Citations (63)
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Chi-Chun Yang & Hisao Masai. (2023) Claspin is Required for Growth Recovery from Serum Starvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells. Molecular and Cellular Biology 43:1, pages 1-21.
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Mo Chen, Tianmu Wen, Hudson T. Horn, Vishwanatha K. Chandrahas, Narendra Thapa, Suyong Choi, Vincent L. Cryns & Richard A. Anderson. (2020) The nuclear phosphoinositide response to stress. Cell Cycle 19:3, pages 268-289.
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Javier Redondo-Muñoz, Vicente Pérez-García, María J. Rodríguez, José M. Valpuesta & Ana C. Carrera. (2015) Phosphoinositide 3-Kinase Beta Protects Nuclear Envelope Integrity by Controlling RCC1 Localization and Ran Activity. Molecular and Cellular Biology 35:1, pages 249-263.
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Vicente Pérez-García, Javier Redondo-Muñoz, Amit Kumar & Ana C. Carrera. (2014) Cell Activation-Induced Phosphoinositide 3-Kinase Alpha/Beta Dimerization Regulates PTEN Activity. Molecular and Cellular Biology 34:18, pages 3359-3373.
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Ana González-García & Ana C. Carrera. (2012) p85β increases phosphoinositide 3-kinase activity and accelerates tumor progression. Cell Cycle 11:19, pages 3523-3524.
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Alberto M. Martelli, Andrea Ognibene, Francesca Buontempo, Milena Fini, Daniela Bressanin, Kaoru Goto, James A. McCubrey, Lucio Cocco & Camilla Evangelisti. (2011) Nuclear phosphoinositides and their roles in cell biology and disease. Critical Reviews in Biochemistry and Molecular Biology 46:5, pages 436-457.
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Articles from other publishers (57)
Zhihui Yang, Juan Liu, Xuekai Zhu, Feng Yang, Qiang Zhang & Hayat Ali Shah. (2022) FragDPI: a novel drug-protein interaction prediction model based on fragment understanding and unified coding. Frontiers of Computer Science 17:5.
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Michelle Palmieri, Bruno Catimel, Dmitri Mouradov, Anuratha Sakthianandeswaren, Eugene Kapp, Ching-Seng Ang, Nicholas A. Williamson, Cameron J. Nowell, Michael Christie, Jayesh Desai, Peter Gibbs, Antony W. Burgess & Oliver M. Sieber. (2023) PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer. Molecular & Cellular Proteomics 22:4, pages 100529.
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Yanhua Zhang, Baoyu He, Dong Zhang, Yifan Zhang, Chengkun Chen, Wenye Zhang, Shiyi Yang, Meilian Yao, Gaoping Cui, Jun Gu, Ting Wang, Zhang Lin, Youben Fan, Zuquan Xiong & Yujun Hao. (2023) FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression. Cell Reports 42:3, pages 112188.
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Sakshi Gupta, Mukund Kumar, Soumi Chaudhuri & Arun Kumar. (2022) The non‐canonical nuclear functions of key players of the PI3K‐AKT‐MTOR pathway. Journal of Cellular Physiology 237:8, pages 3181-3204.
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Xueliang Gao, Yubao Wang, Caroline F. Ribeiro, Cherubin Manokaran, Hyeyoun Chang, Thanh Von, Silvia Rodrigues, Onur Cizmecioglu, Shidong Jia, Manav Korpal, Joshua M. Korn, Zhigang Wang, Fabienne Schmit, Lan Jiang, Raymond Pagliarini, Yi Yang, Isha Sethi, Sabina Signoretti, Guo-Cheng Yuan, Massimo Loda, Jean J. Zhao & Thomas M. Roberts. (2022) Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. Molecular Cancer Research 20:5, pages 673-685.
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Yujun Hao, Baoyu He, Liping Wu, Yamu Li, Chao Wang, Ting Wang, Longci Sun, Yanhua Zhang, Yangyang Zhan, Yiqing Zhao, Sanford Markowitz, Martina Veigl, Ronald A. Conlon & Zhenghe Wang. (2022) Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer. Nature Communications 13:1.
