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Molecular and Cellular Biology Volume 37, 2017 - Issue 8
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Research Article

Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1

Kacy R. Paula Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
,
Amandine Molliexb Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
,
Sean Cascarinaa Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, Colorado, USA
,
Amy E. Boncellac Department of Chemistry, Colorado State University, Fort Collins, Colorado, USA
,
J. Paul Taylorb Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;d HHMI, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
&
Eric D. Rossa Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, Colorado, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6473-9977
ORCID Icon
Article: e00652-16 | Received 12 Dec 2016, Accepted 19 Jan 2017, Published online: 17 Mar 2023

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Yvonne Duernberger, Shu Liu, Katrin Riemschoss, Lydia Paulsen, Romina Bester, Peer-Hendrik Kuhn, Manuel Schölling, Stefan F. Lichtenthaler & Ina Vorberg. (2018) Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance. Molecular and Cellular Biology 38:15.
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Sean M. Cascarina, Kacy R. Paul & Eric D. Ross. (2017) Manipulating the aggregation activity of human prion-like proteins. Prion 11:5, pages 323-331.
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Jenifer E. Shattuck, Aubrey C. Waechter & Eric D. Ross. (2017) The effects of glutamine/asparagine content on aggregation and heterologous prion induction by yeast prion-like domains. Prion 11:4, pages 249-264.
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Carlos Pintado-Grima, Oriol Bárcenas, Andrea Bartolomé-Nafría, Marc Fornt-Suñé, Valentín Iglesias, Javier Garcia-Pardo & Salvador Ventura. (2023) A Review of Fifteen Years Developing Computational Tools to Study Protein Aggregation. Biophysica 3:1, pages 1-20.
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Vitaly V. Kushnirov, Alexander A. Dergalev, Maya K. Alieva & Alexander I. Alexandrov. (2022) Structural Bases of Prion Variation in Yeast. International Journal of Molecular Sciences 23:10, pages 5738.
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Belinda J. Petri, Kellianne M. Piell, Gordon C. South Whitt, Ali E. Wilt, Claire C. Poulton, Norman L. Lehman, Brian F. Clem, Matthew A. Nystoriak, Marcin Wysoczynski & Carolyn M. Klinge. (2021) HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer Letters 518, pages 152-168.
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Sean M. Cascarina, Joshua P. Kaplan, Mikaela R. Elder, Lindsey Brookbank & Eric D. Ross. (2021) Generalizable Compositional Features Influencing the Proteostatic Fates of Polar Low-Complexity Domains. International Journal of Molecular Sciences 22:16, pages 8944.
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Donya Pakravan, Gabriele Orlando, Valérie Bercier & Ludo Van Den Bosch. (2021) Role and therapeutic potential of liquid–liquid phase separation in amyotrophic lateral sclerosis. Journal of Molecular Cell Biology 13:1, pages 15-28.
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Anastasia Fomicheva & Eric D. Ross. (2021) From Prions to Stress Granules: Defining the Compositional Features of Prion-Like Domains That Promote Different Types of Assemblies. International Journal of Molecular Sciences 22:3, pages 1251.
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Sean M. Cascarina & Eric D. Ross. (2020) Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes. BMC Genomics 21:1.
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Robert Dec & Wojciech Dzwolak. (2020) Extremely Amyloidogenic Single-Chain Analogues of Insulin’s H-Fragment: Structural Adaptability of an Amyloid Stretch. Langmuir 36:41, pages 12150-12159.
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Maria S. Rubel, Sergey A. Fedotov, Anastasia V. Grizel, Julia V. Sopova, Oksana A. Malikova, Yury O. Chernoff & Aleksandr A. Rubel. (2020) Functional Mammalian Amyloids and Amyloid-Like Proteins. Life 10:9, pages 156.
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Amy E. Boncella, Jenifer E. Shattuck, Sean M. Cascarina, Kacy R. Paul, Matthew H. Baer, Anastasia Fomicheva, Andrew K. Lamb & Eric D. Ross. (2020) Composition-based prediction and rational manipulation of prion-like domain recruitment to stress granules. Proceedings of the National Academy of Sciences 117:11, pages 5826-5835.
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Yury O. Chernoff, Anastasia V. Grizel, Aleksandr A. Rubel, Andrew A. Zelinsky, Pavithra Chandramowlishwaran & Tatiana A. Chernova. 2020. 293 380 .
Valentin Iglesias, Oscar Conchillo-Sole, Cristina Batlle & Salvador Ventura. (2019) AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity. BMC Bioinformatics 20:1.
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Kamila Sofińska, Agnieszka M. Wojtkiewicz, Patrycja Wójcik, Olga Zastawny, Maciej Guzik, Agnieszka Winiarska, Piotr Waligórski, Michał Cieśla, Jakub Barbasz & Maciej Szaleniec. (2019) Investigation of quaternary structure of aggregating 3-ketosteroid dehydrogenase from Sterolibacterium denitrificans: In the pursuit of consensus of various biophysical techniques. Biochimica et Biophysica Acta (BBA) - General Subjects 1863:6, pages 1027-1039.
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Sean M. Cascarina & Eric D. Ross. (2018) Aggregation and degradation scales for prion-like domains: sequence features and context weigh in. Current Genetics 65:2, pages 387-392.
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Chang Ho Kang, Joung Hun Park, Eun Seon Lee, Seol Ki Paeng, Ho Byoung Chae, Yong Hun Chi & Sang Yeol Lee. (2019) Exploring Novel Functions of the Small GTPase Ypt1p under Heat-Shock by Characterizing a Temperature-Sensitive Mutant Yeast Strain, ypt1-G80D. International Journal of Molecular Sciences 20:1, pages 132.
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Zachary T. Monahan, Shannon N. Rhoads, Debra S. Yee & Frank P. Shewmaker. (2018) Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms. Frontiers in Molecular Neuroscience 11.
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Ioana Dobra, Serhii Pankivskyi, Anastasiia Samsonova, David Pastre & Loic Hamon. (2018) Relation Between Stress Granules and Cytoplasmic Protein Aggregates Linked to Neurodegenerative Diseases. Current Neurology and Neuroscience Reports 18:12.
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Simon Alberti & Serena Carra. (2018) Quality Control of Membraneless Organelles. Journal of Molecular Biology 430:23, pages 4711-4729.
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Dylan T. Murray, Xiaoming Zhou, Masato Kato, Siheng Xiang, Robert TyckoSteven L. McKnight. (2018) Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers. Proceedings of the National Academy of Sciences 115:42.
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Alissa Bleem, Gunna Christiansen, Daniel J. Madsen, Hans Maric, Kristian Strømgaard, James D. Bryers, Valerie Daggett, Rikke L. Meyer & Daniel E. Otzen. (2018) Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms. Journal of Molecular Biology 430:20, pages 3751-3763.
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Katannya Kapeli, Fernando J. Martinez & Gene W. Yeo. (2017) Genetic mutations in RNA-binding proteins and their roles in ALS. Human Genetics 136:9, pages 1193-1214.
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Cristina Batlle, María Rosario Fernández, Valentin Iglesias & Salvador Ventura. (2017) Perfecting prediction of mutational impact on the aggregation propensity of the ALS-associated hnRNPA2 prion-like protein. FEBS Letters 591:13, pages 1966-1971.
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Alice Ford HarrisonJames Shorter. (2017) RNA-binding proteins with prion-like domains in health and disease. Biochemical Journal 474:8, pages 1417-1438.
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