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Molecular and Cellular Biology Volume 30, 2010 - Issue 8
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Article

Competing Upstream 5′ Splice Sites Enhance the Rate of Proximal Splicing

Martin J. HicksDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California92697-4025
,
William F. MuellerDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California92697-4025
,
Peter J. ShepardDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California92697-4025
&
Klemens J. HertelDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California92697-4025Correspondence[email protected]
Pages 1878-1886 | Received 11 Aug 2009, Accepted 22 Jan 2010, Published online: 20 Mar 2023

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Přemysl Souček, Kamila Réblová, Michal Kramárek, Lenka Radová, Tereza Grymová, Pavla Hujová, Tatiana Kováčová, Matej Lexa, Lucie Grodecká & Tomáš Freiberger. (2019) High-throughput analysis revealed mutations’ diverging effects on SMN1 exon 7 splicing. RNA Biology 16:10, pages 1364-1376.
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Terry S. Elton, Victor A. Hernandez, Jessika Carvajal-Moreno, Xinyi Wang, Deborah Ipinmoroti & Jack C. Yalowich. (2022) Intronic Polyadenylation in Acquired Cancer Drug Resistance Circumvented by Utilizing CRISPR/Cas9 with Homology-Directed Repair: The Tale of Human DNA Topoisomerase IIα. Cancers 14:13, pages 3148.
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Victor A. Hernandez, Jessika Carvajal-Moreno, Xinyi Wang, Maciej Pietrzak, Jack C. Yalowich & Terry S. Elton. (2022) Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5’ splice site: Generation of etoposide resistance in human leukemia K562 cells. PLOS ONE 17:5, pages e0265794.
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Namjeong Choi, Yongchao Liu, Jagyeong Oh, Jiyeon Ha, Claudia Ghigna, Xuexiu Zheng & Haihong Shen. (2021) Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA. BMB Reports 54:3, pages 176-181.
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Victor A. Hernandez, Jessika Carvajal-Moreno, Jonathan L. Papa, Nicholas Shkolnikov, Junan Li, Hatice Gulcin Ozer, Jack C. Yalowich & Terry S. Elton. (2021) CRISPR/Cas9 Genome Editing of the Human Topoisomerase II α Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells . Molecular Pharmacology 99:3, pages 226-241.
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Susan E Liao & Oded Regev. (2021) Splicing at the phase-separated nuclear speckle interface: a model. Nucleic Acids Research 49:2, pages 636-645.
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Hossein Shenasa & Klemens J. Hertel. (2019) Combinatorial regulation of alternative splicing. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862:11-12, pages 194392.
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Johannes Ptok, Lisa Müller, Stephan Theiss & Heiner Schaal. (2019) Context matters: Regulation of splice donor usage. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862:11-12, pages 194391.
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Martin Mikl, Amit Hamburg, Yitzhak Pilpel & Eran Segal. (2019) Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries. Nature Communications 10:1.
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Asaf Shilo, Frances Anne Tosto, Jason W Rausch, Stuart F J Le Grice & Tom Misteli. (2019) Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome. Nucleic Acids Research 47:11, pages 5922-5935.
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Leonhard Wachutka, Livia Caizzi, Julien Gagneur & Patrick Cramer. (2019) Global donor and acceptor splicing site kinetics in human cells. eLife 8.
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Kenji Ohe, Shinsuke Miyajima, Tomoko Tanaka, Yuriko Hamaguchi, Yoshihiro Harada, Yuta Horita, Yuki Beppu, Fumiaki Ito, Takafumi Yamasaki, Hiroki Terai, Masayoshi Mori, Yusuke Murata, Makito Tanabe, Ichiro Abe, Kenji Ashida, Kunihisa Kobayashi, Munechika Enjoji, Takashi Nomiyama, Toshihiko Yanase, Nobuhiro Harada, Toshiaki Utsumi & Akila Mayeda. (2018) HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5′ Splice Site. Frontiers in Molecular Biosciences 5.