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Sattrachai Prasopdee, Yodying Yingchutrakul, Sittiruk Roytrakul, Montinee Pholhelm, Teva Phanaksri, Anthicha Kunjantarachot, Jutharat Kulsantiwong, Kritiya Butthongkomvong, Smarn Tesana, Thanakrit Sathavornmanee & Veerachai Thitapakorn. (2021)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta as a potential biomarker for
Opisthorchis viverrini
infection and cholangiocarcinoma
. Parasitology 149:2, pages 171-180.
Crossref
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Andrea Papdiné Morovicz, Fatemeh Mazloumi Gavgani, Rhîan G. Jacobsen, Malene Skuseth Slinning, Diana C. Turcu & Aurélia E. Lewis. (2022) Phosphoinositide 3-kinase signalling in the nucleolus. Advances in Biological Regulation 83, pages 100843.
Crossref
Crossref
Junhao Lin, Chunting Zeng, JiaKang Zhang, Zhenghui Song, Na Qi, Xinhui Liu, Ziyan Zhang, Aimin Li & Fengsheng Chen. (2021) EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop. Molecular Therapy - Nucleic Acids 25, pages 328-341.
Crossref
Crossref
Silvia Arcucci, Fernanda Ramos-Delgado, Coralie Cayron, Nicole Therville, Marie-Pierre Gratacap, Céline Basset, Benoit Thibault & Julie Guillermet-Guibert. (2021) Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent. Biochemical Journal 478:6, pages 1199-1225.
Crossref
Crossref
Fatemeh Mazloumi Gavgani, Thomas Karlsson, Ingvild L. Tangen, Andrea Papdiné Morovicz, Victoria Smith Arnesen, Diana C. Turcu, Sandra Ninzima, Katharina Spang, Camilla Krakstad, Julie Guillermet-Guibert & Aurélia E. Lewis. (2021) Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells. Journal of Cell Science 134:3.
Crossref
Crossref
Caijuan Zhang, Xin Zhang, Yiting Gong, Tong Li, Le Yang, Wenjuan Xu & Ling Dong. (2020) Role of the lncRNA–mRNA network in atherosclerosis using ox-low-density lipoprotein-induced macrophage-derived foam cells. Molecular Omics 16:6, pages 543-553.
Crossref
Crossref
Brittany Aguila, Adina Brett Morris, Raffaella Spina, Eli Bar, Julie Schraner, Robert Vinkler, Jason W. Sohn & Scott M. Welford. (2019) The Ig superfamily protein PTGFRN coordinates survival signaling in glioblastoma multiforme. Cancer Letters 462, pages 33-42.
Crossref
Crossref
Yoshio Kano, Fukumi Hiragami, Hirotoshi Motoda, Junichi Akiyama, Yoshihisa Koike, Yutaka Gomita, Shigeki Inoue, Akihiko Kawaura, Tomohisa Furuta & Kenji Kawamura. (2019) C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene. Scientific Reports 9:1.
Crossref
Crossref
Alessandra Ghigo. (2019) Cell-specific roles of p110β in myocardial ischaemia. Cardiovascular Research 115:8, pages 1264-1265.
Crossref
Crossref
Xueyi Chen, Pavel Zhabyeyev, Abul K Azad, Wang Wang, Rachel A Minerath, Jessica DesAulniers, Chad E Grueter, Allan G Murray, Zamaneh Kassiri, Bart Vanhaesebroeck & Gavin Y Oudit. (2019) Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury. Cardiovascular Research 115:8, pages 1343-1356.
Crossref
Crossref
Rhîan G. Jacobsen, Fatemeh Mazloumi Gavgani, Amanda J. Edson, Marianne Goris, Altanchimeg Altankhuyag & Aurélia E. Lewis. (2019) Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction. Advances in Biological Regulation 72, pages 7-21.
Crossref
Crossref
Paramjeet Singh, Nasima Bano, Md Mehedi Hossain, Rafia Basit & Mohd Jamal Dar. (2018) p110α and p110β isoforms of PI3K are involved in protection against H2O2 induced oxidative stress in cancer cells. Breast Cancer 26:3, pages 378-385.
