41
Views
97
CrossRef citations to date
0
Altmetric
Article

The Chaperone-Like Protein HYPK Acts Together with NatA in Cotranslational N-Terminal Acetylation and Prevention of Huntingtin Aggregation

, , , , , , , , & show all
Pages 1898-1909 | Received 03 Sep 2009, Accepted 27 Jan 2010, Published online: 20 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Debasish Kumar Ghosh & Akash Ranjan. (2022) HYPK coordinates degradation of polyneddylated proteins by autophagy. Autophagy 18:8, pages 1763-1784.
Read now

Articles from other publishers (95)

Gholson J. Lyon, Marall Vedaie, Travis Beisheim, Agnes Park, Elaine Marchi, Leah Gottlieb, Tzung-Chien Hsieh, Hannah Klinkhammer, Katherine Sandomirsky, Hanyin Cheng, Lois J. Starr, Isabelle Preddy, Marcellus Tseng, Quan Li, Yu Hu, Kai Wang, Ana Carvalho, Francisco Martinez, Alfonso Caro-Llopis, Maureen Gavin, Karen Amble, Peter Krawitz, Ronen Marmorstein & Ellen Herr-Israel. (2023) Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome. European Journal of Human Genetics.
Crossref
Fariha Kabir, Rachel Atkinson, Anthony L. Cook, Andrew James Phipps & Anna Elizabeth King. (2023) The role of altered protein acetylation in neurodegenerative disease. Frontiers in Aging Neuroscience 14.
Crossref
Federica Donnarumma, Valeria Tucci, Concetta Ambrosino, Lucia Altucci & Vincenzo Carafa. (2022) NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family. Clinical Epigenetics 14:1.
Crossref
Marlena Pożoga, Laura Armbruster & Markus Wirtz. (2022) From Nucleus to Membrane: A Subcellular Map of the N-Acetylation Machinery in Plants. International Journal of Molecular Sciences 23:22, pages 14492.
Crossref
Jonas Weidenhausen, Jürgen Kopp, Carmen Ruger-Herreros, Frank Stein, Per Haberkant, Karine Lapouge & Irmgard Sinning. (2022) Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity. International Journal of Molecular Sciences 23:18, pages 10805.
Crossref
Julia Sindlinger, Stefan Schön, Jürgen Eirich, Sören Kirchgäßner, Iris Finkemeier & Dirk Schwarzer. (2022) Investigating Peptide‐Coenzyme A Conjugates as Chemical Probes for Proteomic Profiling of N‐Terminal and Lysine Acetyltransferases. ChemBioChem 23:17.
Crossref
Sonia Podvin, Sara Brin Rosenthal, William Poon, Enlin Wei, Kathleen M. Fisch & Vivian Hook. (2022) Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease. Journal of Huntington's Disease 11:3, pages 243-267.
Crossref
Ming-Chieh Lin, Chia-Jung Yu & Fang-Jen S. Lee. (2022) Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane. Proceedings of the National Academy of Sciences 119:30.
Crossref
Ze‐Ting Song, Xiao‐Jie Chen, Ling Luo, Feifei Yu, Jian‐Xiang Liu & Jia‐Jia Han. (2022) UBA domain protein SUF1 interacts with NatA‐complex subunit NAA15 to regulate thermotolerance in Arabidopsis . Journal of Integrative Plant Biology 64:7, pages 1297-1302.
Crossref
Pavlína Miklánková, Eric Linster, Jean-Baptiste Boyer, Jonas WeidenhausenJohannes Mueller, Laura Armbruster, Karine LapougeCarolina De La Torre, Willy Bienvenut, Carsten StichtMatthias Mann, Thierry MeinnelIrmgard Sinning, Carmela GiglioneRüdiger Hell & Markus Wirtz. (2022) HYPK promotes the activity of the N α -acetyltransferase A complex to determine proteostasis of nonAc-X 2 /N-degron–containing proteins . Science Advances 8:24.
Crossref
Angelo Cirinelli, Justin Wheelan, Christopher Grieg & Carlos A. Molina. (2022) Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination. Experimental Cell Research 414:1, pages 113083.
