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Molecular and Cellular Biology Volume 29, 2009 - Issue 23
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Article

Hepatocyte Nuclear Factor 4α, a Key Factor for Homeostasis, Cell Architecture, and Barrier Function of the Adult Intestinal Epithelium

Anne-Laure Cattin1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, France
,
Johanne Le Beyec1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, France
,
Frederick Barreau4 Laboratoire de Pharmacologie Cellulaire et Moléculaire, Ecole Pratique des Hautes Etudes, ParisF-75006, France
,
Susan Saint-Just1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, France;5 Morphogenesis and Intracellular Signaling, UMR 144, Institut Curie-CNRS, Paris, France
,
Anne Houllier1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, France
,
Frank J. Gonzalez6 Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
,
Sylvie Robine7 UMR-S843 INSERM, Université Paris Diderot, Service de Gastroentérologie, Hôpital R. Debré, AP-HP, Paris, France
,
Martine Pinçon-Raymond1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, France
,
Philippe Cardot1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, France
,
Michel Lacasa1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, France
&
Agnès Ribeiro1 Centre de Recherche des Cordeliers, Université Pierre et Marie Curie—Paris 6, UMRS 872, ParisF-75006, France;2 INSERM, U872, ParisF-75006, France;3 Université Paris Descartes, UMRS 872, ParisF-75006, FranceCorrespondence[email protected]
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Pages 6294-6308 | Received 17 Jul 2009, Accepted 17 Sep 2009, Published online: 21 Mar 2023

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Loukia N. Lili, Attila E. Farkas, Christian Gerner-Smidt, Christian E. Overgaard, Carlos S. Moreno, Charles A. Parkos, Christopher T. Capaldo & Asma Nusrat. (2016) Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades. Tissue Barriers 4:3.
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J Luettig, R Rosenthal, C Barmeyer & JD Schulzke. (2015) Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers 3:1-2.
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Sanjay Chahar, Vishal Gandhi, Shiyan Yu, Kinjal Desai, Richard Cowper-Sal·lari, Yona Kim, Ansu O. Perekatt, Namit Kumar, Joshua K. Thackray, Anthony Musolf, Nikhil Kumar, A. Hoffman, Douglas Londono, Berta N. Vazquez, Lourdes Serrano, Hyunjin Shin, Mathieu Lupien, Nan Gao & Michael P. Verzi. (2014) Chromatin Profiling Reveals Regulatory Network Shifts and a Protective Role for Hepatocyte Nuclear Factor 4α during Colitis. Molecular and Cellular Biology 34:17, pages 3291-3304.
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Dawid Skoczek, Józef Dulak & Neli Kachamakova-Trojanowska. (2021) Maturity Onset Diabetes of the Young—New Approaches for Disease Modelling. International Journal of Molecular Sciences 22:14, pages 7553.
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Lei Chen, Shirley Luo, Abigail Dupre, Roshan P. Vasoya, Aditya Parthasarathy, Rohit Aita, Raj Malhotra, Joseph Hur, Natalie H. Toke, Eric Chiles, Min Yang, Weihuan Cao, Juan Flores, Christopher E. Ellison, Nan Gao, Amrik Sahota, Xiaoyang Su, Edward M. Bonder & Michael P. Verzi. (2021) The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac. Nature Communications 12:1.
Crossref
Soledad A Camolotto, Veronika K Belova, Luke Torre-Healy, Jeffery M Vahrenkamp, Kristofer C Berrett, Hannah Conway, Jill Shea, Chris Stubben, Richard Moffitt, Jason Gertz & Eric L Snyder. (2021) Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4. Gut 70:5, pages 900-914.
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Jae Hun Shin, Jaekwang Jeong, Jungmin Choi, Jaechul Lim, Ravi K. Dinesh, Jonathan Braverman, Jun Young Hong, Stephen E. Maher, Maria C. Amezcua Vesely, WonJu Kim, Ja-Hyun Koo, Wenwen Tang, Dianqing Wu, Holly N. Blackburn, Rosa M. Xicola, Xavier Llor, Omer Yilmaz, Je-Min Choi & Alfred L.M. Bothwell. (2021) Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. iScience 24:5, pages 102411.
