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Molecular and Cellular Biology Volume 29, 2009 - Issue 24
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Article

Cyclin A2-Cyclin-Dependent Kinase 2 Cooperates with the PLK1-SCFβ-TrCP1-EMI1-Anaphase-Promoting Complex/Cyclosome Axis To Promote Genome Reduplication in the Absence of Mitosis

Hoi Tang MaDepartment of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
,
Yiu Huen TsangDepartment of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
,
Miriam MarxerDepartment of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
&
Randy Y. C. PoonDepartment of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong KongCorrespondence[email protected]
Pages 6500-6514 | Received 23 May 2009, Accepted 06 Oct 2009, Published online: 21 Mar 2023

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Lau Yan Ng, Hoi Tang Ma, Julio C.Y. Liu, Xiner Huang, Nelson Lee & Randy Y.C. Poon. (2019) Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation. Cell Cycle 18:2, pages 238-248.
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Wing Ki Wong, Terrenz Kelly, Jingjing Li, Hoi Tang Ma & Randy YC Poon. (2015) SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A–B56. Cell Cycle 14:24, pages 3965-3977.
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Victoria C Silva, Melissa Plooster, Jessica C Leung & Lynne Cassimeris. (2015) A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle 14:7, pages 1070-1081.
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Xianxian Han & Randy Y. C. Poon. (2013) Critical Differences between Isoforms of Securin Reveal Mechanisms of Separase Regulation. Molecular and Cellular Biology 33:17, pages 3400-3415.
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Miriam Marxer, Charles E. Foucar, Wing Yu Man, Yu Chen, Hoi Tang & Randy Y.C. Poon. (2012) Tetraploidization increases sensitivity to Aurora B kinase inhibition. Cell Cycle 11:13, pages 2567-2577.
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Xiomaris M. Cotto Rios, Mathew J.K. Jones & Tony T. Huang. (2011) Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle. Cell Cycle 10:23, pages 4009-4016.
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Zakir Ullah, Christelle de Renty & Melvin L. DePamphilis. (2011) Checkpoint Kinase 1 Prevents Cell Cycle Exit Linked to Terminal Cell Differentiation. Molecular and Cellular Biology 31:19, pages 4129-4143.
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Jeremy P. H. Chow, Randy Y. C. Poon & Hoi Tang Ma. (2011) Inhibitory Phosphorylation of Cyclin-Dependent Kinase 1 as a Compensatory Mechanism for Mitosis Exit. Molecular and Cellular Biology 31:7, pages 1478-1491.
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Articles from other publishers (35)