Crossref
Xiaodi Gong, Yaqian Huang, Yan Liang, Yundong Yuan, Yuhao Liu, Tongwen Han, Shujia Li, Hengbin Gao, Bo Lv, Xiahe Huang, Eric Linster, Yingchun Wang, Markus Wirtz & Yonghong Wang. (2022) OsHYPK-mediated protein N-terminal acetylation coordinates plant development and abiotic stress responses in rice. Molecular Plant 15:4, pages 740-754.
Crossref
Leah Gottlieb, Lin Guo, James Shorter & Ronen Marmorstein. (2021) N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate. Journal of Biological Chemistry 297:6, pages 101363.
Crossref
Rasmus Ree, Karoline Krogstad, Nina McTiernan, Magnus E. Jakobsson & Thomas Arnesen. (2021) Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells. International Journal of Molecular Sciences 22:21, pages 11805.
Crossref
Petra Van Damme. (2021) Charting the N-Terminal Acetylome: A Comprehensive Map of Human NatA Substrates. International Journal of Molecular Sciences 22:19, pages 10692.
Crossref
Sunbin Deng, Leah Gottlieb, Buyan Pan, Julianna Supplee, Xuepeng Wei, E James Petersson & Ronen Marmorstein. (2021) Molecular mechanism of N-terminal acetylation by the ternary NatC complex. Structure 29:10, pages 1094-1104.e4.
Crossref
Hyae Yon Kweon, Mi-Ni Lee, Max Dorfel, Seungwoon Seo, Leah Gottlieb, Thomas PaPazyan, Nina McTiernan, Rasmus Ree, David Bolton, Andrew Garcia, Michael Flory, Jonathan Crain, Alison Sebold, Scott Lyons, Ahmed Ismail, Elaine Marchi, Seong-keun Sonn, Se-Jin Jeong, Sejin Jeon, Shinyeong Ju, Simon J Conway, Taesoo Kim, Hyun-Seok Kim, Cheolju Lee, Tae-Young Roh, Thomas Arnesen, Ronen Marmorstein, Goo Taeg Oh & Gholson J Lyon. (2021) Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway. eLife 10.
Crossref
Laura Gogoll, Katharina Steindl, Pascal Joset, Markus Zweier, Alessandra Baumer, Christina Gerth‐Kahlert, Boris Tutschek & Anita Rauch. (2021) Confirmation of Ogden syndrome as an X‐linked recessive fatal disorder due to a recurrent NAA10 variant and review of the literature . American Journal of Medical Genetics Part A 185:8, pages 2546-2560.
Crossref
Anass Chiki, Zhidian Zhang, Kolla Rajasekhar, Luciano A. Abriata, Iman Rostami, Lucien F. Krapp, Driss Boudeffa, Matteo Dal Peraro & Hilal A. Lashuel. (2021) Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation. Frontiers in Molecular Biosciences 8.
Crossref
Jonas Weidenhausen, Jürgen Kopp, Laura Armbruster, Markus Wirtz, Karine Lapouge & Irmgard Sinning. (2021) Structural and functional characterization of the N-terminal acetyltransferase Naa50. Structure 29:5, pages 413-425.e5.
Crossref
Tarsha WardWarren TaiSarah Morton, Francis ImpensPetra Van DammeDelphi Van Haver, Evy TimmermanGabriela Venturini, Kehan Zhang, Min Young JangJon A.L. Willcox, Alireza Haghighi, Bruce D. GelbWendy K. Chung, Elizabeth GoldmuntzGeorge A. PorterJrJrRichard P. LiftonMartina BruecknerH. Joseph YostBenoit G. BruneauJoshua GorhamYuri Kim, Alexandre PereiraJason HomsyCraig C. BensonSteven R. DePalma, Sylvia Varland, Christopher S. ChenThomas Arnesen, Kris GevaertChristine Seidman & J.G. Seidman. (2021) Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency. Circulation Research 128:8, pages 1156-1169.
Crossref
Nina McTiernan, Harinder Gill, Carlos E. Prada, Harry Pachajoa, Juliana Lores & Thomas Arnesen. (2020) NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy. European Journal of Human Genetics 29:2, pages 280-288.
Crossref
Sunbin Deng & Ronen Marmorstein. (2021) Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation. Trends in Biochemical Sciences 46:1, pages 15-27.
