324
Views
447
CrossRef citations to date
0
Altmetric
Article

Wnt/β-Catenin Is Essential for Intestinal Homeostasis and Maintenance of Intestinal Stem Cells

, , &
Pages 7551-7559 | Received 12 Jun 2007, Accepted 23 Aug 2007, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Kuang He & Wen-Juan Gan. (2023) Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer. Cancer Management and Research 15, pages 435-448.
Read now
Shashank Kumar, Eram Fathima, Farhath Khanum & Suttur S. Malini. (2023) Significance of the Wnt canonical pathway in radiotoxicity via oxidative stress of electron beam radiation and its molecular control in mice. International Journal of Radiation Biology 99:3, pages 459-473.
Read now
Jessica Kopenhaver, Madison Crutcher, Scott A. Waldman & Adam E. Snook. (2021) The shifting paradigm of colorectal cancer treatment: a look into emerging cancer stem cell-directed therapeutics to lead the charge toward complete remission. Expert Opinion on Biological Therapy 21:10, pages 1335-1345.
Read now
Rasmus Goll & Atle van Beelen Granlund. (2015) Intestinal barrier homeostasis in inflammatory bowel disease. Scandinavian Journal of Gastroenterology 50:1, pages 3-12.
Read now
Yanhong Deng, Qiao Su, Jianwen Mo, Xinhui Fu, Yan Zhang & Edward H. Lin. (2013) Celecoxib Downregulates CD133 Expression Through Inhibition of the Wnt Signaling Pathway in Colon Cancer Cells. Cancer Investigation 31:2, pages 97-102.
Read now
Daniel Croagh, Shuli Cheng, Anjali Tikoo, Sanjay Nandurkar, Robert J. S. Thomas, Pritinder Kaur & Wayne A. Phillips. (2008) Reconstitution of stratified murine and human oesophageal epithelia in an in vivo transplant culture system. Scandinavian Journal of Gastroenterology 43:10, pages 1158-1168.
Read now

Articles from other publishers (441)

Rodanthi Lyraki, Anaëlle Grabek, Amélie Tison, Lahiru Chamara Weerasinghe Arachchige, Mirko Peitzsch, Nicole Bechmann, Sameh A. Youssef, Alain de Bruin, Elvira R. M. Bakker, Frank Claessens, Marie-Christine Chaboissier & Andreas Schedl. (2023) Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice. Disease Models & Mechanisms 16:6.
Crossref
Buyan-Ochir Orgil, Undral Munkhsaikhan, Joseph F. Pierre, Ning Li, Fuyi Xu, Neely R. Alberson, Jason N. Johnson, Glenn T. Wetzel, Bastiaan J. D. Boukens, Lu Lu, Jeffrey A. Towbin & Enkhsaikhan Purevjav. (2023) The TMEM43 S358L mutation affects cardiac, small intestine, and metabolic homeostasis in a knock-in mouse model . American Journal of Physiology-Heart and Circulatory Physiology 324:6, pages H866-H880.
Crossref
Haruka Miki & Mario C. Manresa. (2023) Novel fibroblast phenotypes in homeostasis and chronic inflammation: From functions to potential regulators. The Journal of Physiology 601:12, pages 2273-2291.
Crossref
Elisa Lozano, Paula Sanchon-Sanchez, Ana Morente-Carrasco, Luis Miguel Chinchilla-Tábora, José L. Mauriz, Paula Fernández-Palanca, Jose J. G. Marin & Rocio I. R. Macias. (2023) Impact of Aberrant β-Catenin Pathway on Cholangiocarcinoma Heterogeneity. Cells 12:8, pages 1141.
Crossref
Yonghyo Kim, Myoung-Hee Kang, Geon-Woo Kim & Yong-Hee Cho. (2023) Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer. Organoid 3, pages e4.
Crossref
David Castillo-Azofeifa, Tomas Wald, Efren A. Reyes, Aaron Gallagher, Julia Schanin, Stephanie Vlachos, Nathalie Lamarche-Vane, Carolyn Bomidi, Sarah Blutt, Mary K. Estes, Todd Nystul & Ophir D. Klein. (2023) A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling. Cell Stem Cell 30:2, pages 188-206.e6.
Crossref
Manosi Banerjee & V. Devi Rajeswari. (2023) Inhibition of WNT signaling by conjugated microRNA nano-carriers: A new therapeutic approach for treating triple-negative breast cancer a perspective review. Critical Reviews in Oncology/Hematology 182, pages 103901.
Crossref
Janna Fröhlich, Katja Rose & Andreas Hecht. (2023) Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines. Scientific Reports 13:1.
Crossref
Metin Caliskan, Guzide Dogan & Seda Orenay-Boyacioglu. (2023) Relationship between villous atrophy and Wnt pathway gene expressions in pediatric celiac patients. Revista da Associação Médica Brasileira 69:5.
Crossref
Ning Ma, Xiyue Chen, Lee J. Johnston & Xi Ma. (2022) Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis. iMeta 1:4.
Crossref
John C. SchimentiRui HuangLiangdao LiRyan James. (2022) Genome Maintenance in Mammalian Stem Cells. Annual Review of Genetics 56:1, pages 145-164.
Crossref
Yonghyo Kim, Myoung-Hee Kang & Yong-Hee Cho. (2022) API-2-Induced Cell Migration Is Overcome by Small Molecular Approaches Inhibiting β-Catenin. Current Issues in Molecular Biology 44:12, pages 6006-6014.
Crossref
Lindyann R. Lessey, Shaiya C. Robinson, Roopali Chaudhary & Juliet M. Daniel. (2022) Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases. Frontiers in Cell and Developmental Biology 10.
Crossref
Ning Yang, Yunhang Zhang, Yuguang Fu, Yang Li, Shanshan Yang, Jianing Chen & Guangliang Liu. (2022) Transmissible Gastroenteritis Virus Infection Promotes the Self-Renewal of Porcine Intestinal Stem Cells via Wnt/β-Catenin Pathway. Journal of Virology 96:18.
Crossref
Gabriele Colozza, So-Yeon Park & Bon-Kyoung Koo. (2022) Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease. Experimental & Molecular Medicine 54:9, pages 1367-1378.
Crossref
Jie Yin, Yiping Wen, Jing Zeng, Yanyan Zhang, Jiayu Chen, Yanmei Zhang, Tiantian Han, Xiaoying Li, Hong Huang, Yan Cai, Ying Jin, Yan Li, Wei Guo & Lingya Pan. (2022) CDC50A might be a novel biomarker of epithelial ovarian cancer-initiating cells. BMC Cancer 22:1.
Crossref
Hamid Iqbal, Gyu-Lee Kim, Ji-Hoon Kim, Prachetash Ghosh, Masaud Shah, Wonsik Lee & Dong-Kwon Rhee. (2022) Pneumococcal pep27-mutant inhibits Wnt5a expression via the regulation of T helper cells to attenuate colitis. International Immunopharmacology 109, pages 108927.
Crossref
Meghan Ferguson & Edan Foley. (2021) Microbial recognition regulates intestinal epithelial growth in homeostasis and disease. The FEBS Journal 289:13, pages 3666-3691.
Crossref
Daniella C. N. Hall & Ralf A. Benndorf. (2022) Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited. Cellular and Molecular Life Sciences 79:7.
Crossref
Han Yang, Xia Ting, Yue-Hang GengYuntao XieJovia L. Nierenberg, Yan-Fei HuoYan-Ting ZhouYang HuangYu-Qing YuXin-Yao YuXiao-Fei LiElad Ziv, Hongquan ZhangWei-Gang FangYin Shen & Xin-Xia Tian. (2022) The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression . Science Advances 8:23.
