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Molecular and Cellular Biology Volume 29, 2009 - Issue 5
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Article

The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends

Eric Weterings1 Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas75390-9187
,
Nicole S. Verkaik2 Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000CA Rotterdam, The Netherlands
,
Guido Keijzers2 Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000CA Rotterdam, The Netherlands
,
Bogdan I. Florea2 Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000CA Rotterdam, The Netherlands
,
Shih-Ya Wang1 Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas75390-9187
,
Laura G. Ortega1 Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas75390-9187
,
Naoya Uematsu1 Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas75390-9187
,
David J. Chen1 Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, Texas75390-9187Correspondence[email protected] [email protected]
&
Dik C. van Gent2 Department of Cell Biology and Genetics, Erasmus MC, University Medical Center, Dr. Molewaterplein 50, P.O. Box 2040, 3000CA Rotterdam, The NetherlandsCorrespondence[email protected] [email protected]
 show all
Pages 1134-1142 | Received 19 Jun 2008, Accepted 02 Dec 2008, Published online: 21 Mar 2023

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Sunetra Roy, Abinadabe J. de Melo, Yao Xu, Satish K. Tadi, Aurélie Négrel, Eric Hendrickson, Mauro Modesti & Katheryn Meek. (2015) XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation. Molecular and Cellular Biology 35:17, pages 3017-3028.
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Guido Keijzers, Scott Maynard, Raghavendra A. Shamanna, Lene Juel Rasmussen, Deborah L. Croteau & Vilhelm A. Bohr. (2014) The role of RecQ helicases in non-homologous end-joining. Critical Reviews in Biochemistry and Molecular Biology 49:6, pages 463-472.
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Derek Woods & John J. Turchi. (2013) Chemotherapy induced DNA damage response. Cancer Biology & Therapy 14:5, pages 379-389.
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Anthony J. Davis, Sairei So & David J. Chen. (2010) Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks. Cell Cycle 9:13, pages 2529-2536.
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Adrian C. Begg. (2010) Radiobiology: State of the present art. A conference report. International Journal of Radiation Biology 86:1, pages 71-78.
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Yu-Hsiu Wang, Teresa L. F. Ho, Anushya Hariharan, Hui Chin Goh, Yao Liang Wong, Nicole S. Verkaik, May Yin Lee, Wai Leong Tam, Dik C. van Gent, Ashok R. Venkitaraman, Michael P. Sheetz & David P. Lane. (2022) Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity. Proceedings of the National Academy of Sciences 119:10.
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Sanna Abbasi, Gursimran Parmar, Rachel D. Kelly, Nileeka Balasuriya & Caroline Schild-Poulter. (2021) The Ku complex: recent advances and emerging roles outside of non-homologous end-joining. Cellular and Molecular Life Sciences 78:10, pages 4589-4613.
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Katheryn Meek. (2020) Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation. Nucleic Acids Research 48:16, pages 9098-9108.
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Takabumi Inagawa, Thomas Wennink, Joyce H. G. Lebbink, Guido Keijzers, Bogdan I. Florea, Nicole S. Verkaik & Dik C. van Gent. (2020) C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties. International Journal of Molecular Sciences 21:18, pages 6725.
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Sarvan Kumar Radhakrishnan & Susan P. Lees-Miller. (2017) DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA Repair 57, pages 17-28.
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