Crossref
Alyssa Ritter, Justin H. Berger, Matthew Deardorff, Kosuke Izumi, Kimberly Y. Lin, Livija Medne & Rebecca C. Ahrens‐Nicklas. (2020) Variants in NAA15 cause pediatric hypertrophic cardiomyopathy . American Journal of Medical Genetics Part A 185:1, pages 228-233.
Crossref
Ingrid Bader, Nina McTiernan, Christine Darbakk, Eugen Boltshauser, Rasmus Ree, Sabine Ebner, Johannes A. Mayr & Thomas Arnesen. (2020) Severe syndromic ID and skewed X-inactivation in a girl with NAA10 dysfunction and a novel heterozygous de novo NAA10 p.(His16Pro) variant - a case report. BMC Medical Genetics 21:1.
Crossref
Nina McTiernan, Christine Darbakk, Rasmus Ree & Thomas Arnesen. (2020) NAA10 p.(D10G) and NAA10 p.(L11R) Variants Hamper Formation of the NatA N-Terminal Acetyltransferase Complex. International Journal of Molecular Sciences 21:23, pages 8973.
Crossref
Thuy P. Dao & Carlos A. Castañeda. (2020) Ubiquitin‐Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?. BioEssays 42:11, pages 2000036.
Crossref
Chandrasekhar Natarajan, Anthony V. SignoreVikas KumarRoy E. Weber, Angela Fago & Jay F. Storz. (2020) Effect of NH2-terminal acetylation on the oxygenation properties of vertebrate haemoglobin. Biochemical Journal 477:19, pages 3839-3850.
Crossref
Sunbin Deng, Buyan Pan, Leah Gottlieb, E James Petersson & Ronen Marmorstein. (2020) Molecular basis for N-terminal alpha-synuclein acetylation by human NatB. eLife 9.
Crossref
Chandrasekhar Natarajan, Anthony V. Signore, Vikas Kumar & Jay F. Storz. (2020) Synthesis of Recombinant Human Hemoglobin With NH 2 ‐Terminal Acetylation in Escherichia coli . Current Protocols in Protein Science 101:1.
Crossref
Sunbin Deng, Nina McTiernan, Xuepeng Wei, Thomas Arnesen & Ronen Marmorstein. (2020) Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK. Nature Communications 11:1.
Crossref
Nitai P. Bhattacharyya, Srijit Das, Kamalika Roy Choudhury, Swasti Raychaudhuri & Jayeeta Ghose. 2021. Heat Shock Proteins in Human Diseases. Heat Shock Proteins in Human Diseases 249 274 .
Rasmus Ree, Anni Sofie Geithus, Pernille Mathiesen Tørring, Kristina Pilekær Sørensen, Mads Damkjær, Sally Ann Lynch & Thomas Arnesen. (2019) A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephaly. BMC Medical Genetics 20:1.
Crossref
Mercy W. Macharia, Wilfred Y. Z. Tan, Prem P. Das, Naweed I. Naqvi & Sek-Man Wong. (2019) Proximity-dependent biotinylation screening identifies NbHYPK as a novel interacting partner of ATG8 in plants. BMC Plant Biology 19:1.
Crossref
Chen-Cheng Lee, Yi-Chun Shih, Ming-Lun Kang, Yi-Cheng Chang, Lee-Ming Chuang, Ramanan Devaraj & Li-Jung Juan. (2019) Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α. Molecular Cell 76:3, pages 500-515.e8.
Crossref
Hanyin Cheng, Leah Gottlieb, Elaine Marchi, Robert Kleyner, Puja Bhardwaj, Alan F Rope, Sarah Rosenheck, Sébastien Moutton, Christophe Philippe, Wafaa Eyaid, Fowzan S Alkuraya, Janet Toribio, Rafael Mena, Carlos E Prada, Holly Stessman, Raphael Bernier, Marieke Wermuth, Birgit Kauffmann, Bettina Blaumeiser, R Frank Kooy, Diana Baralle, Grazia M S Mancini, Simon J Conway, Fan Xia, Zhao Chen, Linyan Meng, Ljubisa Mihajlovic, Ronen Marmorstein & Gholson J Lyon. (2019) Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. Human Molecular Genetics 28:17, pages 2900-2919.
Crossref
Sunbin Deng, Robert S. Magin, Xuepeng Wei, Buyan Pan, E. James Petersson & Ronen Marmorstein. (2019) Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex. Structure 27:7, pages 1057-1070.e4.