Crossref
Dan Li, Xiaolin Yao, Jianxiong Yue, Yapeng Fang, Guifang Cao, Adam C. Midgley, Katsuyoshi Nishinari & Yongli Yang. (2022) Advances in Bioactivity of MicroRNAs of Plant-Derived Exosome-Like Nanoparticles and Milk-Derived Extracellular Vesicles. Journal of Agricultural and Food Chemistry 70:21, pages 6285-6299.
Crossref
Marion M. France, Tony del Rio, Hannah Travers, Erin Raftery, Robert Langer, Giovanni Traverso & Carl M. Schoellhammer. (2022) Platform for the Delivery of Unformulated RNA In Vivo. Journal of Pharmaceutical Sciences 111:6, pages 1770-1775.
Crossref
Huldani Huldani, Saade Abdalkareem Jasim, Klunko Nataliya Sergeenva, Dmitry Olegovich Bokov, Walid Kamal Abdelbasset, Rustam Turakulov, Moaed E. Al-Gazally, Behnam Ahmadzadeh, Zanko Hassan Jawhar & Homayoon Siahmansouri. (2022) Mechanisms of cancer stem cells drug resistance and the pivotal role of HMGA2. Pathology - Research and Practice 234, pages 153906.
Crossref
Yang Yang, Maria Gomez, Timothy Marsh, Laura Poillet-Perez, Akshada Sawant, Lei Chen, Noel R. Park, S. RaElle Jackson, Zhixian Hu, Noa Alon, Chen Liu, Jayanta Debnath, Jun-Lin Guan, Shawn Davidson, Michael Verzi & Eileen White. (2022) Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival. Proceedings of the National Academy of Sciences 119:21.
Crossref
Won Jin Ho, Julianne N. P. Smith, Young Soo Park, Matthew Hadiono, Kelsey Christo, Alvin Jogasuria, Yongyou Zhang, Alyssia V. Broncano, Lakshmi Kasturi, Dawn M. Dawson, Stanton L. Gerson, Sanford D. Markowitz & Amar B. Desai. (2022) 15-PGDH regulates hematopoietic and gastrointestinal fitness during aging. PLOS ONE 17:5, pages e0268787.
Crossref
Peipei Ding, Yanqing Xu, Luying Li, Xinyue Lv, Ling Li, Jianfeng Chen, Danlei Zhou, Xiaochao Wang, Qi Wang, Wei Zhang, Tian Liao, Qing-Hai Ji, Qun-Ying Lei & Weiguo Hu. (2022) Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis. Cell Reports 39:9, pages 110851.
Crossref
Takashi Hasebe, Kenta Fujimoto & Atsuko Ishizuya-Oka. (2022) Essential roles of YAP-TEAD complex in adult stem cell development during thyroid hormone-induced intestinal remodeling of Xenopus laevis. Cell and Tissue Research 388:2, pages 313-329.
Crossref
Jung Kyu Choi, Ihn-Sil Kwak, Sae-Bom Yoon, Heeyeong Cho & Byoung-San Moon. (2022) A Small Molecule Promoting Neural Differentiation Suppresses Cancer Stem Cells in Colorectal Cancer. Biomedicines 10:4, pages 859.
Crossref
Johanna Grinat, Frauke Kosel, Neha Goveas, Andrea Kranz, Dimitra Alexopoulou, Klaus Rajewsky, Michael Sigal, A Francis Stewart & Julian Heuberger. (2022) Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells. Life Science Alliance 5:4, pages e202101187.
Crossref
Suze A. Jansen, Edward E.S. Nieuwenhuis, Alan M. Hanash & Caroline A. Lindemans. (2022) Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease. Mucosal Immunology 15:4, pages 605-619.
Crossref
Mehran Pashirzad, Thozhukat Sathyapalan, Afsana Sheikh, Prashant Kesharwani & Amirhossein Sahebkar. (2022) Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry 115, pages 19-29.
Crossref
Yang Chen, Sirong Shi, Bo Li, Tian Lan, Kefei Yuan, Jingsheng Yuan, Yongjie Zhou, Jiulin Song, Tao Lv, Yujun Shi, Bo Xiang, Taoran Tian, Tao Zhang, Jiayin Yang & Yunfeng Lin. (2022) Therapeutic Effects of Self-Assembled Tetrahedral Framework Nucleic Acids on Liver Regeneration in Acute Liver Failure. ACS Applied Materials & Interfaces 14:11, pages 13136-13146.
Crossref
Francesco M. STALLA, Marco ASTEGIANO, Davide G. RIBALDONE, Giorgio M. SARACCO & Rinaldo PELLICANO. (2022) The small intestine: barrier, permeability and microbiota. Minerva Gastroenterology 68:1.
Crossref
Guofeng Xie, Zhongsheng Peng, Jinqing Liang, Shannon M. Larabee, Cinthia B. Drachenberg, Harris Yfantis & Jean-Pierre Raufman. (2022) Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene. JCI Insight 7:4.
Crossref
Lingchen Fu, Jia Fan, Sudipa Maity, Grant McFadden, Yixin Shi & Wei Kong. (2022) PD-L1 interacts with Frizzled 6 to activate β-catenin and form a positive feedback loop to promote cancer stem cell expansion. Oncogene 41:8, pages 1100-1113.
Crossref
Christopher Berlin, Félicie Cottard, Dominica Willmann, Sylvia Urban, Stephan M. Tirier, Lisa Marx, Karsten Rippe, Mark Schmitt, Valentina Petrocelli, Florian R. Greten, Stefan Fichtner-Feigl, Rebecca Kesselring, Eric Metzger & Roland Schüle. (2022) KMT9 Controls Stemness and Growth of Colorectal Cancer. Cancer Research 82:2, pages 210-220.
Crossref
Daniel Gonzalez-Bohorquez, Isabel M. Gallego López, Baptiste N. JaegerSibylle Pfammatter, Megan Bowers, Clay F. Semenkovich & Sebastian Jessberger. (2022) FASN-dependent de novo lipogenesis is required for brain development. Proceedings of the National Academy of Sciences 119:2.
Crossref
Soumyashree Das, Qiang Feng, Iyshwarya Balasubramanian, Xiang Lin, Haoran Liu, Oscar Pellón-Cardenas, Shiyan Yu, Xiao Zhang, Yue Liu, Zhi Wei, Edward M. Bonder, Michael P. Verzi, Wei Hsu, Lanjing Zhang, Timothy C. Wang & Nan Gao. (2022) Colonic healing requires Wnt produced by epithelium as well as Tagln+ and Acta2+ stromal cells. Development 149:1.
Crossref
Amna N. Naser, Tiaosi Xing, Qun Lu & Yan-Hua Chen. 2022. Tight Junctions. Tight Junctions 199 215 .
Holly R. Eggington, Eoghan J. Mulholland & Simon J. Leedham. (2021) Morphogen regulation of stem cell plasticity in intestinal regeneration and carcinogenesis. Developmental Dynamics 251:1, pages 61-74.
Crossref
Stina Hellman. (2021) Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics. Veterinary Research 52:1.
Crossref
Meng-Han Wu, Marco Padilla-Rodriguez, Isabella Blum, Abigail Camenisch, Vanessa Figliuolo da Paz, Matthew Ollerton, John Muller, Samina Momtaz, Stefanie A.T. Mitchell, Pawel Kiela, Curtis Thorne, Jean M. Wilson & Christopher M. Cox. (2021) Proliferation in the developing intestine is regulated by the endosomal protein Endotubin. Developmental Biology 480, pages 50-61.