Yang Wang & Randy Y. C. Poon. (2022) MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms. Cell Death & Differentiation 30:3, pages 753-765.
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Zhixiang Wang. 2022. Cell-Cycle Synchronization. Cell-Cycle Synchronization 3 23 .
Anna Ligasová & Karel Koberna. (2021) Strengths and Weaknesses of Cell Synchronization Protocols Based on Inhibition of DNA Synthesis. International Journal of Molecular Sciences 22:19, pages 10759.
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Ho Wai Lau, Hoi Tang Ma, Tsz Kwan Yeung, Man Yee Tam, Danyi Zheng, Siu Ki Chu & Randy Yat Choi Poon. (2021) Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells. Cell Reports 37:2, pages 109808.
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Tsz Kwan Yeung, Ho Wai Lau, Hoi Tang Ma & Randy Y. C. Poon. (2021) One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines. Molecular Biology of the Cell 32:14, pages 1320-1330.
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Nousheen Bibi, Ted Hupp, Mohammad Amjad Kamal & Sajid Rashid. (2021) Elucidation of PLK1 Linked Biomarkers in Oesophageal Cancer Cell Lines: A Step Towards Novel Signaling Pathways by p53 and PLK1-Linked Functions Crosstalk. Protein & Peptide Letters 28:3, pages 340-358.
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Christine Lee, Kristine J. Fernandez, Sarah Alexandrou, C. Marcelo Sergio, Niantao Deng, Samuel Rogers, Andrew Burgess & C. Elizabeth Caldon. (2020) Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer. Cancers 12:8, pages 2268.
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Tsun Ming Lok, Yang Wang, Wendy Kaichun Xu, Siwei Xie, Hoi Tang Ma & Randy Y. C. Poon. (2020) Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint. Oncogene 39:13, pages 2819-2834.
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Nishtha Pandey & P. K. Vinod. (2018) Mathematical modelling of reversible transition between quiescence and proliferation. PLOS ONE 13:6, pages e0198420.
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Hoi Tang Ma & Randy Y.C. Poon. (2018) TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2. Cell Reports 22:6, pages 1439-1450.
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Zhe Zhang, Guojun Zhang, Zhipeng Gao, Shiguang Li, Zeliang Li, Jianbin Bi, Xiankui Liu, Zhenhua Li & Chuize Kong. (2017) Comprehensive analysis of differentially expressed genes associated with PLK1 in bladder cancer. BMC Cancer 17:1.
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Hoi Tang Ma & Randy Y. C. Poon. 2017. Cell Cycle Synchronization. Cell Cycle Synchronization 189 201 .
Xueli Fan, Yunying Zhou & Jason J. Chen. (2016) Role of Cdc6 in re-replication in cells expressing human papillomavirus E7 oncogene. Carcinogenesis 37:8, pages 799-809.
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Shan Huang, Rui Tang & Randy Y.C. Poon. (2016) BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death. Oncotarget 7:25, pages 38718-38730.
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Po Yee Wong, Hoi Tang Ma, Hyun-jung Lee & Randy Y. C. Poon. (2016) MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation. Scientific Reports 6:1.
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Erik Voets, Judith Marsman, Jeroen Demmers, Roderick Beijersbergen & Rob Wolthuis. (2015) The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1. Scientific Reports 5:1.
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Xiaohui Man, Timothy L. Megraw & Yoon Pin Lim. (2015) Cep68 can be regulated by Nek2 and SCF complex. European Journal of Cell Biology 94:3-4, pages 162-172.
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Tony Ly, Aki Endo & Angus I Lamond. (2015) Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells. eLife 4.
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Joyce P.Y. Mak, Wing Yu Man, Hoi Tang Ma & Randy Y.C. Poon. (2014) Pharmacological targeting the ATR-CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis. Oncotarget 5:21, pages 10546-10557.
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H Chen, S Huang, X Han, J Zhang, C Shan, Y H Tsang, H T Ma & R Y C Poon. (2014) Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death. Cell Death & Disease 5:4, pages e1177-e1177.
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Ivanesa Pardo, Heather A Lillemoe, Rachel J Blosser, MiRan Choi, Candice A M Sauder, Diane K Doxey, Theresa Mathieson, Bradley A Hancock, Dadrie Baptiste, Rutuja Atale, Matthew Hickenbotham, Jin Zhu, Jarret Glasscock, Anna Maria V Storniolo, Faye Zheng, RW Doerge, Yunlong Liu, Sunil Badve, Milan Radovich & Susan E Clare. (2014) Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank. Breast Cancer Research 16:2.
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Bruce A. Edgar, Norman Zielke & Crisanto Gutierrez. (2014) Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth. Nature Reviews Molecular Cell Biology 15:3, pages 197-210.
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Christelle de Renty, Kotaro J. Kaneko & Melvin L. DePamphilis. (2014) The dual roles of geminin during trophoblast proliferation and differentiation. Developmental Biology 387:1, pages 49-63.
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Linda Clijsters & Rob Wolthuis. (2014) PIP-box mediated degradation prohibits re-accumulation of Cdc6 during S phase. Journal of Cell Science.
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J P H Chow & R Y C Poon. (2012) The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery. Oncogene 32:40, pages 4778-4788.
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Polly Gravells, Kazunori Tomita, Alexander Booth, Joshua Poznansky & Andrew C.G. Porter. (2013) Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle. Human Molecular Genetics 22:14, pages 2842-2851.
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Lin Zhou, Ye Yang, Juanjuan Zhang, Xuejiang Guo, Ye Bi, Xin Li, Ping Zhang, Junqiang Zhang, Min Lin, Zuomin Zhou, Rong Shen, Xirong Guo, Ran Huo, Xiufeng Ling & Jiahao Sha. (2013) The Role of RING Box Protein 1 in Mouse Oocyte Meiotic Maturation. PLoS ONE 8:7, pages e68964.
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Yiu Huen Tsang, Xianxian Han, Wing Yu Man, Nelson Lee & Randy Y. C. Poon. (2012) Novel Functions of the Phosphatase SHP2 in the DNA Replication and Damage Checkpoints. PLoS ONE 7:11, pages e49943.
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Hoi Tang Ma, Yan Yan Chan, Xiao Chen, Kin Fan On & Randy Y.C. Poon. (2012) Depletion of p31comet Protein Promotes Sensitivity to Antimitotic Drugs. Journal of Biological Chemistry 287:25, pages 21561-21569.
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Suzanna L. Prosser, Mugdha D. Samant, Joanne E. Baxter, Ciaran G. Morrison & Andrew M. Fry. (2012) Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. Journal of Cell Science.
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Asako Sakaue-Sawano, Tamiyo Kobayashi, Kenji Ohtawa & Atsushi Miyawaki. (2011) Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication. BMC Cell Biology 12:1.
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Kin Fan On, Yue Chen, Hoi Tang Ma, Jeremy P.H. Chow & Randy Y.C. Poon. (2011) Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN-01. Molecular Cancer Therapeutics 10:5, pages 784-794.
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Hoi Tang Ma & Randy Y.C. Poon. (2011) Orderly Inactivation of the Key Checkpoint Protein Mitotic Arrest Deficient 2 (MAD2) during Mitotic Progression. Journal of Biological Chemistry 286:15, pages 13052-13059.
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Wenge Zhu, Chrissie Y. Lee, Ronald L. Johnson, Jennifer Wichterman, Ruili Huang & Melvin L. DePamphilis. (2011) An Image-Based, High-Throughput Screening Assay for Molecules that Induce Excess DNA Replication in Human Cancer Cells. Molecular Cancer Research 9:3, pages 294-310.
Crossref
Hoi Tang Ma & Randy Y.C. Poon. 2011. Cell Cycle Synchronization. Cell Cycle Synchronization 151 161 .

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