Crossref
Henriette Aksnes, Rasmus Ree & Thomas Arnesen. (2019) Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases. Molecular Cell 73:6, pages 1097-1114.
Crossref
Sylvia Varland & Thomas Arnesen. (2018) Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae. BMC Research Notes 11:1.
Crossref
Debasish Kumar Ghosh, Abhishek Kumar & Akash Ranjan. (2018) Metastable states of HYPK-UBA domain's seeds drive the dynamics of its own aggregation. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:12, pages 2846-2861.
Crossref
Chris Nevitt, John G. Tooley & Christine E. Schaner Tooley. (2018) N-terminal acetylation and methylation differentially affect the function of MYL9. Biochemical Journal 475:20, pages 3201-3219.
Crossref
Jun Zheng, Lichun Sun, Wumei Yuan, Jiang Xu, Xinle Yu, Fazhan Wang, Lisha Sun & Yan Zeng. (2018) Clinical value of Naa10p and CEA levels in saliva and serum for diagnosis of oral squamous cell carcinoma . Journal of Oral Pathology & Medicine 47:9, pages 830-835.
Crossref
Hongyu Chen, Shuqin Li, Lu Li, Weiying Wu, Xiaolong Ke, Wenxuan Zou & Jie Zhao. (2018) Nα-Acetyltransferases 10 and 15 are Required for the Correct Initiation of Endosperm Cellularization in Arabidopsis. Plant and Cell Physiology 59:10, pages 2113-2128.
Crossref
Eric Linster & Markus Wirtz. (2018) N-terminal acetylation: an essential protein modification emerges as an important regulator of stress responses. Journal of Experimental Botany 69:19, pages 4555-4568.
Crossref
Rasmus Ree, Sylvia Varland & Thomas Arnesen. (2018) Spotlight on protein N-terminal acetylation. Experimental & Molecular Medicine 50:7, pages 1-13.
Crossref
Danbi Lee, Myoung-Kuk Jang, Ji Hae Seo, Soo Hyung Ryu, Jeong A. Kim & Young-Hwa Chung. (2018) ARD1/NAA10 in hepatocellular carcinoma: pathways and clinical implications. Experimental & Molecular Medicine 50:7, pages 1-12.
Crossref
Tam Thuy Lu Vo, Chul-Ho Jeong, Sooyeun Lee, Kyu-Won Kim, Eunyoung Ha & Ji Hae Seo. (2018) Versatility of ARD1/NAA10-mediated protein lysine acetylation. Experimental & Molecular Medicine 50:7, pages 1-13.
Crossref
Kha The Nguyen, Sang-Hyeon Mun, Chang-Seok Lee & Cheol-Sang Hwang. (2018) Control of protein degradation by N-terminal acetylation and the N-end rule pathway. Experimental & Molecular Medicine 50:7, pages 1-8.
Crossref
Leah Gottlieb & Ronen Marmorstein. (2018) Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. Structure 26:7, pages 925-935.e8.
Crossref
Hanyin Cheng, Avinash V. Dharmadhikari, Sylvia Varland, Ning Ma, Deepti Domingo, Robert Kleyner, Alan F. Rope, Margaret Yoon, Asbjørg Stray-Pedersen, Jennifer E. Posey, Sarah R. Crews, Mohammad K. Eldomery, Zeynep Coban Akdemir, Andrea M. Lewis, Vernon R. Sutton, Jill A. Rosenfeld, Erin Conboy, Katherine Agre, Fan Xia, Magdalena Walkiewicz, Mauro Longoni, Frances A. High, Marjon A. van Slegtenhorst, Grazia M.S. Mancini, Candice R. Finnila, Arie van Haeringen, Nicolette den Hollander, Claudia Ruivenkamp, Sakkubai Naidu, Sonal Mahida, Elizabeth E. Palmer, Lucinda Murray, Derek Lim, Parul Jayakar, Michael J. Parker, Stefania Giusto, Emanuela Stracuzzi, Corrado Romano, Jennifer S. Beighley, Raphael A. Bernier, Sébastien Küry, Mathilde Nizon, Mark A. Corbett, Marie Shaw, Alison Gardner, Christopher Barnett, Ruth Armstrong, Karin S. Kassahn, Anke Van Dijck, Geert Vandeweyer, Tjitske Kleefstra, Jolanda Schieving, Marjolijn J. Jongmans, Bert B.A. de Vries, Rolph Pfundt, Bronwyn Kerr, Samantha K. Rojas, Kym M. Boycott, Richard Person, Rebecca Willaert, Evan E. Eichler, R. Frank Kooy, Yaping Yang, Joseph C. Wu, James R. Lupski, Thomas Arnesen, Gregory M. Cooper, Wendy K. Chung, Jozef Gecz, Holly A.F. Stessman, Linyan Meng & Gholson J. Lyon. (2018) Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies. The American Journal of Human Genetics 102:5, pages 985-994.