Crossref
Maryam Yavartanoo & Gwan-Su Yi. (2021) Development and Validation of Tumor Immunogenicity Based Gene Signature for Skin Cancer Risk Stratification. International Journal of Molecular Sciences 22:21, pages 12025.
Crossref
Cristina Brischetto, Karsten Krieger, Christian Klotz, Inge Krahn, Séverine Kunz, Marina Kolesnichenko, Patrick Mucka, Julian Heuberger, Claus Scheidereit & Ruth Schmidt-Ullrich. (2021) NF-κB determines Paneth versus goblet cell fate decision in the small intestine. Development 148:21.
Crossref
Carlos A Rubio & Peter T Schmidt. (2021) Asymmetric crypt fission in sessile serrated lesions. Journal of Clinical Pathology 74:11, pages 712-717.
Crossref
Zhuo Xie, Mudan Zhang, Gaoshi Zhou, Lihui Lin, Jing Han, Ying Wang, Li Li, Yao He, Zhirong Zeng, Minhu Chen & Shenghong Zhang. (2021) Emerging roles of the Hedgehog signalling pathway in inflammatory bowel disease. Cell Death Discovery 7:1.
Crossref
Alexia Gomart, Alexandre Vallée & Yves Lecarpentier. (2021) Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGF-β/Wnt/β-Catenin Pathways and PPARγ. Frontiers in Pediatrics 9.
Crossref
Alexandra Aliluev, Sophie Tritschler, Michael Sterr, Lena Oppenländer, Julia Hinterdobler, Tobias Greisle, Martin Irmler, Johannes Beckers, Na Sun, Axel Walch, Kerstin Stemmer, Alida Kindt, Jan Krumsiek, Matthias H. Tschöp, Malte D. Luecken, Fabian J. Theis, Heiko Lickert & Anika Böttcher. (2021) Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice. Nature Metabolism 3:9, pages 1202-1216.
Crossref
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui & Shaoping Nie. (2021) Glucomannan from Aloe vera Gel Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration via the Wnt/β-Catenin Pathway . Journal of Agricultural and Food Chemistry 69:36, pages 10581-10591.
Crossref
Wenduerma, Nami O. Yamada, Tuya Wang & Takao Senda. (2021) A further study on a disturbance of intestinal epithelial cell population and kinetics in APC1638T mice. Medical Molecular Morphology 54:3, pages 203-215.
Crossref
Hui Zhang, Moubin Lin, Chao Dong, Yang Tang, Liwei An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, Min Chen, Yun Zhao, Jixi Li, Steven X. Hou, Xinhua Lin, Lulu Hu, Wenbo Bu, Dianqing Wu, Lin Li, Shi Jiao & Zhaocai Zhou. (2021) An MST4‐p β ‐Catenin Thr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis . Advanced Science 8:17, pages 2004850.
Crossref
Sigita Malijauskaite, Sinead Connolly, David Newport & Kieran McGourty. (2021) Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms. Cytokine & Growth Factor Reviews 60, pages 76-88.
Crossref
Giuliana Catara, Antonino Colanzi & Daniela Spano. (2021) Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells. Frontiers in Oncology 11.
Crossref
Jennifer Raisch, Anthony Côté-Biron, Marie-Josée Langlois, Caroline Leblanc & Nathalie Rivard. (2021) Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis. Cells 10:7, pages 1792.
Crossref
Oriane Guillermin, Nikolaos Angelis, Clara M Sidor, Rachel Ridgway, Anna Baulies, Anna Kucharska, Pedro Antas, Melissa R Rose, Julia Cordero, Owen Sansom, Vivian S W Li & Barry J Thompson. (2021) Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration. The EMBO Journal 40:13.
Crossref
Shaida Ouladan & Alex Gregorieff. (2021) Taking a Step Back: Insights into the Mechanisms Regulating Gut Epithelial Dedifferentiation. International Journal of Molecular Sciences 22:13, pages 7043.
Crossref
Yuanyuan Chen, Kun Cao, Hu Liu, Tingting Liu, Lei Liu, Hongran Qin, Zebin Liao, Xuguang Hu, Bailong Li, Cong Liu, Jianming Cai, Jianguo Cui, Fu Gao & Yanyong Yang. (2021) Heat Killed Salmonella typhimurium Protects Intestine Against Radiation Injury Through Wnt Signaling Pathway. Journal of Oncology 2021, pages 1-10.
Crossref
Sanne M. van Neerven, Nina E. de Groot, Lisanne E. Nijman, Brendon P. Scicluna, Milou S. van Driel, Maria C. Lecca, Daniël O. Warmerdam, Vaishali Kakkar, Leandro F. Moreno, Felipe A. Vieira Braga, Delano R. Sanches, Prashanthi Ramesh, Sanne ten Hoorn, Arthur S. Aelvoet, Marouska F. van Boxel, Lianne Koens, Przemek M. Krawczyk, Jan Koster, Evelien Dekker, Jan Paul Medema, Douglas J. Winton, Maarten F. Bijlsma, Edward Morrissey, Nicolas Léveillé & Louis Vermeulen. (2021) Apc-mutant cells act as supercompetitors in intestinal tumour initiation. Nature 594:7863, pages 436-441.
Crossref
Ohman Kwon, Kwang Bo Jung, Kyeong-Ryoon Lee, Ye Seul SonHana Lee, Jong-Jin Kim, Kwangho Kim, Seop Lee, Yoo-Kyung Song, Jaeeun Jung, Kunhyang Park, Dae-Soo Kim, Myung Jin SonMi-Ok Lee, Tae-Su HanHyun-Soo Cho, Soo Jin OhHaeun ChungSang-Heon Kim, Kyung-Sook Chung, Janghwan Kim, Cho-Rok Jung & Mi-Young Son. (2021) The development of a functional human small intestinal epithelium model for drug absorption. Science Advances 7:23.
Crossref
Brittany R. Jenkins, Nathan A. Blaseg, Heather M. Grifka‐Walk, Benjamin Deuling, Steve D. Swain, Eric L. Campbell, Seth T. Walk & Douglas J. Kominsky. (2021) Loss of interleukin‐10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate. The FASEB Journal 35:6.
Crossref
Travis Walrath, Kiran U Dyamenahalli, Holly J Hulsebus, Rebecca L McCullough, Juan-Pablo Idrovo, Devin M Boe, Rachel H McMahan & Elizabeth J Kovacs. (2021) Age-related changes in intestinal immunity and the microbiome. Journal of Leukocyte Biology 109:6, pages 1045-1061.
Crossref
Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao & Tien C. Ko. (2021) Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery. Mediators of Inflammation 2021, pages 1-13.
Crossref
Xingming Zhao, Zhuo Han, Jiahui Ma, Shiqing Jiang & Xia Li. (2021) A Novel N-Sulfonylamidine-Based Derivative Inhibits Proliferation, Migration, and Invasion in Human Colorectal Cancer Cells by Suppressing Wnt/β-Catenin Signaling Pathway. Pharmaceutics 13:5, pages 651.
Crossref
Arnab Sarkar, Sanjukta Saha, Abhik Paul, Avik Maji, Puspita Roy & Tapan Kumar Maity. (2021) Understanding stem cells and its pivotal role in regenerative medicine. Life Sciences 273, pages 119270.
