12
Views
34
CrossRef citations to date
0
Altmetric
Article

Integrity of the Mod(mdg4)-67.2 BTB Domain Is Critical to Insulator Function in Drosophila melanogaster

, , , , , , , , & show all
Pages 963-974 | Received 05 May 2006, Accepted 30 Oct 2006, Published online: 27 Mar 2023

REFERENCES

  • Ahmad, K. F., C. K. Engel, and G. G. Prive. 1998. Crystal structure of the BTB domain from PLZF. Proc. Natl. Acad. Sci. USA 95:12123–12128.
  • Ahmad, K. F., A. Melnick, S. Lax, D. Bouchard, J. Liu, C. L. Kiang, S. Mayer, S. Takahashi, J. D. Licht, and G. G. Prive. 2003. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol. Cell 12:1551–1564.
  • Buchner, K., P. Roth, G. Schotta, V. Krauss, H. Saumweber, G. Reuter, and R. Dorn. 2000. Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila. Genetics 155:141–157.
  • Cai, H. N., and M. Levine. 1997. The gypsy insulator can function as a promoter-specific silencer in the Drosophila embryo. EMBO J. 16:1732–1741.
  • Campuzano, S., L. Carramolino, C. V. Cabrera, M. Ruiz-Gomez, R. Villares, A. Boronat, and J. Modolell. 1985. Molecular genetics of the achaete-scute gene complex of D. melanogaster. Cell 40:327–338.
  • Capelson, M., and V. G. Corces. 2004. Boundary elements and nuclear organization. Biol. Cell 96:617–629.
  • Dorn, R., H. Morawietz, G. Reuter, and H. Saumweber. 1993. Identification of an essential Drosophila gene that is homologous to the translation initiation factor eIF-4A of yeast and mouse. Mol. Gen. Genet. 237:233–240.
  • Dorn, R., and V. Krauss. 2003. The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing. Genetica 117:165–177.
  • Dorsett, D. 1990. Potentiation of a polyadenylylation site by a downstream protein-DNA interaction. Proc. Natl. Acad. Sci. USA 87:4373–4377.
  • Dorsett, D. 1999. Distant liaisons: long-range enhancer-promoter interactions in Drosophila. Curr. Opin. Genet. Dev. 9:505–514.
  • Espinas, M. L., E. Jimenez-Garcia, A. Vaquero, S. Canudas, J. Bernues, and F. Azorin. 1999. The N-terminal POZ domain of GAGA mediates the formation of oligomers that bind DNA with high affinity and specificity. J. Biol. Chem. 274:16461–16469.
  • Gause, M., P. Morcillo, and D. Dorsett. 2001. Insulation of enhancer-promoter communication by a gypsy transposon insert in the Drosophila cut gene: cooperation between suppressor of hairy-wing and modifier of mdg4 proteins. Mol. Cell. Biol. 21:4807–4817.
  • Gdula, D. A., and V. G. Corces. 1997. Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations. Genetics 145:153–161.
  • Georgiev, P., and M. Kozycina. 1996. Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations. Genetics 142:425–436.
  • Gerasimova, T. I., D. A. Gdula, D. V. Gerasimov, O. Simonova, and V. G. Corces. 1995. A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. Cell 82:587–597.
  • Gerasimova, T. I., and V. G. Corces. 1998. Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Cell 92:511–521.
  • Geyer, P. K., C. Spana, and V. G. Corces. 1986. On the molecular mechanism of gypsy-induced mutations at the yellow locus of Drosophila melanogaster. EMBO J. 5:2657–2662.
  • Geyer, P. K., and V. G. Corces. 1987. Separate regulatory elements are responsible for the complex pattern of tissue-specific and developmental transcription of the yellow locus in Drosophila melanogaster. Genes Dev. 1:996–1004.
  • Geyer, P. K., and V. G. Corces. 1992. DNA position-specific repression of transcription by a Drosophila zinc finger protein. Genes Dev. 6:1865–1873.
  • Ghosh, D., T. I. Gerasimova, and V. G. Corces. 2001. Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function. EMBO J. 20:2518–2527.
  • Golovnin, A., I. Birukova, O. Romanova, M. Silicheva, A. Parshikov, E. Savitskaya, V. Pirrotta, and P. Georgiev. 2003. An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila. Development 130:3249–3258.
  • Hagstrom, K., M. Muller, and P. Schedl. 1996. Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex. Genes Dev. 10:3202–3215.
