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Molecular and Cellular Biology Volume 27, 2007 - Issue 4
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Article

The Natural Osmolyte Trehalose Is a Positive Regulator of the Heat-Induced Activity of Yeast Heat Shock Transcription Factor

Laura K. ConlinDepartment of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 813A Stellar-Chance, 422 Curie Blvd., Philadelphia, Pennsylvania19104-6059
&
Hillary C. M. NelsonDepartment of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 813A Stellar-Chance, 422 Curie Blvd., Philadelphia, Pennsylvania19104-6059Correspondence[email protected]
Pages 1505-1515 | Received 27 Jun 2006, Accepted 17 Nov 2006, Published online: 27 Mar 2023

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Ivana Sirangelo & Gaetano Irace. (2010) Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose. Expert Opinion on Therapeutic Targets 14:12, pages 1311-1321.
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Zhongpeng Guo, Moying Li, Zitao Guo, Rui Zhu, Yu Xin, Zhenghua Gu & Liang Zhang. (2023) Trehalose metabolism targeting as a novel strategy to modulate acid tolerance of yeasts and its application in food industry. Food Microbiology 114, pages 104300.
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Mario Guadalupe-Daqui, Renee M Goodrich-Schneider, Paul J Sarnoski, John C Carriglio, Charles A Sims, Brian J Pearson & Andrew J MacIntosh. (2023) The effect of CO2 concentration on yeast fermentation: rates, metabolic products, and yeast stress indicators. Journal of Industrial Microbiology and Biotechnology 50:1.
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Noura Sh. A. Hagaggi & Usama M. Abdul-Raouf. (2022) Drought-tolerant Sphingobacterium changzhouense Alv associated with Aloe vera mediates drought tolerance in maize (Zea mays). World Journal of Microbiology and Biotechnology 38:12.
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Kritika Kumari, Khuraijam Surjalal Singh, Kuldeep Singh, Radhika Bakhshi & Laishram Rajendrakumar Singh. (2022) TMAO to the rescue of pathogenic protein variants. Biochimica et Biophysica Acta (BBA) - General Subjects 1866:11, pages 130214.
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Han Gao, Jin-Song Gong, Chang Su, Heng Li, Zheng-Hong Xu & Jin-Song Shi. (2022) Characterization, heterologous expression and engineering of trehalase for biotechnological applications. Systems Microbiology and Biomanufacturing 2:3, pages 445-460.
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Juntao Zhang, Yaozhi Huang, Wei Liu, Lvqin Xie, Benmei Wei, Chengzhi Xu, Yuling Xu, Mingming Zheng & Haibo Wang. (2022) Improvement of collagen self-assembly and thermal stability in the presence of trehalose. New Journal of Chemistry 46:19, pages 9264-9271.
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Meriam Bouri, Samina Mehnaz & Fikrettin Şahin. 2022. Secondary Metabolites and Volatiles of PGPR in Plant-Growth Promotion. Secondary Metabolites and Volatiles of PGPR in Plant-Growth Promotion 249 276 .
Brian D Alford, Eduardo Tassoni-Tsuchida, Danish Khan, Jeremy J Work, Gregory Valiant & Onn Brandman. (2021) ReporterSeq reveals genome-wide dynamic modulators of the heat shock response across diverse stressors. eLife 10.
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Ajay Shankar, Anjali Singh, Shivani Chaudhary & Vishal Prasad. 2021. Agricultural Water Management. Agricultural Water Management 81 100 .
Li Shen, Yu-Ting Wang, Xing-Xing Tang, Ke Zhang, Pin-Mei Wang, Yang Sui & Dao-Qiong Zheng. (2020) Heat shock drives genomic instability and phenotypic variations in yeast. AMB Express 10:1.
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Joshua Eardley & David J. Timson. (2020) Yeast Cellular Stress: Impacts on Bioethanol Production. Fermentation 6:4, pages 109.
