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Molecular and Cellular Biology Volume 30, 2010 - Issue 11
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Article

The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function

Foon Wu-BaerInstitute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York10032
,
Thomas LudwigInstitute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York10032
&
Richard BaerInstitute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York10032Correspondence[email protected]
Pages 2787-2798 | Received 09 Aug 2009, Accepted 21 Mar 2010, Published online: 20 Mar 2023

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Danae Fonseca, Jorge Baquero, Michael R. Murphy, Gamage Aruggoda, Sophia Varriano, Carmen Sapienza, Oksana Mashadova, Shadaqur Rahman & Frida E. Kleiman. (2018) mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response. Molecular and Cellular Biology 38:4.
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Sanam Sane, Rekha Srinivasan, Rashaun A. Potts, Morgan Eikanger, Diana Zagirova, Jessica Freeling, Casey A. Reihe, Ryan M. Antony, Brij K. Gupta, Douglas Lynch, Jonathan Bleeker, Hassan Turaihi, Angela Pillatzki, Wei Zhou, Xu Luo, Michael Linnebacher, Diing Agany, Etienne Gnimpieba Zohim, Lisa E. Humphrey, Adrian R. Black & Khosrow Rezvani. (2023) UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer. Oncogene 42:21, pages 1763-1776.
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Xiu Yin, Qingbin Liu, Fen Liu, Xinchen Tian, Tinghao Yan, Jie Han & Shulong Jiang. (2022) Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis. Frontiers in Cell and Developmental Biology 10.
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Jong Jin Oh, Jin-Nyoung Ho & Seok-Soo Byun. (2021) ARRDC4 and UBXN1: Novel Target Genes Correlated with Prostate Cancer Gleason Score. Cancers 13:20, pages 5209.
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Loretta Giummarra Vocale, Sheila Crewther, Nina Riddell, Nathan E. Hall, Melanie Murphy & David Crewther. (2021) RNA-seq and GSEA identifies suppression of ligand-gated chloride efflux channels as the major gene pathway contributing to form deprivation myopia. Scientific Reports 11:1.
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Fabin Dang, Li Nie & Wenyi Wei. (2020) Ubiquitin signaling in cell cycle control and tumorigenesis. Cell Death & Differentiation 28:2, pages 427-438.
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Rui-Xue Huang & Ping-Kun Zhou. (2020) DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transduction and Targeted Therapy 5:1.
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Dharjath Shahul Hameed, Gabrielle B. A. van Tilburg, Remco Merkx, Dennis Flierman, Hans Wienk, Farid El Oualid, Kay Hofmann, Rolf Boelens & Huib Ovaa. (2020) Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1. Frontiers in Chemistry 7.
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Josef Gladitz, Barbara Klink & Michael Seifert. (2018) Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion. Acta Neuropathologica Communications 6:1.
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Isabelle Cusin, Daniel Teixeira, Monique Zahn-Zabal, Valentine Rech de Laval, Anne Gleizes, Valeria Viassolo, Pierre O. Chappuis, Pierre Hutter, Amos Bairoch & Pascale Gaudet. (2018) A new bioinformatics tool to help assess the significance of BRCA1 variants. Human Genomics 12:1.
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Shotaro Uchida, Ryo Horie, Hiroki Sato, Chieko Kai & Misako Yoneda. (2018) Possible role of the Nipah virus V protein in the regulation of the interferon beta induction by interacting with UBX domain-containing protein1. Scientific Reports 8:1.
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Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner & Petra Beli. (2018) Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function. EMBO reports 19:4.
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Matin Asghari, Mohammad Foad Abazari, Hanieh Bokharaei, Maryam Nouri Aleagha, Vahdat Poortahmasebi, Hassan Askari, Sepehr Torabinejad, Abbas Ardalan, Navid Negaresh, Atousa Ataei, Parisa Pazooki & Mansour Poorebrahim. (2018) Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer. Future Science OA 4:3, pages FSO278.
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Lasse StachPaul S. Freemont. (2017) The AAA+ ATPase p97, a cellular multitool. Biochemical Journal 474:17, pages 2953-2976.
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Yani Hu, Kaitlin O’Boyle, Jim Auer, Sagar Raju, Fuping You, Penghua Wang, Erol Fikrig & Richard E. Sutton. (2017) Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. PLOS Pathogens 13:2, pages e1006187.
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Takeshi Ohsawa, Shota Fujimoto, Akane Tsunakawa, Yuka Shibano, Hideki Kawasaki & Masashi Iwanaga. (2016) Cloning and characterization of carboxyl terminus of heat shock cognate 70-interacting protein gene from the silkworm, Bombyx mori. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 201, pages 29-36.
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Khosrow Rezvani. (2016) UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer. International Journal of Molecular Sciences 17:10, pages 1724.
