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Molecular and Cellular Biology Volume 26, 2006 - Issue 24
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Article

Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress

Jaime D. Blais1 Ottawa Health Research Institute, 501 Smyth Rd., Ottawa, OntarioK1H 8L6, Canada;2 Department of Biochemistry, University of Ottawa, Ottawa, Ontario, Canada
,
Christina L. Addison1 Ottawa Health Research Institute, 501 Smyth Rd., Ottawa, OntarioK1H 8L6, Canada
,
Robert Edge1 Ottawa Health Research Institute, 501 Smyth Rd., Ottawa, OntarioK1H 8L6, Canada;2 Department of Biochemistry, University of Ottawa, Ottawa, Ontario, Canada
,
Theresa Falls1 Ottawa Health Research Institute, 501 Smyth Rd., Ottawa, OntarioK1H 8L6, Canada
,
Huijun Zhao1 Ottawa Health Research Institute, 501 Smyth Rd., Ottawa, OntarioK1H 8L6, Canada
,
Kishore Wary4 Department of Pharmacology, University of Illinois at Chicago, 835 S. Wolcott, Room E403, Chicago, Illinois60612
,
Costas Koumenis5 Department of Radiation Oncology, University of Pennsylvania School of Medicine, 185 John Morgan Building, 3620 Hamilton Walk, Philadelphia, Pennsylvania19104-6072
,
Heather P. Harding6 Skirball Institute, New York University School of Medicine, New York, New York10016
,
David Ron6 Skirball Institute, New York University School of Medicine, New York, New York10016
,
Martin Holcik3 Apoptosis Research Centre, Children's Hospital of Eastern Ontario, 401 Smyth Rd., Ottawa, OntarioK1H 8L1, Canada
&
John C. Bell1 Ottawa Health Research Institute, 501 Smyth Rd., Ottawa, OntarioK1H 8L6, CanadaCorrespondence[email protected]
 show all
Pages 9517-9532 | Received 26 Jun 2006, Accepted 20 Sep 2006, Published online: 27 Mar 2023

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Jeffrey M. Axten. (2017) Protein kinase R(PKR)–like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015). Expert Opinion on Therapeutic Patents 27:1, pages 37-48.
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Jana Alexandrova, Caroline Paulus, Joëlle Rudinger-Thirion, Fabrice Jossinet & Magali Frugier. (2015) Elaborate uORF/IRES features control expression and localization of human glycyl-tRNA synthetase. RNA Biology 12:12, pages 1301-1313.
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Nizar M. Mhaidat, Karem H. Alzoubi & Ayed Abushbak. (2015) X-box binding protein 1 (XBP-1) enhances colorectal cancer cell invasion. Journal of Chemotherapy 27:3, pages 167-173.
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Anne Cammas, Alexandre Dubrac, Benjamin Morel, Assala Lamaa, Christian Touriol, Marie-Paule Teulade-Fichou, Hervé Prats & Stefania Millevoi. (2015) Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation. RNA Biology 12:3, pages 320-329.
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Olivier Pluquet, Nicolas Dejeans & Eric Chevet. (2014) Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer. Annals of Medicine 46:4, pages 233-243.
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Yan Gao, Daniel J. Sartori, Changhong Li, Qian-Chun Yu, Jake A. Kushner, M. Celeste Simon & J. Alan Diehl. (2012) PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis. Molecular and Cellular Biology 32:24, pages 5129-5139.
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Fabio Martinon. (2012) Targeting endoplasmic reticulum signaling pathways in cancer. Acta Oncologica 51:7, pages 822-830.
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Ekaterina Bobrovnikova-Marjon, Dariusz Pytel, Matthew J. Riese, Laura Pontano Vaites, Nickpreet Singh, Gary A. Koretzky, Eric S. Witze & J. Alan Diehl. (2012) PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation. Molecular and Cellular Biology 32:12, pages 2268-2278.
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Alvaro Avivar-Valderas, Eduardo Salas, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Chandandeep Nagi, Jayanta Debnath & Julio A. Aguirre-Ghiso. (2011) PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment. Molecular and Cellular Biology 31:17, pages 3616-3629.
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Navin R Mahadevan, Antonio Fernandez, Jeffrey J Rodvold, Gonzalo Almanza & Maurizio Zanetti. (2010) Prostate cancer cells undergoing ER stress in vitro and in vivo activate transcription of pro-inflammatory cytokines. Journal of Inflammation Research 3, pages 99-103.
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Donavon C Hiss & Gary A Gabriels. (2009) Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part I: targeting p53, Mdm2, GADD153/CHOP, GRP78/BiP and heat shock proteins. Expert Opinion on Drug Discovery 4:8, pages 799-821.
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Lawrence B. Gardner. (2008) Hypoxic Inhibition of Nonsense-Mediated RNA Decay Regulates Gene Expression and the Integrated Stress Response . Molecular and Cellular Biology 28:11, pages 3729-3741.
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Ola Larsson & Robert Nadon. (2008) Gene Expression – Time to Change Point of View?. Biotechnology and Genetic Engineering Reviews 25:1, pages 77-92.
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