Crossref
Debasish Kumar Ghosh, Ajit Roy & Akash Ranjan. (2018) Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation. Biochemistry 57:13, pages 2009-2023.
Crossref
Debasish Kumar Ghosh, Ajit Roy & Akash Ranjan. (2018) Aggregation-prone Regions in HYPK Help It to Form Sequestration Complex for Toxic Protein Aggregates. Journal of Molecular Biology 430:7, pages 963-986.
Crossref
Surbhi Sharma, Richard J. Young, Jingchun Chen, Xiangning Chen, Edwin C. Oh & Martin R. Schiller. (2018) Minimotifs dysfunction is pervasive in neurodegenerative disorders. Alzheimer's & Dementia: Translational Research & Clinical Interventions 4:1, pages 414-432.
Crossref
Felix Alexander Weyer, Andrea Gumiero, Karine Lapouge, Gert Bange, Jürgen Kopp & Irmgard Sinning. (2017) Structural basis of HypK regulating N-terminal acetylation by the NatA complex. Nature Communications 8:1.
Crossref
Willy V. Bienvenut, Carmela Giglione & Thierry Meinnel. 2017. Protein Terminal Profiling. Protein Terminal Profiling 17 34 .
Jinmin Gao, Consuelo Barroso, Pan Zhang, Hyun-Min Kim, Shangtong Li, Leticia Labrador, James Lightfoot, Maxim V. Gerashchenko, Vyacheslav M. Labunskyy, Meng-Qiu Dong, Enrique Martinez-Perez & Monica P. Colaiácovo. (2016) N-terminal acetylation promotes synaptonemal complex assembly in C. elegans . Genes & Development 30:21, pages 2404-2416.
Crossref
Adrian Drazic, Line M. Myklebust, Rasmus Ree & Thomas Arnesen. (2016) The world of protein acetylation. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864:10, pages 1372-1401.
Crossref
Henriette Aksnes, Adrian Drazic, Michaël Marie & Thomas Arnesen. (2016) First Things First: Vital Protein Marks by N-Terminal Acetyltransferases. Trends in Biochemical Sciences 41:9, pages 746-760.
Crossref
Deepika Pathak, Aadil Hussain Bhat, Vandana Sapehia, Jagdish Rai & Alka Rao. (2016) Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. Scientific Reports 6:1.
Crossref
Sophie Vieweg, Annalisa Ansaloni, Zhe-Ming Wang, John B. Warner & Hilal A. Lashuel. (2016) An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation. Journal of Biological Chemistry 291:23, pages 12074-12086.
Crossref
Kamalika Roy Choudhury, Sudha Bucha, Shounak Baksi, Debashis Mukhopadhyay & Nitai P. Bhattacharyya. (2016) Chaperone-like protein HYPK and its interacting partners augment autophagy. European Journal of Cell Biology 95:6-7, pages 182-194.
Crossref
Srijit Das & Nitai Pada Bhattacharyya. (2016) Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease. Experimental Cell Research 343:2, pages 107-117.
Crossref
. (2016) N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway. Molecules and Cells 39:3, pages 169-178.
Crossref
Om Singh Rathore, Alexandra Faustino, Pedro Prudêncio, Petra Van Damme, Cymon J. Cox & Rui Gonçalo Martinho. (2016) Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Scientific Reports 6:1.
Crossref
Guylaine Hoffner & Philippe Djian. (2014) Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?. Molecular Neurobiology 52:3, pages 1297-1314.