Crossref
Crossref
Bok Sil Hong, Han Suk Ryu, Namshin Kim, Jisun Kim, Eunshin Lee, Hyunhye Moon, Kyoung Hyoun Kim, Min-Sun Jin, Nam Hoon Kwon, Sunghoon Kim, Donghyun Kim, Doo Hyun Chung, Kyeonghun Jeong, Kwangsoo Kim, Ki Yoon Kim, Han-Byoel Lee, Wonshik Han, Jihui Yun, Jong-Il Kim, Dong-Young Noh & Hyeong-Gon Moon. (2019) Tumor Suppressor miRNA-204-5p Regulates Growth, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer. Cancer Research 79:7, pages 1520-1534.
Crossref
Crossref
Jesús Vallejo-Díaz, Monica Chagoyen, Manuel Olazabal-Morán, Ana González-García & Ana Clara Carrera. (2019) The Opposing Roles of PIK3R1/p85α and PIK3R2/p85β in Cancer. Trends in Cancer 5:4, pages 233-244.
Crossref
Crossref
Anne R Bresnick & Jonathan M Backer. (2019) PI3Kβ—A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling. Endocrinology 160:3, pages 536-555.
Crossref
Crossref
Jamal M. Bryant & Raymond D. Blind. (2019) Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease. Journal of Lipid Research 60:2, pages 299-311.
Crossref
Crossref
Manuel Olazabal-Morán, Ana González-García & Ana C. Carrera. 2020. Lipid Signaling in Human Diseases. Lipid Signaling in Human Diseases
163
181
.
Fatemeh Mazloumi Gavgani, Victoria Smith Arnesen, Rhîan Jacobsen, Camilla Krakstad, Erling Hoivik & Aurélia Lewis. (2018) Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer. International Journal of Molecular Sciences 19:12, pages 3931.
Crossref
Crossref
Kyungeun Kim & Hyoun Wook Lee. (2018) Expression of Phosphoinositide 3-Kinase p110α and p110β Subunits and PIK3CA Mutation in Patients With Advanced Gastric Carcinoma. Applied Immunohistochemistry & Molecular Morphology 26:10, pages 740-748.
Crossref
Crossref
Klaudia Szymonowicz, Sebastian Oeck, Adam Krysztofiak, Jansje van der Linden, George Iliakis & Verena Jendrossek. (2018) Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells. International Journal of Molecular Sciences 19:8, pages 2233.
Crossref
Crossref
Klaudia Szymonowicz, Sebastian Oeck, Nathalie Malewicz & Verena Jendrossek. (2018) New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. Cancers 10:3, pages 78.
Crossref
Crossref
Su Jin Choi & Hye Sun Kim. (2018) Deregulation of Nrf2/ARE signaling pathway causes susceptibility of dystrophin-deficient myotubes to menadione-induced oxidative stress. Experimental Cell Research 364:2, pages 224-233.
Crossref
Crossref
Alice Biosa, Federica Sandrelli, Mariano Beltramini, Elisa Greggio, Luigi Bubacco & Marco Bisaglia. (2017) Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease. Neurobiology of Disease 108, pages 65-72.
Crossref
Crossref
Jing Zhang, Xueliang Gao, Fabienne Schmit, Guillaume Adelmant, Michael J. Eck, Jarrod A. Marto, Jean J. Zhao & Thomas M. Roberts. (2017) CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. Cell Reports 20:3, pages 549-557.
Crossref
Crossref
Stanley Andrisse, Shameka Childress, Yaping Ma, Katelyn Billings, Yi Chen, Ping Xue, Ashley Stewart, Momodou L. Sonko, Andrew Wolfe & Sheng Wu. (2017) Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and
Nuclear Hepatic Androgen Receptor Mechanisms. Endocrinology 158:3, pages 531-544.
Crossref
Crossref
Thomas Karlsson, Camilla Krakstad, Ingvild Løberg Tangen, Erling A. Hoivik, Pamela M. Pollock, Helga B. Salvesen & Aurélia E. Lewis. (2016) Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation. Oncotarget 8:3, pages 3881-3894.