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Athma A Pai, Telmo Henriques, Kayla McCue, Adam Burkholder, Karen Adelman & Christopher B Burge. (2017) The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture. eLife 6.
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Wei Liu, Xia Li, Shengjie Liao, Kefeng Dou & Yi Zhang. (2017) Activation of the intronic cryptic 5′ splice site depends on its distance to the upstream cassette exon. Gene 619, pages 30-36.
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Tiing Jen Loh, Namjeong Choi, Heegyum Moon, Ha Na Jang, Yongchao Liu, Jianhua Zhou, Xuexiu Zheng & Haihong Shen. (2017) Suppression of 5′ splice-sites through multiple exonic motifs by hnRNP L. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1860:3, pages 363-373.
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Matthew R. Gazzara, Jorge Vaquero-Garcia, Kristen W. Lynch & Yoseph Barash. (2014) In silico to in vivo splicing analysis using splicing code models. Methods 67:1, pages 3-12.
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William F. Mueller & Klemens J. Hertel. 2014. Spliceosomal Pre-mRNA Splicing. Spliceosomal Pre-mRNA Splicing 161 168 .
Jian Zhang & James L. Manley. (2013) Misregulation of Pre-mRNA Alternative Splicing in Cancer. Cancer Discovery 3:11, pages 1228-1237.
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Amy Pandya-Jones, Dev M. Bhatt, Chia-Ho Lin, Ann-Jay Tong, Stephen T. Smale & Douglas L. Black. (2013) Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression. RNA 19:6, pages 811-827.
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Xavier Roca, Adrian R. Krainer & Ian C. Eperon. (2013) Pick one, but be quick: 5′ splice sites and the problems of too many choices. Genes & Development 27:2, pages 129-144.
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Senthilkumar Sivanesan, Matthew Howell, Christine DiDonato & Ravindra Singh. (2013) Antisense oligonucleotide mediated therapy of spinal muscular atrophy. Translational Neuroscience 4:1, pages 1-7.
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Steffen Erkelenz, William F. Mueller, Melanie S. Evans, Anke Busch, Katrin Schöneweis, Klemens J. Hertel & Heiner Schaal. (2013) Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms. RNA 19:1, pages 96-102.
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Erming Wang, Vahid Aslanzadeh, Filomena Papa, Haiyan Zhu, Pierre de la Grange & Franca Cambi. (2012) Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F. PLoS ONE 7:12, pages e51266.
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M. J. Hodson, A. J. Hudson, D. Cherny & I. C. Eperon. (2012) The transition in spliceosome assembly from complex E to complex A purges surplus U1 snRNPs from alternative splice sites. Nucleic Acids Research 40:14, pages 6850-6862.
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A. Farlow, M. Dolezal, L. Hua & C. Schlotterer. (2011) The Genomic Signature of Splicing-Coupled Selection Differs between Long and Short Introns. Molecular Biology and Evolution 29:1, pages 21-24.
Crossref
Umasuthan Srirangalingam & Shern L. Chew. 2012. Exon Skipping. Exon Skipping 3 16 .
Peter J. Shepard, Eun-A. Choi, Anke Busch & Klemens J. Hertel. (2011) Efficient internal exon recognition depends on near equal contributions from the 3′ and 5′ splice sites. Nucleic Acids Research 39:20, pages 8928-8937.
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Angela N. Brooks, Julie L. Aspden, Anna I. Podgornaia, Donald C. Rio & Steven E. Brenner. (2011) Identification and experimental validation of splicing regulatory elements in Drosophila melanogaster reveals functionally conserved splicing enhancers in metazoans . RNA 17:10, pages 1884-1894.
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Jana Kralovicova, Gyulin Hwang, A. Charlotta Asplund, Alexander Churbanov, C. I. Edvard Smith & Igor Vorechovsky. (2011) Compensatory signals associated with the activation of human GC 5′ splice sites. Nucleic Acids Research 39:16, pages 7077-7091.
Crossref

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