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Molecular and Cellular Biology Volume 27, 2007 - Issue 3
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Article

Integrity of the Mod(mdg4)-67.2 BTB Domain Is Critical to Insulator Function in Drosophila melanogaster

Anton Golovnin1 Institute of Gene Biology, Russian Academy of Sciences, Moscow119334, Russia;2 University of Oslo, Centre for Medical Studies in Russia, Moscow119334, Russia
,
Alexander Mazur1 Institute of Gene Biology, Russian Academy of Sciences, Moscow119334, Russia
,
Marina Kopantseva3 Institute of Molecular Biology, Moscow119334, Russia
,
Maria Kurshakova1 Institute of Gene Biology, Russian Academy of Sciences, Moscow119334, Russia
,
Pavel V. Gulak1 Institute of Gene Biology, Russian Academy of Sciences, Moscow119334, Russia
,
Brian Gilmore4 Department of Biochemistry, University of Iowa, Iowa City, Iowa52242
,
William G. F. Whitfield5 Department of Biological Sciences, University of Dundee, DundeeDD1 4HN, Scotland, United Kingdom
,
Pamela Geyer4 Department of Biochemistry, University of Iowa, Iowa City, Iowa52242
,
Vincenzo Pirrotta6 Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey08854
&
Pavel Georgiev1 Institute of Gene Biology, Russian Academy of Sciences, Moscow119334, RussiaCorrespondence[email protected]
 show all
Pages 963-974 | Received 05 May 2006, Accepted 30 Oct 2006, Published online: 27 Mar 2023