Crossref
Crossref
Shaowen Xiao & Mei Yang. (2016) Discovery of a novel target for cancer: PRR14. Cell Death & Disease 7:12, pages e2502-e2502.
Crossref
Crossref
Paramjeet Singh, Mohd Saleem Dar, Gurjinder Singh, Gayatri Jamwal, Parduman Raj Sharma, Muzamil Ahmad & Mohd Jamal Dar. (2016) Dynamics of GFP-Fusion p110α and p110β Isoforms of PI3K Signaling Pathway in Normal and Cancer Cells. Journal of Cellular Biochemistry 117:12, pages 2864-2874.
Crossref
Crossref
Thomas Karlsson, Altanchimeg Altankhuyag, Olena Dobrovolska, Diana C. Turcu & Aurélia E. Lewis. (2016) A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction. Biochemical Journal 473:14, pages 2033-2047.
Crossref
Crossref
Jie Gao, Xiao-Li Zhou, Rui-Na Kong, Lian-Mei Ji, Ling-Ling He & Dong-Bao Zhao. (2016) microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway. Experimental and Molecular Pathology 100:1, pages 192-198.
Crossref
Crossref
Pradip De, Jennifer H. Carlson, Brian Leyland-Jones & Nandini Dey. 2016. PI3K-mTOR in Cancer and Cancer Therapy. PI3K-mTOR in Cancer and Cancer Therapy
65
108
.
Erin Zekas & Eric R. Prossnitz. (2015) Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer 15:1.
Crossref
Crossref
Julie Guillermet-Guibert, Lee B. Smith, Guillaume Halet, Maria A. Whitehead, Wayne Pearce, Diane Rebourcet, Kelly León, Pascale Crépieux, Gemma Nock, Maria Strömstedt, Malin Enerback, Claude Chelala, Mariona Graupera, John Carroll, Sabina Cosulich, Philippa T. K. Saunders, Ilpo Huhtaniemi & Bart Vanhaesebroeck. (2015) Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells. PLOS Genetics 11:7, pages e1005304.
Crossref
Crossref
Marta Dueñas, Mónica Martínez-Fernández, Ramón García-Escudero, Felipe Villacampa, Miriam Marqués, Cristina Saiz-Ladera, José Duarte, Victor Martínez, Mª José Gómez, Mª Luisa Martín, Manoli Fernández, Daniel Castellano, Francisco X. Real, Jose L. Rodriguez-Peralto, Federico De La Rosa & Jesús M. Paramio. (2015)
PIK3CA
gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors
. Molecular Carcinogenesis 54:7, pages 566-576.
Crossref
Crossref
Suyong Choi, Narendra Thapa, Xiaojun Tan, Andrew C. Hedman & Richard A. Anderson. (2015) PIP kinases define PI4,5P2 signaling specificity by association with effectors. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1851:6, pages 711-723.
Crossref
Crossref
Carlotta Costa, Hiromichi Ebi, Miriam Martini, Sean A. Beausoleil, Anthony C. Faber, Charles T. Jakubik, Alan Huang, Youzhen Wang, Madhuri Nishtala, Ben Hall, Klarisa Rikova, Jean Zhao, Emilio Hirsch, Cyril H. Benes & Jeffrey A. Engelman. (2015) Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer. Cancer Cell 27:1, pages 97-108.
Crossref
Crossref
Yoshihiro Ito, Jonathan R. Hart, Lynn Ueno & Peter K. Vogt. (2014) Oncogenic activity of the regulatory subunit p85β of phosphatidylinositol 3-kinase (PI3K). Proceedings of the National Academy of Sciences 111:47, pages 16826-16829.
Crossref
Crossref
Ariel E. Cariaga-Martínez, Isabel Cortés, Esther García, Vicente Pérez-García, María J. Pajares, Miguel A. Idoate, Javier Redondo-Muñóz, Inés M. Antón & Ana C. Carrera. (2014) Phosphoinositide 3-kinase p85beta regulates invadopodium formation. Biology Open 3:10, pages 924-936.