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Julie E. Horowitz, Neil Warner, Jeffrey Staples, Eileen Crowley, Nehal Gosalia, Ryan Murchie, Cristopher Van Hout, Karoline Fiedler, Gabriel Welch, Alejandra Klauer King, Jeffrey G. Reid, John D. Overton, Aris Baras, Alan R. Shuldiner, Anne Griffiths, Omri Gottesman, Aleixo M. Muise & Claudia Gonzaga-Jauregui. (2021) Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease. Scientific Reports 11:1.
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Jennifer K. Heppert, James M. Davison, Cecelia Kelly, Gilberto Padilla Mercado, Colin R. Lickwar & John F. Rawls. (2020) Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium. Nature Reviews Gastroenterology & Hepatology 18:1, pages 7-23.
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Duo-Duo Lv, Ling-Yun Zhou & Hong Tang. (2021) Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment. Experimental & Molecular Medicine 53:1, pages 8-18.
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Vanessa Dubois, Bart Staels, Philippe Lefebvre, Michael Verzi & Jérôme Eeckhoute. (2020) Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology. Cells 9:10, pages 2185.
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Cristina Martínez, Felix Lasitschka, Cornelia Thöni, Carolin Wohlfarth, Alexander Braun, Martin Granzow, Ralph Röth, Vernesa Dizdar, Gudrun A. Rappold, Trygve Hausken, Nina Langeland, Kurt Hanevik & Beate Niesler. (2020) Comparative expression profiling in the intestine of patients with Giardia ‐induced postinfectious functional gastrointestinal disorders . Neurogastroenterology & Motility 32:9.
Crossref
Lei Chen, Roshan P. Vasoya, Natalie H. Toke, Aditya Parthasarathy, Shirley Luo, Eric Chiles, Juan Flores, Nan Gao, Edward M. Bonder, Xiaoyang Su & Michael P. Verzi. (2020) HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice. Gastroenterology 158:4, pages 985-999.e9.
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Moritz Middelhoff, Henrik Nienhüser, Giovanni Valenti, H. Carlo Maurer, Yoku Hayakawa, Ryota Takahashi, Woosook Kim, Zhengyu Jiang, Ermanno Malagola, Krystle Cuti, Yagnesh Tailor, Leah B. Zamechek, Bernhard W. Renz, Michael Quante, Kelley S. Yan & Timothy C. Wang. (2020) Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche. Nature Communications 11:1.
Crossref
Ross J Porter, Rahul Kalla & Gwo-Tzer Ho. (2020) Ulcerative colitis: Recent advances in the understanding of disease pathogenesis. F1000Research 9, pages 294.
Crossref
Paula S. Montenegro-Miranda, Jonathan H.M. van der Meer, Christine Jones, Sander Meisner, Jacqueline L.M. Vermeulen, Jan Koster, Manon E. Wildenberg, Jarom Heijmans, Francois Boudreau, Agnes Ribeiro, Gijs R. van den Brink & Vanesa Muncan. (2020) A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration. Cellular and Molecular Gastroenterology and Hepatology 10:2, pages 209-223.
Crossref
Valentina Marchesin, Albert Pérez-Martí, Gwenn Le Meur, Roman Pichler, Kelli Grand, Enriko D. Klootwijk, Anne Kesselheim, Robert Kleta, Soeren Lienkamp & Matias Simons. (2019) Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A. Cell Reports 29:13, pages 4407-4421.e5.
Crossref
Meng Chen, Qinglan Li, Nan Cao, Yanan Deng, Lianyun Li, Qiu Zhao, Min Wu & Mei Ye. (2019) Profiling of histone 3 lysine 27 acetylation reveals its role in a chronic DSS-induced colitis mouse model. Molecular Omics 15:4, pages 296-307.
Crossref
Bruno Kotska Rodiño-Janeiro, Cristina Pardo-Camacho, Javier Santos & Cristina Martínez. (2019) Mucosal RNA and protein expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal mucosa. American Journal of Physiology-Gastrointestinal and Liver Physiology 316:6, pages G701-G719.
Crossref
Jean-Philippe Babeu, Samuel D. Wilson, Élie Lambert, Dominique Lévesque, François-Michel Boisvert & François Boudreau. (2019) Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4α in Colorectal Cancer Cells. Cancers 11:5, pages 626.
Crossref
Lei Chen, Natalie H. Toke, Shirley Luo, Roshan P. Vasoya, Robert L. Fullem, Aditya Parthasarathy, Ansu O. Perekatt & Michael P. Verzi. (2019) A reinforcing HNF4–SMAD4 feed-forward module stabilizes enterocyte identity. Nature Genetics 51:5, pages 777-785.
