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Molecular and Cellular Biology Volume 36, 2016 - Issue 5
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Article

The N Terminus of the Retinoblastoma Protein Inhibits DNA Replication via a Bipartite Mechanism Disrupted in Partially Penetrant Retinoblastomas

Sergiy I. Borysova Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USAView further author information
,
Brook S. Nepon-Sixta Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA;b University of South Florida Cancer Biology Ph.D. Program, Tampa, Florida, USAView further author information
&
Mark G. Alexandrowa Department of Molecular Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA;b University of South Florida Cancer Biology Ph.D. Program, Tampa, Florida, USACorrespondence[email protected]
View further author information
Pages 832-845 | Received 24 Jun 2015, Accepted 22 Dec 2015, Published online: 17 Mar 2023

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Charles A. Ishak, Courtney H. Coschi, Michael V. Roes & Frederick A. Dick. (2017) Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment. Cell Cycle 16:15, pages 1430-1439.
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Articles from other publishers (6)

Shengyan Xiang, Damon R. Reed & Mark G. Alexandrow. (2022) The CMG helicase and cancer: a tumor “engine” and weakness with missing mutations. Oncogene 42:7, pages 473-490.
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Kyle M. Ford, Rebecca Panwala, Dai-Hua Chen, Andrew Portell, Nathan Palmer & Prashant Mali. (2021) Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors. Cell Systems 12:7, pages 716-732.e7.
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Brook S. Nepon-Sixt & Mark G. Alexandrow. (2019) TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions. Molecular Cancer Research 17:1, pages 277-288.
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Valentina Imperatore, Anna Maria Pinto, Elisa Gelli, Eva Trevisson, Valeria Morbidoni, Elisa Frullanti, Theodora Hadjistilianou, Sonia De Francesco, Paolo Toti, Elena Gusson, Gaia Roversi, Andrea Accogli, Valeria Capra, Maria Antonietta Mencarelli, Alessandra Renieri & Francesca Ariani. (2018) Parent-of-origin effect of hypomorphic pathogenic variants and somatic mosaicism impact on phenotypic expression of retinoblastoma. European Journal of Human Genetics 26:7, pages 1026-1037.
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Yeon-Soo Seo & Young-Hoon Kang. (2018) The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy. Frontiers in Molecular Biosciences 5.
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Michael J. Thwaites, Matthew J. Cecchini, Srikanth Talluri, Daniel T. Passos, Jasmyne Carnevale & Frederick A. Dick. (2017) Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control. Cell Division 12:1.
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