Crossref
Daniel R. Hunt, Katarina C. Klett, Shamik Mascharak, Huiyuan Wang, Diana Gong, Junzhe Lou, Xingnan Li, Pamela C. Cai, Riley A. Suhar, Julia Y. Co, Bauer L. LeSavage, Abbygail A. Foster, Yuan Guan, Manuel R. Amieva, Gary Peltz, Yan Xia, Calvin J. Kuo & Sarah C. Heilshorn. (2021) Engineered Matrices Enable the Culture of Human Patient‐Derived Intestinal Organoids. Advanced Science 8:10.
Crossref
Arie C. van Vliet, Jinhui Lee, Marlijn van der Poel, Matthew R. J. Mason, Jasprina N. Noordermeer, Lee G. Fradkin, Martijn R. Tannemaat, Martijn J. A. Malessy, Joost Verhaagen & Fred De Winter. (2021) Coordinated changes in the expression of Wnt pathway genes following human and rat peripheral nerve injury. PLOS ONE 16:4, pages e0249748.
Crossref
Fiona L. Cousins, Ronald Pandoy, Shiying Jin & Caroline E. Gargett. (2021) The Elusive Endometrial Epithelial Stem/Progenitor Cells. Frontiers in Cell and Developmental Biology 9.
Crossref
William Farnaby, Manfred Koegl, Darryl B. McConnell & Alessio Ciulli. (2021) Transforming targeted cancer therapy with PROTACs: A forward-looking perspective. Current Opinion in Pharmacology 57, pages 175-183.
Crossref
Ji-Youn Kim, Tae-Young Kim, Eui-Seon Lee, Yam Prasad Aryal, Elina Pokharel, Shijin Sung, Wern-Joo Sohn, Jae-Young Kim & Jae-Kwang Jung. (2021) Implications of the specific localization of YAP signaling on the epithelial patterning of circumvallate papilla. Journal of Molecular Histology 52:2, pages 313-320.
Crossref
Paul J. Wisniewski, Mitzi Nagarkatti & Prakash S. Nagarkatti. (2021) Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands. Frontiers in Immunology 12.
Crossref
Ester Díez-Sainz, Silvia Lorente-Cebrián, Paula Aranaz, José I. Riezu-Boj, J. Alfredo Martínez & Fermín I. Milagro. (2021) Potential Mechanisms Linking Food-Derived MicroRNAs, Gut Microbiota and Intestinal Barrier Functions in the Context of Nutrition and Human Health. Frontiers in Nutrition 8.
Crossref
Costanza Borrelli, Tomas Valenta, Kristina Handler, Karelia Vélez, Alessandra Gurtner, Giulia Moro, Atefeh Lafzi, Laura de Vargas Roditi, George Hausmann, Isabelle C. Arnold, Andreas E. Moor & Konrad Basler. (2021) Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells. Nature Communications 12:1.
Crossref
Stephen J. Gaudino, Michael Beaupre, Xun Lin, Preet Joshi, Sonika Rathi, Patrick A. McLaughlin, Cody Kempen, Neil Mehta, Onur Eskiocak, Brian Yueh, Richard S. Blumberg, Adrianus W.M. van der Velden, Kenneth R. Shroyer, Agnieszka B. Bialkowska, Semir Beyaz & Pawan Kumar. (2021) IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity. Mucosal Immunology 14:2, pages 389-401.
Crossref
Nathalie Sphyris, Michael C. Hodder & Owen J. Sansom. (2021) Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell. Cancers 13:5, pages 1000.
Crossref
Yang Zhou, Jun-Ting Cheng, Zi-Xian Feng, Ying-Ying Wang, Ying Zhang, Wen-Qi Cai, Zi-Wen Han, Xian-Wang Wang, Ying Xiang, Hui-Yu Yang, Bing-Rong Liu, Xiao-Chun Peng, Shu-Zhong Cui & Hong-Wu Xin. (2021) Could gastrointestinal tumor-initiating cells originate from cell-cell fusion in vivo ? . World Journal of Gastrointestinal Oncology 13:2, pages 92-108.
Crossref
Parag D Dabir, Rachel S Post & Iris D Nagtegaal. (2020) Incidental morphological findings in colorectal adenomas. Histopathology 78:3, pages 348-357.
Crossref
Guijuan Yu, Yang Liu, Jihong Dai, Weihao Ou, Qinghui Ai, Wenbing Zhang, Kangsen Mai & Yanjiao Zhang. (2020) Dietary daidzein improves the development of intestine subjected to soybean meal in juvenile turbot ( Scophthalmus maximus L.) . Aquaculture Nutrition 27:1, pages 17-27.
Crossref
Michal Caspi, Amnon Wittenstein, Michal Kazelnik, Yarden Shor-Nareznoy & Rina Rosin-Arbesfeld. (2021) Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders. Advanced Drug Delivery Reviews 169, pages 118-136.
Crossref
Guoli Zhu, Jiulong Hu & Rongwen Xi. (2021) The cellular niche for intestinal stem cells: a team effort. Cell Regeneration 10:1.
Crossref
Rosalie G. Hoyle, Huiqun Wang, Yana Cen, Yan Zhang & Jiong Li. (2021) IOX1 Suppresses Wnt Target Gene Transcription and Colorectal Cancer Tumorigenesis through Inhibition of KDM3 Histone Demethylases. Molecular Cancer Therapeutics 20:1, pages 191-202.
Crossref
Sampath Kumar Katakam, Valeria Tria, Wey‐Cheng Sim, George W. Yip, Stefano Molgora, Theodoros Karnavas, Eslam A. Elghonaimy, Paride Pelucchi, Eleonora Piscitelli, Sherif Abdelaziz Ibrahim, Ileana Zucchi, Rolland Reinbold, Burkhard Greve & Martin Götte. (2020) The heparan sulfate proteoglycan syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase—Wnt signaling axis. The FEBS Journal 288:2, pages 486-506.
Crossref
Joep Beumer & Hans Clevers. (2020) Cell fate specification and differentiation in the adult mammalian intestine. Nature Reviews Molecular Cell Biology 22:1, pages 39-53.
Crossref
Kyle O.C. De La Cena, Rachel X.-Y. Ho, Razie Amraei, Nick Woolf, Joseph Y. Tashjian, Qing Zhao, Sean Richards, Josh Walker, Juanni Huang, Vipul C. Chitalia & Nader Rahimi. (2021) Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells. The American Journal of Pathology 191:1, pages 157-167.
Crossref
Huimei Lu, Caiyong Ye, Jingmei Liu, Arnold B. Rabson, Michael Verzi, Subhajyoti De & Zhiyuan Shen. (2021) Requirement of Bccip for the Regeneration of Intestinal Progenitors. The American Journal of Pathology 191:1, pages 66-78.
Crossref
Chase Cockrell & Gary An. 2021. Complex Systems and Computational Biology Approaches to Acute Inflammation. Complex Systems and Computational Biology Approaches to Acute Inflammation 245 261 .
Moon Jong Kim, Yuanjian Huang & Jae-Il Park. (2020) Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views. Cancers 12:12, pages 3638.
Crossref
Laura Di Magno, Fiorella Di Pastena, Michela Puxeddu, Giuseppe La Regina, Antonio Coluccia, Alessia Ciogli, Simone Manetto, Marella Maroder, Gianluca Canettieri, Romano Silvestri & Marianna Nalli. (2020) Sulfonamide Inhibitors of β‐Catenin Signaling as Anticancer Agents with Different Output on c‐MYC. ChemMedChem 15:23, pages 2264-2268.