Crossref
Rasmus Ree, Line M. Myklebust, Puja Thiel, Håvard Foyn, Kari E. Fladmark & Thomas Arnesen. (2015) The N-terminal acetyltransferase Naa10 is essential for zebrafish development. Bioscience Reports 35:5.
Crossref
Max J. Dörfel & Gholson J. Lyon. (2015) The biological functions of Naa10 — From amino-terminal acetylation to human disease. Gene 567:2, pages 103-131.
Crossref
Sylvia Varland, Camilla Osberg & Thomas Arnesen. (2015) N‐terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects. PROTEOMICS 15:14, pages 2385-2401.
Crossref
Line M. Myklebust, Petra Van Damme, Svein I. Støve, Max J. Dörfel, Angèle Abboud, Thomas V. Kalvik, Cedric Grauffel, Veronique Jonckheere, Yiyang Wu, Jeffrey Swensen, Hanna Kaasa, Glen Liszczak, Ronen Marmorstein, Nathalie Reuter, Gholson J. Lyon, Kris Gevaert & Thomas Arnesen. (2015) Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Human Molecular Genetics 24:7, pages 1956-1976.
Crossref
Srinivas Ayyadevara, Meenakshisundaram Balasubramaniam, Yuan Gao, Li‐Rong Yu, Ramani Alla & Robert Shmookler Reis. (2014) Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome‐blocking complexes. Aging Cell 14:1, pages 35-48.
Crossref
Henriette Aksnes, Kristine Hole & Thomas Arnesen. 2015. 267 305 .
John G. Tooley & Christine E. Schaner Tooley. (2014) New roles for old modifications: Emerging roles of N-terminal post-translational modifications in development and disease. Protein Science 23:12, pages 1641-1649.
Crossref
Swasti Raychaudhuri, Rachana Banerjee, Subhasish Mukhopadhyay & Nitai P Bhattacharyya. (2014) Conserved C-terminal nascent peptide binding domain of HYPK facilitates its chaperone-like activity. Journal of Biosciences 39:4, pages 659-672.
Crossref
Taraneh Esmailpour, Hamidreza Riazifar, Linan Liu, Sandra Donkervoort, Vincent H Huang, Shreshtha Madaan, Bassem M Shoucri, Anke Busch, Jie Wu, Alexander Towbin, Robert B Chadwick, Adolfo Sequeira, Marquis P Vawter, Guoli Sun, Jennifer J Johnston, Leslie G Biesecker, Riki Kawaguchi, Hui Sun, Virginia Kimonis & Taosheng Huang. (2014) A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome . Journal of Medical Genetics 51:3, pages 185-196.
Crossref
Hiroshi Sakurai, Maki Sawai, Yukio Ishikawa, Azumi Ota & Ei Kawahara. (2014) Heat shock transcription factor HSF1 regulates the expression of the Huntingtin-interacting protein HYPK. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:3, pages 1181-1187.
Crossref
Srijit Das & Nitai Pada Bhattacharyya. (2014) Transcription Regulation of HYPK by Heat Shock Factor 1. PLoS ONE 9:1, pages e85552.
Crossref
Glen Liszczak, Jacob M Goldberg, Håvard Foyn, E James Petersson, Thomas Arnesen & Ronen Marmorstein. (2013) Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nature Structural & Molecular Biology 20:9, pages 1098-1105.
Crossref
T V Kalvik & T Arnesen. (2012) Protein N-terminal acetyltransferases in cancer. Oncogene 32:3, pages 269-276.
Crossref
Håvard Foyn, Petra Van Damme, Svein I. Støve, Nina Glomnes, Rune Evjenth, Kris Gevaert & Thomas Arnesen. (2013) Protein N-terminal Acetyltransferases Act as N-terminal Propionyltransferases In Vitro and In Vivo. Molecular & Cellular Proteomics 12:1, pages 42-54.
Crossref
Petra Van Damme, Thomas Arnesen, Bart Ruttens & Kris Gevaert. 2013. Protein Acetylation. Protein Acetylation 115 126 .
Kamalika Roy Choudhury, Swasti Raychaudhuri & Nitai P. Bhattacharyya. (2012) Identification of HYPK-Interacting Proteins Reveals Involvement of HYPK in Regulating Cell Growth, Cell Cycle, Unfolded Protein Response and Cell Death. PLoS ONE 7:12, pages e51415.