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Sara Norouzi, Nazanin Hajati Birgani, Parvaneh Maghami & Shohreh Ariaeenejad. (2020) Improvement of PersiXyn2 activity and stability in presence of Trehalose and proline as a natural osmolyte. International Journal of Biological Macromolecules 163, pages 348-357.
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Xiao Li, Han Ye, Chao-Qun Xu, Xiang-ling Shen, Xiao-Long Zhang, Cong Huang, Ben Cheng, Ya-Li Tan, Ze-Tao Xiao, Yu-Peng Pei & Kun Zou. (2020) Transcriptomic analysis reveals MAPK signaling pathways affect the autolysis in baker's yeast. FEMS Yeast Research 20:5.
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Varvara Yu Sekova, Daria I. Dergacheva, Elena P. Isakova, Natalya N. Gessler, Vera M. Tereshina & Yulia I. Deryabina. (2019) Soluble Sugar and Lipid Readjustments in the Yarrowia lipolytica Yeast at Various Temperatures and pH. Metabolites 9:12, pages 307.
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Moritz Mühlhofer, Evi Berchtold, Chris G. Stratil, Gergely Csaba, Elena Kunold, Nina C. Bach, Stephan A. Sieber, Martin Haslbeck, Ralf Zimmer & Johannes Buchner. (2019) The Heat Shock Response in Yeast Maintains Protein Homeostasis by Chaperoning and Replenishing Proteins. Cell Reports 29:13, pages 4593-4607.e8.
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Arnab Bandyopadhyay, Indrani Bose & Krishnananda Chattopadhyay. (2019) Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae. PLOS ONE 14:9, pages e0222723.
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Carina Sá, Paulo Cardoso & Etelvina Figueira. (2019) Alginate as a feature of osmotolerance differentiation among soil bacteria isolated from wild legumes growing in Portugal. Science of The Total Environment 681, pages 312-319.
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Jordan T. Bird, Eric D. Tague, Laura Zinke, Jenna M. Schmidt, Andrew D. Steen, Brandi Reese, Ian P. G. Marshall, Gordon Webster, Andrew Weightman, Hector F. Castro, Shawn R. Campagna & Karen G. Lloyd. (2019) Uncultured Microbial Phyla Suggest Mechanisms for Multi-Thousand-Year Subsistence in Baltic Sea Sediments. mBio 10:2.
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Luuk Mestrom, Stefan R. Marsden, Marit Dieters, Puck Achterberg, Lysanne Stolk, Isabel Bento, Ulf Hanefeld & Peter-Leon Hagedoorn. (2019) Artificial Fusion of mCherry Enhances Trehalose Transferase Solubility and Stability. Applied and Environmental Microbiology 85:8.
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Xiu-ming LIU, Xiang-li WU, Wei GAO, Ji-bin QU, Qiang CHEN, Chen-yang HUANG & Jin-xia ZHANG. (2019) Protective roles of trehalose in Pleurotus pulmonarius during heat stress response. Journal of Integrative Agriculture 18:2, pages 428-437.
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Ratnika Sethi, Shantanu S Iyer, Eshita Das & Ipsita Roy. (2018) Discrete roles of trehalose and Hsp104 in inhibition of protein aggregation in yeast cells. FEMS Yeast Research 18:6.
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Tingting Liu, Liying Zhu, Zhiping Zhang, He Huang, Zhidong Zhang & Ling Jiang. (2017) Protective role of trehalose during radiation and heavy metal stress in Aureobasidium subglaciale F134. Scientific Reports 7:1.
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Qian Wu, Liying Zhu, Qing Xu, He Huang, Ling Jiang & Shang-Tian Yang. (2017) Tailoring the Oxidative Stress Tolerance of Clostridium tyrobutyricum CCTCC W428 by Introducing Trehalose Biosynthetic Capability . Journal of Agricultural and Food Chemistry 65:40, pages 8892-8901.