Crossref
Cecilia Battistelli, Giovanna Sabarese, Laura Santangelo, Claudia Montaldo, Frank J. Gonzalez, Marco Tripodi & Carla Cicchini. (2018) The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation. Cell Death & Differentiation 26:5, pages 890-901.
Crossref
Juan F. Burgueño, Jessica K. Lang, Ana M. Santander, Irina Fernández, Ester Fernández, Julia Zaias & Maria T. Abreu. (2019) Fluid supplementation accelerates epithelial repair during chemical colitis. PLOS ONE 14:4, pages e0215387.
Crossref
Longgui Ning, Xinhe Lou, Fenming Zhang & Guoqiang Xu. (2019) Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease. Mediators of Inflammation 2019, pages 1-13.
Crossref
Lei Chen, Natalie H. Toke, Shirley Luo, Roshan P. Vasoya, Rohit Aita, Aditya Parthasarathy, Yu-Hwai Tsai, Jason R. Spence & Michael P. Verzi. (2019) HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine. Development.
Crossref
Namit Kumar, Yu-Hwai Tsai, Lei Chen, Anbo Zhou, Kushal K. Banerjee, Madhurima Saxena, Sha Huang, Natalie H. Toke, Jinchuan Xing, Ramesh A. Shivdasani, Jason R. Spence & Michael P. Verzi. (2019) The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development.
Crossref
Qian Hu, Lingli Li, Xin Zou, Lijun Xu & Ping Yi. (2018) Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma. Frontiers in Pharmacology 9.
Crossref
Morgane Rabineau, Florence Flick, Claire Ehlinger, Eric Mathieu, Isabelle Duluc, Matthieu Jung, Bernard Senger, Leyla Kocgozlu, Pierre Schaaf, Philippe Lavalle, Jean-Noël Freund, Youssef Haikel & Dominique Vautier. (2018) Chromatin de-condensation by switching substrate elasticity. Scientific Reports 8:1.
Crossref
Hong Xue, Feng Yun Wang, Qian Kang & Xu Dong Tang. (2018) c-Kit mutation reduce intestinal epithelial cell proliferation and migration, but not influence intestinal permeability stimulated by lipopolysaccharide. Acta Histochemica 120:6, pages 534-541.
Crossref
Ramon U. Jin & Jason C. Mills. (2018) Are Gastric and Esophageal Metaplasia Relatives? The Case for Barrett’s Stemming from SPEM. Digestive Diseases and Sciences 63:8, pages 2028-2041.
Crossref
Shaoyang Zhao, Jianhong Xia, Xiuhua Wu, Leilei Zhang, Pengtao Wang, Haiyun Wang, Heying Li, Xiaoshan Wang, Yan Chen, Jean Agnetti, Yinxiong Li, Duanqing Pei & Xiaodong Shu. (2018) Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish. Nature Communications 9:1.
Crossref
Rik GH Lindeboom, Lisa van Voorthuijsen, Koen C Oost, Maria J Rodríguez‐Colman, Maria V Luna‐Velez, Cristina Furlan, Floriane Baraille, Pascal WTC Jansen, Agnès Ribeiro, Boudewijn MT Burgering, Hugo J Snippert & Michiel Vermeulen. (2018) Integrative multi‐omics analysis of intestinal organoid differentiation. Molecular Systems Biology 14:6.
Crossref
Hwee Hui Lau, Natasha Hui Jin Ng, Larry Sai Weng Loo, Joanita Binte Jasmen & Adrian Kee Keong Teo. (2018) The molecular functions of hepatocyte nuclear factors – In and beyond the liver. Journal of Hepatology 68:5, pages 1033-1048.
Crossref
Carolyn M. Klinge. 2018. Principles of Endocrinology and Hormone Action. Principles of Endocrinology and Hormone Action 187 232 .
Christopher T. Capaldo, Domonica N. Powell & Daniel Kalman. (2017) Layered defense: how mucus and tight junctions seal the intestinal barrier. Journal of Molecular Medicine 95:9, pages 927-934.
Crossref
Xinyang Li, Jun Shen & Zhihua Ran. (2017) Crosstalk between the gut and the liver via susceptibility loci: Novel advances in inflammatory bowel disease and autoimmune liver disease. Clinical Immunology 175, pages 115-123.
Crossref
Rafael Cypriano Dutra. (2017) Kinin receptors: Key regulators of autoimmunity. Autoimmunity Reviews 16:2, pages 192-207.