Crossref
Samer Matta, Kristof Van Kolen, Raquel da Cunha, Geert van den Bogaart, Wim Mandemakers, Katarzyna Miskiewicz, Pieter-Jan De Bock, Vanessa A. Morais, Sven Vilain, Dominik Haddad, Lore Delbroek, Jef Swerts, Lucía Chávez-Gutiérrez, Giovanni Esposito, Guy Daneels, Eric Karran, Matthew Holt, Kris Gevaert, Diederik W. Moechars, Bart De Strooper & Patrik Verstreken. (2012) LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis. Neuron 75:6, pages 1008-1021.
Crossref
María Elena Chánez-Cárdenas & Edgar Vázquez-Contreras. (2012) The Aggregation of Huntingtin and α -Synuclein . Journal of Biophysics 2012, pages 1-14.
Crossref
Kristian K. Starheim, Kris Gevaert & Thomas Arnesen. (2012) Protein N-terminal acetyltransferases: when the start matters. Trends in Biochemical Sciences 37:4, pages 152-161.
Crossref
Meixian Zhou, Fan Zhu, Yirong Li, Hua Zhang & Hui Wu. (2012) Gap1 functions as a molecular chaperone to stabilize its interactive partner Gap3 during biogenesis of serine-rich repeat bacterial adhesin. Molecular Microbiology 83:4, pages 866-878.
Crossref
Kyoji Ohyama, Kunihiko Yasuda, Kazuko Onga, Akira Kakizuka & Nozomu Mori. (2012) Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: Implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Gene Expression Patterns 12:1-2, pages 36-45.
Crossref
Petra Van Damme, Thomas Arnesen & Kris Gevaert. (2011) Protein alpha-N-acetylation studied by N-terminomics. FEBS Journal 278:20, pages 3822-3834.
Crossref
Ewa Szolajska & Jadwiga Chroboczek. (2011) Faithful chaperones. Cellular and Molecular Life Sciences 68:20, pages 3307-3322.
Crossref
Kristine Hole, Petra Van Damme, Monica Dalva, Henriette Aksnes, Nina Glomnes, Jan Erik Varhaug, Johan R. Lillehaug, Kris Gevaert & Thomas Arnesen. (2011) The Human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) Is Conserved from Yeast and N-Terminally Acetylates Histones H2A and H4. PLoS ONE 6:9, pages e24713.
Crossref
Petra Van Damme, Kristine Hole, Ana Pimenta-Marques, Kenny Helsens, Joël Vandekerckhove, Rui G. Martinho, Kris Gevaert & Thomas Arnesen. (2011) NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. PLoS Genetics 7:7, pages e1002169.
Crossref
Jens Staal, Yasmine Driege, Tine Bekaert, Annelies Demeyer, David Muyllaert, Petra Van Damme, Kris Gevaert & Rudi Beyaert. (2011) T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. The EMBO Journal 30:9, pages 1742-1752.
Crossref
Petra Van Damme, Rune Evjenth, Håvard Foyn, Kimberly Demeyer, Pieter-Jan De Bock, Johan R. Lillehaug, Joël Vandekerckhove, Thomas Arnesen & Kris Gevaert. (2011) Proteome-derived Peptide Libraries Allow Detailed Analysis of the Substrate Specificities of Nα-acetyltransferases and Point to hNaa10p as the Post-translational Actin Nα-acetyltransferase. Molecular & Cellular Proteomics 10:5, pages M110.004580.
Crossref
Nikolai Mischerikow & Albert J. R. Heck. (2011) Targeted large-scale analysis of protein acetylation. PROTEOMICS 11:4, pages 571-589.
Crossref
Swasti Raychaudhuri, Kamalika Roy Choudhury, Shreoshi Palchoudhuri, Shradha Chopra, Nitai P. Bhattacharyya & Debashis Mukhopadhyay. (2011) Spectroscopic studies reveal conformational flexibility of intrinsically unstructured protein HYPK. Journal of Biophysical Chemistry 02:04, pages 434-442.
Crossref
Andreas O Helbig, Sara Rosati, Pim WWM Pijnappel, Bas van Breukelen, Marc HTH Timmers, Shabaz Mohammed, Monique Slijper & Albert JR Heck. (2010) Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels. BMC Genomics 11:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.