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Mo Li, Zhibo Ma, Jiayang K. Liu, Sharmila Roy, Sapna K. Patel, Derrick C. Lane & Haini N. Cai. (2015) An Organizational Hub of Developmentally Regulated Chromatin Loops in the Antennapedia Complex. Molecular and Cellular Biology 35:23, pages 4018-4029.
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Yury Stefanov, Veniamin Salenko & Ivan Glukhov. (2012) Drosophila errantiviruses. Mobile Genetic Elements 2:1, pages 36-45.
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L. V. Boldyreva, E. N. Andreyeva & A. V. Pindyurin. (2022) Position Effect Variegation: Role of the Local Chromatin Context in Gene Expression Regulation. Molecular Biology 56:3, pages 307-338.
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Olga Kyrchanova & Pavel Georgiev. (2021) Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes. International Journal of Molecular Sciences 22:2, pages 671.
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Larisa Melnikova, Varvara Molodina, Maksim Erokhin, Pavel Georgiev & Anton Golovnin. (2019) HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex. Scientific Reports 9:1.
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M. V. Kostyuchenko, L. S. Melnikova, Academician P. G. Georgiev & A. K. Golovnin. (2019) Studying Interactions between the Mod(mdg4)-67.2 Protein and Other Mod(mdg4) Isoforms in the Embryonic Cells of Drosophila melanogaster. Doklady Biochemistry and Biophysics 486:1, pages 175-180.
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L. S. MelnikovaM. V. KostyuchenkoV. V. MolodinaP. G. GeorgievA. K. Golovnin. (2019) Functional properties of the Su(Hw) complex are determined by its regulatory environment and multiple interactions on the Su(Hw) protein platform. Vavilov Journal of Genetics and Breeding 23:2, pages 168-173.
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Larisa Melnikova, Pavel Elizar’ev, Maksim Erokhin, Varvara Molodina, Darya Chetverina, Margarita Kostyuchenko, Pavel Georgiev & Anton Golovnin. (2019) The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression. Scientific Reports 9:1.
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Mo Li, Zhibo Ma, Sharmila Roy, Sapna K. Patel, Derrick C. Lane, Carly R. Duffy & Haini N. Cai. (2018) Selective interactions between diverse STEs organize the ANT-C Hox cluster. Scientific Reports 8:1.
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Larisa Melnikova, Margarita Kostyuchenko, Varvara Molodina, Alexander Parshikov, Pavel Georgiev & Anton Golovnin. (2017) Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation. Chromosoma 127:1, pages 59-71.
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Larisa Melnikova, Margarita Kostyuchenko, Alexander Parshikov, Pavel Georgiev & Anton Golovnin. (2018) Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila. PLOS ONE 13:2, pages e0193497.
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Michael R Stadler, Jenna E Haines & Michael B Eisen. (2017) Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo. eLife 6.
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Larisa Melnikova, Margarita Kostyuchenko, Varvara Molodina, Alexander Parshikov, Pavel Georgiev & Anton Golovnin. (2017) Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila . Open Biology 7:10, pages 170150.
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Larisa Melnikova, Igor Shapovalov, Margarita Kostyuchenko, Pavel Georgiev & Anton Golovnin. (2016) EAST affects the activity of Su(Hw) insulators by two different mechanisms in Drosophila melanogaster. Chromosoma 126:2, pages 299-311.
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Yuri B Schwartz & Giacomo Cavalli. (2017) Three-Dimensional Genome Organization and Function in Drosophila . Genetics 205:1, pages 5-24.
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A. K. Golovnin, M. V. Kostyuchenko, P. G. Georgiev & L. S. Melnikova. (2017) Mod(mdg4)-58.0, the product of mod(mdg4) locus, directly interacts with kermit protein of Drosophila melanogaster. Russian Journal of Genetics 53:1, pages 153-156.
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O. V. Kyrchanova, N. Y. Postika, A. F. Parshikov & P. G. Georgiev. (2016) Insulators can disrupt weak transcription derived from the white gene enhancer in Drosophila transgenic lines. Russian Journal of Genetics 52:11, pages 1204-1207.
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Mikhail Savitsky, Maria Kim, Oksana Kravchuk & Yuri B Schwartz. (2016) Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex . Genetics 202:2, pages 601-617.
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A. K. Golovnin, M. V. Kostyuchenko, P. G. Georgiev & L. S. Melnikova. (2016) Mod(mdg4)-58.8, isoform of mod(mdg4) loci, directly interacts with MTACP1A and MTACP1B proteins of Drosophila melanogaster. Doklady Biochemistry and Biophysics 466:1, pages 5-8.
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P. V. Elizar’ev, D. A. Chetverina, A. K. Golovnin, P. G. Georgiev & M. M. Erokhin. (2015) The role of Su(Hw) protein in transcription regulation in Drosophila melanogaster. Russian Journal of Genetics 51:11, pages 1060-1068.
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Anton Golovnin, Larisa Melnikova, Igor Shapovalov, Margarita Kostyuchenko & Pavel Georgiev. (2015) EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin. PLOS ONE 10:10, pages e0140991.
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Jutta Vogelmann, Antoine Le Gall, Stephanie Dejardin, Frederic Allemand, Adrien Gamot, Gilles Labesse, Olivier Cuvier, Nicolas Nègre, Martin Cohen-Gonsaud, Emmanuel Margeat & Marcelo Nöllmann. (2014) Chromatin Insulator Factors Involved in Long-Range DNA Interactions and Their Role in the Folding of the Drosophila Genome. PLoS Genetics 10:8, pages e1004544.
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Darya Chetverina, Tsutomu Aoki, Maksim Erokhin, Pavel Georgiev & Paul Schedl. (2014) Making connections: Insulators organize eukaryotic chromosomes into independent cis - regulatory networks . BioEssays 36:2, pages 163-172.
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Olga Kyrchanova & Pavel Georgiev. (2014) Chromatin insulators and long-distance interactions in Drosophila . FEBS Letters 588:1, pages 8-14.
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A. K. Golovnin, I. S. Shapovalov, M. V. Kostyuchenko, M. F. Shamsutdinov, P. G. Georgiev & L. S. Melnikova. (2014) Chromator protein directly interacts with the common part of the Drosophila melanogaster Mod(mdg4) family proteins. Doklady Biochemistry and Biophysics 454:1, pages 21-24.
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Olga Kyrchanova, Oksana Maksimenko, Viacheslav Stakhov, Tatyana Ivlieva, Alexander Parshikov, Vasily M. Studitsky & Pavel Georgiev. (2013) Effective Blocking of the White Enhancer Requires Cooperation between Two Main Mechanisms Suggested for the Insulator Function. PLoS Genetics 9:7, pages e1003606.
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Nadezhda E. Vorobyeva, Marina U. Mazina, Anton K. Golovnin, Daria V. Kopytova, Dmitriy Y. Gurskiy, Elena N. Nabirochkina, Sofia G. Georgieva, Pavel G. Georgiev & Aleksey N. Krasnov. (2013) Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome. Nucleic Acids Research 41:11, pages 5717-5730.
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Anton Golovnin, Ilya Volkov & Pavel Georgiev. (2012) SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation . Journal of Cell Science.
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Daniel Oliver, Brian Sheehan, Heather South, Omar Akbari & Chi-Yun Pai. (2010) The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions. BMC Cell Biology 11:1.
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O. Kyrchanova, D. Chetverina, O. Maksimenko, A. Kullyev & P. Georgiev. (2008) Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements. Nucleic Acids Research 36:22, pages 7019-7028.
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Mariano Labrador, Ky Sha, Alice Li & Victor G Corces. (2008) Insulator and Ovo Proteins Determine the Frequency and Specificity of Insertion of the gypsy Retrotransposon in Drosophila melanogaster . Genetics 180:3, pages 1367-1378.
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Anton Golovnin, Larisa Melnikova, Ilya Volkov, Margarita Kostuchenko, Alexander V Galkin & Pavel Georgiev. (2008) ‘Insulator bodies’ are aggregates of proteins but not of insulators. EMBO reports 9:5, pages 440-445.
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