Crossref
Linda Zhu, Xiaoxi Lu, Li Liu, Josef Voglmeir, Xiang Zhong & Qinghua Yu. (2020) Akkermansia muciniphila protects intestinal mucosa from damage caused by S. pullorum by initiating proliferation of intestinal epithelium. Veterinary Research 51:1.
Crossref
María Álvarez-Izquierdo, J. Guillermo Esteban, Carla Muñoz-Antoli & Rafael Toledo. (2020) Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections. Parasites & Vectors 13:1.
Crossref
Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Dong-Kyu Kwak, Jaebeom Cho, Dong Woo Kang, Ho-Young Lee & Kang-Yell Choi. (2020) Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells. Cell Communication and Signaling 18:1.
Crossref
Hiroko Endo, Jumpei Kondo, Kunishige Onuma, Masayuki Ohue & Masahiro Inoue. (2020) Small subset of Wnt‐activated cells is an initiator of regrowth in colorectal cancer organoids after irradiation. Cancer Science 111:12, pages 4429-4441.
Crossref
Carlos S. Moreno. (2020) SOX4: The unappreciated oncogene. Seminars in Cancer Biology 67, pages 57-64.
Crossref
Sam O. Kleeman & Simon J. Leedham. (2020) Not All Wnt Activation Is Equal: Ligand-Dependent versus Ligand-Independent Wnt Activation in Colorectal Cancer. Cancers 12:11, pages 3355.
Crossref
Ignacio López, Eleftheria Chalatsi, Saskia I. J. Ellenbroek, Alexandra Andrieux, Pierre-François Roux, Juan P. Cerapio, Grégory Jouvion, Jacco van Rheenen, Jacob-S. Seeler & Anne Dejean. (2020) An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency. Oncogene 39:43, pages 6692-6703.
Crossref
Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Tomohiro Mizutani, Dong-Woo Kang, Jong-Chan Park, Tae Il Kim, Hans Clevers & Kang-Yell Choi. (2020) 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation. Nature Communications 11:1.
Crossref
Teng Han, Sukanya Goswami, Yang Hu, Fanying Tang, Maria Paz Zafra, Charles Murphy, Zhen Cao, John T. Poirier, Ekta Khurana, Olivier Elemento, Jaclyn F. Hechtman, Karuna Ganesh, Rona Yaeger & Lukas E. Dow. (2020) Lineage Reversion Drives WNT Independence in Intestinal Cancer. Cancer Discovery 10:10, pages 1590-1609.
Crossref
Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, Dejan Maglic, Qi Li, Basanta Gurung, Raffaele A. Calogero, Ömer H. Yilmaz, Junhao Mao & Fernando D. Camargo. (2020) Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. Cell Stem Cell 27:4, pages 590-604.e9.
Crossref
Tianfang Wang, Sang-Ho Kwon, Xiao Peng, Severine Urdy, Zefu Lu, Robert J. Schmitz, Stephen Dalton, Keith E. Mostov & Shaying Zhao. (2020) A Qualitative Change in the Transcriptome Occurs after the First Cell Cycle and Coincides with Lumen Establishment during MDCKII Cystogenesis. iScience 23:10, pages 101629.
Crossref
Kefan Bi, Xujun Zhang, Wenbiao Chen & Hongyan Diao. (2020) MicroRNAs Regulate Intestinal Immunity and Gut Microbiota for Gastrointestinal Health: A Comprehensive Review. Genes 11:9, pages 1075.
Crossref
Kana Minamide, Taku Sato, Yusuke Nakanishi, Hiroshi Ohno, Tamotsu Kato, Jumpei Asano & Toshiaki Ohteki. (2020) IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Scientific Reports 10:1.
Crossref
Neil McCarthy, Judith Kraiczy & Ramesh A. Shivdasani. (2020) Cellular and molecular architecture of the intestinal stem cell niche. Nature Cell Biology 22:9, pages 1033-1041.
Crossref
William A. Flavahan. (2020) Epigenetic plasticity, selection, and tumorigenesis. Biochemical Society Transactions 48:4, pages 1609-1621.
Crossref
Ludovica F. Buttó, Adam Pelletier, Shyam K. More, Nan Zhao, Abdullah Osme, Christopher L. Hager, Mahmoud A. Ghannoum, Rafick-Pierre Sekaly, Fabio Cominelli & Maneesh Dave. (2020) Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis. Stem Cell Reports 15:2, pages 389-407.
Crossref
Fei Chen, Yushuo Zhang, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Longxin Lin, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang & Chunlin Shao. (2020) TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation. Cell Death & Disease 11:7.
Crossref
Tomas Castro-Dopico, Aaron Fleming, Thomas W. Dennison, John R. Ferdinand, Katherine Harcourt, Benjamin J. Stewart, Zaeem Cader, Zewen K. Tuong, Chenzhi Jing, Laurence S.C. Lok, Rebeccah J. Mathews, Anaïs Portet, Arthur Kaser, Simon Clare & Menna R. Clatworthy. (2020) GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation. Cell Reports 32:1, pages 107857.
Crossref
Shuang Xie, Yuchen Li, Shiyi Zhao, Yingjun Lv & Qinghua Yu. (2020) Salmonella infection induced intestinal crypt hyperplasia through Wnt/β-catenin pathway in chicken. Research in Veterinary Science 130, pages 179-183.
Crossref
Nadine Mikuda, Ruth Schmidt‐Ullrich, Eva Kärgel, Laura Golusda, Jana Wolf, Uta E Höpken, Claus Scheidereit, Anja A Kühl & Marina Kolesnichenko. (2020) Deficiency in IκBα in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut . The Journal of Pathology 251:2, pages 160-174.
Crossref
Daniela Unterleuthner, Patrick Neuhold, Katharina Schwarz, Lukas Janker, Benjamin Neuditschko, Harini Nivarthi, Ilija Crncec, Nina Kramer, Christine Unger, Markus Hengstschläger, Robert Eferl, Richard Moriggl, Wolfgang Sommergruber, Christopher Gerner & Helmut Dolznig. (2019) Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer. Angiogenesis 23:2, pages 159-177.
Crossref
Andrew Cogswell, Natasha Ferguson & Edward Barker. (2020) Presence of Inflammatory Group I and III Innate Lymphoid Cells in the Colon of Simian Immunodeficiency Virus-Infected Rhesus Macaques. Journal of Virology 94:9.
Crossref
Toshio Takahashi. (2020) Roles of nAChR and Wnt signaling in intestinal stem cell function and inflammation. International Immunopharmacology 81, pages 106260.
Crossref
Nadja Gebert, Chia-Wei Cheng, Joanna M. Kirkpatrick, Domenico Di Fraia, Jina Yun, Patrick Schädel, Simona Pace, George B. Garside, Oliver Werz, K. Lenhard Rudolph, Henri Jasper, Ömer H. Yilmaz & Alessandro Ori. (2020) Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction. Cell Reports 31:4, pages 107565.
Crossref
Toshio Takahashi & Akira Shiraishi. (2020) Stem Cell Signaling Pathways in the Small Intestine. International Journal of Molecular Sciences 21:6, pages 2032.
Crossref
Michelle C. Coleman, Canaan Whitfield-Cargile, Noah D. Cohen, Jennifer L. Goldsby, Laurie Davidson, Ana M. Chamoun-Emanuelli, Ivan Ivanov, Susan Eades, Nancy Ing & Robert S. Chapkin. (2020) Non-invasive evaluation of the equine gastrointestinal mucosal transcriptome. PLOS ONE 15:3, pages e0229797.