Crossref
Hong Lu, Xiaohong Lei, Jerry Liu & Curtis Klaassen. (2017) Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha. World Journal of Hepatology 9:4, pages 191.
Crossref
Hong Lu. (2016) Crosstalk of HNF4 α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids. Acta Pharmaceutica Sinica B 6:5, pages 393-408.
Crossref
Benjamin D. Moore, Shradha S. Khurana, Won Jae Huh & Jason C. Mills. (2016) Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. American Journal of Physiology-Gastrointestinal and Liver Physiology 311:2, pages G267-G275.
Crossref
Tim Y. Hou, Laurie A. Davidson, Eunjoo Kim, Yang-Yi Fan, Natividad R. Fuentes, Karen TriffRobert S. Chapkin. (2016) Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology. Annual Review of Nutrition 36:1, pages 543-570.
Crossref
William E Barry & Carl S Thummel. (2016) The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults. eLife 5.
Crossref
Karthikeyani Chellappa, Poonamjot Deol, Jane R Evans, Linh M Vuong, Gang Chen, Nadege Briançon, Eugene Bolotin, Christian Lytle, Meera G Nair & Frances M Sladek. (2016) Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer. eLife 5.
Crossref
Hou Shan Yao, Juan Wang, Xiao Ping Zhang, Liang Zhe Wang, Yi Wang, Xin Xing Li, Kai Zhou Jin, Zhi Qian Hu & Wei Jun Wang. (2016) Hepatocyte nuclear factor 4α suppresses the aggravation of colon carcinoma. Molecular Carcinogenesis 55:5, pages 458-472.
Crossref
Rui Yang, Jenny L. Kerschner & Ann Harris. (2016) Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:4, pages 591-598.
Crossref
Benjamin D. Moore, Ramon U. Jin, Heiyong Lo, Min Jung, Haiyan Wang, Michele A. Battle, Claes B. Wollheim, Fumihiko Urano & Jason C. Mills. (2016) Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function. Journal of Biological Chemistry 291:12, pages 6146-6157.
Crossref
Audrey Lasry, Adar Zinger & Yinon Ben-Neriah. (2016) Inflammatory networks underlying colorectal cancer. Nature Immunology 17:3, pages 230-240.
Crossref
Hae Ryung Chang, Seungyoon Nam, Myeong-Cherl Kook, Kyung-Tae Kim, Xiuping Liu, Hui Yao, Hae Rim Jung, Robert LemosJrJr, Hye Hyun Seo, Hee Seo Park, Youme Gim, Dongwan Hong, Iksoo Huh, Young-Woo Kim, Dongfeng Tan, Chang-Gong Liu, Garth Powis, Taesung Park, Han Liang & Yon Hui Kim. (2016) HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. Gut 65:1, pages 19-32.
Crossref
Carolyn M. Klinge. 2018. Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment. Diabetes. Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment 1 47 .
Matthias Prager, Janine Buettner & Carsten Buening. (2015) Genes involved in the regulation of intestinal permeability and their role in ulcerative colitis. Journal of Digestive Diseases 16:12, pages 713-722.
Crossref
ANWAR AZAD PALAKKAN, ROBERT DRUMMOND, RICHARD ALEXANDER ANDERSON, SEBASTIAN GREENHOUGH, KUMARY TV, DAVID COLIN HAY & JAMES ALEXANDER ROSS. (2015) Polarisation and functional characterisation of hepatocytes derived from human embryonic and mesenchymal stem cells. Biomedical Reports 3:5, pages 626-636.
Crossref
Floriane Baraille, Sami Ayari, Véronique Carrière, Céline Osinski, Kevin Garbin, Bertrand Blondeau, Ghislaine Guillemain, Patricia Serradas, Monique Rousset, Michel Lacasa, Philippe Cardot & Agnès Ribeiro. (2015) Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage. Diabetes 64:8, pages 2744-2756.
Crossref
Jian-mei Zhang, Ya-bi Zhu, Hong-guang Li, Shuang-mei Luan, Chun-yan Song, Xing Deng & Yue-xiang Chen. (2015) Protection of Sophocarpine on Colonic Barrier in DSS-induced Acute Colitis in Mice by Increasing Expression of HNF4α. Chinese Herbal Medicines 7:3, pages 261-266.
