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Molecular and Cellular Biology Volume 30, 2010 - Issue 17
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Article

The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA

Dong Hyun Kim1 Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas78245
,
Varija N. Budhavarapu1 Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas78245
,
Carlos R. Herrera1 Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas78245
,
Hyung Wook Nam2 Department of Biochemistry and Protein Network Research Center, Yonsei University, Seoul120-749, South Korea
,
Yu Sam Kim2 Department of Biochemistry and Protein Network Research Center, Yonsei University, Seoul120-749, South Korea
&
P. Renee Yew1 Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas78245Correspondence[email protected]
Pages 4120-4133 | Received 20 Aug 2009, Accepted 25 Jun 2010, Published online: 20 Mar 2023

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Yasushi Shiomi, Akiyo Hayashi, Takashi Ishii, Kaori Shinmyozu, Jun-ichi Nakayama, Kaoru Sugasawa & Hideo Nishitani. (2012) Two Different Replication Factor C Proteins, Ctf18 and RFC1, Separately Control PCNA-CRL4Cdt2-Mediated Cdt1 Proteolysis during S Phase and following UV Irradiation. Molecular and Cellular Biology 32:12, pages 2279-2288.
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Etsuko Shibata, Tarek Abbas, Xinhua Huang, James A. Wohlschlegel & Anindya Dutta. (2011) Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4Cdt2 Ubiquitin Ligase Complex . Molecular and Cellular Biology 31:15, pages 3136-3145.
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Tarek Abbas & Anindya Dutta. (2011) CRL4Cdt2. Cell Cycle 10:2, pages 241-249.
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Articles from other publishers (28)