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Arthit Thani, Pattana Laopaiboon & Lakkana Laopaiboon. (2017) Improvement of a continuous ethanol fermentation from sweet sorghum stem juice using a cell recycling system. Journal of Biotechnology 251, pages 21-29.
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Natalie Romanov, David Maria Hollenstein, Marion Janschitz, Gustav AmmererDorothea AnratherWolfgang Reiter. (2017) Identifying protein kinase–specific effectors of the osmostress response in yeast. Science Signaling 10:469.
Crossref
Anusha R. Pallapati, Eshita Das & Ipsita Roy. 2017. Cellular Osmolytes. Cellular Osmolytes 55 75 .
Esther Ngumbi & Joseph Kloepper. (2016) Bacterial-mediated drought tolerance: Current and future prospects. Applied Soil Ecology 105, pages 109-125.
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José Antonio Cervantes-Chávez, Laura Valdés-Santiago, Guus Bakkeren, Edda Hurtado-Santiago, Claudia Geraldine León-Ramírez, Edgardo Ulises Esquivel-Naranjo, Fidel Landeros-Jaime, Yolanda Rodríguez-Aza & José Ruiz-Herrera. (2016) Trehalose is required for stress resistance and virulence of the Basidiomycota plant pathogen Ustilago maydis. Microbiology 162:6, pages 1009-1022.
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Agata Święciło. (2016) Cross-stress resistance in Saccharomyces cerevisiae yeast—new insight into an old phenomenon. Cell Stress and Chaperones 21:2, pages 187-200.
Crossref
Marta Rubio-Texeira, Griet Van Zeebroeck & Johan M. Thevelein. 2016. Biochemistry and Molecular Biology. Biochemistry and Molecular Biology 191 277 .
A Bérard, M Ben Sassi, A Kaisermann & P Renault. (2015) Soil microbial community responses to heat wave components: drought and high temperature. Climate Research 66:3, pages 243-264.
Crossref
Nelly A. Odintsova, Natalya V. Ageenko, Yulia O. Kipryushina, Mariia A. Maiorova & Andrey V. Boroda. (2015) Freezing tolerance of sea urchin embryonic cells: Differentiation commitment and cytoskeletal disturbances in culture. Cryobiology 71:1, pages 54-63.
Crossref
Marjorie Petitjean, Marie-Ange Teste, Jean M. François & Jean-Luc Parrou. (2015) Yeast Tolerance to Various Stresses Relies on the Trehalose-6P Synthase (Tps1) Protein, Not on Trehalose. Journal of Biological Chemistry 290:26, pages 16177-16190.
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Safaa Al-Hamdani, Austen Stoelting & Mustafa Morsy. (2015) Influence of Symbiotic Interaction between Fungus, Virus, and Tomato Plant in Combating Drought Stress. American Journal of Plant Sciences 06:10, pages 1633-1640.
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Sumit Sarkar, Srinivasulu Chigurupati, James Raymick, Dushyant Mann, John F. Bowyer, Tom Schmitt, Richard D. Beger, Joseph P. Hanig, Larry C. Schmued & Merle G. Paule. (2014) Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model. NeuroToxicology 44, pages 250-262.
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Weina Xu, Jinjing Wang & Qi Li. (2014) Microarray studies on lager brewer's yeasts reveal cell status in the process of autolysis. FEMS Yeast Research 14:5, pages 714-728.
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Aliabbas A. Saleh, Uma S. Gune, Rajeev Kumar Chaudhary, Ankit P. Turakhiya & Ipsita Roy. (2014) Roles of Hsp104 and trehalose in solubilisation of mutant huntingtin in heat shocked Saccharomyces cerevisiae cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:4, pages 746-757.
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Nobushige Nakazawa, Yoshiko Obata, Kaori Ito, Makiko Oto, Toshihiko Ito & Keitaro Takahashi. (2014) Mechanism of high trehalose accumulation in a spore clone isolated from Shirakami kodama yeast. The Journal of General and Applied Microbiology 60:4, pages 147-155.