Crossref
Seth Rakoff-Nahoum, Yong Kong, Steven H. KleinsteinSathish Subramanian, Philip P. Ahern, Jeffrey I. Gordon & Ruslan Medzhitov. (2015) Analysis of gene–environment interactions in postnatal development of the mammalian intestine. Proceedings of the National Academy of Sciences 112:7, pages 1929-1936.
Crossref
Karen Triff, Eunjoo Kim & Robert S. Chapkin. (2015) Chemoprotective Epigenetic Mechanisms in a Colorectal Cancer Model: Modulation by n-3 PUFA in Combination With Fermentable Fiber. Current Pharmacology Reports 1:1, pages 11-20.
Crossref
Noah F. Shroyer, Kristin Bell & Yuan-Hung Lo. 2015. Intestinal Tumorigenesis. Intestinal Tumorigenesis 55 99 .
Declan F. McCole. (2014) IBD Candidate Genes and Intestinal Barrier Regulation. Inflammatory Bowel Diseases 20:10, pages 1829-1849.
Crossref
Carmen Berasain & Matías A. Avila. (2014) Deciphering liver zonation: New insights into the β-catenin, Tcf4, and HNF4α triad. Hepatology 59:6, pages 2080-2082.
Crossref
Angélique Gougelet, Cyril Torre, Philippe Veber, Chiara Sartor, Laura Bachelot, Pierre-Damien Denechaud, Cécile Godard, Marthe Moldes, Anne-Françoise Burnol, Céline Dubuquoy, Benoit Terris, François Guillonneau, Tao Ye, Michael Schwarz, Albert Braeuning, Christine Perret & Sabine Colnot. (2014) T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice. Hepatology 59:6, pages 2344-2357.
Crossref
Ruifang Li, Sara A. Grimm, Kaliopi Chrysovergis, Justin Kosak, Xingya Wang, Ying Du, Adam Burkholder, Kyathanahalli Janardhan, Deepak Mav, Ruchir Shah, Thomas E. Eling & Paul A. Wade. (2014) Obesity, Rather Than Diet, Drives Epigenomic Alterations in Colonic Epithelium Resembling Cancer Progression. Cell Metabolism 19:4, pages 702-711.
Crossref
Bernadette Neve, Olivier Le Bacquer, Sandrine Caron, Marlène Huyvaert, Audrey Leloire, Odile Poulain-Godefroy, Cécile Lecoeur, François Pattou, Bart Staels & Philippe Froguel. (2014) Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level. Diabetologia 57:4, pages 785-796.
Crossref
Shannon E Mullican, Joanna R DiSpirito & Mitchell A Lazar. (2013) The orphan nuclear receptors at their 25-year reunion. Journal of Molecular Endocrinology 51:3, pages T115-T140.
Crossref
T Saandi, F Baraille, L Derbal-Wolfrom, A-L Cattin, F Benahmed, E Martin, P Cardot, B Duclos, A Ribeiro, J-N Freund & I Duluc. (2012) Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer. Oncogene 32:32, pages 3782-3788.
Crossref
Amit Tiwari, Mirjam Schneider, Antonio Fiorino, Ritva Haider, Michal J. Okoniewski, Bernd Roschitzki, Anuli Uzozie, Mirco Menigatti, Josef Jiricny & Giancarlo Marra. (2013) Early Insights into the Function of KIAA1199, a Markedly Overexpressed Protein in Human Colorectal Tumors. PLoS ONE 8:7, pages e69473.
Crossref
Soichiro Ogaki, Nobuaki Shiraki, Kazuhiko Kume & Shoen Kume. (2013) Wnt and Notch Signals Guide Embryonic Stem Cell Differentiation into the Intestinal Lineages. Stem Cells 31:6, pages 1086-1096.
Crossref
Eric L. Snyder, Hideo Watanabe, Margaret Magendantz, Sebastian Hoersch, Tiffany A. Chen, Diana G. Wang, Denise Crowley, Charles A. Whittaker, Matthew Meyerson, Shioko Kimura & Tyler Jacks. (2013) Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma. Molecular Cell 50:2, pages 185-199.
Crossref
Anna Algamas-Dimantov, Einav Yehuda-Shnaidman, Irena Peri & Betty Schwartz. (2013) Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. Cellular Oncology 36:2, pages 155-167.
Crossref
Rachel Marion-Letellier, Guillaume Savoye, Paul L. Beck, Remo Panaccione & Subrata Ghosh. (2013) Polyunsaturated Fatty Acids in Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 19:3, pages 650-661.