Crossref
Yoon-A Kang, Eric M. Pietras & Emmanuelle Passegué. (2020) Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia. Journal of Experimental Medicine 217:3.
Crossref
Xiang Li, Maria A Ortiz & Leszek Kotula. (2020) The physiological role of Wnt pathway in normal development and cancer. Experimental Biology and Medicine 245:5, pages 411-426.
Crossref
Yaoyan Dun, Jing Chen, Jie Liu, Yuhui Guo, Changcheng Zhang & Ding Yuan. (2020) Changes of Wnt/β-catenin signalling, BMP2, and BMP4 in the jejunum during ageing in rats. Arab Journal of Gastroenterology 21:1, pages 43-48.
Crossref
Peter Yuli Xing, Sven Pettersson & Parag Kundu. (2020) Microbial Metabolites and Intestinal Stem Cells Tune Intestinal Homeostasis. PROTEOMICS 20:5-6.
Crossref
Heinrich Jasper. (2020) Intestinal Stem Cell Aging: Origins and Interventions. Annual Review of Physiology 82:1, pages 203-226.
Crossref
Michael L. Salinas, Natividad R. Fuentes, Rachel Choate, Rachel C. Wright, David N. McMurray & Robert S. Chapkin. (2020) AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity. Biophysical Journal 118:4, pages 885-897.
Crossref
Yiting Wang, Hui Cui, Si Tao, Ting Zeng, Jianying Wu, Zhendong Tao, Liu Zhang, Bing Zou, Zhiyang Chen, George B. Garside & Duozhuang Tang. (2019) High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage. Stem Cell Reviews and Reports 16:1, pages 212-221.
Crossref
Satoshi Kondo, Shota Mizuno, Tadahiro Hashita, Takahiro Iwao & Tamihide Matsunaga. (2020) Establishment of a novel culture method for maintaining intestinal stem cells derived from human induced pluripotent stem cells. Biology Open 9:1.
Crossref
Alice Behrens, Fariba Jousheghany, Aiwei Yao-Borengasser, Eric R. Siegel, Thomas Kieber-Emmons & Behjatolah Monzavi-Karbassi. (2020) Carbohydrate (Chondroitin 4) Sulfotransferase-11-Mediated Induction of Epithelial-Mesenchymal Transition and Generation of Cancer Stem Cells. Pharmacology 105:5-6, pages 246-259.
Crossref
Anita Sveen, Scott Kopetz & Ragnhild A. Lothe. (2019) Biomarker-guided therapy for colorectal cancer: strength in complexity. Nature Reviews Clinical Oncology 17:1, pages 11-32.
Crossref
Chang Li, Yuning Zhou, Piotr Rychahou, Heidi L. Weiss, Eun Y. Lee, Courtney L. Perry, Terrence A. Barrett, Qingding Wang & B. Mark Evers. (2020) SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation. Cellular and Molecular Gastroenterology and Hepatology 10:1, pages 43-57.
Crossref
Tiaosi Xing, Lesley Jasmine Benderman, Stephiya Sabu, Joel Parker, Jeffrey Yang, Qun Lu, Lei Ding & Yan-Hua Chen. (2020) Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation. Cellular and Molecular Gastroenterology and Hepatology 9:4, pages 641-659.
Crossref
Thierry Jardé, Christian M. Nefzger, Jose M. Polo & Helen E. Abud. 2020. The Stem Cell Niche during Ageing. The Stem Cell Niche during Ageing 25 40 .
Dafu Chen, Huazhi Chen, Yu Du, Zhiwei Zhu, Jie Wang, Sihai Geng, Cuiling Xiong, Yanzhen Zheng, Chunsheng Hou, Qingyun Diao & Rui Guo. (2019) Systematic identification of circular RNAs and corresponding regulatory networks unveil their potential roles in the midguts of eastern honeybee workers. Applied Microbiology and Biotechnology 104:1, pages 257-276.
Crossref
Diya Das, Russell B. Fletcher & John Ngai. (2019) Cellular mechanisms of epithelial stem cell self‐renewal and differentiation during homeostasis and repair. WIREs Developmental Biology 9:1.
Crossref
Sonal Gupta, Pradeep Tiwari, Nidhi Gupta, Vandana Nunia, Amulya K Saxena, Anita Simlot, Shanker Lal Kothari, Prashanth Suravajhala, Krishna Mohan Medicherla & Praveen Mathur. (2019) Is Pouch Specific to Colon and Not Ileum?. Current Pediatric Reviews 15:4, pages 259-264.
Crossref
Charlotte Gröschel, Maximilian Prinz-Wohlgenannt, Ildiko Mesteri, Sobha Karuthedom George, Lena Trawnicek, Denise Heiden, Abhishek Aggarwal, Samawansha Tennakoon, Maximilian Baumgartner, Christoph Gasche, Michaela Lang, Rodrig Marculescu, Teresa Manhardt, Martin Schepelmann & Enikö Kallay. (2019) Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model. Nutrients 12:1, pages 45.
Crossref
Eun Ji Ro, Yong-Hee Cho, Woo-Jeong Jeong, Jong-Chan Park, Do Sik Min & Kang-Yell Choi. (2019) WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer. Cell Communication and Signaling 17:1.
Crossref
Wei‐Chung Cheng, Tsai‐Tsen Liao, Chun‐Chi Lin, Lan‐Ting Emily Yuan, Hsin‐Yi Lan, Hung‐Hsin Lin, Hao‐Wei Teng, Hsin‐Chuan Chang, Chi‐Hung Lin, Chih‐Yung Yang, Shih‐Ching Huang, Jeng‐Kai Jiang, Shung‐Haur Yang, Muh‐Hwa Yang & Wei‐Lun Hwang. (2019) RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer. International Journal of Cancer 145:8, pages 2209-2224.
Crossref
Paul B. RomesserAmanda S. KimJeho Jeong, Allison MayleLukas E. DowScott W. Lowe. (2019) Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome. Proceedings of the National Academy of Sciences 116:41, pages 20672-20678.
Crossref
Bo Li, Carol Lee, Marissa Cadete, Haitao Zhu, Yuhki Koike, Alison Hock, Richard Y. Wu, Steven R. Botts, Adam Minich, Mashriq Alganabi, Lijun Chi, Elke Zani-Ruttenstock, Hiromu Miyake, Yong Chen, Annika Mutanen, Bo Ngan, Kathene C. Johnson-Henry, Paolo De Coppi, Simon Eaton, Pekka Määttänen, Paul Delgado-Olguin, Philip M. Sherman, Augusto Zani & Agostino Pierro. (2019) Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis. Cell Death & Disease 10:10.
Crossref
Ji Tae Kim, Chang Li, Heidi L. Weiss, Yuning Zhou, Chunming Liu, Qingding Wang & B. Mark Evers. (2019) Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells. Cells 8:9, pages 1106.
Crossref
Gian Paolo Caviglia, Chiara Rosso, Davide G. Ribaldone, Francesca Dughera, Sharmila Fagoonee, Marco Astegiano & Rinaldo Pellicano. (2019) Physiopathology of intestinal barrier and the role of zonulin. Minerva Biotecnologica 31:3.
Crossref
Sanne M. van Neerven & Louis Vermeulen. (2019) The interplay between intrinsic and extrinsic Wnt signaling in controlling intestinal transformation. Differentiation 108, pages 17-23.
Crossref
Liang Yang, Shuo Yang, Xinyu Li, Bowen Li, Yan Li, Xiaodong Zhang, Yingbo Ma, Xueqiang Peng, Hongyuan Jin, Qing Fan, Shibo Wei, Jingang Liu & Hangyu Li. (2019) Tumor organoids: From inception to future in cancer research. Cancer Letters 454, pages 120-133.