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S. Fischer, S. Procopio & T. Becker. (2013) Self-cloning brewing yeast: a new dimension in beverage production. European Food Research and Technology 237:6, pages 851-863.
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Ling Jiang, Ming Lin, Yang Zhang, Yanping Li, Xian Xu, Shuang Li & He Huang. (2013) Identification and Characterization of a Novel Trehalose Synthase Gene Derived from Saline-Alkali Soil Metagenomes. PLoS ONE 8:10, pages e77437.
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Rohit Ruhal, Rashmi Kataria & Bijan Choudhury. (2013) Trends in bacterial trehalose metabolism and significant nodes of metabolic pathway in the direction of trehalose accumulation. Microbial Biotechnology 6:5, pages 493-502.
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Joke Serneels, Hélène Tournu & Patrick Van Dijck. (2012) Tight Control of Trehalose Content Is Required for Efficient Heat-induced Cell Elongation in Candida albicans. Journal of Biological Chemistry 287:44, pages 36873-36882.
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Jacob Verghese, Jennifer Abrams, Yanyu Wang & Kevin A. Morano. (2012) Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System. Microbiology and Molecular Biology Reviews 76:2, pages 115-158.
Crossref
Jean Marie François, Thomas Walther & Jean Luc Parrou. 2012. Microbial Stress Tolerance for Biofuels. Microbial Stress Tolerance for Biofuels 29 55 .
Beatrix Fahnert. 2012. Recombinant Gene Expression. Recombinant Gene Expression 3 36 .
Chunkeng HU, Qing QIN & Peipei GAO. (2011) Medium Optimization for Improved Ethanol Production in Very High Gravity Fermentation. Chinese Journal of Chemical Engineering 19:6, pages 1017-1022.
Crossref
Carmen-Lisset Flores, Carlos Gancedo & Thomas Petit. (2011) Disruption of Yarrowia lipolytica TPS1 Gene Encoding Trehalose-6-P Synthase Does Not Affect Growth in Glucose but Impairs Growth at High Temperature. PLoS ONE 6:9, pages e23695.
Crossref
Xi-Ming Chen, Ying Jiang, Yuan-Ting Li, Hai-Hong Zhang, Jie Li, Xing Chen, Qi Zhao, Jing Zhao, Jing Si, Zhi-Wei Lin, Hua Zhang, Paul Dyson & Li-Zhe An. (2011) Regulation of expression of trehalose-6-phosphate synthase during cold shock in Arthrobacter strain A3. Extremophiles 15:4, pages 499-508.
Crossref
Jonathan L. Hart, Zachary M. Harris & Stephen M. Testa. (2010) Analyzing and predicting the thermodynamic effects of the metabolite trehalose on nucleic acids. Biopolymers 93:12, pages 1085-1092.
Crossref
Ying Jiang, Xi-Ming Chen, Ya-Jie Liu, Yuan-Ting Li, Hai-Hong Zhang, Paul Dyson, Hong-Mei Sheng & Li-Zhe An. (2010) The catalytic efficiency of trehalose-6-phosphate synthase is effected by the N-loop at low temperatures. Archives of Microbiology 192:11, pages 937-943.
Crossref
Takahiro Seki, Nana Abe-Seki, Takahiro Kikawada, Hideyuki Takahashi, Kazuhiro Yamamoto, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Naoaki Saito & Norio Sakai. (2010) Effect of Trehalose on the Properties of Mutant γPKC, Which Causes Spinocerebellar Ataxia Type 14, in Neuronal Cell Lines and Cultured Purkinje Cells*. Journal of Biological Chemistry 285:43, pages 33252-33264.
Crossref
Mustafa R. Morsy, Jennifer Oswald, Ji He, Yuhong Tang & Marilyn J. Roossinck. (2010) Teasing apart a three-way symbiosis: Transcriptome analyses of Curvularia protuberata in response to viral infection and heat stress. Biochemical and Biophysical Research Communications 401:2, pages 225-230.
