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Molecular and Cellular Biology Volume 31, 2011 - Issue 3
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Article

Mre11 Nuclease Activity and Ctp1 Regulate Chk1 Activation by Rad3ATR and Tel1ATM Checkpoint Kinases at Double-Strand Breaks

Oliver LimboDepartment of Molecular Biology, 10550 N. Torrey Pines Road, La Jolla, California92037
,
Mary E. Porter-GoffDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts01605
,
Nicholas RhindDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts01605
&
Paul RussellDepartment of Molecular Biology, 10550 N. Torrey Pines Road, La Jolla, California92037;Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California92037Correspondence[email protected]
Pages 573-583 | Received 25 Aug 2010, Accepted 15 Nov 2010, Published online: 21 Mar 2023

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Yong-jie Xu, Saman Khan, Adam C. Didier, Michal Wozniak, Yufeng Liu, Amanpreet Singh & Toru M. Nakamura. (2019) A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast. Molecular and Cellular Biology 39:20.
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Stela S. Palii, Yuxia Cui, Cynthia L. Innes & Richard S. Paules. (2013) Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit. Cell Cycle 12:7, pages 1105-1118.
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Kenzo Fukunaga, Youngho Kwon, Patrick Sung & Katsunori Sugimoto. (2011) Activation of Protein Kinase Tel1 through Recognition of Protein-Bound DNA Ends. Molecular and Cellular Biology 31:10, pages 1959-1971.
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Articles from other publishers (30)

