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Molecular and Cellular Biology Volume 35, 2015 - Issue 7
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Article

Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae

Wataru NomuraLaboratory of Molecular Microbiology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
&
Yoshiharu InoueLaboratory of Molecular Microbiology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, JapanCorrespondence[email protected]
Pages 1269-1280 | Received 02 Sep 2014, Accepted 18 Jan 2015, Published online: 20 Mar 2023

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Wataru Nomura & Yoshiharu Inoue. (2019) Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae . Small GTPases 10:6, pages 449-455.
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Ming-Hua Wu, Qin Yu, Tian-Yi Tao, Li-Xiao Sun, Hui Qian, Xue-Ming Zhu, Lin Li, Shuang Liang, Jian-Ping Lu, Fu-Cheng Lin & Xiao-Hong Liu. (2022) Genome-Wide Analysis of AGC Kinases Reveals that MoFpk1 Is Required for Development, Lipid Metabolism, and Autophagy in Hyperosmotic Stress of the Rice Blast Fungus Magnaporthe oryzae. mBio 13:6.
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Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto & Yoshiharu Inoue. (2022) Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes. Biochemical Journal 479:21, pages 2279-2296.
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Fellipe da Silveira Bezerra de Mello, Alessandro Luis Venega Coradini, Marcelo Falsarella Carazzolle, Carla Maneira, Monique Furlan, Gonçalo Amarante Guimarães Pereira & Gleidson Silva Teixeira. (2022) Genetic mapping of a bioethanol yeast strain reveals new targets for hydroxymethylfurfural- and thermotolerance. Microbiological Research 263, pages 127138.
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Jeremy Thorner. (2022) TOR complex 2 is a master regulator of plasma membrane homeostasis. Biochemical Journal 479:18, pages 1917-1940.
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Elena Jiménez-Gutiérrez, Teresa Fernández-Acero, Esmeralda Alonso-Rodríguez, María Molina & Humberto Martín. (2022) Neomycin Interferes with Phosphatidylinositol-4,5-Bisphosphate at the Yeast Plasma Membrane and Activates the Cell Wall Integrity Pathway. International Journal of Molecular Sciences 23:19, pages 11034.
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Wataru Nomura, Su-Ping Ng, Terunao Takahara, Tatsuya Maeda, Teruo Kawada, Tsuyoshi Goto & Yoshiharu Inoue. (2022) Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae . Journal of Cell Science 135:17.
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Ken‐taro Sakata, Keisuke Hashii, Koushiro Yoshizawa, Yuhei O. Tahara, Kaori Yae, Ryohei Tsuda, Naotaka Tanaka, Tatsuya Maeda, Makoto Miyata & Mitsuaki Tabuchi. (2022) Coordinated regulation of TORC2 signaling by MCC /eisosome‐associated proteins, Pil1 and tetraspan membrane proteins during the stress response . Molecular Microbiology 117:5, pages 1227-1244.
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Peng An, Wenyi Xu, Junjie Luo & Yongting Luo. (2021) Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections. Frontiers in Cell and Developmental Biology 9.
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Wataru Nomura, Ryota Futamata & Yoshiharu Inoue. (2021) Role of RhoGAP Rgd1 in Pkc1 signaling-related actin repolarization under heat shock stress in Saccharomyces cerevisiae. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:5, pages 129853.
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Wenxiang Fu & Michael N. Hall. (2020) Regulation of mTORC2 Signaling. Genes 11:9, pages 1045.
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Wataru Nomura, Miho Aoki & Yoshiharu Inoue. (2020) Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae. Scientific Reports 10:1.
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Min-Gi Shin, Jae-Woong Lee, Jun-Seok HanBora LeeJin-Hyuck JeongSo-Hyun ParkJong-Hwan Kim, Sumi JangMooncheol Park, Seon-Young KimSeokho Kim, Yong Ryoul YangJeong-Yoon Kim, Kwang-Lae Hoe, Chankyu ParkKwang-Pyo Lee, Ki-Sun KwonEun-Soo Kwon. (2020) Bacteria-derived metabolite, methylglyoxal, modulates the longevity of C. elegans through TORC2/SGK-1/DAF-16 signaling . Proceedings of the National Academy of Sciences 117:29, pages 17142-17150.
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Margot Riggi, Beata Kusmider & Robbie Loewith. (2020) The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance. Journal of Cell Science 133:9.
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João Henrique T.M. Fabri, Marina C. Rocha & Iran Malavazi. (2020) Overview of the Interplay Between Cell Wall Integrity Signaling Pathways and Membrane Lipid Biosynthesis in Fungi: Perspectives for Aspergillus fumigatus . Current Protein & Peptide Science 21:3, pages 265-283.
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Elena Jiménez-Gutiérrez, Estíbaliz Alegría-Carrasco, Ángela Sellers-Moya, María Molina & Humberto Martín. (2019) Not just the wall: the other ways to turn the yeast CWI pathway on. International Microbiology 23:1, pages 107-119.
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Yukari Yabuki, Atsuko Ikeda, Misako Araki, Kentaro Kajiwara, Keiko Mizuta & Kouichi Funato. (2019) Sphingolipid/Pkh1/2-TORC1/Sch9 Signaling Regulates Ribosome Biogenesis in Tunicamycin-Induced Stress Response in Yeast. Genetics 212:1, pages 175-186.