Garima Singh, Sonika Kumari Sharma & Samarendra Kumar Singh. (2022) miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells. BMC Cancer 22:1.
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Muadz Ahmad Mazian, Kumpei Yamanishi, Mohd Zulhilmi Abdul Rahman, Menega Ganasen & Hideo Nishitani. (2022) CRL4Cdt2 Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA. Genes 13:2, pages 266.
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Xiaojun Wu, Min Yu, Zhuxia Zhang, Feng Leng, Yue Ma, Ni Xie & Fei Lu. (2021) DDB2 regulates DNA replication through PCNA-independent degradation of CDT2. Cell & Bioscience 11:1.
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Hui Zhang. (2021) Regulation of DNA Replication Licensing and Re-Replication by Cdt1. International Journal of Molecular Sciences 22:10, pages 5195.
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Jun Ho Ko, Mi Young Son, Qing Zhou, Lucia Molnarova, Lambert Song, Jarmila Mlcouskova, Atis Jekabsons, Cristina Montagna, Lumir Krejci & Paul Hasty. (2020) TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A. Cell Reports 33:12, pages 108543.
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Sang-Min Jang, Christophe E. Redon, Bhushan L. Thakur, Meriam K. Bahta & Mirit I. Aladjem. (2020) Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases. Experimental & Molecular Medicine 52:10, pages 1637-1651.
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Jia-Min Zhang, Jin-Xin Zheng, Yue-He Ding, Xiao-Ran Zhang, Fang Suo, Jing-Yi Ren, Meng-Qiu Dong & Li-Lin Du. (2020) CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation. PLOS Genetics 16:7, pages e1008933.
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Sabrina Florencia Mansilla, María Belén De La Vega, Nicolás Luis Calzetta, Sebastián Omar Siri & Vanesa Gottifredi. (2020) CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication. Genes 11:6, pages 593.
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Andreas Panagopoulos, Stavros Taraviras, Hideo Nishitani & Zoi Lygerou. (2020) CRL4Cdt2: Coupling Genome Stability to Ubiquitination. Trends in Cell Biology 30:4, pages 290-302.
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Yuan Xue, Terence C Theisen, Suchita Rastogi, Abel Ferrel, Stephen R Quake & John C Boothroyd. (2020) A single-parasite transcriptional atlas of Toxoplasma Gondii reveals novel control of antigen expression. eLife 9.
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Akiyo Hayashi, Nickolaos Nikiforos Giakoumakis, Tatjana Heidebrecht, Takashi Ishii, Andreas Panagopoulos, Christophe Caillat, Michiyo Takahara, Richard G Hibbert, Naohiro Suenaga, Magda Stadnik-Spiewak, Tatsuro Takahashi, Yasushi Shiomi, Stavros Taraviras, Eleonore von Castelmur, Zoi Lygerou, Anastassis Perrakis & Hideo Nishitani. (2018) Direct binding of Cdt2 to PCNA is important for targeting the CRL4 Cdt2 E3 ligase activity to Cdt1 . Life Science Alliance 1:6, pages e201800238.
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Feng Leng, Lovely Saxena, Nam Hoang, Chunxiao Zhang, Logan Lee, Wenjing Li, Xiaoshan Gong, Fei Lu, Hong Sun & Hui Zhang. (2018) Proliferating cell nuclear antigen interacts with the CRL4 ubiquitin ligase subunit CDT2 in DNA synthesis–induced degradation of CDT1. Journal of Biological Chemistry 293:49, pages 18879-18889.
Crossref
Kohei Nukina, Akiyo Hayashi, Yasushi Shiomi, Kaoru Sugasawa, Motoaki Ohtsubo & Hideo Nishitani. (2018) Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4 Cdt2 for PCNA and its ubiquitination activity in S phase . Genes to Cells 23:3, pages 200-213.
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Katherine N. Choe & George-Lucian Moldovan. (2017) Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork. Molecular Cell 65:3, pages 380-392.
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Christina I. Swanson, Joy H. Meserve, Patrick C. McCarter, Alexis Thieme, Tony Mathew, Timothy C. Elston & Robert J. Duronio. (2015) Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication. Development.
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Etsuko Shibata, Ashraf Dar & Anindya Dutta. (2014) CRL4Cdt2 E3 Ubiquitin Ligase and Proliferating Cell Nuclear Antigen (PCNA) Cooperate to Degrade Thymine DNA Glycosylase in S Phase. Journal of Biological Chemistry 289:33, pages 23056-23064.
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Tamara J. Slenn, Benjamin Morris, Courtney G. Havens, Robert M. FreemanJr.Jr., Tatsuro S. Takahashi & Johannes C. Walter. (2014) Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate. Journal of Biological Chemistry 289:33, pages 23043-23055.
Crossref
Linda Clijsters & Rob Wolthuis. (2014) PIP-box mediated degradation prohibits re-accumulation of Cdc6 during S phase. Journal of Cell Science.
Crossref
Xi-Ning Zhu, Dong Hyun Kim, Horng-Ru Lin, Varija N Budhavarapu, Herbert B Rosenbaum, Paul R Mueller & P Renee Yew. (2013) Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation. Cell Division 8:1.
Crossref
Lingchuan Hu, Tae Moon Kim, Mi Young Son, Sung-A Kim, Cory L. Holland, Satoshi Tateishi, Dong Hyun Kim, P. Renee Yew, Cristina Montagna, Lavinia C. Dumitrache & Paul Hasty. (2013) Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes. Nature 501:7468, pages 569-572.
Crossref
Yuan-Hung Lo, Po-Chun Ho & Shao-Chun Wang. (2012) Epidermal Growth Factor Receptor Protects Proliferating Cell Nuclear Antigen from Cullin 4A Protein-mediated Proteolysis. Journal of Biological Chemistry 287:32, pages 27148-27157.
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Courtney G. Havens, Nadia Shobnam, Estrella Guarino, Richard C. Centore, Lee Zou, Stephen E. Kearsey & Johannes C. Walter. (2012) Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2. Journal of Biological Chemistry 287:14, pages 11410-11421.
Crossref
Philipp KaldisHelena E. Richardson. (2012) When cell cycle meets development. Development 139:2, pages 225-230.
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Malavika Raman, Courtney G. Havens, Johannes C. Walter & J. Wade Harper. (2011) A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction. Molecular Cell 44:1, pages 72-84.
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Ann L. Kirchmaier. (2011) Ub-family modifications at the replication fork: Regulating PCNA-interacting components. FEBS Letters 585:18, pages 2920-2928.
Crossref
Courtney G. Havens & Johannes C. Walter. (2011) Mechanism of CRL4 Cdt2 , a PCNA-dependent E3 ubiquitin ligase . Genes & Development 25:15, pages 1568-1582.
Crossref
Estrella Guarino, Marianne E. A. Shepherd, Israel Salguero, Hui Hua, Rachel S. Deegan & Stephen E. Kearsey. (2011) Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation. Nucleic Acids Research 39:14, pages 5978-5990.
Crossref
Jun-Ho Lee & Hua Lu. (2011) 14-3-3γ Inhibition of MDMX-mediated p21 Turnover Independent of p53. Journal of Biological Chemistry 286:7, pages 5136-5142.
Crossref

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