Natalie Willingham, Daniel Stover, Jeffery Vandeusen, Sagar Sardesai, Nicole Williams, Robert Wesolowski, Maryam Lustberg, Ramesh K. Ganju, Bhuvaneswari Ramaswamy & Mathew A. Cherian. (2020) Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor. Frontiers in Oncology 10.
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Stefan Steurer, Lara Schwemmer, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Andreas M. Luebke, Ronald Simon, Guido Sauter, Jakob Izbicki, Cornelia Schroeder, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Alexander Haese, Markus Graefen, Cosima Göbel, Sören Weidemann, Patrick Lebok, David Dum, Christoph Fraune, Sarah Minner & Jan Meiners. (2019) Nuclear up regulation of the BRCA1-associated ubiquitinase BAP1 is associated with tumor aggressiveness in prostate cancers lacking the TMPRSS2:ERG fusion. Oncotarget 10:67, pages 7096-7111.
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Xin Li, Tingting Yang & Zheng Sun. (2019) Hormesis in Health and Chronic Diseases. Trends in Endocrinology & Metabolism 30:12, pages 944-958.
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Qingxia Hu, Baotong Zhang, Rui Chen, Changying Fu, Jun A, Xing Fu, Juan Li, Liya Fu, Zhiqian Zhang & Jin-Tang Dong. (2019) ZFHX3 is indispensable for ERβ to inhibit cell proliferation via MYC downregulation in prostate cancer cells. Oncogenesis 8:4.
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AKM Moyeenul Huq, Lam Kok Wai, Kamal Rullah, Mohd Fadhlizil Fasihi Mohd Aluwi, Johnson Stanslas & Jamia Azdina Jamal. (2019) Oestrogenic activity of mimosine on MCF-7 breast cancer cell line through the ERα-mediated pathway. Chemical Biology & Drug Design 93:3, pages 222-231.
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Jian Wang, Yanfeng Chu, Mei Xu, Xiumei Zhang, Yumei Zhou & Mei Xu. (2018) miR-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting KLF5. Oncology Letters.
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Laura Smy & Joely A. Straseski. (2018) Measuring estrogens in women, men, and children: Recent advances 2012–2017. Clinical Biochemistry 62, pages 11-23.
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Ana Molina, Nieves Abril, Noelia Morales-Prieto, José Monterde, Nahúm Ayala, Antonio Lora & Rosario Moyano. (2018) Hypothalamic-pituitary-ovarian axis perturbation in the basis of bisphenol A (BPA) reproductive toxicity in female zebrafish (Danio rerio). Ecotoxicology and Environmental Safety 156, pages 116-124.
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Zhenwei Han, Yong Zhang, Yin Sun, Jiaqi Chen, Chawnshang Chang, Xiaolu Wang & Shuyuan Yeh. (2018) ERβ-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma. Cancer Research 78:10, pages 2550-2563.
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Tetsuya Fujimura, Kenichi Takayama, Satoru Takahashi & Satoshi Inoue. (2018) Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine. Cancers 10:2, pages 29.
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Yuen Ting Lam, Laura Lecce, Christina A. Bursill & Martin K. C. Ng. 2017. Biochemical Basis and Therapeutic Implications of Angiogenesis. Biochemical Basis and Therapeutic Implications of Angiogenesis 445 471 .
Panida Loutchanwoot, Tina Vortherms & Hubertus Jarry. (2016) Evaluation of in vivo estrogenic potency of natural estrogen-active chemical, puerarin, on pituitary function in gonadectomized female rats. Life Sciences 165, pages 75-82.
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Lailai Li, Ningning Liu, Xiangdong Dai, Haifeng Yan, Ling Zhang, Leilei Xing, Yi Wang & Yi Wang. (2016) Development of a dual screening strategy to identify pro-angiogenic compounds from natural products: application on Tongmai Yangxin Pills. RSC Advances 6:116, pages 115308-115316.
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Z. M. Nidoieva & A. P. Iatsyshyna. (1970) Human MGMT expression is regulated by estrogen in vitro. Faktori eksperimental'noi evolucii organizmiv, pages 79-83.
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