Crossref
Crossref
Kelly Brooks, Max Ranall, Loredana Spoerri, Alex Stevenson, Gency Gunasingh, Sandra Pavey, Fred Meunier, Thomas J. Gonda & Brian Gabrielli. (2014) Decatenation checkpoint-defective melanomas are dependent on PI3K for survival. Pigment Cell & Melanoma Research 27:5, pages 813-821.
Crossref
Crossref
Amit Kumar, Michele Mazzanti, Martin Mistrik, Martin Kosar, Galina V. Beznoussenko, Alexandre A. Mironov, Massimiliano Garrè, Dario Parazzoli, G.V. Shivashankar, Giorgio Scita, Jiri Bartek & Marco Foiani. (2014) ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress. Cell 158:3, pages 633-646.
Crossref
Crossref
Steve Jean & Amy A. Kiger. (2014) Classes of phosphoinositide 3-kinases at a glance. Journal of Cell Science 127:5, pages 923-928.
Crossref
Crossref
Zahid H. Shah, David R. Jones, Lilly Sommer, Rebecca Foulger, Yvette Bultsma, Clive D'Santos & Nullin Divecha. (2013) Nuclear phosphoinositides and their impact on nuclear functions. FEBS Journal 280:24, pages 6295-6310.
Crossref
Crossref
David Tamborero, Abel Gonzalez-Perez, Christian Perez-Llamas, Jordi Deu-Pons, Cyriac Kandoth, Jüri Reimand, Michael S. Lawrence, Gad Getz, Gary D. Bader, Li Ding & Nuria Lopez-Bigas. (2013) Comprehensive identification of mutational cancer driver genes across 12 tumor types. Scientific Reports 3:1.
Crossref
Crossref
Borja L. Holgado, Laura Martínez-Muñoz, Juan Antonio Sánchez-Alcañiz, Pilar Lucas, Vicente Pérez-García, Gema Pérez, José Miguel Rodríguez-Frade, Marta Nieto, Óscar Marín, Yolanda R. Carrasco, Ana C. Carrera, Manuel Álvarez-Dolado & Mario Mellado. (2013) CXCL12-Mediated Murine Neural Progenitor Cell Movement Requires PI3Kβ Activation. Molecular Neurobiology 48:1, pages 217-231.
Crossref
Crossref
Rachel Schnur Salamon & Jonathan M. Backer. (2013) Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases. BioEssays 35:7, pages 602-611.
Crossref
Crossref
Brent A. McLean, Pavel Zhabyeyev, Edith Pituskin, Ian Paterson, Mark J. Haykowsky & Gavin Y. Oudit. (2013) PI3K Inhibitors as Novel Cancer Therapies: Implications for Cardiovascular Medicine. Journal of Cardiac Failure 19:4, pages 268-282.
Crossref
Crossref
Xiao Wang, Lingdi Wang, Lu Zhu, Yi Pan, Fei Xiao, Weizhong Liu, Zhenzhen Wang, Feifan Guo, Yong Liu, Walter G. Thomas & Yan Chen. (2013) PAQR3 Modulates Insulin Signaling by Shunting Phosphoinositide 3-Kinase p110α to the Golgi Apparatus. Diabetes 62:2, pages 444-456.
Crossref
Crossref
Javier Redondo-Muñoz, María Josefa Rodríguez, Virginia Silió, Vicente Pérez-García, José María Valpuesta & Ana C. Carrera. (2013) Phosphoinositide 3-kinase beta controls replication factor C assembly and function. Nucleic Acids Research 41:2, pages 855-868.
Crossref
Crossref
Mohamed Kodiha & Ursula Stochaj. (2012) Nuclear Transport: A Switch for the Oxidative Stress—Signaling Circuit?. Journal of Signal Transduction 2012, pages 1-18.
Crossref
Crossref
Zhi-wei Ye, Aram Ghalali, Johan Högberg & Ulla Stenius. (2011) Silencing p110β prevents rapid depletion of nuclear pAkt. Biochemical and Biophysical Research Communications 415:4, pages 613-618.
Crossref
Crossref
Oscar Vadas, John E. Burke, Xuxiao ZhangAlex Berndt & Roger L. Williams. (2011) Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases. Science Signaling 4:195.
Crossref
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