  • Harrison, D. A., D. A. Gdula, R. S. Coyne, and V. G. Corces. 1993. A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function. Genes Dev. 7:1966–1978.
  • Holdridge, C., and D. Dorsett. 1991. Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster. Mol. Cell. Biol. 11:1894–1900.
  • Hoover, K. K., T. I. Gerasimova, A. J. Chien, and V. G. Corces. 1992. Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster. Genetics 132:691–697.
  • Jack, J., D. Dorsett, Y. Delotto, and S. Liu. 1991. Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer. Development 113:735–747.
  • Karess, R. E., and G. M. Rubin. 1984. Analysis of P transposable element functions in Drosophila. Cell 38:135–146.
  • Katsani, K. R., M. A. Hajibagheri, and C. P. Verrijzer. 1999. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology. EMBO J. 18:698–708.
  • Kim, J., B. Shen, C. Rosen, and D. Dorsett. 1996. The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein. Mol. Cell. Biol. 16:3381–3392.
  • Kuhn, E. J., and P. K. Geyer. 2003. Genomic insulators: connecting properties to mechanism. Curr. Opin. Cell Biol. 15:259–265.
  • LaJeunesse, D., and A. Shearn. 1996. E (z): a polycomb group gene or a trithorax group gene? Development 122:2189–2197.
  • Mazur, A. M., P. G. Georgiev, and A. K. Golovnin. 2005. The acid domain located at the C terminus of the Su(Hw) protein represses transcription in the yeast two-hybrid system. Dokl. Biochem. Biophys. 400:1–3.
  • Melnick, A., K. F. Ahmad, S. Arai, A. Polinger, H. Ball, K. L. Borden, G. W. Carlile, G. G. Prive, and J. D. Licht. 2000. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions. Mol. Cell. Biol. 20:6550–6567.
  • Melnick, A., G. Carlile, K. F. Ahmad, C. L. Kiang, C. Corcoran, V. Bardwell, G. G. Prive, and J. D. Licht. 2002. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Mol. Cell. Biol. 22:1804–1818.
  • Melnikova, L., F. Juge, N. Gruzdeva, A. Mazur, G. Cavalli, and P. Georgiev. 2004. Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila. Proc. Natl. Acad. Sci. USA 101:14806–14811.
  • Modolell, J., and S. Campuzano. 1998. The achaete-scute complex as an integrating device. Int. J. Dev. Biol. 42:275–282.
  • Pagans, S., M. Ortiz-Lombardia, M. L. Espinas, J. Bernues, and F. Azorin. 2002. The Drosophila transcription factor tramtrack (TTK) interacts with Trithorax-like (GAGA) and represses GAGA-mediated activation. Nucleic Acids Res. 30:4406–4413.
  • Pai, C.-Y., E. P. Lei, D. Ghosh, and V. G. Corces. 2004. The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Mol. Cell 16:737–748.
  • Parnell, T. J., M. M. Viering, A. Skjesol, C. Helou, E. J. Kuhn, and P. K. Geyer. 2003. An endogenous Suppressor of hairy-wing insulator separates regulatory domains in Drosophila. Proc. Natl. Acad. Sci. USA 100:13436–13441.
  • Platero, J. S., E. J. Sharp, P. N. Adler, and J. C. Eissenberg. 1996. In vivo assay for protein-protein interactions using Drosophila chromosomes. Chromosoma 104:393–404.
  • Read, D., M. J. Butte, A. F. Dernburg, M. Frasch, and T. B. Kornberg. 2000. Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins. Nucleic Acids Res. 28:3864–3870.
  • Spana, C., and V. G. Corces. 1990. DNA bending is a determinant of binding specificity for a Drosophila zinc finger protein. Genes Dev. 4:1505–1515.
  • Stogios, P. G., G. S. Downs, J. S. Jauhal, S. K. Nandra, and G. G. Prive. 2005. Sequence and structural analysis of BTB domain proteins. Genome Biol. 6:R82.
  • West, A. G., M. Gaszner, and G. Felsenfeld. 2002. Insulators: many functions, many mechanisms. Genes Dev. 16:271–288.
  • West, A. G., and P. Fraser. 2005. Remote control of gene transcription. Hum. Mol. Genet. 14:101–111.
  • Wilkins, R. S., and J. T. Lis. 1999. DNA distortion and multimerization: novel functions of the glutamine-rich domain of GAGA factor. J. Mol. Biol. 285:515–525.
  • Zollman, S., D. Godt, G. G. Prive, J. L. Couderc, and F. A. Laski. 1994. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc. Natl. Acad. Sci. USA 91:10717–10721.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.