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Molecular and Cellular Biology Volume 35, 2015 - Issue 9
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Article

Brk/Protein Tyrosine Kinase 6 Phosphorylates p27KIP1, Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4

Priyank Patela School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York, USA
,
Benedikt Asbachb Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany
,
Elina Shteyna School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York, USA
,
Cindy Gomezc Departments of Pediatrics and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA
,
Alexander Coltoffd College of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA
,
Sadia Bhuyanc Departments of Pediatrics and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA
,
Angela L. Tynere Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA
,
Ralf Wagnerb Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany
&
Stacy W. Blainc Departments of Pediatrics and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USACorrespondence[email protected]
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Pages 1506-1522 | Received 30 Sep 2014, Accepted 17 Jan 2015, Published online: 20 Mar 2023

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Katia Coulonval, Vincent Vercruysse, Sabine Paternot, Jaime M. Pita, Robert Corman, Eric Raspé & Pierre P. Roger. (2022) Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27. Cell Cycle 21:1, pages 12-32.
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Sarah E. Nataraj & Stacy W. Blain. (2021) A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity. Cell Cycle 20:8, pages 808-818.
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Jamie O. Brett, Paige E. Herman, Erica L. Mayer, Aditya Bardia & Seth A. Wander. (2022) Mechanisms of Resistance to CDK4/6 Inhibitors in Hormone Receptor-Positive (HR +) Breast Cancer: Spotlight on Convergent CDK6 Upregulation and Immune Signaling. Current Breast Cancer Reports 14:4, pages 222-232.
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Hsuan-Hsiang Peng, Hao-Chin Yang, Darius Rupa, Chun-Han Yen, Ya-Wen Chiu, Wei-Jia Yang, Fuh-Jinn Luo & Ta-Chun Yuan. (2022) ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation. Journal of Cell Communication and Signaling 16:4, pages 567-578.
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Emily K. Moore, Marianne Strazza & Adam Mor. (2022) Combination Approaches to Target PD-1 Signaling in Cancer. Frontiers in Immunology 13.
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Jacob B. Swadling, Tobias Warnecke, Kyle L. Morris & Alexis R. Barr. (2022) Conserved Cdk inhibitors show unique structural responses to tyrosine phosphorylation. Biophysical Journal 121:12, pages 2312-2329.
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Bin Wang, Rui Li, Shuai Wu, Xin Liu, Jianlin Ren, Jing Li, Kaixin Bi, Yanhong Wang & Hongyan Jia. (2021) Breast Cancer Resistance to Cyclin-Dependent Kinases 4/6 Inhibitors: Intricacy of the Molecular Mechanisms. Frontiers in Oncology 11.
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Georgia Gomatou, Ioannis Trontzas, Stephanie Ioannou, Maria Drizou, Nikolaos Syrigos & Elias Kotteas. (2021) Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors. Molecular Biology Reports 48:1, pages 915-925.
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Samuel Hume, Grigory L Dianov & Kristijan Ramadan. (2020) A unified model for the G1/S cell cycle transition. Nucleic Acids Research 48:22, pages 12483-12501.
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Milica B. Gilic & Angela L. Tyner. (2020) Targeting protein tyrosine kinase 6 in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:2, pages 188432.
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Eleanor Wendy Trotter & Iain Michael Hagan. (2020) Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture. Open Biology 10:10.
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Stephen M. Smith. (2020) Molecular biology meets the endocrine pathologist: an appraisal of p27 in thyroid malignancy. Diagnostic Histopathology 26:5, pages 216-223.
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Scott F. Schoninger & Stacy W. Blain. (2020) The Ongoing Search for Biomarkers of CDK4/6 Inhibitor Responsiveness in Breast Cancer. Molecular Cancer Therapeutics 19:1, pages 3-12.
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Charles J. Sherr. (2019) Surprising regulation of cell cycle entry. Science 366:6471, pages 1315-1316.
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Keelan Z. Guiley, Jack W. Stevenson, Kevin Lou, Krister J. BarkovichVishnu KumarasamyTilini U. Wijeratne, Katharine L. Bunch, Sarvind Tripathi, Erik S. KnudsenAgnieszka K. WitkiewiczKevan M. Shokat & Seth M. Rubin. (2019) p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science 366:6471.
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Noelia V. Miret, Carolina A. Pontillo, Lorena V. Zárate, Diana Kleiman de Pisarev, Claudia Cocca & Andrea S. Randi. (2019) Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far. Environmental Research 173, pages 330-341.
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Susan R.S. Gottesman, Jonathan Somma, Vladislav Tsiperson, Lisa Dresner, Usha Govindarajulu, Priyank Patel & Stacy W. Blain. (2019) Tyrosine Phosphorylation of p27Kip1 Correlates with Palbociclib Responsiveness in Breast Cancer Tumor Cells Grown in Explant Culture. Molecular Cancer Research 17:3, pages 669-675.
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Oriol Bachs, Edurne Gallastegui, Serena Orlando, Anna Bigas, José Manuel Morante-Redolat, Joan Serratosa, Isabel Fariñas, Rosa Aligué & Maria Jesús Pujol. (2018) Role of p27Kip1 as a transcriptional regulator. Oncotarget 9:40, pages 26259-26278.
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Priyank Patel, Vladislav Tsiperson, Susan R.S. Gottesman, Jonathan Somma & Stacy W. Blain. (2018) Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells. Molecular Cancer Research 16:3, pages 361-377.
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Matthew InghamGary K. Schwartz. (2017) Cell-Cycle Therapeutics Come of Age. Journal of Clinical Oncology 35:25, pages 2949-2959.
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Cristina Guarducci, Martina Bonechi, Giulia Boccalini, Matteo Benelli, Emanuela Risi, Angelo Di Leo, Luca Malorni & Ilenia Migliaccio. (2017) Mechanisms of Resistance to CDK4/6 Inhibitors in Breast Cancer and Potential Biomarkers of Response. Breast Care 12:5, pages 304-308.
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Alessandro Del Gobbo & Stefano Ferrero. (2017) Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art. Gastroenterology Research and Practice 2017, pages 1-6.
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Raghuveera Kumar Goel & Kiven Erique Lukong. (2015) Tracing the footprints of the breast cancer oncogene BRK — Past till present. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1856:1, pages 39-54.
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