Crossref
Sara El-Sahli, Ying Xie, Lisheng Wang & Sheng Liu. (2019) Wnt Signaling in Cancer Metabolism and Immunity. Cancers 11:7, pages 904.
Crossref
Shaiya C. Robinson, Roopali Chaudhary, Rodrigo Jiménez-Saiz, Lyndsay G. A. Rayner, Luke Bayer, Manel Jordana & Juliet M. Daniel. (2019) Kaiso-induced intestinal inflammation is preceded by diminished E-cadherin expression and intestinal integrity. PLOS ONE 14:6, pages e0217220.
Crossref
Mubina A. Isani, Kristin Gee, Kathy Schall, Christopher R. Schlieve, Alexa Fode, Kathryn L. Fowler & Tracy C. Grikscheit. (2019) Wnt signaling inhibition by monensin results in a period of Hippo pathway activation during intestinal adaptation in zebrafish. American Journal of Physiology-Gastrointestinal and Liver Physiology 316:6, pages G679-G691.
Crossref
Viviana I. Torres, Juan A. Godoy & Nibaldo C. Inestrosa. (2019) Modulating Wnt signaling at the root: Porcupine and Wnt acylation. Pharmacology & Therapeutics 198, pages 34-45.
Crossref
Hui Cui, Duozhuang Tang, George B. Garside, Ting Zeng, Yiting Wang, Zhendong Tao, Liu Zhang & Si Tao. (2019) Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem Cells. Stem Cell Reviews and Reports 15:3, pages 448-455.
Crossref
Yu Usami, Aruni T Gunawardena, Noelle B Francois, Satoru Otsuru, Hajime Takano, Katsutoshi Hirose, Masatake Matsuoka, Akiko Suzuki, Jiahui Huang, Ling Qin, Masahiro Iwamoto, Wentian Yang, Satoru Toyosawa & Motomi Enomoto‐Iwamoto. (2019) Possible Contribution of Wnt‐Responsive Chondroprogenitors to the Postnatal Murine Growth Plate. Journal of Bone and Mineral Research 34:5, pages 964-974.
Crossref
Hoi Leong Xavier Wong, Hong-yan Qin, Siu Wai Tsang, Xiao Zuo, Sijia Che, Chi Fung Willis Chow, Xi Li, Hai-tao Xiao, Ling Zhao, Tao Huang, Cheng Yuan Lin, Hiu Yee Kwan, Tao Yang, Frank M. Longo, Aiping Lyu & Zhao-xiang Bian. (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10:1.
Crossref
Di Chen, Rong Xie, Bing Shu, Alan L. Landay, Changli Wei, Jochen Reiser, Anna Spagnoli, Alfonso Torquati, Christopher B. Forsyth, Ali Keshavarzian & D. Rick Sumner. (2018) Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging. Annals of the New York Academy of Sciences 1442:1, pages 48-60.
Crossref
Shunsuke Kimura, Nobuhide Kobayashi, Yutaka Nakamura, Takashi Kanaya, Daisuke Takahashi, Ryoji Fujiki, Mami Mutoh, Yuuki Obata, Toshihiko Iwanaga, Tomoo Nakagawa, Naoya Kato, Shintaro Sato, Tsuneyasu Kaisho, Hiroshi Ohno & Koji Hase. (2019) Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice. Journal of Experimental Medicine 216:4, pages 831-846.
Crossref
Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L. Wood & Steven W. Levison. (2019) Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports 12:4, pages 816-830.
Crossref
Mirjam B Zeisel, Punita Dhawan & Thomas F Baumert. (2019) Tight junction proteins in gastrointestinal and liver disease. Gut 68:3, pages 547-561.
Crossref
Kesong Peng, Lele Kou, Li Yu, Chaonan Bai, Ming Li, Pingli Mo, Wengang Li & Chundong Yu. (2019) Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice. Gastroenterology 156:4, pages 1112-1126.
Crossref
Juliusz Mieszczanek, Laurens M. van Tienen, Ashraf E. K. Ibrahim, Douglas J. Winton & Mariann Bienz. (2019) Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models. Nature Communications 10:1.
Crossref
Miguel QuirósAsma Nusrat. (2019) Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair. Annual Review of Physiology 81:1, pages 189-209.
Crossref
Stephane Thibault, Wenyue Hu, Brad Hirakawa, Dalia Kalabat, Tania Franks, Tae Sung, Su Khoh-Reiter, Shuyan Lu, Martin Finkelstein, Bart Jessen & Aida Sacaan. (2019) Intestinal Toxicity in Rats Following Administration of CDK4/6 Inhibitors Is Independent of Primary Pharmacology. Molecular Cancer Therapeutics 18:2, pages 257-266.
Crossref
Malini Menon, Richard Elliott, Leandra Bowers, Nicolae Balan, Rumana Rafiq, Sara Costa-Cabral, Felix Munkonge, Ines Trinidade, Roderick Porter, Andrew D. Campbell, Emma R. Johnson, Christina Esdar, Hans-Peter Buchstaller, Birgitta Leuthner, Felix Rohdich, Richard Schneider, Owen Sansom, Dirk Wienke, Alan Ashworth & Christopher J. Lord. (2019) A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Scientific Reports 9:1.
Crossref
Yetis Gultekin & Hermann Steller. (2019) Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila . Development.
Crossref
Zhi Yang, Shuai Jiang, Chenxi Lu, Ting Ji, Wenwen Yang, Tian Li, Jianjun Lv, Wei Hu, Yang Yang & Zhenxiao Jin. (2019) SOX11: friend or foe in tumor prevention and carcinogenesis?. Therapeutic Advances in Medical Oncology 11, pages 175883591985344.
Crossref
Louis R. Parham, Patrick A. Williams, Priya Chatterji, Kelly A. Whelan & Kathryn E. Hamilton. (2019) RNA regulons are essential in intestinal homeostasis. American Journal of Physiology-Gastrointestinal and Liver Physiology 316:1, pages G197-G204.
Crossref
Shixiong Jiang, Dazhuang Miao, Muhong Wang, Jiachen Lv, Yihui Wang & Jinxue Tong. (2019) MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/β-catenin signaling axis. Journal of Cellular and Molecular Medicine 23:1, pages 630-640.
Crossref
Felipe de Sousa e Melo & Frederic J. de Sauvage. (2019) Cellular Plasticity in Intestinal Homeostasis and Disease. Cell Stem Cell 24:1, pages 54-64.
Crossref
Fulvio Chiacchiera. 2019. Epigenetics and Regeneration. Epigenetics and Regeneration 259 286 .
Michal Hershfinkel, Johnny Iv & Shannon L. Kelleher. 2019. Zinc Signaling. Zinc Signaling 347 363 .
Younggeon Jin, Dina Ibrahim, Scott T. Magness & Anthony T. Blikslager. (2018) Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity. American Journal of Physiology-Gastrointestinal and Liver Physiology 315:6, pages G966-G979.
Crossref
Shujie Jiao, Yaling Liu, Yaobing Yao & Junfang Teng. (2018) miR-124 promotes proliferation and neural differentiation of neural stem cells through targeting DACT1 and activating Wnt/β-catenin pathways. Molecular and Cellular Biochemistry 449:1-2, pages 305-314.