Crossref
Meng Yang, Sheng-Nan Li, Khalid M Anjum, Long-Xin Gui, Shan-Shan Zhu, Jun Liu, Jia-Kun Chen, Qing-Feng Liu, Guo-Dong Ye, Wen-Jie Wang, Jia-Fa Wu, Wang-Yu Cai, Guang-Bin Sun, Yun-Jia Liu, Rong-Fu Liu, Zhi-Ming Zhang & Bo-An Li. (2013) Double-negative feedback loop between Wnt/β-catenin signaling and HNF4α regulates epithelial-mesenchymal transition in hepatocellular carcinoma. Journal of Cell Science.
Crossref
Pablo García-MirandaMaría D. Vázquez-CarreteroPilar SesmaMaría J. PeralAnunciación A. Ilundain. (2013) Reelin Is Involved in the Crypt-Villus Unit Homeostasis. Tissue Engineering Part A 19:1-2, pages 188-198.
Crossref
Eleanora Anna Margaretha Festen, Cisca Wijmenga & Rinse K Weersma. 2013. Genomic and Personalized Medicine. Genomic and Personalized Medicine 863 878 .
Stefan Koch, Asma Nusrat & Charles A. Parkos. 2013. Molecular Genetics of Inflammatory Bowel Disease. Molecular Genetics of Inflammatory Bowel Disease 265 280 .
V Marcil, D Sinnett, E Seidman, F Boudreau, F-P Gendron, J-F Beaulieu, D Menard, M Lambert, A Bitton, R Sanchez, D Amre & E Levy. (2012) Association between genetic variants in the HNF4A gene and childhood-onset Crohn’s disease. Genes & Immunity 13:7, pages 556-565.
Crossref
Stephanie C. Nnadi, Rayneisha Watson, Julie Innocent, Gregory E. Gonye, Arthur M. Buchberg & Linda D. Siracusa. (2012) Identification of five novel modifier loci of ApcMin harbored in the BXH14 recombinant inbred strain. Carcinogenesis 33:8, pages 1589-1597.
Crossref
Thomas F. Gallegos, Gleb Martovetsky, Valentina Kouznetsova, Kevin T. Bush & Sanjay K. Nigam. (2012) Organic Anion and Cation SLC22 “Drug” Transporter (Oat1, Oat3, and Oct1) Regulation during Development and Maturation of the Kidney Proximal Tubule. PLoS ONE 7:7, pages e40796.
Crossref
Constance S.V. Petit, Frédérick Barreau, Laura Besnier, Pierre Gandille, Béatrice Riveau, Danielle Chateau, Maryline Roy, Dominique Berrebi, Magali Svrcek, Philippe Cardot, Monique Rousset, Caroline Clair & Sophie Thenet. (2012) Requirement of Cellular Prion Protein for Intestinal Barrier Function and Mislocalization in Patients With Inflammatory Bowel Disease. Gastroenterology 143:1, pages 122-132.e15.
Crossref
Karthikeyani Chellappa, Graham R Robertson & Frances M Sladek. (2012) HNF4α: a new biomarker in colon cancer?. Biomarkers in Medicine 6:3, pages 297-300.
Crossref
Anna Algamas-Dimantov, Dana Davidovsky, Julius Ben-Ari, Jing X. Kang, Irena Peri, Rachel Hertz, Jacob Bar-Tana & Betty Schwartz. (2012) Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice. Journal of Lipid Research 53:6, pages 1056-1070.
Crossref
Camille Jung, Ulrich Meinzer, Nicolas Montcuquet, Elodie Thachil, Danielle Château, Raphaële Thiébaut, Maryline Roy, Ziad Alnabhani, Dominique Berrebi, Monique Dussaillant, Eric Pedruzzi, Sophie Thenet, Nadine Cerf-Bensussan, Jean-Pierre Hugot & Frederick Barreau. (2012) Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. Journal of Clinical Investigation 122:6, pages 2239-2251.
Crossref
Vincent FrochotMalik AlqubAnne-Laure CattinVéronique CarrièreAnne HoullierFloriane BarailleLaurence Barbot, Susan Saint-JustAgnès RibeiroMichel LacasaPhilippe CardotJean ChambazMonique RoussetJean-Marc Lacorte. (2012) The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse. American Journal of Physiology-Gastrointestinal and Liver Physiology 302:11, pages G1253-G1263.