Tom Egger, Benoît Bordignon & Arnaud Coquelle. (2022) A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress. Scientific Reports 12:1.
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Hannah M. Hylton, Bailey E. Lucas & Ruben C. Petreaca. (2020) Schizosaccharomyces pombe Assays to Study Mitotic Recombination Outcomes. Genes 11:1, pages 79.
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Kevin J. Barnum, Y. Tram Nguyen & Matthew J. O’Connell. (2019) XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection. Journal of Biological Chemistry 294:19, pages 7632-7643.
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Tai-Yuan YuMichael T. Kimble & Lorraine S. Symington. (2018) Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection. Proceedings of the National Academy of Sciences 115:51.
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Min Zhu, Hongchang Zhao, Oliver Limbo & Paul Russell. (2018) Mre11 complex links sister chromatids to promote repair of a collapsed replication fork. Proceedings of the National Academy of Sciences 115:35, pages 8793-8798.
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Mridula Nambiar & Gerald R. Smith. (2018) Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers. Molecular Cell 71:4, pages 540-553.e4.
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Kim Kiat Lim, Thi Thuy Trang Nguyen, Adelicia Yongling Li, Yee Phan Yeo & Ee Sin Chen. (2018) Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast. Nucleic Acids Research 46:10, pages 5061-5074.
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Oliver Limbo, Yoshiki Yamada & Paul Russell. (2018) Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1. Molecular Biology of the Cell 29:11, pages 1389-1399.
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Davide Moiani, Daryl A. Ronato, Chris A. Brosey, Andrew S. Arvai, Aleem Syed, Jean-Yves Masson, Elena Petricci & John A. Tainer. 2018. Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair. Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair 205 241 .
Amanpreet Singh & Yong-jie Xu. (2017) Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea. Journal of Biological Chemistry 292:22, pages 9088-9103.
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Yanhui Li, Jinyu Wang, Gang Zhou, Michael Lajeunesse, Nga Le, Brittany N Stawicki, Yalitza Lopez Corcino, Kathleen L Berkner & Kurt W Runge. (2017) Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe . Genetics 206:1, pages 481-496.
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Christiane Rothe, Gro Elise Rødland, Silje Anda, Vilte Stonyte, Erik Boye, Sandra Lopez-Aviles & Beáta Grallert. (2017) A checkpoint-independent mechanism delays entry into mitosis after UV irradiation. Journal of Cell Science.
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Yong-jie Xu, Amanpreet Singh & Gerald M Alter. (2016) Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway. Genetics 204:3, pages 959-973.
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Yong-jie Xu. (2016) Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast. Cellular Signalling 28:4, pages 235-245.
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Eva Mejia-Ramirez, Oliver Limbo, Petra Langerak & Paul Russell. (2015) Critical Function of γH2A in S-Phase. PLOS Genetics 11:9, pages e1005517.
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Tanya T. Paull. (2015) Mechanisms of ATM Activation. Annual Review of Biochemistry 84:1, pages 711-738.
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Huan Chen, Roberto A. DonnianniNaofumi Handa, Sarah K. DengJulyun Oh, Leonid A. TimashevStephen C. Kowalczykowski & Lorraine S. Symington. (2015) Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling. Proceedings of the National Academy of Sciences 112:15.
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Catia Caetano, Oliver Limbo, Sarah Farmer, Steffi Klier, Claire Dovey, Paul Russell & Robertus Antonius Maria de Bruin. (2014) Tolerance of Deregulated G1/S Transcription Depends on Critical G1/S Regulon Genes to Prevent Catastrophic Genome Instability. Cell Reports 9:6, pages 2279-2289.
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Ming Yue, Li Zeng, Amanpreet Singh & Yongjie Xu. (2014) Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe. PLoS ONE 9:3, pages e92936.
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Martin Kupiec. (2014) Biology of telomeres: lessons from budding yeast. FEMS Microbiology Reviews 38:2, pages 144-171.
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Katayoun Omidi, Mohsen Hooshyar, Matthew Jessulat, Bahram Samanfar, Megan Sanders, Daniel Burnside, Sylvain Pitre, Andrew Schoenrock, Jianhua Xu, Mohan Babu & Ashkan Golshani. (2014) Phosphatase Complex Pph3/Psy2 Is Involved in Regulation of Efficient Non-Homologous End-Joining Pathway in the Yeast Saccharomyces cerevisiae. PLoS ONE 9:1, pages e87248.
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Zhong-Wei Zhou, Cong Liu, Tang-Liang Li, Christopher Bruhn, Anja Krueger, WooKee Min, Zhao-Qi Wang & Antony M. Carr. (2013) An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence. PLoS Genetics 9:8, pages e1003702.
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Karen Kuntz & Matthew J O’Connell. (2012) Initiation of DNA damage responses through XPG-related nucleases. The EMBO Journal 32:2, pages 290-302.
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Oliver Limbo, Davide Moiani, Aryandi Kertokalio, Claire Wyman, John A. Tainer & Paul Russell. (2012) Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair. Nucleic Acids Research 40:22, pages 11435-11449.
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Wytse Bruinsma, Jonne A. Raaijmakers & René H. Medema. (2012) Switching Polo-like kinase-1 on and off in time and space. Trends in Biochemical Sciences 37:12, pages 534-542.
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Meng Qu, Bing Yang, Li Tao, John R. Yates, Paul Russell, Meng-Qiu Dong & Li-Lin Du. (2012) Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint. PLoS Genetics 8:7, pages e1002817.
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Su-Jiun Lin, Christopher P. Wardlaw, Takashi Morishita, Izumi Miyabe, Charly Chahwan, Thomas Caspari, Ulrike Schmidt, Antony M. Carr & Valerie Garcia. (2012) The Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner. PLoS Genetics 8:6, pages e1002801.
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Youngsoo Lee, Erin RP Shull, Pierre-Olivier Frappart, Sachin Katyal, Vanessa Enriquez-Rios, Jingfeng Zhao, Helen R Russell, Eric J Brown & Peter J McKinnon. (2012) ATR maintains select progenitors during nervous system development. The EMBO Journal 31:5, pages 1177-1189.
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Lorraine S. SymingtonJean Gautier. (2011) Double-Strand Break End Resection and Repair Pathway Choice. Annual Review of Genetics 45:1, pages 247-271.
Crossref
Petra Langerak, Eva Mejia-Ramirez, Oliver Limbo & Paul Russell. (2011) Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks. PLoS Genetics 7:9, pages e1002271.
Crossref

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