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Jan B. Heidelberger, Sebastian A. Wagner & Petra Beli. (2016) Mass Spectrometry-Based Proteomics for Investigating DNA Damage-Associated Protein Ubiquitylation. Frontiers in Genetics 7.
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Carlos A. Castañeda, Emma K. Dixon, Olivier Walker, Apurva Chaturvedi, Mark A. Nakasone, Joseph E. Curtis, Megan R. Reed, Susan Krueger, T. Ashton Cropp & David Fushman. (2016) Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins. Structure 24:3, pages 423-436.
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Carlos A. Castañeda, Apurva Chaturvedi, Christina M. Camara, Joseph E. Curtis, Susan Krueger & David Fushman. (2016) Linkage-specific conformational ensembles of non-canonical polyubiquitin chains. Physical Chemistry Chemical Physics 18:8, pages 5771-5788.
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Yanfen Teng, Khosrow Rezvani & Mariella De Biasi. (2015) UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. Biochemical Pharmacology 97:4, pages 518-530.
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Ammara Abdullah, Sanam Sane, Kate A. Branick, Jessica L. Freeling, Hongmin Wang, Dong Zhang & Khosrow Rezvani. (2015) A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget 6:27, pages 23561-23581.
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Yu-Bo Wang, Bo Tan, Rui Mu, Yan Chang, Min Wu, Hai-Qing Tu, Yu-Cheng Zhang, Sai-Sai Guo, Xuan-He Qin, Tao Li, Wei-Hua Li, Ai-Ling Li, Xue-Min Zhang & Hui-Yan Li. (2015) Ubiquitin-associated Domain-containing Ubiquitin Regulatory X (UBX) Protein UBXN1 Is a Negative Regulator of Nuclear Factor κB (NF-κB) Signaling. Journal of Biological Chemistry 290:16, pages 10395-10405.
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Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian & Michelle Letarte. (2014) Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks. Molecular & Cellular Proteomics 13:2, pages 489-502.
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Xiaozhen Wang, Guang Lu, Li Li, Juan Yi, Kaowen Yan, Yaqing Wang, Baili Zhu, Jingyu Kuang, Ming Lin, Sha Zhang & Genze Shao. (2014) HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin–proteasome pathway. Biochemical and Biophysical Research Communications 444:4, pages 549-554.
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Xiaozhen Wang, Guang Lu, Li Li, Juan Yi, Kaowen Yan, Yaqing Wang, Baili Zhu, Jingyu Kuang, Ming Lin, Sha Zhang & Genze Shao. (2014) HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin–proteasome pathway. Biochemical and Biophysical Research Communications 444:3, pages 290-295.
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S Shabbeer, D Omer, D Berneman, O Weitzman, A Alpaugh, A Pietraszkiewicz, S Metsuyanim, A Shainskaya, M Z Papa & R I Yarden. (2012) BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation. Oncogene 32:42, pages 5005-5016.
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Penghua Wang, Long Yang, Gong Cheng, Guang Yang, Zhengyun Xu, Fuping You, Qiang Sun, Rongtuan Lin, Erol Fikrig & Richard E. Sutton. (2013) UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVS. Cell Reports 3:4, pages 1057-1070.
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Yogesh Kulathu & David Komander. (2012) Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. Nature Reviews Molecular Cell Biology 13:8, pages 508-523.
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Bram Stynen, Hélène Tournu, Jan Tavernier & Patrick Van Dijck. (2012) Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System . Microbiology and Molecular Biology Reviews 76:2, pages 331-382.
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Eric R. Strieter & David A. Korasick. (2012) Unraveling the Complexity of Ubiquitin Signaling. ACS Chemical Biology 7:1, pages 52-63.
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Tomohiko Ohta, Ko Sato & Wenwen Wu. (2011) The BRCA1 ubiquitin ligase and homologous recombination repair. FEBS Letters 585:18, pages 2836-2844.
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Ariel G. Herman, Miki Hayano, Masha V. Poyurovsky, Kenichi Shimada, Rachid Skouta, Carol Prives & Brent R. Stockwell. (2011) Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay. Cancer Discovery 1:4, pages 312-325.
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David P. LaLonde & Anthony Bretscher. (2011) The UBX Protein SAKS1 Negatively Regulates Endoplasmic Reticulum-associated Degradation and p97-dependent Degradation. Journal of Biological Chemistry 286:6, pages 4892-4901.
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Apichart Atipairin, Bhutorn Canyuk & Adisorn Ratanaphan. (2010) The RING heterodimer BRCA1–BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs. Breast Cancer Research and Treatment 126:1, pages 203-209.
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Apichart Atipairin, Bhutorn Canyuk & Adisorn Ratanaphan. (2010) Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature. JBIC Journal of Biological Inorganic Chemistry 16:2, pages 217-226.
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Apichart AtipairinAdisorn Ratanaphan. (2011) In Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein. Breast Cancer: Basic and Clinical Research 5, pages BCBCR.S8184.
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