Crossref
Karthikeyani ChellappaLucy JankovaJake M. SchnablSongqin PanYann BrelivetCaroline L-S. FungCharles ChanOwen F. Dent, Stephen J. Clarke, Graham R. RobertsonFrances M. Sladek. (2012) Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer. Proceedings of the National Academy of Sciences 109:7, pages 2302-2307.
Crossref
Anders Krüger Olsen, Mette BoydErik Thomas DanielsenJesper Thorvald Troelsen. (2012) Current and emerging approaches to define intestinal epithelium-specific transcriptional networks. American Journal of Physiology-Gastrointestinal and Liver Physiology 302:3, pages G277-G286.
Crossref
Eugene Bolotin, Karthikeyani Chellappa, Wendy Hwang-Verslues, Jake M Schnabl, Chuhu Yang & Frances M Sladek. (2011) Nuclear Receptor HNF4α Binding Sequences are Widespread in Alu Repeats. BMC Genomics 12:1.
Crossref
Maria Hatziapostolou, Christos Polytarchou, Eleni Aggelidou, Alexandra Drakaki, George A. Poultsides, Savina A. Jaeger, Hisanobu Ogata, Michael Karin, Kevin Struhl, Margarita Hadzopoulou-Cladaras & Dimitrios Iliopoulos. (2011) An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis. Cell 147:6, pages 1233-1247.
Crossref
Hao Chen, Yu Fang, Whitney Tevebaugh, Roy C. Orlando, Nicholas J. Shaheen & Xiaoxin Chen. (2011) Molecular Mechanisms of Barrett’s Esophagus. Digestive Diseases and Sciences 56:12, pages 3405-3420.
Crossref
Taeko K. Noah, Bridgitte Donahue & Noah F. Shroyer. (2011) Intestinal development and differentiation. Experimental Cell Research 317:19, pages 2702-2710.
Crossref
Suk-Kyun Yang, Yusun Jung, Hyeri Kim, Myunghee Hong, Byong Duk Ye & Kyuyoung Song. (2011) Association of FCGR2A, JAK2 or HNF4A variants with ulcerative colitis in Koreans. Digestive and Liver Disease 43:11, pages 856-861.
Crossref
Florian Ehehalt, Petra Rümmele, Stephan Kersting, Corinna Lang-Schwarz, Felix Rückert, Arndt Hartmann, Wolfgang Dietmaier, Luigi Terracciano, Daniela E. Aust, Beatrix Jahnke, Hans-Detlev Saeger, Christian Pilarsky & Robert Grützmann. (2011) Hepatocyte Nuclear Factor (HNF) 4α Expression Distinguishes Ampullary Cancer Subtypes and Prognosis After Resection. Annals of Surgery 254:2, pages 302-310.
Crossref
Suzanne van Sommeren, Marijn C. Visschedijk, Eleonora A.M. Festen, Dirk J. de Jong, Cyriel Y. Ponsioen, Cisca Wijmenga & Rinse K. Weersma. (2011) HNF4α and CDH1 are associated with ulcerative colitis in a Dutch cohort. Inflammatory Bowel Diseases 17:8, pages 1714-1718.
Crossref
Bernard Khor, Agnès Gardet & Ramnik J. Xavier. (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474:7351, pages 307-317.
Crossref
Mia M. Pingul, Nkecha Hughes, Anthony Wu, Charles A. Stanley & Philip A. Gruppuso. (2011) Hepatocyte Nuclear Factor 4α Gene Mutation Associated with Familial Neonatal Hyperinsulinism and Maturity-Onset Diabetes of the Young. The Journal of Pediatrics 158:5, pages 852-854.
Crossref
Alexandra I. Thompson & Charlie W. Lees. (2011) Genetics of ulcerative colitis. Inflammatory Bowel Diseases 17:3, pages 831-848.
Crossref
Jason R. Spence, Ryan Lauf & Noah F. Shroyer. (2011) Vertebrate intestinal endoderm development. Developmental Dynamics 240:3, pages 501-520.
Crossref
Mathieu Darsigny, Jean-Philippe Babeu, Ernest G. Seidman, Fernand-Pierre Gendron, Emile Levy, Julie Carrier, Nathalie Perreault & François Boudreau. (2010) Hepatocyte Nuclear Factor-4α Promotes Gut Neoplasia in Mice and Protects against the Production of Reactive Oxygen Species. Cancer Research 70:22, pages 9423-9433.
Crossref

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