Crossref
Yoko Honda, Masashi Tanaka & Shuji Honda. (2010) Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging Cell 9:4, pages 558-569.
Crossref
Siraje Arif Mahmud, Takashi Hirasawa & Hiroshi Shimizu. (2010) Differential importance of trehalose accumulation in Saccharomyces cerevisiae in response to various environmental stresses. Journal of Bioscience and Bioengineering 109:3, pages 262-266.
Crossref
Nora Plesofsky. 2010. Cellular and Molecular Biology of Filamentous Fungi. Cellular and Molecular Biology of Filamentous Fungi 488 497 .
Yue-Qin Tang, Ming-Zhe An, Ya-Ling Zhong, Morimura Shigeru, Xiao-Lei Wu & Kenji Kida. (2010) Continuous ethanol fermentation from non-sulfuric acid-washed molasses using traditional stirred tank reactors and the flocculating yeast strain KF-7. Journal of Bioscience and Bioengineering 109:1, pages 41-46.
Crossref
Olena P. Ishchuk, Andriy Y. Voronovsky, Charles A. Abbas & Andriy A. Sibirny. (2009) Construction of Hansenula polymorpha strains with improved thermotolerance . Biotechnology and Bioengineering 104:5, pages 911-919.
Crossref
LiLi Li, YanRui Ye, Li Pan, Yi Zhu, SuiPing Zheng & Ying Lin. (2009) The induction of trehalose and glycerol in Saccharomyces cerevisiae in response to various stresses. Biochemical and Biophysical Research Communications 387:4, pages 778-783.
Crossref
Yanrui Ye, Yi Zhu, Li Pan, Lili Li, Xiaoning Wang & Ying Lin. (2009) Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways. Biochemical and Biophysical Research Communications 385:3, pages 357-362.
Crossref
Siraje Arif Mahmud, Keisuke Nagahisa, Takashi Hirasawa, Katsunori Yoshikawa, Kengo Ashitani & Hiroshi Shimizu. (2009) Effect of trehalose accumulation on response to saline stress in Saccharomyces cerevisiae . Yeast 26:1, pages 17-30.
Crossref
KiYoung Lee, Han-Yu Chuang, Andreas Beyer, Min-Kyung Sung, Won-Ki Huh, Bonghee Lee & Trey Ideker. (2008) Protein networks markedly improve prediction of subcellular localization in multiple eukaryotic species. Nucleic Acids Research 36:20, pages e136-e136.
Crossref
Curt R. Fischer, Daniel Klein-Marcuschamer & Gregory Stephanopoulos. (2008) Selection and optimization of microbial hosts for biofuels production. Metabolic Engineering 10:6, pages 295-304.
Crossref
Noritaka Yamamoto, Yuka Maeda, Aya Ikeda & Hiroshi Sakurai. (2008) Regulation of Thermotolerance by Stress-Induced Transcription Factors in Saccharomyces cerevisiae . Eukaryotic Cell 7:5, pages 783-790.
Crossref
Jennifer L. Dashnau, Laura K. Conlin, Hillary C.M. Nelson & Jane M. Vanderkooi. (2008) Water structure in vitro and within Saccharomyces cerevisiae yeast cells under conditions of heat shock. Biochimica et Biophysica Acta (BBA) - General Subjects 1780:1, pages 41-50.
Crossref
Katherine A. Smart. (2007) Brewing yeast genomes and genome-wide expression and proteome profiling during fermentation. Yeast 24:11, pages 993-1013.
Crossref
. (2007) Current awareness on yeast. Yeast 24:10, pages 921-928.
Crossref
Brian R. Gibson, Stephen J. Lawrence, Jessica P. R. Leclaire, Chris D. Powell & Katherine A. Smart. (2007) Yeast responses to stresses associated with industrial brewery handling: Figure 1. FEMS Microbiology Reviews 31:5, pages 535-569.
Crossref

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