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Article

SR Proteins Induce Alternative Exon Skipping through Their Activities on the Flanking Constitutive Exons

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Pages 793-802 | Received 23 Sep 2010, Accepted 29 Nov 2010, Published online: 20 Mar 2023

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Gesine Goldammer, Alexander Neumann, Miriam Strauch, Michaela Müller-McNicoll, Florian Heyd & Marco Preußner. (2018) Characterization of cis-acting elements that control oscillating alternative splicing. RNA Biology 15:8, pages 1081-1092.
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Audrey-Ann Dumont, Lauralyne Dumont, Jonathan Berthiaume & Mannix Auger-Messier. (2019) p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:12, pages 118557.
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Patricia P. Coltri, Maria G.P. dos Santos & Guilherme H.G. da Silva. (2019) Splicing and cancer: Challenges and opportunities. WIREs RNA 10:3.
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Yang Liang, Toma Tebaldi, Kai Rejeski, Poorval Joshi, Giovanni Stefani, Ashley Taylor, Yuanbin Song, Radovan Vasic, Jamie Maziarz, Kunthavai Balasubramanian, Anastasia Ardasheva, Alicia Ding, Alessandro Quattrone & Stephanie Halene. (2018) SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells. Leukemia 32:12, pages 2659-2671.
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Beatrix Suess, Katrin Kemmerer & Julia E. Weigand. 2018. Synthetic Biology. Synthetic Biology 131 168 .
Jieqiong Zhou, Guozhen Gao, Panpan Hou, Chun‐Mei Li & Deyin Guo. (2017) Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2. Journal of Cellular Biochemistry 118:11, pages 4020-4032.
Crossref
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Crossref
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Crossref
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Crossref
Heidi Dvinge, Eunhee Kim, Omar Abdel-Wahab & Robert K. Bradley. (2016) RNA splicing factors as oncoproteins and tumour suppressors. Nature Reviews Cancer 16:7, pages 413-430.
Crossref
Michaela Müller-McNicoll, Valentina Botti, Antonio M. de Jesus Domingues, Holger Brandl, Oliver D. Schwich, Michaela C. Steiner, Tomaz Curk, Ina Poser, Kathi Zarnack & Karla M. Neugebauer. (2016) SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export. Genes & Development 30:5, pages 553-566.
Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Jonathan M. Howard & Jeremy R. Sanford. (2015) The RNAissance family: SR proteins as multifaceted regulators of gene expression. Wiley Interdisciplinary Reviews: RNA 6:1, pages 93-110.
Crossref
Supriya Sen, Magda Langiewicz, Hassan Jumaa & Nicholas J.G. Webster. (2014) Deletion of serine/arginine‐rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology 61:1, pages 171-183.
Crossref
Shafiul Alam, Hitoshi Suzuki & Toshifumi Tsukahara. (2014) Alternative splicing regulation of APP exon 7 by RBFox proteins. Neurochemistry International 78, pages 7-17.
Crossref
Xiang-Dong Fu & Manuel AresJrJr. (2014) Context-dependent control of alternative splicing by RNA-binding proteins. Nature Reviews Genetics 15:10, pages 689-701.
Crossref
Minna-Liisa Änkö. (2014) Regulation of gene expression programmes by serine–arginine rich splicing factors. Seminars in Cell & Developmental Biology 32, pages 11-21.
Crossref
Magdalena M Maslon, Sara R Heras, Nicolas Bellora, Eduardo Eyras & Javier F Cáceres. (2014) The translational landscape of the splicing factor SRSF1 and its role in mitosis. eLife 3.
Crossref