Crossref
Hao ZengBo LuRaffaella ZamponiZinger YangKristie WetzelJoseph Loureiro, Sina MohammadiMartin Beibel, Sebastian Bergling, John Reece-HoyesCarsten RussGuglielmo Roma, Jan S. Tchorz, Paola CapodieciFeng Cong. (2018) mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level. Proceedings of the National Academy of Sciences 115:44.
Crossref
Nicola Tempest, Alison Maclean & Dharani Hapangama. (2018) Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions. International Journal of Molecular Sciences 19:10, pages 3240.
Crossref
Santosh Kumar, Shubhankar Suman, Albert J. FornaceJr.Jr. & Kamal Datta. (2018) Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine. Proceedings of the National Academy of Sciences 115:42.
Crossref
Pragyan Acharya, Rintu Kutum, Rajesh Pandey, Asha Mishra, Rohini Saha, Akshay Munjal, Vineet Ahuja, Mitali Mukerji & Govind K. Makharia. (2018) First Degree Relatives of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect them from Enterocyte Damage. Clinical and Translational Gastroenterology 9:10, pages e195.
Crossref
Zhanyao Tan, Libing Song, Wenjiao Wu, Yanqing Zhou, Jinrong Zhu, Geyan Wu, Lixue Cao, Junwei Song, Jun Li & Wei Zhang. (2018) TRIM14 promotes chemoresistance in gliomas by activating Wnt/β-catenin signaling via stabilizing Dvl2. Oncogene 37:40, pages 5403-5415.
Crossref
Madhurima Das & Sujata Law. (2018) Role of tumor microenvironment in cancer stem cell chemoresistance and recurrence. The International Journal of Biochemistry & Cell Biology 103, pages 115-124.
Crossref
Pandurangan Ashokkumar, Thomas Divya, Kalaivani Kumar, Vadivel Dineshbabu, Bakthavatchalam Velavan & Ganapasam Sudhandiran. (2018) Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review. World Journal of Gastrointestinal Oncology 10:9, pages 244-259.
Crossref
Stephanie Jaeckel, Markus Kaller, Rene Jackstadt, Ursula Götz, Susanna Müller, Sophie Boos, David Horst, Peter Jung & Heiko Hermeking. (2018) Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells. Nature Communications 9:1.
Crossref
William McAlpine, Kuan-wen Wang, Jin Huk Choi, Miguel San Miguel, Sarah Grace McAlpine, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Xiaoming Zhan, Mihwa Choi, Tao Wang, Chun Hui Bu, Anne R. Murray, Eva Marie Y. Moresco, Emre E. Turer & Bruce Beutler. (2018) The class I myosin MYO1D binds to lipid and protects against colitis. Disease Models & Mechanisms 11:9.
Crossref
Maureen Spit, Bon-Kyoung Koo & Madelon M. Maurice. (2018) Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer. Open Biology 8:9.
Crossref
Zahra Kabiri, Gediminas Greicius, Hamed Zaribafzadeh, Amanda Hemmerich, Christopher M. Counter & David M. Virshup. (2018) Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells. Journal of Clinical Investigation 128:9, pages 3806-3812.
Crossref
Jeffrey A. Rappaport & Scott A. Waldman. (2018) The Guanylate Cyclase C—cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. Frontiers in Oncology 8.
Crossref
Johanne Davidsen, Sylvester Larsen, Mehmet Coskun, Ismail Gögenur, Katja Dahlgaard, Eric Paul Bennett & Jesper Thorvald Troelsen. (2018) The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2. PLOS ONE 13:7, pages e0200215.
Crossref
Kesong Peng, Guoqiang Su, Jinmeng Ji, Xiaojia Yang, Mengmeng Miao, Pingli Mo, Ming Li, Jianming Xu, Wengang Li & Chundong Yu. (2018) Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/β-catenin signaling. Journal of Biological Chemistry 293:27, pages 10606-10619.
Crossref
Huicong Li, Yali Ma, Baoping Chen & Jun Shi. (2018) miR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/β-catenins pathway. European Journal of Pharmacology 831, pages 20-27.
Crossref
Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa & Antony Wilks Burgess. (2018) Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts. PLOS ONE 13:6, pages e0199412.
Crossref
Zachary Steinhart & Stephane Angers. (2018) Wnt signaling in development and tissue homeostasis. Development 145:11.
Crossref
Bahar Degirmenci, Tomas Valenta, Slavica Dimitrieva, George Hausmann & Konrad Basler. (2018) GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Nature 558:7710, pages 449-453.
Crossref
Brooks Emerick, Gilberto Schleiniger & Bruce M. Boman. (2018) Multi-scale modeling of APC and $$\beta $$β-catenin regulation in the human colonic crypt. Journal of Mathematical Biology 76:7, pages 1797-1830.
Crossref
Youhei Mantani, Miho Nishida, Kyouji Yamamoto, Kazuki Miyamoto, Hideto Yuasa, Natsumi Masuda, Takuya Omotehara, Hiroki Tsuruta, Toshifumi Yokoyama, Nobuhiko Hoshi & Hiroshi Kitagawa. (2018) Ultrastructural and Immunohistochemical Study on the Lamina Propria Cells Beneath Paneth Cells in the Rat Ileum. The Anatomical Record 301:6, pages 1074-1085.
Crossref
Stéphanie Bussières-Marmen, Valérie Vinette, Jeremy Gungabeesoon, Isabelle Aubry, Luis Alberto Pérez-Quintero & Michel L Tremblay. (2017) Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation. Cellular & Molecular Immunology 15:4, pages 367-376.
Crossref
Gurpreet Kaur, Praveen Sharma, Nilambra Dogra & Sandeep Singh. (2018) Eradicating Cancer Stem Cells: Concepts, Issues, and Challenges. Current Treatment Options in Oncology 19:4.
Crossref
Fredrik E.O. Holmberg, Jannie Pedersen, Peter Jørgensen, Christoffer Soendergaard, Kim B. Jensen & Ole H. Nielsen. (2017) Intestinal barrier integrity and inflammatory bowel disease: Stem cell‐based approaches to regenerate the barrier. Journal of Tissue Engineering and Regenerative Medicine 12:4, pages 923-935.
Crossref
Ai Tian, Hassina Benchabane & Yashi Ahmed. (2018) Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective. Journal of Developmental Biology 6:2, pages 8.
Crossref
Jessica Perochon, Lynsey Carroll & Julia Cordero. (2018) Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies. Genes 9:3, pages 138.
Crossref
Curtis A. Thorne, Ina W. Chen, Laura E. Sanman, Melanie H. Cobb, Lani F. Wu & Steven J. Altschuler. (2018) Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Developmental Cell 44:5, pages 624-633.e4.
Crossref
William Hankey, Wendy L. Frankel & Joanna Groden. (2018) Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting. Cancer and Metastasis Reviews 37:1, pages 159-172.
Crossref
Antoine Gleizes, Vincent Cavaillès & Marion Lapierre. 2018. Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics. Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics.
Alistair J. Langlands, Thomas D. Carroll, Yu Chen & Inke Näthke. (2018) Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells. Cell Death & Disease 9:3.
Crossref
Feihong Deng, Liang Peng, Zhijun Li, Gao Tan, Erbo Liang, Shengbo Chen, Xinmei Zhao & Fachao Zhi. (2018) YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury. Cell Death & Disease 9:2.
Crossref
William Hankey, Michael A. McIlhatton, Kenechi Ebede, Brian Kennedy, Baris Hancioglu, Jie Zhang, Guy N. Brock, Kun Huang & Joanna Groden. (2018) Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients. Cancer Research 78:3, pages 617-630.
Crossref

Displaying 200 of 447 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.