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Christian Q. Scheckhuber. (2019) Studying the mechanisms and targets of glycation and advanced glycation end-products in simple eukaryotic model systems. International Journal of Biological Macromolecules 127, pages 85-94.
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Kristin L. Leskoske, Françoise M. Roelants, Anita Emmerstorfer-Augustin, Christoph M. Augustin, Edward P. Si, Jennifer M. Hill & Jeremy Thorner. (2018) Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2. Genes & Development 32:23-24, pages 1576-1590.
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Wataru Nomura, Miho Aoki & Yoshiharu Inoue. (2018) Toxicity of dihydroxyacetone is exerted through the formation of methylglyoxal in Saccharomyces cerevisiae : effects on actin polarity and nuclear division . Biochemical Journal 475:16, pages 2637-2652.
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Seiya Tanaka & Motohiro Tani. (2018) Mannosylinositol phosphorylceramides and ergosterol coodinately maintain cell wall integrity in the yeast Saccharomyces cerevisiae . The FEBS Journal 285:13, pages 2405-2427.
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Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, Andrea Perrelli, Martina Daga, Stefania Pizzimenti, Giuseppina Barrera, Paola Cassoni, Adriano Angelucci, Lorenza Trabalzini, Vincenzo Nicola Talesa, Luca Goitre & Saverio Francesco Retta. (2018) KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease. Free Radical Biology and Medicine 115, pages 202-218.
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Rahul Jandial, Josh Neman, Punnajit Lim, Daniel Tamae, Claudia Kowolik, Gerald Wuenschell, Sarah Shuck, Alexandra Ciminera, Luis De Jesus, Ching Ouyang, Mike Chen & John Termini. (2018) Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models. International Journal of Molecular Sciences 19:2, pages 406.
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Yoshiharu Inoue & Wataru Nomura. 2018. The Yeast Role in Medical Applications. The Yeast Role in Medical Applications.
Sena Homoto & Shingo Izawa. (2018) Persistent actin depolarization caused by ethanol induces the formation of multiple small cortical septin rings in yeast. Journal of Cell Science.
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Jürgen J Heinisch & Rosaura Rodicio. (2017) Protein kinase C in fungi—more than just cell wall integrity. FEMS Microbiology Reviews 42:1.
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Françoise Roelants, Kristin Leskoske, Maria Nieves Martinez Marshall, Melissa Locke & Jeremy Thorner. (2017) The TORC2‐Dependent Signaling Network in the Yeast Saccharomyces cerevisiae. Biomolecules 7:4, pages 66.
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Kristin L Leskoske, Françoise M Roelants, Maria Nieves Martinez Marshall, Jennifer M Hill & Jeremy Thorner. (2017) The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites. Genetics 207:1, pages 179-195.
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Wataru Nomura, Kazuhiro Maeta & Yoshiharu Inoue. (2017) Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade in Saccharomyces cerevisiae. Journal of Biological Chemistry 292:36, pages 15039-15048.
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Prabuddha Dey, Wen-Min Su, Gil-Soo Han & George M. Carman. (2017) Phosphorylation of lipid metabolic enzymes by yeast protein kinase C requires phosphatidylserine and diacylglycerol. Journal of Lipid Research 58:4, pages 742-751.
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Ahmad Merhi, Paul Delrée & Anna Maria Marini. (2017) The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling. Scientific Reports 7:1.
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Wataru Nomura, Yusuke Ito & Yoshiharu Inoue. (2017) Role of phosphatidylserine in the activation of Rho1-related Pkc1 signaling in Saccharomyces cerevisiae. Cellular Signalling 31, pages 146-153.
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Riko Hatakeyama, Keiko Kono & Satoshi Yoshida. (2017) Ypk1/Ypk2 kinases maintain Rho1 at the plasma membrane by flippase-dependent lipid remodelling after membrane stresses. Journal of Cell Science.
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Christl Gaubitz, Manoel Prouteau, Beata Kusmider & Robbie Loewith. (2016) TORC2 Structure and Function. Trends in Biochemical Sciences 41:6, pages 532-545.
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Wataru NOMURA & Yoshiharu INOUE. (2016) Activation of TOR Signaling by Metabolic Stress. Kagaku To Seibutsu KAGAKU TO SEIBUTSU 54:4, pages 273-280.
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Gang Leng & Kiwon Song. (2016) Direct interaction of Ste11 and Mkk1/2 through Nst1 integrates high-osmolarity glycerol and pheromone pathways to the cell wall integrity MAPK pathway. FEBS Letters 590:1, pages 148-160.
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Zoulfia Darieva, Aaron Webber, Stacey Warwood & Andrew D Sharrocks. (2015) Protein kinase C coordinates histone H3 phosphorylation and acetylation. eLife 4.
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