Xuexia Zhou, Wenwu Wu, Huang Li, Yuanming Cheng, Ning Wei, Jie Zong, Xiaoyan Feng, Zhiqin Xie, Dai Chen, James L. Manley, Hui Wang & Ying Feng. (2022) Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Research 42:6, pages 4019-4030.
Crossref
Chao Huang, Wenwen Cao, Rujia Liao, Jia Wang, Yuzhe Wang, Lijuan Tong, Xiangfan Chen, Weizhong Zhu & Wei Zhang. (2014) PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF. American Journal of Physiology-Cell Physiology 306:2, pages C167-C177.
Crossref
Natasha G. Caminsky, Eliseos J. Mucaki & Peter K. Rogan. (2015) Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis. F1000Research 3, pages 282.
Crossref
Natasha G. Caminsky, Eliseos J. Mucaki & Peter K. Rogan. (2014) Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis. F1000Research 3, pages 282.
Crossref
Antoine CléryRahul SinhaOlga AnczukówAnna Corrionero, Ahmed MoursyGerrit M. DaubnerJuan Valcárcel, Adrian R. KrainerFrédéric H.-T. Allain. (2013) Isolated pseudo–RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition. Proceedings of the National Academy of Sciences 110:30.
Crossref
Zhihong Zhou & Xiang-Dong Fu. (2013) Regulation of splicing by SR proteins and SR protein-specific kinases. Chromosoma 122:3, pages 191-207.
Crossref
Shatakshi Pandit, Yu Zhou, Lily Shiue, Gabriela Coutinho-Mansfield, Hairi Li, Jinsong Qiu, Jie Huang, Gene W. Yeo, Manuel AresJr.Jr. & Xiang-Dong Fu. (2013) Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing. Molecular Cell 50:2, pages 223-235.
Crossref
Michal Cohen-Eliav, Regina Golan-Gerstl, Zahava Siegfried, Claus L Andersen, Kasper Thorsen, Torben F Ørntoft, David Mu & Rotem Karni. (2013) The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers. The Journal of Pathology 229:4, pages 630-639.
Crossref
Laura De Conti, Marco Baralle & Emanuele Buratti. (2013) Exon and intron definition in pre-mRNA splicing. Wiley Interdisciplinary Reviews: RNA 4:1, pages 49-60.
Crossref
Madapura M. Pradeepa, Heidi G. Sutherland, Jernej Ule, Graeme R. Grimes & Wendy A. Bickmore. (2012) Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing. PLoS Genetics 8:5, pages e1002717.
Crossref
Hong Ki Song, Seong-Eui Hong, Taeyong Kim & Do Han Kim. (2012) Deep RNA Sequencing Reveals Novel Cardiac Transcriptomic Signatures for Physiological and Pathological Hypertrophy. PLoS ONE 7:4, pages e35552.
Crossref
Rui Xiao, Peng Tang, Bo Yang, Jie Huang, Yu Zhou, Changwei Shao, Hairi Li, Hui Sun, Yi Zhang & Xiang-Dong Fu. (2012) Nuclear Matrix Factor hnRNP U/SAF-A Exerts a Global Control of Alternative Splicing by Regulating U2 snRNP Maturation. Molecular Cell 45:5, pages 656-668.
Crossref
Mingyang Zhang, Haiyan Shan, Zhenyong Gu, Donglin Wang, Tao Wang, Zhiwei Wang & Luyang Tao. (2011) Increased Expression of Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta after Rat Traumatic Brain Injury. Journal of Molecular Neuroscience 46:3, pages 631-643.
Crossref
J. P. Venables, E. Vignal, S. Baghdiguian, P. Fort & J. Tazi. (2011) Tissue-Specific Alternative Splicing of Tak1 Is Conserved in Deuterostomes. Molecular Biology and Evolution 29:1, pages 261-269.
Crossref
Naama Sebbag-Sznajder, Oleg Raitskin, Minna Angenitzki, Taka-Aki Sato, Joseph Sperling & Ruth Sperling. (2012) Regulation of alternative splicing within the supraspliceosome. Journal of Structural Biology 177:1, pages 152-159.
Crossref
Auinash Kalsotra & Thomas A. Cooper. (2011) Functional consequences of developmentally regulated alternative splicing. Nature Reviews Genetics 12:10, pages 715-729.
Crossref
Joonhee Han, Ji Xiong, Dong Wang & Xiang-Dong Fu. (2011) Pre-mRNA splicing: where and when in the nucleus. Trends in Cell Biology 21:6, pages 336-343.
Crossref

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